Does aspartate aminotransferase platelet ratio index predict gestational diabetes mellitus? A retrospective cohort study.
Abstract
Objective: Our aim was to determine the significance of aspartate aminotransferase platelet ratio index (APRI), neutrophil to lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in predicting gestational diabetes mellitus (GDM) at first trimester screening in a retrospective study of pregnant women.
Method: In this study, a retrospective analysis of pregnant women (n=216) screened at the antenatal clinic and diagnosed with gestational diabetes between 24-28 weeks of gestation was performed. APRI score, NLR and PLR were calculated in the blood of these pregnant women in the first trimester and compared with the results of patients in the control group (n=250).
Results: The ROC -analysis for APRI yielded an AUC value of 0.489 (p=0.684). Maternal age was found to be an independent risk factor for GDM. The risk increased 1.162-fold with increasing maternal age (p < 0.001). The optimal cutoff value for NLR was 3.55, sensitivity was 65%, specificity was 49%, and the area under the ROC curve was 0.544.
Conclusion: In the results we compared with those of the control group, we found no significant change in APRI value and PLR. However, we found that NLR has a predictive value for GDM.
Keywords
gestational diabetes mellitus aspartate aminotransferase platelet ratio index liver fibrosis neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio
References
- 1. Hasan M, Ahmed S, Soares Magalhaes RJ, Fatima Y, Biswas T, Mamun AA. Double burden of malnutrition among women of reproductive age in 55 low-and middle-income countries: progress achieved and opportunities for meeting the global target. Eur J Clin Nutr. 2022;76(2):277-287. doi:10.1038/s41430-021-00945-y.
- 2. Lenoir-Wijnkoop I, Van der Beek EM, Garssen J, Nuijten MJ, Uauy RD. Health economic modeling to assess short-term costs of maternal overweight, gestational diabetes, and related macrosomia–a pilot evaluation. Front Pharmacol. 2015; 6:103. doi:10.3389/fphar.2015.00103.
Aspartat aminotransferaz trombosit oranı indeksi gestasyonel diabetes mellitus öngörür mü? Retrospektif bir kohort çalışması.
Abstract
Amaç: Bu retrospektif çalışmada amacımız, aspartat aminotransferaz trombosit oran indeksi (APRI), nötrofil lenfosit oranı (NLR) ve trombosit lenfosit oranının (PLR) birinci trimester taramasında gestasyonel diyabeti (GDM) öngörmedeki önemini belirlemekti.
Yöntem: Bu çalışmada antenatal polikliniğinde taranan ve 24-28. gebelik haftaları arasında gestasyonel diyabet tanısı alan gebelerin (n=216) retrospektif analizi yapılmıştır. Bu gebelerin ilk trimesterdeki kanlarında APRI skoru, NLR ve PLR hesaplandı ve kontrol grubundaki hastaların (n=250) sonuçları ile karşılaştırıldı.
Bulgular: APRI için ROC analizi, 0,489'luk bir AUC değeri verdi (p=0,684). Anne yaşı GDM için bağımsız bir risk faktörü olarak bulundu. Artan anne yaşı ile risk 1,162 kat arttı (p < 0,001). NLR için optimal kesme değeri 3,55, duyarlılık %65, özgüllük %49 ve ROC eğrisinin altındaki alan 0,544 idi.
Sonuç: Kontrol grubu ile karşılaştırdığımız sonuçlar da APRI değeri ve PLR'de anlamlı bir değişiklik bulamadık. Ancak NLR'nin GDM için prediktif bir değere sahip olduğunu bulduk.
Keywords
gestational diabetes mellitus aspartate aminotransferase platelet ratio index liver fibrosis neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio
References
- 1. Hasan M, Ahmed S, Soares Magalhaes RJ, Fatima Y, Biswas T, Mamun AA. Double burden of malnutrition among women of reproductive age in 55 low-and middle-income countries: progress achieved and opportunities for meeting the global target. Eur J Clin Nutr. 2022;76(2):277-287. doi:10.1038/s41430-021-00945-y.
- 2. Lenoir-Wijnkoop I, Van der Beek EM, Garssen J, Nuijten MJ, Uauy RD. Health economic modeling to assess short-term costs of maternal overweight, gestational diabetes, and related macrosomia–a pilot evaluation. Front Pharmacol. 2015; 6:103. doi:10.3389/fphar.2015.00103.
Details
| Primary Language | English |
|---|---|
| Subjects | Obstetrics and Gynaecology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | February 28, 2023 |
| Submission Date | January 6, 2023 |
| Acceptance Date | January 23, 2023 |
| Published in Issue | Year 2023 Volume: 6 Issue: 1 |
The articles in the Journal of "Acta Medica Nicomedia" are open access articles licensed under a Creative Commons Attribution-ShareAlike 4.0 International License at the web address https://dergipark.org.tr/tr/pub/actamednicomedia