Abstract
References
- Wang L, Wang C, Wu S, Li Y, Guo W, Liu M. Red blood cell distribution width is associated with mortality after acute ischemic stroke: a cohort study and systematic review. Ann Transl Med. 2020; 8(4):81.
- Charlson ME, Pompei P, Ales KL, Mackenzie CR. A newmethod of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373-383.
- Warwick R, Mediratta N, Shackcloth M, Shaw M, McShane J, Poullis M. Preoperative red cell distribution width in patients under going pulmonary resections for non-small-cell lung cancer. Eur J Cardiothorac Surg. 2014;45:108-113.
- Shin NR, Lee YY, Kim SH, et al. Prognostic value of pretreatment haemoglobin level in patients with early cervical cancer. Obstet Gynecol Sci. 2014;57:28-36.
- Riedl J, Posch F, Königsbrügge O, et al. Red cell distribution width and other red blood cell parameters in patients with cancer: association with risk of venous thromboembolism and mortality. PLoS ONE. 2014;9:e111440.
- Fanti S, Farsad M, Battista G.Somatostatin Receptor Scintigraphy for Bronchial Carcinoid Follow-Up. Clin Nucl Med. 2003;28:548–552.
- Seretis C, Seretis F, Lagoudianakis E, Gemenetzis G, Salemis N.S. Is red cell distribution width a novel biomarker of breast cancer activity? Data from a pilot study. J Clin Med Res. 2013;5:121-126.
- Wang FM, Xu G, Zhang Y, Ma LL. Red cell distribution width ıs associated with presence, stage, and grade in patients with renal cell carcinoma. Dis Markers. 2014;7:e 860419.
- Sun P, Zhang F, Chen C. The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China. Onco Target. 2016;7:42650-42660.
- Wu F, Yang S, Tang X, Liu W, Chen H, Gao H. Prognostic value of baseline hemoglobin-to-red blood cell distribution width ratio in small cell lung cancer: a retrospective analysis. Thorac Cancer. 2020; 11:888-897.
- Petrella F, Casiraghi M, Radice D, Cara A. Prognostic value of the hemoglobin/red cell distribution width ratio in resected lung adenocarcinoma. Cancers. 2021;13:710.
- Tertemiz KC, Ozgen Alpaydin A, Sevinç C, Ellidokuz H, Acara AC, Cimrina A. Could ‘‘red cell distribution width’’ predict COPD severity? Revista Portuguesa de Pneumologia (English Edition) 2016; 22:196-201.
- Malandrino N, Wu WC, Taveira TH, Whitlatch HB, Smith RJ. Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia. 2012; 55: 226-235.
- Jili Hou, Cheng Yao, Potential prognostic biomarkers of lung adenocarcinoma based on bioinformatic analysis. BioMed Res Int. 2021;14:e8859996.
- Hu L, Li M, Ding Y, Pu L, Liu J, Xie J etc. Prognostic value of RDW in cancers: a systematic review and meta-analysis. Oncotarget. 2017;8:16027-16035.
- Koma Y, Onishi A, Matsuako H, et al. Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer. Plos ONE. 2013;8(11):e80240.
- Kos M, Hocazade C, Kos T, et al. Evaluation of the effects of red blood cell distribution width on survival in lung cancer patients. Contemp Onco (Pozn). 2016;20(2):153-157.
- Bozkaya Y, Kurt B, Gürler F. A prognostic parameter in advanced non-small cell lung cancer: the ratio of hemoglobin-to-red cell distribution width. Int J Clin Oncol. 2019;24:798-806.
- Ergür Öztürk F, Öztürk A. A new prognostic marker in small cell lung cancer: red cell distribution width ratio of hemoglobin. Anatolian Curr Med J. 2023;5(2);148-152.
- Chi G, Lee J, Montazerin S, Marszalek J. Metaanaliz prognostic value of hemoglobin-to-red cell distribution width ratio in cancer: systematic review and meta-analysis. Biomarkers Med. 2022;16:6.
Hemoglobin red cell distribution width ratio as a prognostic marker in patients with locally advanced lung adenocarcinoma
Abstract
Aims: Hemoglobin/red cell distribution width ratio (HRR) has been defined as an effective prognostic factor in various malignancies. The aim of this study is to investigate the prognostic role of HRR in locally advanced lung adenocarcinoma.
Methods: 626 patients diagnosed with locally advanced lung adenocarcinoma were screened. The best cut-off point of HRR for overall survival (OS) and progression free survival (PFS) was determined by ROC analysis. A HRR cut-off value was determined, patients were classified as having lower or higher HRR. Both groups’ clinical, demographic, laboratory values were compared. To identify independent predictors of prognosis, multivariate cox regression analysis was used.
Results: A total of119 patients were included. The best cut-off point of HRR in determining OS was 0.963%.HRR below the cut-off value increased mortality by 2.2fold.The group with HRR<0.963% had higher mean age and RDW and lower mean albumin. At the same time, the 5-year OS value of the group with HRR ≥0.9632 was 52.6% and the median OS of this group was 62.7months,while the 5year OS vale of the group with HRR <0.9632 was 24.7% and the median OS was 32.4 months. In multivariate cox-regression analysis, HRR was not independent predictor of mortality risk.
Conclusion: HRR is a potential biomarker for prognosis in patients with locally advanced lung adenocarcinoma.
References
- Wang L, Wang C, Wu S, Li Y, Guo W, Liu M. Red blood cell distribution width is associated with mortality after acute ischemic stroke: a cohort study and systematic review. Ann Transl Med. 2020; 8(4):81.
- Charlson ME, Pompei P, Ales KL, Mackenzie CR. A newmethod of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373-383.
- Warwick R, Mediratta N, Shackcloth M, Shaw M, McShane J, Poullis M. Preoperative red cell distribution width in patients under going pulmonary resections for non-small-cell lung cancer. Eur J Cardiothorac Surg. 2014;45:108-113.
- Shin NR, Lee YY, Kim SH, et al. Prognostic value of pretreatment haemoglobin level in patients with early cervical cancer. Obstet Gynecol Sci. 2014;57:28-36.
- Riedl J, Posch F, Königsbrügge O, et al. Red cell distribution width and other red blood cell parameters in patients with cancer: association with risk of venous thromboembolism and mortality. PLoS ONE. 2014;9:e111440.
- Fanti S, Farsad M, Battista G.Somatostatin Receptor Scintigraphy for Bronchial Carcinoid Follow-Up. Clin Nucl Med. 2003;28:548–552.
- Seretis C, Seretis F, Lagoudianakis E, Gemenetzis G, Salemis N.S. Is red cell distribution width a novel biomarker of breast cancer activity? Data from a pilot study. J Clin Med Res. 2013;5:121-126.
- Wang FM, Xu G, Zhang Y, Ma LL. Red cell distribution width ıs associated with presence, stage, and grade in patients with renal cell carcinoma. Dis Markers. 2014;7:e 860419.
- Sun P, Zhang F, Chen C. The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China. Onco Target. 2016;7:42650-42660.
- Wu F, Yang S, Tang X, Liu W, Chen H, Gao H. Prognostic value of baseline hemoglobin-to-red blood cell distribution width ratio in small cell lung cancer: a retrospective analysis. Thorac Cancer. 2020; 11:888-897.
- Petrella F, Casiraghi M, Radice D, Cara A. Prognostic value of the hemoglobin/red cell distribution width ratio in resected lung adenocarcinoma. Cancers. 2021;13:710.
- Tertemiz KC, Ozgen Alpaydin A, Sevinç C, Ellidokuz H, Acara AC, Cimrina A. Could ‘‘red cell distribution width’’ predict COPD severity? Revista Portuguesa de Pneumologia (English Edition) 2016; 22:196-201.
- Malandrino N, Wu WC, Taveira TH, Whitlatch HB, Smith RJ. Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia. 2012; 55: 226-235.
- Jili Hou, Cheng Yao, Potential prognostic biomarkers of lung adenocarcinoma based on bioinformatic analysis. BioMed Res Int. 2021;14:e8859996.
- Hu L, Li M, Ding Y, Pu L, Liu J, Xie J etc. Prognostic value of RDW in cancers: a systematic review and meta-analysis. Oncotarget. 2017;8:16027-16035.
- Koma Y, Onishi A, Matsuako H, et al. Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer. Plos ONE. 2013;8(11):e80240.
- Kos M, Hocazade C, Kos T, et al. Evaluation of the effects of red blood cell distribution width on survival in lung cancer patients. Contemp Onco (Pozn). 2016;20(2):153-157.
- Bozkaya Y, Kurt B, Gürler F. A prognostic parameter in advanced non-small cell lung cancer: the ratio of hemoglobin-to-red cell distribution width. Int J Clin Oncol. 2019;24:798-806.
- Ergür Öztürk F, Öztürk A. A new prognostic marker in small cell lung cancer: red cell distribution width ratio of hemoglobin. Anatolian Curr Med J. 2023;5(2);148-152.
- Chi G, Lee J, Montazerin S, Marszalek J. Metaanaliz prognostic value of hemoglobin-to-red cell distribution width ratio in cancer: systematic review and meta-analysis. Biomarkers Med. 2022;16:6.
Details
| Primary Language | English |
|---|---|
| Subjects | Predictive and Prognostic Markers |
| Journal Section | Research Articles |
| Authors | |
| Early Pub Date | October 26, 2023 |
| Publication Date | October 27, 2023 |
| Published in Issue | Year 2023 Volume: 5 Issue: 4 |
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