Abstract
SENKRON KOLOREKTAL TÜMÖRLER: KLİNİK DENEYİMLERİMİZ
GİRİŞ VE AMAÇ:
Senkron kolorektal kanserler; tüm kolorektal kanserlerin (KRK) %1,1-8,1’ini oluşturur ve preoperatif tespit edilmeleri, cerrahi tedaviyi ve prognozu doğrudan etkilemektedir. Bu nedenle çalışmamızda kliniğimizde senkron kolon tümörü tanısı koyduğumuz olguların klinikopatolojik özellikleri, tedavi ve sağkalım sonuçları değerlendirilmiştir.
YÖNTEM ve GEREÇLER:
Ocak 2009- Aralık 2018 tarihleri arasında, senkron kolon tümörü tanısı almış 17 olgunun hastane kayıtları retrospektif olarak incelenerek; tümör lokalizasyonları, cerrahi teknikler, patolojik özellikler ve hasta sağkalımları değerlendirilmiştir.
BULGULAR:
Kliniğimizde opere edilen 757 KRK hastasının 17’sinde(%2,2) senkron kolon tümörü tespit edilmiş olup, vakaların 14’ü erkek(%82,3) ve 3‘ü kadındı (%17,7). Hastaların 16’sında iki senkron tümör tespit edilirken, bir hastada üç senkron tümör tespit edildi. Hastaların 2’sine (%11,7) çoklu kolon rezeksiyonu, 7’sine (%41,1) segmenter kolon rezeksiyonu ve 8’ine (%47,1) geniş kolon rezeksiyon ameliyatı uygulandı. Takipleri devam eden hastaların 2’si ex olmuş olup diğer vakaların takipleri devam etmektedir.
TARIŞMA ve SONUÇ:
Senkron kolon tümörü tespitinde preoperatif değerlendirme önemli olup; cerrahi tekniği ve hastanın prognozu doğrudan etkilemektedir. Tüm KRK hastaları acil veya elektif ayrımı yapılmaksızın eksiksiz preoperatif değerlendirilmeleri yapılmalıdır.
SYNCHRONOUS COLORECTAL CANCERS: SINGLE CENTER EXPERIENCE
INTRODUCTION:
Synchrous colorectal cancers forms %1,1-8,1of all colorectal cancers (CRC) and preoperatif diagnosis of them effects directly surgical procedure and prognosis.We present our clinical experience about synchronous CRC patients with their clinicopathologic charasteritics, treatment options and survival rates.
METHODS:
Since January 2009 till December 2018, 17 synchronous CRC diagnosed patients’ hospital records were evaluated retrospectively. Localization and histopathology of tumor, surgery procedures and survival rates were concluded.
RESULTS:
Synchronous colon tumors were detected in 17 (2.2%) out of 757 CRC patients operated in our clinic, 14 of them were male (82.3%) and 3 were female (17.7%). Two synchronous tumors were detected in 16 patients and three synchronous tumors in one patient. Two patients (11.7%) underwent multiple colon resection, 7 patients (41.1%) underwent segmental colon resection, and 8 patients (47.1%) underwent extensive colon resection. Two of the patients who were followed-up were exitus.
CONCLUSION:
Preoperative evaluation of synchronous colon tumor is very important, because presence will change directly the surgical technique and the prognosis of the patient, so all CRC patients should undergo complete preoperative evaluation.
Keywords
References
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- 2)Cunliffe WJ, Hasleton PS, Tweedle DE, Schofield PF. Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg. 1984; 71: 941–943.
- 3)Leersum NJ, Aalbers AG, Snijders HS, et al. Synchronous colorectal carcinoma: a risk factor in colorectal cancer surgery. Dis Colon Rectum. 2014; 57: 460–6.
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- 6)Lam AK, Chan SS, Leung M. Synchronous colorectal cancer: clinical, pathological and molecular implications. World J Gastroenterol. 2014; 20: 6815-6820.
- 7)Latournerie M, Jooste V, Cottet V, Lepage C, Faivre J, Bouvier AM. Epidemiology and prog¬nosis of synchronous colorectal cancers. Br J Surg. 2008; 95: 1528-1533.
- 8)Pajares JA, Perea J. Multiple primary colorectal cancer: Individual or familial predisposition? World J Gastrointest Oncol. 2015 Dec 15; 7: 434-44.
- 9)Nosho K, Kure S, Irahara N, et al. A prospective cohort study shows unique epigenetic, genetic, and prog¬nostic features of synchronous colorectal can¬cers. Gastroenterology. 2009; 137: 1609-1620.
- 10)Cai SJ, Xu Y, Cai GX, et al. Clinical characteristics and diagnosis of patients with hereditary nonpolyposis colorectal cancer. World J Gastroenterol. 2003; 9: 284-87.
- 11)Arriba M, Sánchez R, Rueda D, et al.Toward a Molecular Classification of Synchronous Colorectal Cancer: Clinical and Molecular Characterization. Clin Colorectal Cancer. 2017 Mar; 16: 31-37.
- 12)Drew DA, Nishihara R, Lochhead P, et al. A Prospective Study of Smoking and Risk of Synchronous Colorectal Cancers. Am J Gastroenterol. 2017 Mar; 112: 493-501.
- 13)Borda A, Martínez-Peñuela JM, Muñoz-Navas M, Prieto C, Betés M, Borda F. Synchronous neoplastic lesions in colorectal cancer. An analysis of possible risk factors favouring presentation. Rev Esp Enferm Dig. 2008; 100: 139-145.
- 14)Lam AK, Carmichael R, Gertraud Buettner P, Gopalan V, Ho YH, Siu S. Clinicopathological significance of synchronous carcinoma in colorectal cancer. Am J Surg. 2011; 202: 39-44.
- 15)Thiels CA, Naik ND, Bergquist JR, et al. Survival following synchronous colon cancer resection. J Surg Oncol. 2016 Jul; 114: 80-5.
- 16)Chen HS, Sheen-Chen SM. Synchronous and “early” metachronous colorectal adenocarcinoma: analysis of prognosis and current trends. Dis Colon Rectum. 2000; 43: 1093–9.
- 17)Passman MA, Pommier RF, Vetto JT. Synchronous colon primaries have the same prognosis as solitary colon cancers. Dis Colon Rectum. 1996; 39: 329–34.
- 18)Wang HZ, Huang XF, Wang Y, Ji JF, Gu J. Clinical features, diagnosis, treatment and prognosis of multiple primary colorectal carcinoma. World J Gastroenterol. 2004; 10: 2136–9.
- 19)Çağlıkülekçi M, Bayramoğlu E, Yılmaz S, Oruğ T, Kırımlıoğlu V, Akoğlu M. Kolon ve rektumun senkronize tümörleri. UCD. 1999; 15: 96-100.
- 20)Adloff M, Arnaud JP, Bergamaschi R, Schloegel M. Synchronous carcinoma of the colon and rectum: prognostic and therapeutic implications. Am J Surg. 1989; 157: 299–302.
- 21)Holubar SD, Wolff BG, Poola VP, Soop M. Multiple synchronous colonic anastomoses: are they safe? Colorectal Dis. 2010; 12: 135–40.
- 22)You YN, Chua HK, Nelson H, Hassan I, Barnes SA, Harrington J. Segmental vs. extended colectomy: Measurable differences in morbidity, function, and quality of life. Dis Colon Rectum. 2008; 51: 1036–1043.
- 23)Berg AO, Armstrong K, Botkin J, et al.: Recommendations from the EGAPP Working Group: Genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. Genet Med. 2009; 11: 35–41.
- 24)Akça T, Dağ A, Çolak T, Çağlıkulekçi M, Dirlik M, Şahan E. Kolon Ve Rektumun Senkronize Tümörleri. Kolon Rektum Hast Derg. 2010; 20: 166-171.
Abstract
References
- 1)Kato T, Alonso S, Muto Y, et al. Clinical characteristics of synchronous colorectal cancers in Japan. World Journal of Surgical Oncology. 2016; 14: 272.
- 2)Cunliffe WJ, Hasleton PS, Tweedle DE, Schofield PF. Incidence of synchronous and metachronous colorectal carcinoma. Br J Surg. 1984; 71: 941–943.
- 3)Leersum NJ, Aalbers AG, Snijders HS, et al. Synchronous colorectal carcinoma: a risk factor in colorectal cancer surgery. Dis Colon Rectum. 2014; 57: 460–6.
- 4)Amin MB, Edge S, Greene F, et al. AJCC Cancer Staging Manual. 8th ed. New York, NY: Springer 2017: 252-254.
- 5)Lee BC, Yu CS, Kim J, et al. Clinicopathological features and surgical options for synchronous colorectal cancer. Medicine (Baltimore). 2017 Mar; 96: e6224.
- 6)Lam AK, Chan SS, Leung M. Synchronous colorectal cancer: clinical, pathological and molecular implications. World J Gastroenterol. 2014; 20: 6815-6820.
- 7)Latournerie M, Jooste V, Cottet V, Lepage C, Faivre J, Bouvier AM. Epidemiology and prog¬nosis of synchronous colorectal cancers. Br J Surg. 2008; 95: 1528-1533.
- 8)Pajares JA, Perea J. Multiple primary colorectal cancer: Individual or familial predisposition? World J Gastrointest Oncol. 2015 Dec 15; 7: 434-44.
- 9)Nosho K, Kure S, Irahara N, et al. A prospective cohort study shows unique epigenetic, genetic, and prog¬nostic features of synchronous colorectal can¬cers. Gastroenterology. 2009; 137: 1609-1620.
- 10)Cai SJ, Xu Y, Cai GX, et al. Clinical characteristics and diagnosis of patients with hereditary nonpolyposis colorectal cancer. World J Gastroenterol. 2003; 9: 284-87.
- 11)Arriba M, Sánchez R, Rueda D, et al.Toward a Molecular Classification of Synchronous Colorectal Cancer: Clinical and Molecular Characterization. Clin Colorectal Cancer. 2017 Mar; 16: 31-37.
- 12)Drew DA, Nishihara R, Lochhead P, et al. A Prospective Study of Smoking and Risk of Synchronous Colorectal Cancers. Am J Gastroenterol. 2017 Mar; 112: 493-501.
- 13)Borda A, Martínez-Peñuela JM, Muñoz-Navas M, Prieto C, Betés M, Borda F. Synchronous neoplastic lesions in colorectal cancer. An analysis of possible risk factors favouring presentation. Rev Esp Enferm Dig. 2008; 100: 139-145.
- 14)Lam AK, Carmichael R, Gertraud Buettner P, Gopalan V, Ho YH, Siu S. Clinicopathological significance of synchronous carcinoma in colorectal cancer. Am J Surg. 2011; 202: 39-44.
- 15)Thiels CA, Naik ND, Bergquist JR, et al. Survival following synchronous colon cancer resection. J Surg Oncol. 2016 Jul; 114: 80-5.
- 16)Chen HS, Sheen-Chen SM. Synchronous and “early” metachronous colorectal adenocarcinoma: analysis of prognosis and current trends. Dis Colon Rectum. 2000; 43: 1093–9.
- 17)Passman MA, Pommier RF, Vetto JT. Synchronous colon primaries have the same prognosis as solitary colon cancers. Dis Colon Rectum. 1996; 39: 329–34.
- 18)Wang HZ, Huang XF, Wang Y, Ji JF, Gu J. Clinical features, diagnosis, treatment and prognosis of multiple primary colorectal carcinoma. World J Gastroenterol. 2004; 10: 2136–9.
- 19)Çağlıkülekçi M, Bayramoğlu E, Yılmaz S, Oruğ T, Kırımlıoğlu V, Akoğlu M. Kolon ve rektumun senkronize tümörleri. UCD. 1999; 15: 96-100.
- 20)Adloff M, Arnaud JP, Bergamaschi R, Schloegel M. Synchronous carcinoma of the colon and rectum: prognostic and therapeutic implications. Am J Surg. 1989; 157: 299–302.
- 21)Holubar SD, Wolff BG, Poola VP, Soop M. Multiple synchronous colonic anastomoses: are they safe? Colorectal Dis. 2010; 12: 135–40.
- 22)You YN, Chua HK, Nelson H, Hassan I, Barnes SA, Harrington J. Segmental vs. extended colectomy: Measurable differences in morbidity, function, and quality of life. Dis Colon Rectum. 2008; 51: 1036–1043.
- 23)Berg AO, Armstrong K, Botkin J, et al.: Recommendations from the EGAPP Working Group: Genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives. Genet Med. 2009; 11: 35–41.
- 24)Akça T, Dağ A, Çolak T, Çağlıkulekçi M, Dirlik M, Şahan E. Kolon Ve Rektumun Senkronize Tümörleri. Kolon Rektum Hast Derg. 2010; 20: 166-171.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original research article |
| Authors | |
| Publication Date | December 31, 2020 |
| Submission Date | August 6, 2020 |
| Published in Issue | Year 2020 Volume: 53 Issue: 3 |
