Abstract
Çalışmaya Ait Türkçe Öz
Amaç: Ülseratif kolit (ÜK) insidansı, potansiyel
çevresel risk etkenlerine maruziyetteki artış ile yükselme eğilimindedir. Bu
çalışmada, insidanstaki bu artışın klinik başvuruda farklılıklar oluşturup
oluşturmadığının araştırılması amaçlanmıştır.
Yöntem: Çalışma
retrospektif, hastane bazlı çalışmadır. Ağustos 2017 ile Eylül 2019 tarihleri
arasında başvuran ve yeni tanı almış, yetişkin ÜK’li hastalar çalışmaya dahil
edilmiştir.
Bulgular: Çalışmaya 99 ÜK’li olgu alındı; erkek
kadın oranı 1,54 olarak bulundu. Cinsiyete göre yaş ortalamalarına
bakıldığında; erkeklerde ortalama yaş 45,67 (SD±17,02) iken kadınlarda 37,67
(SD±12,47) bulundu. Aralarındaki fark istatiksel olarak anlamlıydı (p=0,01;
p<0,05). 30-39 yaş grubu hastalığın en sık görüldüğü yaş aralığı olarak
saptandı (%30,3). Cinsiyete göre tutulum sıklığı erkeklerde 3 bölge için hemen
hemen aynıyken (%33,9 pankolit, %33,9 sol kolit, %32,2 distal kolit) kadınlarda
sol taraf tutulumunun belirgin düşük olduğunu görüldü (%42,4 pankolit, %18,2
sol kolit, %39,4 distal kolit). Cinsiyetler arasındaki bu fark istatiksel
olarak anlamsızdı. Erkeklerde başvurudaki endoskopik aktivite indeksi kadınlara
göre, istatiksel olarak anlamlı, belirgin yüksekti (median 3 ve 2 sırasıyla;
min 0 max 3; p=0,01, p<0,05).
Sonuç: Çalışmamız bu hastalığın hem daha ileri
yaşta hem de daha şiddetli bir şekilde erkeklerde daha sık görüldüğünü ortaya koydu.
Buna rağmen kesin yargıya varılabilmesi için geniş çaplı, toplum kökenli
çalışmalara ihtiyaç vardır.
References
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- Matsuoka K, Kobayashi T, Ueno F, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease. J Gastroenterol. 2018;53(3):305-353. doi:10.1007/s00535-018-1439-1
- Mak WY, Zhao M, Ng SC, Burisch J. The epidemiology of inflammatory bowel disease: East meets West. J Gastroenterol Hepatol. 2019 Oct 9. doi:10.1111/jgh.14 872.
- Molodecky NA, Kaplan GG. Environmental risk factors for inflammatory bowel disease. Gastroenterol Hepatol. 2010;6:339-346.
- Tozun N, Atug O, Imeryuz N, et al. Members of the Turkish IBD Study Group. Clinical characteristics of inflammatory bowel disease in Turkey: a multicenter epidemiologic survey. J Clin Gastroenterol. 2009;43:51-57. doi:10.1097/MCG.0b013e3181574636
- Özer Çakır Ö. Bölgemizdeki inflamatuar barsak hastalıkları tanılı olguların insidansı, demografik ve klinik özellikleri. Akademik Gastroenteroloji Dergisi. 2019;18(2):49-58. doi:10.17941/agd.521248
- Tezel A, Dökmeci G, Eskiocak M, et al. Epidemiological features of ulcerative colitis in Trakya, Turkey. J Int Med Res. 2003;31:141-148. doi:10.1177/14732 3000303100211
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- Vegh Z, Burisch J, Pedersen N, et al. Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia: Results of the 2011 ECCO-EpiCom inception cohort. J Crohn’s Colitis. 2014;8(11):1506-1515. doi:10.1016/j.crohns.2014.06.004
- Shivashankar R, Tremaine WJ, Harmsen WS, Loftus EVJ. Incidence and Prevalence of Crohn’s Disease and Ulcerative Colitis in Olmsted County, Minnesota From 1970 Through 2010. Clin Gastroenterol Hepatol. 2017;15(6):857-863. doi:10.1016/j.cgh.2016.10.039
- Ng SC, Tang W, Ching JY, et al. Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn’s and colitis epidemiology study. Gastroenterology. 2013;145(1):158-165. doi:10.1053/j.gastro.2013.04.007
- Ng SC, Kaplan GG, Tang W, et al. Population Density and Risk of Inflammatory Bowel Disease. Am J Gastroenterol. 2019;114(1):107-115. doi:10.1038/s41 395-018-0233-2
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- Harries AD, Baird A, Rhodes J. Nonsmoking: a feature of ulcerative colitis. Br Med J (Clin Res Ed). 1982;284:706. doi: 10.1136/bmj.285.6339.440-a
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- Lakatos PL, Vegh Z, Lovasz BD, et al. Is Current Smoking Still an Important Environmental Factor in Inflammatory Bowel Diseases? Results from a Population-based Incident Cohort. Inflamm Bowel Dis. 2013;19(5):1010-1017. doi:10.1097/MIB.0b013e3182 802b3e
- Bernstein CN. Assessing environmental risk factors affecting the inflammatory bowel diseases: a joint workshop of the Crohn’s & Colitis Foundations of Canada and the USA. Inflamm Bowel Dis 2008;14:1139-1146. doi:10.1002/ibd.20494
- Monsen U, Brostrom O, Nordenvall B, et al. Prevalence of inflammatory bowel disease among relatives of patients with ulcerative colitis. Scand J Gastroenterol. 1987;22:214–218. doi: 10.3109/00365528708991882
What's changing in ulcerative colitis patients? Retrospective evaluation of 99 newly diagnosed cases
Abstract
English Version Abstract of The Manuscript
Objective: The incidence
of ulcerative colitis (UC) tends to increase with increment exposure to
potential environmental risk factors. In this study, it was aimed to
investigate whether this increase in incidence causes differences in clinical
presentation.
Methods: This is a retrospective, hospital-based
study. Between August 2017 and September 2019, newly diagnosed adult UC
patients were included in the study.
Results: 99 patients with UC were included in the
study; male to female ratio was found to be 1.54. When the average age is
examined by gender; The mean age was 45.67 (SD ± 17.02) in males and 37.67 (SD±12.47) in females. The difference was statistically significant (p=0.01; p
<0.05). 30-39 age group was found to be the most common age range (30.3%).
While the frequency of involvement by gender was almost the same for 3 regions
in men (33.9% pancolitis, 33.9% left colitis, 32.2% distal colitis), it was
found that left side involvement was significantly lower in women (42.4%
pancolitis, 18.2% left colitis, 39.4% distal colitis). This difference between
the sexes was statistically insignificant. At the time of admission, the
endoscopic activity index was notably higher in men than in women. This
difference was statistically significant (median 3 and 2, respectively; min 0
max 3; p=0.01, p <0.05).
Conclusion: Our study
revealed that this disease is more common in men, both at an older age and more
severely. Nevertheless, large-scale, community-based studies are needed to
reach a final judgement.
Keywords
Ulcerative colitis Epidemiology Distribution of colon involvement Endoscopic activity index
References
- Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults: American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 2010;105(3):501–523. doi:10.103 8/ajg.2009.727
- Matsuoka K, Kobayashi T, Ueno F, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease. J Gastroenterol. 2018;53(3):305-353. doi:10.1007/s00535-018-1439-1
- Mak WY, Zhao M, Ng SC, Burisch J. The epidemiology of inflammatory bowel disease: East meets West. J Gastroenterol Hepatol. 2019 Oct 9. doi:10.1111/jgh.14 872.
- Molodecky NA, Kaplan GG. Environmental risk factors for inflammatory bowel disease. Gastroenterol Hepatol. 2010;6:339-346.
- Tozun N, Atug O, Imeryuz N, et al. Members of the Turkish IBD Study Group. Clinical characteristics of inflammatory bowel disease in Turkey: a multicenter epidemiologic survey. J Clin Gastroenterol. 2009;43:51-57. doi:10.1097/MCG.0b013e3181574636
- Özer Çakır Ö. Bölgemizdeki inflamatuar barsak hastalıkları tanılı olguların insidansı, demografik ve klinik özellikleri. Akademik Gastroenteroloji Dergisi. 2019;18(2):49-58. doi:10.17941/agd.521248
- Tezel A, Dökmeci G, Eskiocak M, et al. Epidemiological features of ulcerative colitis in Trakya, Turkey. J Int Med Res. 2003;31:141-148. doi:10.1177/14732 3000303100211
- Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749-753. doi:10.1136/gut.2005.082909
- Tezel A, Ümit H. İnflamatuvar barsak hastalıklarında endoskopik izlem: Kime? Ne zaman? Nasıl? Endoskopi Dergisi. 2010;18(2):52-55.
- Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 2012;142:46-54. doi:10.1053/j.ga stro.2011.10.001
- Can G, Poşul E, Yılmaz B ve ark. Bolu/Düzce Bölgesi inflamatuvar barsak hastalıklarının insidans ve prevalans özellikleri: 2004-2013 Retrospektif kohort çalışması. Abant Med J. 2015;4(3):210-220. doi:10.5505/abantmedj.2015.89410
- Balakan O, Kıdır V, Süner A, Yalçın K. Dicle Üniversitesi Tıp Fakültesi Hastanesinde 1999-2005 Yılları Arasındaki İnflamatuvar Barsak Hastalıklı Olgularının Değerlendirilmesi. Düzce Üniversitesi Tıp Fakültesi Dergisi. 2007;3:26-30.
- Vegh Z, Burisch J, Pedersen N, et al. Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia: Results of the 2011 ECCO-EpiCom inception cohort. J Crohn’s Colitis. 2014;8(11):1506-1515. doi:10.1016/j.crohns.2014.06.004
- Shivashankar R, Tremaine WJ, Harmsen WS, Loftus EVJ. Incidence and Prevalence of Crohn’s Disease and Ulcerative Colitis in Olmsted County, Minnesota From 1970 Through 2010. Clin Gastroenterol Hepatol. 2017;15(6):857-863. doi:10.1016/j.cgh.2016.10.039
- Ng SC, Tang W, Ching JY, et al. Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn’s and colitis epidemiology study. Gastroenterology. 2013;145(1):158-165. doi:10.1053/j.gastro.2013.04.007
- Ng SC, Kaplan GG, Tang W, et al. Population Density and Risk of Inflammatory Bowel Disease. Am J Gastroenterol. 2019;114(1):107-115. doi:10.1038/s41 395-018-0233-2
- Mercimek K. Trakya Bölgesinde İnflamatuar Hastalıkların Epidemiyolojik Özellikleri [Tez]. Edirne,Türkiye: Trakya Üniversitesi, 2010.
- Shi HY, Levy AN, Trivedi HD, Chan FKL, Ng SC, Ananthakrishnan AN. Ethnicity Influences Phenotype and Outcomes in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis of Population-based Studies. Clin Gastroenterol Hepatol. 2018;16(2):190-197. doi:10.1016/j.cgh.2017.05.047
- Harries AD, Baird A, Rhodes J. Nonsmoking: a feature of ulcerative colitis. Br Med J (Clin Res Ed). 1982;284:706. doi: 10.1136/bmj.285.6339.440-a
- Lunney PC, Leong RW. Review article: ulcerative colitis, smoking and nicotine therapy. Aliment Pharmacol Ther. 2012; 36:997–1008. doi:10.1111/apt.12086
- Lakatos PL, Vegh Z, Lovasz BD, et al. Is Current Smoking Still an Important Environmental Factor in Inflammatory Bowel Diseases? Results from a Population-based Incident Cohort. Inflamm Bowel Dis. 2013;19(5):1010-1017. doi:10.1097/MIB.0b013e3182 802b3e
- Bernstein CN. Assessing environmental risk factors affecting the inflammatory bowel diseases: a joint workshop of the Crohn’s & Colitis Foundations of Canada and the USA. Inflamm Bowel Dis 2008;14:1139-1146. doi:10.1002/ibd.20494
- Monsen U, Brostrom O, Nordenvall B, et al. Prevalence of inflammatory bowel disease among relatives of patients with ulcerative colitis. Scand J Gastroenterol. 1987;22:214–218. doi: 10.3109/00365528708991882
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Gastroenterology and Hepatology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | February 20, 2020 |
| Submission Date | November 17, 2019 |
| Acceptance Date | February 5, 2020 |
| Published in Issue | Year 2020 Volume: 3 Issue: 1 |
The articles in the Journal of "Acta Medica Nicomedia" are open access articles licensed under a Creative Commons Attribution-ShareAlike 4.0 International License at the web address https://dergipark.org.tr/tr/pub/actamednicomedia