Research Article
Year 2022,
Volume: 4 Issue: 4, 356 - 361, 22.10.2022
Abstract
References
- Lee J, Park W, Choi DH, et al. Patient-reported symptoms of radiation dermatitis during breast cancer radiotherapy: a pilot study. Qual Life Res 2017; 26: 1713-9.
- Pires AM, Segreto RA, Segreto HR. RTOG criteria to evaluate acute skin reaction and its risk factors in patients with breast cancer submitted to radiotherapy. Rev Lat Am Enfermagem 2008; 16: 844-9.
- Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006; 354: 567-78.
- Sourati A, Ameri A, Malekzadeh M. Acute side effects of radiation therapy, 1st ed, Chapter 1: Radiation dermatitis. Springer; 2018: 1-13.
- NE Abd Elazim, MS El-Nagga, RH Mohamed, et al.The impact of acute radiodermatitis on quality of life in breast cancer patients receiving conventionally fractionated versus hypofractionated breast irradiation. Int J Dermatol Clin Res 2020; 136: 1-4.
- Park SY, Kim JH, Chang JH, et al. Quantitative evaluation of radiodermatitis following whole-breast radiotherapy with various color space models: A feasibility study. PLoS One 2022; 17: 0264925.
- Kitajima M, Mikami K, Noto Y, et al: Quantitative assessment of radiodermatitis through a non‑invasive objective procedure in patients with breast cancer. Mol Clin Oncol 2020; 12: 89-93.
- Yang X, Ren H, Guo X, et al. Radiation-induced skin injury: pathogenesis, treatment, and management. Aging (Albany NY) 2020; 16; 12: 23379-93.
- Gosselin T, Ginex PK, Backler C, et al. ONS Guidelines™ for Cancer Treatment-Related Radiodermatitis. Oncol Nurs Forum 2020; 47: 654-70.
- Finkelstein S, Kanee L, Behroozian T, et al. Comparison of clinical practice guidelines on radiation dermatitis: a narrative review. Support Care Cancer 2022; 30: 4663- 74.
- Porock D, Kristjanson L, Nicoletti S, et al. Predicting the severity of radiation skin reactions in women with breast cancer. Oncol Nurs Forum 1998; 25: 1019-29.
- Borm KJ, Voppichler J, Düsberg M, et al. FDG/PET-CT-based lymph node atlas in breast cancer patients. Int J Radiat Oncol Biol Phys 2019; 103: 574-82.
- Lee N. Target Volume Delineation for Conformal and Intensity-Modulated Radiation Therapy (Medical Radiology) 2016; Springer. 1st Edition 1-330.
- Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995; 31: 1341-6.
- Malkinson FD, Keane JT. Radiobiology of the skin: review of some effects on epidermis and hair. J Invest Dermatol 1981; 77: 133-8.
- Brown KR, Rzucidlo E. Acute and chronic radiation injury. J Vasc Surg 2011; 53: 1521.
- Müller K, Meineke V. Radiation-induced alterations in cytokine production by skin cells. Exp Hematol 2007; 35: 96-104.
- Hopewell W, Nyman J, Turesson I. Time factor for acute tissue reactions following fractionated irradiation: a balance between repopulation and enhanced radiosensitivity, Int J Radiation Biol 2003; 79: 513-24.
- Mendelsohn FA, Divino CM, Reis ED, et al. Wound care after radiation therapy. Adv Skin Wound Care 2002; 15: 216-24.
- Bernier J, Russi EG, Homey B, et al. Management of radiation dermatitis in patients receiving cetuximab and radiotherapy for locally advanced squamous cell carcinoma of the head and neck: proposals for a revised grading system and consensus management guidelines Ann Oncol 2011; 22: 2191-200.
- Martelletti LBSJ, Aguiar BRL, Vieira LAC, et al. Incidence of acute radiodermatitis in women with breast cancer undergoing hypofractionated radiotherapy. Rev Bras Enferm 2021; 75: e20210118.
- Collen EB, Mayer MN. Acute effects of radiation treatment: skin reactions. Can Vet J 2006; 47: 931-2.
- Frederick DM, Renato GP. Radiobiology and radiation effects. In: Fitzpatrick’s Dermatology in General Medicine. New York, 2008, 7th ed. p858-62.
- Bontempo PSM, Ciol MA, Menêses AG, et al Acute radiodermatitis in cancer patients: incidence and severity estimates. Rev Esc Enferm USP 2021; 55: e03676.
- Gangopadhyay A, Das J, Nath P, Biswas J. Hemoglobin levels may predict toxicities in patients on pelvic chemoradiation for carcinoma of the cervix-experience of a regional cancer center. Ecancermedicalscience 2014; 8: 431.
- Henke M, Bechtold C, Momm F, Guttenberg R. Blood hemoglobin level may affect radiosensitivity-preliminary results on acutely reacting normal tissues. Int J Radiat Oncol Biol Phys 2000; 48: 339-45.
- Mochizuki S, Takano M, Sugano N, et al. The effect of B vitamin supplementation on wound healing in type 2 diabetic mice. J Clin Biochem Nutr 2016; 58: 64-8.
- Debowska R, Vincent C, Kruszewski M, et al. The repair effect of folacin reduces skin damage due to radiotherapy. 15th Congress of the European Academy of Dermatology and Venereology. Rhodes, Greece, October 4-8, 2006.
- Kraus-Tiefenbacher U, Sfintizky A, Welzel G, et al. Factors of influence on acute skin toxicity of breast cancer patients treated with standard three-dimensional conformal radiotherapy (3D-CRT) after breast conserving surgery (BCS). Radiat Oncol 2012; 7: 217.
- Wong G, Lam E, Karam I, et al. The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review. Cancer Treat Res Commun 2020; 24: 100185.
- Salvo N, Barnes E, van Draanen J, et al. Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature. Curr Oncol 2010; 17: 94-112.
- Pollock D. Predicting the severity of radiation skin reactions in women with breast cancer. Edith Cowan University 1988: 1; 5.
- Vieira DS, Reisner ML, Panichella JD, Barbosa IP. Evaluation of acute skin toxicity during radiotherapy for breast cancer in elderly patients. Transl Cancer Res 2020; 9: 8-11.
- Wong JHD, Zaili Z, Abdul Malik R, et al. Evaluation of skin dose and skin toxicity in patients undergoing intraoperative radiotherapy for early breast cancer. J Appl Clin Med Phys 2021; 22: 139-47.
- Bonomo P, Desideri I, Loi M, et al. Elderly patients affected by head and neck squamous cell carcinoma unfit for standard curative treatment: Is de-intensified, hypofractionated radiotherapy a feasible strategy? Oral Oncol 2017; 74: 142-7.
- Kalman NS, Hugo GD, Mahon RN, et al. Diabetes mellitus and radiation induced lung injury after thoracic stereotactic body radiotherapy. Radiother Oncol 2018; 129: 270-6.
- Dong G, Li Y, Zhao Q, Pang B, et al. Effects of diabetes on the development of radiation pneumonitis. Respir Res 2021; 22: 160.
- Kuo HC, Chang PH, Wang CH. Impact of Diabetes Mellitus on Head and Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy. Sci Rep 2020; 10: 7702.
Year 2022,
Volume: 4 Issue: 4, 356 - 361, 22.10.2022
Abstract
Aim: Although prior literature has examined the treatment and patient-associated factors affecting the development and severity of acute radiodermatitis, there are relatively few prospective studies evaluating both. This study was prospectively designed to evaluate factors affecting the development and extent of radiation-induced acute skin toxicity called radiodermatitis (RD).
Material and Method: A total of 63 patients who underwent radiotherapy (RT) in Ankara Atatürk Research and Education Hospital between July 2017 and October 2018 were evaluated. Patients’ demographic status, disease/treatment details, hemoglobin, ferritin, folic acid, Vit B12, and hemoglobin A1c values were recorded. The development and grade of RD were evaluated weekly by the same radiation oncologist using the Radiation Therapy Oncology Group (RTOG) radiation toxicity guideline.
Results: There was no significant relationship between the development of any degree of RD and gender, concomitant chemotherapy (CT), pre-RT CT, comorbid disease, RT technique and blood parameters (Hb, Hba1c, ferritin, folic acid and B12). The development of grade 2-3 RD was significantly affected by the number of operations (p=0.032) and total dose of RT (p=0.008). In patients with grade 2/3 RD, the RT dose at which RD first appeared was 20 Gy (range, 14-36); in patients with grade 1 RD, this value was 32 Gy (range, 16-56) (p=0.018).
Conclusion: There is no significant relationship between the development of acute radiodermatitis and Hba1c, hemoglobin, ferritin, B12 and folic acid levels. There was a significant correlation between grade of RD and repeated surgery, increase in total RT dose and early onset of RD.
Keywords
References
- Lee J, Park W, Choi DH, et al. Patient-reported symptoms of radiation dermatitis during breast cancer radiotherapy: a pilot study. Qual Life Res 2017; 26: 1713-9.
- Pires AM, Segreto RA, Segreto HR. RTOG criteria to evaluate acute skin reaction and its risk factors in patients with breast cancer submitted to radiotherapy. Rev Lat Am Enfermagem 2008; 16: 844-9.
- Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006; 354: 567-78.
- Sourati A, Ameri A, Malekzadeh M. Acute side effects of radiation therapy, 1st ed, Chapter 1: Radiation dermatitis. Springer; 2018: 1-13.
- NE Abd Elazim, MS El-Nagga, RH Mohamed, et al.The impact of acute radiodermatitis on quality of life in breast cancer patients receiving conventionally fractionated versus hypofractionated breast irradiation. Int J Dermatol Clin Res 2020; 136: 1-4.
- Park SY, Kim JH, Chang JH, et al. Quantitative evaluation of radiodermatitis following whole-breast radiotherapy with various color space models: A feasibility study. PLoS One 2022; 17: 0264925.
- Kitajima M, Mikami K, Noto Y, et al: Quantitative assessment of radiodermatitis through a non‑invasive objective procedure in patients with breast cancer. Mol Clin Oncol 2020; 12: 89-93.
- Yang X, Ren H, Guo X, et al. Radiation-induced skin injury: pathogenesis, treatment, and management. Aging (Albany NY) 2020; 16; 12: 23379-93.
- Gosselin T, Ginex PK, Backler C, et al. ONS Guidelines™ for Cancer Treatment-Related Radiodermatitis. Oncol Nurs Forum 2020; 47: 654-70.
- Finkelstein S, Kanee L, Behroozian T, et al. Comparison of clinical practice guidelines on radiation dermatitis: a narrative review. Support Care Cancer 2022; 30: 4663- 74.
- Porock D, Kristjanson L, Nicoletti S, et al. Predicting the severity of radiation skin reactions in women with breast cancer. Oncol Nurs Forum 1998; 25: 1019-29.
- Borm KJ, Voppichler J, Düsberg M, et al. FDG/PET-CT-based lymph node atlas in breast cancer patients. Int J Radiat Oncol Biol Phys 2019; 103: 574-82.
- Lee N. Target Volume Delineation for Conformal and Intensity-Modulated Radiation Therapy (Medical Radiology) 2016; Springer. 1st Edition 1-330.
- Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995; 31: 1341-6.
- Malkinson FD, Keane JT. Radiobiology of the skin: review of some effects on epidermis and hair. J Invest Dermatol 1981; 77: 133-8.
- Brown KR, Rzucidlo E. Acute and chronic radiation injury. J Vasc Surg 2011; 53: 1521.
- Müller K, Meineke V. Radiation-induced alterations in cytokine production by skin cells. Exp Hematol 2007; 35: 96-104.
- Hopewell W, Nyman J, Turesson I. Time factor for acute tissue reactions following fractionated irradiation: a balance between repopulation and enhanced radiosensitivity, Int J Radiation Biol 2003; 79: 513-24.
- Mendelsohn FA, Divino CM, Reis ED, et al. Wound care after radiation therapy. Adv Skin Wound Care 2002; 15: 216-24.
- Bernier J, Russi EG, Homey B, et al. Management of radiation dermatitis in patients receiving cetuximab and radiotherapy for locally advanced squamous cell carcinoma of the head and neck: proposals for a revised grading system and consensus management guidelines Ann Oncol 2011; 22: 2191-200.
- Martelletti LBSJ, Aguiar BRL, Vieira LAC, et al. Incidence of acute radiodermatitis in women with breast cancer undergoing hypofractionated radiotherapy. Rev Bras Enferm 2021; 75: e20210118.
- Collen EB, Mayer MN. Acute effects of radiation treatment: skin reactions. Can Vet J 2006; 47: 931-2.
- Frederick DM, Renato GP. Radiobiology and radiation effects. In: Fitzpatrick’s Dermatology in General Medicine. New York, 2008, 7th ed. p858-62.
- Bontempo PSM, Ciol MA, Menêses AG, et al Acute radiodermatitis in cancer patients: incidence and severity estimates. Rev Esc Enferm USP 2021; 55: e03676.
- Gangopadhyay A, Das J, Nath P, Biswas J. Hemoglobin levels may predict toxicities in patients on pelvic chemoradiation for carcinoma of the cervix-experience of a regional cancer center. Ecancermedicalscience 2014; 8: 431.
- Henke M, Bechtold C, Momm F, Guttenberg R. Blood hemoglobin level may affect radiosensitivity-preliminary results on acutely reacting normal tissues. Int J Radiat Oncol Biol Phys 2000; 48: 339-45.
- Mochizuki S, Takano M, Sugano N, et al. The effect of B vitamin supplementation on wound healing in type 2 diabetic mice. J Clin Biochem Nutr 2016; 58: 64-8.
- Debowska R, Vincent C, Kruszewski M, et al. The repair effect of folacin reduces skin damage due to radiotherapy. 15th Congress of the European Academy of Dermatology and Venereology. Rhodes, Greece, October 4-8, 2006.
- Kraus-Tiefenbacher U, Sfintizky A, Welzel G, et al. Factors of influence on acute skin toxicity of breast cancer patients treated with standard three-dimensional conformal radiotherapy (3D-CRT) after breast conserving surgery (BCS). Radiat Oncol 2012; 7: 217.
- Wong G, Lam E, Karam I, et al. The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review. Cancer Treat Res Commun 2020; 24: 100185.
- Salvo N, Barnes E, van Draanen J, et al. Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature. Curr Oncol 2010; 17: 94-112.
- Pollock D. Predicting the severity of radiation skin reactions in women with breast cancer. Edith Cowan University 1988: 1; 5.
- Vieira DS, Reisner ML, Panichella JD, Barbosa IP. Evaluation of acute skin toxicity during radiotherapy for breast cancer in elderly patients. Transl Cancer Res 2020; 9: 8-11.
- Wong JHD, Zaili Z, Abdul Malik R, et al. Evaluation of skin dose and skin toxicity in patients undergoing intraoperative radiotherapy for early breast cancer. J Appl Clin Med Phys 2021; 22: 139-47.
- Bonomo P, Desideri I, Loi M, et al. Elderly patients affected by head and neck squamous cell carcinoma unfit for standard curative treatment: Is de-intensified, hypofractionated radiotherapy a feasible strategy? Oral Oncol 2017; 74: 142-7.
- Kalman NS, Hugo GD, Mahon RN, et al. Diabetes mellitus and radiation induced lung injury after thoracic stereotactic body radiotherapy. Radiother Oncol 2018; 129: 270-6.
- Dong G, Li Y, Zhao Q, Pang B, et al. Effects of diabetes on the development of radiation pneumonitis. Respir Res 2021; 22: 160.
- Kuo HC, Chang PH, Wang CH. Impact of Diabetes Mellitus on Head and Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy. Sci Rep 2020; 10: 7702.
There are 38 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Early Pub Date | October 21, 2022 |
| Publication Date | October 22, 2022 |
| Published in Issue | Year 2022 Volume: 4 Issue: 4 |
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