Research Article
Year 2023,
Volume: 5 Issue: 1, 34 - 38, 20.01.2023
Abstract
References
- Luo L, Chen M, Wen Y, Zhang L, Zhou C, Wang Q. Pregnancy outcome and cost-effectiveness comparisons of artificial cycle-prepared frozen embryo transfer with or without GnRH agonist pretreatment for polycystic ovary syndrome: a randomised controlled trial. BJOG 2021; 128: 667-74.
- Thakre N, Homburg R. A review of IVF in PCOS patients at risk of ovarian hyperstimulation syndrome. Expert Rev Endocrinol Metab 2019; 14: 315-9.
- Joham AE, Norman RJ, Stener-Victorin E, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol 2022; 10: 668-80.
- Dokuzeylül-Güngör N, Gürbüz T, Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates J Surg Med 2020; 4: 733-7.
- Güngör ND, Gürbüz T, Yurci A. Does depot analog suppression have positive effects on all other frozen-thawed embryo transfer cycles in addition to endometriosis. Ulutas Med J 2021; 7: 22-30.
- Cerrillo M, Herrero L, Guillén A, Mayoral M, García-Velasco JA. Impact of endometrial preparation protocols for frozen embryo transfer on live birth rates. Rambam Maimonides Med J 2017; 8: e0020.
- Mumusoglu S, Polat M, Ozbek IY, et al. Preparation of the endometrium for frozen embryo transfer: a systematic review. Front Endocrinol (Lausanne) 2021; 12: 688237.
- Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril 2010; 94: 2054-8.
- Groenewoud ER, Cantineau AE, Kollen BJ, Macklon NS, Cohlen BJ. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update 2013; 19: 458-70.
- Zhang Y, Wu L, Li TC, Wang CC, Zhang T, Chung JPW. Systematic review update and meta-analysis of randomized and non-randomized controlled trials of ovarian stimulation versus artificial cycle for endometrial preparation prior to frozen embryo transfer in women with polycystic ovary syndrome. Reprod Biol Endocrinol 2022; 20: 62.
- Aghahoseini M, Alyasin A, Rashidi S, Samaei-Nouroozi A, Saeidi H, Shabani-Nashtaei M. The efficacy of gonadotropin-releasing hormone (GNRH) agonist before frozen embryo transfer in improving pregnancy outcome and decreasing miscarriage rate in hyperandrogenic polycystic ovary syndrome women: a randomized clinical trial. Minerva Ginecol 2020; 72: 212-8.
- Mensing L, Dahlberg ES, Bay B, Gabrielsen A, Knudsen UB. Endometrial preparation methods prior to frozen embryo transfer: A retrospective cohort study comparing true natural cycle, modified natural cycle and artificial cycle. Arch Gynecol Obstet 2022; 306: 1381-8.
- Demirdağ E, Güler İ, Cevher Akdulum MF, et al. Comparison of natural and artificial cycles in frozen-thawed embryo transfer: A retrospective analysis of 1696 cycles. Turk J Obstet Gynecol 2022; 19: 28-34.
- Dokuzeylul Gungor N, Gurbuz T, Ture T. Prolonged luteal phase support with progesterone may increase papules and plaques of pregnancy frequency in pregnancies through in vitro fertilization. An Bras Dermatol 2021; 96: 171-5.
- Dokuzeylül Güngör N, Güngör K, Yurci A, Cil K, Hatırnaz Ş. Ovarian drilling down-regulates endometrial nuclear factor-κB p65 expression in women with PCOS: A prospective case-control study. Turk J Obstet Gynecol 2022; 19: 45-50.
- Giviziez CR, Sanchez EGM, Lima YAR, Approbato MS. Association of overweight and consistent anovulation among infertile women with regular menstrual cycle: a case-control study. Rev Bras Ginecol Obstet 2021; 43: 834-9.
- Liu X, Shi J, Bai H, Wen W. Pretreatment with a GnRH agonist and hormone replacement treatment protocol could not improve live birth rate for PCOS women undergoing frozen-thawed embryo transfer cycles. BMC Pregnancy Childbirth 2021; 21: 835.
- Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009; 41: 1149-60.
- Li L, Gao DD, Zhang Y, Song JY, Sun ZG. Comparison of stimulated cycles with low dose r-fsh versus hormone replacement cycles for endometrial preparation prior to frozen-thawed embryo transfer in young women with polycystic ovarian syndrome: a single-center retrospective cohort study from China. Drug Des Devel Ther 2021; 15: 2805-13.
- Hosseini-Najarkolaei A, Moini A, Kashani L, Farid Mojtahedi M, Hosseini-Najarkolaee E, Salehi E. The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial. Reprod Biol Endocrinol 2020; 18: 115.
- Peigné M, Devouche E, Ferraretto X, et al. Higher live birth rate with stimulated rather than artificial cycle for frozen-thawed embryo transfer. Eur J Obstet Gynecol Reprod Biol 2019; 243: 144-9.
- Yu J, Ma Y, Wu Z, et al. Endometrial preparation protocol of the frozen-thawed embryo transfer in patients with polycystic ovary syndrome. Arch Gynecol Obstet 2015; 291: 201-11.
- Man Y, Bian Y, Zhao S, et al. The effect of different endometrial preparations on women with polycystic ovary syndrome undergoing initial frozen embryo transfer: A historical cohort analysis. Acta Obstet Gynecol Scand 2021; 100: 1116-23.
- Wang Y, Hu WH, Wan Q, et al. Effect of artificial cycle with or without GnRH-a pretreatment on pregnancy and neonatal outcomes in women with PCOS after frozen embryo transfer: a propensity score matching study. Reprod Biol Endocrinol 2022; 20: 56.
- Niu Y, Zhao D, Wang Y, Suo L, Zou J, Wei D. Ovulation induction regimens are associated with a higher rate of livebirth after frozen single-blastocyst transfer among women with polycystic ovary syndrome. Front Endocrinol (Lausanne) 2022; 13: 987813.
- Guan L, Wu H, Wei C, et al. The effect of mildly stimulated cycle versus artificial cycle on pregnancy outcomes in overweight/obese women with PCOS prior to frozen embryo transfer: a retrospective cohort study. BMC Pregnancy Childbirth 2022; 22: 394.
- Zhang J, Liu H, Wang Y, et al. Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome. Fertil Steril 2019; 112: 371-7.
Comparison of different endometrial preparation protocols in frozen-thawed embryo transfer cycles in women with polycystic ovary syndrome
Abstract
Aim: This study aimed to evaluate the most suitable endometrial preparation protocols such as hormone replacement therapy (HRT) with gonadotropin releasing hormone analogue (GnRH-a) suppression, HRT without GnRH-a suppression and mild ovarian stimulation (OS) for women with polycystic ovary syndrome (PCOS) undergoing frozen-thawed embryo transfer (FET).
Material and Method: We conducted a historical cohort analysis of 161 women with PCOS who underwent the “freeze-all” strategy between December 2018 and August 2020 because of their high risk for ovarian hyperstimulation syndrome. Three endometrial preparation protocols were used: HRT with GnRH-a suppression (n=43); HRT without GnRH-a suppression (n=86); mild-OS (n=32).
Results: The biochemical pregnancy results (55.8 % vs 54.65 % vs 53, p=0.900), ongoing pregnancy rates (44.2 % vs 43 % vs 40.62, p=0.572), and abort rates (20.8 % vs 21.3 % vs 23.52, p=0.900) were similar between the HRT with GnRH-a suppression, without GnRH-a suppression and mild-OS, respectively. This study showed no statistically significant difference between the three protocols in laboratory parameters (p>0.05).
Conclusion: There was no statistically difference between three groups in terms of pregnancy outcomes. Dependent on clinical experience and facility, one of these protocols could be deployed for FET in women with PCOS.
References
- Luo L, Chen M, Wen Y, Zhang L, Zhou C, Wang Q. Pregnancy outcome and cost-effectiveness comparisons of artificial cycle-prepared frozen embryo transfer with or without GnRH agonist pretreatment for polycystic ovary syndrome: a randomised controlled trial. BJOG 2021; 128: 667-74.
- Thakre N, Homburg R. A review of IVF in PCOS patients at risk of ovarian hyperstimulation syndrome. Expert Rev Endocrinol Metab 2019; 14: 315-9.
- Joham AE, Norman RJ, Stener-Victorin E, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol 2022; 10: 668-80.
- Dokuzeylül-Güngör N, Gürbüz T, Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates J Surg Med 2020; 4: 733-7.
- Güngör ND, Gürbüz T, Yurci A. Does depot analog suppression have positive effects on all other frozen-thawed embryo transfer cycles in addition to endometriosis. Ulutas Med J 2021; 7: 22-30.
- Cerrillo M, Herrero L, Guillén A, Mayoral M, García-Velasco JA. Impact of endometrial preparation protocols for frozen embryo transfer on live birth rates. Rambam Maimonides Med J 2017; 8: e0020.
- Mumusoglu S, Polat M, Ozbek IY, et al. Preparation of the endometrium for frozen embryo transfer: a systematic review. Front Endocrinol (Lausanne) 2021; 12: 688237.
- Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril 2010; 94: 2054-8.
- Groenewoud ER, Cantineau AE, Kollen BJ, Macklon NS, Cohlen BJ. What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update 2013; 19: 458-70.
- Zhang Y, Wu L, Li TC, Wang CC, Zhang T, Chung JPW. Systematic review update and meta-analysis of randomized and non-randomized controlled trials of ovarian stimulation versus artificial cycle for endometrial preparation prior to frozen embryo transfer in women with polycystic ovary syndrome. Reprod Biol Endocrinol 2022; 20: 62.
- Aghahoseini M, Alyasin A, Rashidi S, Samaei-Nouroozi A, Saeidi H, Shabani-Nashtaei M. The efficacy of gonadotropin-releasing hormone (GNRH) agonist before frozen embryo transfer in improving pregnancy outcome and decreasing miscarriage rate in hyperandrogenic polycystic ovary syndrome women: a randomized clinical trial. Minerva Ginecol 2020; 72: 212-8.
- Mensing L, Dahlberg ES, Bay B, Gabrielsen A, Knudsen UB. Endometrial preparation methods prior to frozen embryo transfer: A retrospective cohort study comparing true natural cycle, modified natural cycle and artificial cycle. Arch Gynecol Obstet 2022; 306: 1381-8.
- Demirdağ E, Güler İ, Cevher Akdulum MF, et al. Comparison of natural and artificial cycles in frozen-thawed embryo transfer: A retrospective analysis of 1696 cycles. Turk J Obstet Gynecol 2022; 19: 28-34.
- Dokuzeylul Gungor N, Gurbuz T, Ture T. Prolonged luteal phase support with progesterone may increase papules and plaques of pregnancy frequency in pregnancies through in vitro fertilization. An Bras Dermatol 2021; 96: 171-5.
- Dokuzeylül Güngör N, Güngör K, Yurci A, Cil K, Hatırnaz Ş. Ovarian drilling down-regulates endometrial nuclear factor-κB p65 expression in women with PCOS: A prospective case-control study. Turk J Obstet Gynecol 2022; 19: 45-50.
- Giviziez CR, Sanchez EGM, Lima YAR, Approbato MS. Association of overweight and consistent anovulation among infertile women with regular menstrual cycle: a case-control study. Rev Bras Ginecol Obstet 2021; 43: 834-9.
- Liu X, Shi J, Bai H, Wen W. Pretreatment with a GnRH agonist and hormone replacement treatment protocol could not improve live birth rate for PCOS women undergoing frozen-thawed embryo transfer cycles. BMC Pregnancy Childbirth 2021; 21: 835.
- Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009; 41: 1149-60.
- Li L, Gao DD, Zhang Y, Song JY, Sun ZG. Comparison of stimulated cycles with low dose r-fsh versus hormone replacement cycles for endometrial preparation prior to frozen-thawed embryo transfer in young women with polycystic ovarian syndrome: a single-center retrospective cohort study from China. Drug Des Devel Ther 2021; 15: 2805-13.
- Hosseini-Najarkolaei A, Moini A, Kashani L, Farid Mojtahedi M, Hosseini-Najarkolaee E, Salehi E. The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial. Reprod Biol Endocrinol 2020; 18: 115.
- Peigné M, Devouche E, Ferraretto X, et al. Higher live birth rate with stimulated rather than artificial cycle for frozen-thawed embryo transfer. Eur J Obstet Gynecol Reprod Biol 2019; 243: 144-9.
- Yu J, Ma Y, Wu Z, et al. Endometrial preparation protocol of the frozen-thawed embryo transfer in patients with polycystic ovary syndrome. Arch Gynecol Obstet 2015; 291: 201-11.
- Man Y, Bian Y, Zhao S, et al. The effect of different endometrial preparations on women with polycystic ovary syndrome undergoing initial frozen embryo transfer: A historical cohort analysis. Acta Obstet Gynecol Scand 2021; 100: 1116-23.
- Wang Y, Hu WH, Wan Q, et al. Effect of artificial cycle with or without GnRH-a pretreatment on pregnancy and neonatal outcomes in women with PCOS after frozen embryo transfer: a propensity score matching study. Reprod Biol Endocrinol 2022; 20: 56.
- Niu Y, Zhao D, Wang Y, Suo L, Zou J, Wei D. Ovulation induction regimens are associated with a higher rate of livebirth after frozen single-blastocyst transfer among women with polycystic ovary syndrome. Front Endocrinol (Lausanne) 2022; 13: 987813.
- Guan L, Wu H, Wei C, et al. The effect of mildly stimulated cycle versus artificial cycle on pregnancy outcomes in overweight/obese women with PCOS prior to frozen embryo transfer: a retrospective cohort study. BMC Pregnancy Childbirth 2022; 22: 394.
- Zhang J, Liu H, Wang Y, et al. Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome. Fertil Steril 2019; 112: 371-7.
There are 27 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Early Pub Date | January 17, 2023 |
| Publication Date | January 20, 2023 |
| Published in Issue | Year 2023 Volume: 5 Issue: 1 |
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