Clinical Research
Year 2023,
Volume: 6 Issue: 2, 231 - 234, 30.06.2023
Abstract
References
- 1. Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord Off J Mov Disord Soc. 2010;25(5):534-541. doi:10.1002/mds.22838
- 2. Louis ED, Huang CC, Dyke JP, Long Z, Dydak U. Neuroimaging Studies of Essential Tremor: How Well Do These Studies Support/Refute the Neurodegenerative Hypothesis? Tremor Hyperkinetic Mov. 2014;4(0):235. doi:10.5334/tohm.224
- 3. Rajput AH, Adler CH, Shill HA, Rajput A. Essential tremor is not a neurodegenerative disease. Neurodegener Dis Manag. 2012;2(3):259-268. doi:10.2217/nmt.12.23
- 4. Tarakad A, Jankovic J. Essential Tremor and Parkinson’s Disease: Exploring the Relationship. Tremor Hyperkinetic Mov. 2019;8(0):589. doi:10.5334/tohm.441
- 5. Yilmaz R, Berg D. Transcranial B-Mode Sonography in Movement Disorders. In: International Review of Neurobiology. Vol 143. Elsevier; 2018:179-212. doi:10.1016/bs.irn.2018.10.008
- 6. Berg D, Siefker C, Becker G. Echogenicity of the substantia nigra in Parkinson’s disease and its relation to clinical findings. J Neurol. 2001;248(8):684-689. doi:10.1007/s004150170114
- 7. Stockner H, Sojer M, K KS, et al. Midbrain sonography in patients with essential tremor. Mov Disord. 2007;22(3):414-417. doi:10.1002/mds.21344
- 8. Walter U, Školoudík D. Transcranial sonography (TCS) of brain parenchyma in movement disorders: quality standards, diagnostic applications and novel technologies. Ultraschall Med Stuttg Ger 1980. 2014;35(4):322-331. doi:10.1055/s-0033-1356415
- 9. Budisic M, Trkanjec Z, Bosnjak J, Lovrencic-Huzjan A, Vukovic V, Demarin V. Distinguishing Parkinson’s disease and essential tremor with transcranial sonography. Acta Neurol Scand. 2009;119(1):17-21. doi:10.1111/j.1600-0404.2008.01056.x
- 10. Chitsaz A, Mehrbod N, Saadatnia M, Fereidan-Esfahani M, Akbari M, Abtahi SH. Transcranial sonography on Parkinson’s disease and essential tremor. J Res Med Sci Off J Isfahan Univ Med Sci. 2013;18(Suppl 1):S28-31.
- 11. Doepp F, Plotkin M, Siegel L, et al. Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson’s disease and essential tremor. Mov Disord Off J Mov Disord Soc. 2008;23(3):405-410. doi:10.1002/mds.21861
- 12. Kim JS, Oh YS, Kim YI, Koo JS, Yang DW, Lee KS. Transcranial sonography (TCS) in Parkinson’s disease (PD) and essential tremor (ET) about putative premotor symptoms of PD. Arch Gerontol Geriatr. 2012;54(3):e436-e439. doi:10.1016/j.archger.2012.01.001
- 13. Luo WF, Zhang YC, Sheng YJ, Fang JC, Liu CF. Transcranial sonography on Parkinson’s disease and essential tremor in a Chinese population. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol. 2012;33(5):1005-1009. doi:10.1007/s10072-011-0876-x
- 14. Laučkaitė K, Rastenytė D, Šurkienė D, et al. Ultrasonographic (TCS) and clinical findings in overlapping phenotype of essential tremor and Parkinson’s disease (ET-PD). BMC Neurol. 2014;14(1):54. doi:10.1186/1471-2377-14-54
- 15. Sprenger FS, Wurster I, Seppi K, et al. Substantia nigra hyperechogenicity and Parkinson’s disease risk in patients with essential tremor: SN + and PD Risk In Patients With ET. Mov Disord. 2016;31(4):579-583. doi:10.1002/mds.26515
- 16. Cardaioli G, Ripandelli F, Paolini Paoletti F, et al. Substantia nigra hyperechogenicity in essential tremor and Parkinson’s disease: a longitudinal study. Eur J Neurol. 2019;26(11):1370-1376. doi:10.1111/ene.13988
- 17. Louis ED, Ottman R, Ford B, et al. The Washington Heights-Inwood Genetic Study of Essential Tremor: methodologic issues in essential-tremor research. Neuroepidemiology. 1997;16(3):124-133. doi:10.1159/000109681
- 18. Zecca L, Berg D, Arzberger T, et al. In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage. Mov Disord Off J Mov Disord Soc. 2005;20(10):1278-1285. doi:10.1002/mds.20550
Esansiyel Tremor Hastalarında Transkraniyla Sonografi ile Substantia Nigra Hiperekojenitesinin Araştırılması
Abstract
Amaç:Esansiyel tremor (ET) en sık görülen hareket bozukluğudur. ET ayrı bir hastalık olarak kabul edilse de, klinik takipte ET tanılı vakaların Parkinson Hastalığına (PH) ilerleyebildiği bilinmektedir. Transkraniyal sonografide (TKS) Substantia nigra (SN) hiperekojenitesi saptanması, PH ile ilişkili bulunmuştur. Ancak bu radyolojik bulgunun etiyolojisi ve klinik anlamı belirsizliğini korumaktadır. Biz de bu çalışmada esansiyel tremorlu hastalarda SN hiperekojenisitenin önemini araştırmayı amaçladık.
Yöntem: Bu çalışmada ET tanısı olan toplam 55 hastaya ve yaşları benzer 60 kontrole TKS uygulandı ve SN hipekojeniteleri ölçüldü. Başlangıç TKS'lerinden yaklaşık on yıl sonra, tüm hastalara tekrar ulaşıldı ve PD teşhisi alıp almadıkları, mevcut durumları, tedavileri ve ilaçları hakkında sorular soruldu.
Bulgular:Çalışmaya dahil edilen 115 hastadan 15’i yetersiz görüntü kalitesi nedeniyle çalışmadan dışlandı. SN'nin ekojenik alanı hasta grubunda 0,01 ile 0,86 cm2 (ortalama 0,25±0,15), kontrol grubunda ise 0,02 ile 0,72 cm2 (ortalama 0,15±0,16) arasında değişiyordu. ET'li hastalarda kontrollere göre anlamlı ölçüde daha büyük bir ekojenik alan ölçüldü (p=0,001). Hastaların %47'si (26/55) hiperekojenik SN'ye sahipken, sağlıklı kontrollerin sadece %15'i (9/60) substantia nigra'da hiperekojeniteye sahipti. Hastaların hiçbiri takipte ET tanılarında bir değişiklik olduğunu bildirmedi.
Sonuç:Bu çalışmanın sonuçları, ET'li hastalarda SN hiperekojenitesinin arttığını göstermektedir. Transkraniyal sonografi ET patofizyolojisini anlamaya katkı sağlayabilir.
References
- 1. Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord Off J Mov Disord Soc. 2010;25(5):534-541. doi:10.1002/mds.22838
- 2. Louis ED, Huang CC, Dyke JP, Long Z, Dydak U. Neuroimaging Studies of Essential Tremor: How Well Do These Studies Support/Refute the Neurodegenerative Hypothesis? Tremor Hyperkinetic Mov. 2014;4(0):235. doi:10.5334/tohm.224
- 3. Rajput AH, Adler CH, Shill HA, Rajput A. Essential tremor is not a neurodegenerative disease. Neurodegener Dis Manag. 2012;2(3):259-268. doi:10.2217/nmt.12.23
- 4. Tarakad A, Jankovic J. Essential Tremor and Parkinson’s Disease: Exploring the Relationship. Tremor Hyperkinetic Mov. 2019;8(0):589. doi:10.5334/tohm.441
- 5. Yilmaz R, Berg D. Transcranial B-Mode Sonography in Movement Disorders. In: International Review of Neurobiology. Vol 143. Elsevier; 2018:179-212. doi:10.1016/bs.irn.2018.10.008
- 6. Berg D, Siefker C, Becker G. Echogenicity of the substantia nigra in Parkinson’s disease and its relation to clinical findings. J Neurol. 2001;248(8):684-689. doi:10.1007/s004150170114
- 7. Stockner H, Sojer M, K KS, et al. Midbrain sonography in patients with essential tremor. Mov Disord. 2007;22(3):414-417. doi:10.1002/mds.21344
- 8. Walter U, Školoudík D. Transcranial sonography (TCS) of brain parenchyma in movement disorders: quality standards, diagnostic applications and novel technologies. Ultraschall Med Stuttg Ger 1980. 2014;35(4):322-331. doi:10.1055/s-0033-1356415
- 9. Budisic M, Trkanjec Z, Bosnjak J, Lovrencic-Huzjan A, Vukovic V, Demarin V. Distinguishing Parkinson’s disease and essential tremor with transcranial sonography. Acta Neurol Scand. 2009;119(1):17-21. doi:10.1111/j.1600-0404.2008.01056.x
- 10. Chitsaz A, Mehrbod N, Saadatnia M, Fereidan-Esfahani M, Akbari M, Abtahi SH. Transcranial sonography on Parkinson’s disease and essential tremor. J Res Med Sci Off J Isfahan Univ Med Sci. 2013;18(Suppl 1):S28-31.
- 11. Doepp F, Plotkin M, Siegel L, et al. Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson’s disease and essential tremor. Mov Disord Off J Mov Disord Soc. 2008;23(3):405-410. doi:10.1002/mds.21861
- 12. Kim JS, Oh YS, Kim YI, Koo JS, Yang DW, Lee KS. Transcranial sonography (TCS) in Parkinson’s disease (PD) and essential tremor (ET) about putative premotor symptoms of PD. Arch Gerontol Geriatr. 2012;54(3):e436-e439. doi:10.1016/j.archger.2012.01.001
- 13. Luo WF, Zhang YC, Sheng YJ, Fang JC, Liu CF. Transcranial sonography on Parkinson’s disease and essential tremor in a Chinese population. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol. 2012;33(5):1005-1009. doi:10.1007/s10072-011-0876-x
- 14. Laučkaitė K, Rastenytė D, Šurkienė D, et al. Ultrasonographic (TCS) and clinical findings in overlapping phenotype of essential tremor and Parkinson’s disease (ET-PD). BMC Neurol. 2014;14(1):54. doi:10.1186/1471-2377-14-54
- 15. Sprenger FS, Wurster I, Seppi K, et al. Substantia nigra hyperechogenicity and Parkinson’s disease risk in patients with essential tremor: SN + and PD Risk In Patients With ET. Mov Disord. 2016;31(4):579-583. doi:10.1002/mds.26515
- 16. Cardaioli G, Ripandelli F, Paolini Paoletti F, et al. Substantia nigra hyperechogenicity in essential tremor and Parkinson’s disease: a longitudinal study. Eur J Neurol. 2019;26(11):1370-1376. doi:10.1111/ene.13988
- 17. Louis ED, Ottman R, Ford B, et al. The Washington Heights-Inwood Genetic Study of Essential Tremor: methodologic issues in essential-tremor research. Neuroepidemiology. 1997;16(3):124-133. doi:10.1159/000109681
- 18. Zecca L, Berg D, Arzberger T, et al. In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage. Mov Disord Off J Mov Disord Soc. 2005;20(10):1278-1285. doi:10.1002/mds.20550
There are 18 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Neurology and Neuromuscular Diseases |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | June 30, 2023 |
| Submission Date | January 6, 2023 |
| Acceptance Date | May 2, 2023 |
| Published in Issue | Year 2023 Volume: 6 Issue: 2 |
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