Abstract
43 yaşında kadın hasta acil servise karın ağrısı, sarılık ve idrar renginde koyulaşma şikâyeti ile başvurdu. Hastanın adet düzensizliği nedeniyle bir ay didrogesteron preperatı aldığı öğrenildi. Labaratuar değerlerinde karaciğer enzimlerinde yükseklik saptanan ve diğer etyolojik faktörler dışlanan hastada ilaca bağlı toksik hepatit düşünüldü. Hastaya karaciğer biyopsisi yapıldı, biyopsi sonucu toksik hepatit ile uyumlu gelen hastanın ilacı kesildi ve hastaya destek tedavisi başlandı. Takipte enzimleri ve kliniği düzelen hasta önerilerle taburcu edildi. Didrogesteron her ne kadar güvenli bir ilaç olarak bilinse de ilaç kullanımında sarılık gelişen hastalarda ilacın indüklediği toksik hepatit akla gelmelidir.
Keywords
References
- 1. Coelingh Bennink HJ, Boerrigter PJ. Use of dydrogesterone as a progestogen for oral contraception. Steroids. 2003;68(10-13):927-929.
- 2. Altintaş E, Oğuz D, Kaçar S, Ozderin Y, Sezgin O, Zengin NI. Dydrogesterone-induced hepatitis and autoimmune hemolytic anemia. Turk J Gastroenterol. 2004;15(1):49-52.
- 3. Franco Hidalgo S, Prieto de Paula JM, Salado Valdivieso I. Toxic hepatitis associated with the use of medroxyprogesterone. Gastroenterol Hepatol. 2009;32(1):72-73.
- 4. Arıcı S. Toksik Hepatit. Pamukkale Tıp Dergisi. 2008;1(2):113-119.
- 5. Chitturi S. Farrell G.C. Drug Induced Liver Injury. In Schiff ER, Sorrell MF, Maddrey WC. Schiff's Diseases of Liver. 10th ed. United States: John Wiley and Sons, Inc; 2011:923–1003.
- 6. Hee L, Kettner LO, Vejtorp M. Continuous use of oral contraceptives: an overview of effects and side-effects. Acta Obstet Gynecol Scand. 2013;92(2):125-136.
- 7. Choudhary NS, Bodh V, Chaudhari S, Saraf N, Saigal S. Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases. J Clin Exp Hepatol. 2017;7(3):266-268.
- 8. Andrade RJ, Chalasani N, Björnsson ES, ve ark. Drug-induced liver injury. Nat Rev Dis Primers. 2019;5(1):58.
Abstract
43 years old female patient admitted to our clinic with icter, abdominal pain and darkness in urine. It was learned that she used a didrogesterone preparation for one month due to menstrual irregularity. Drug-induced toxic hepatitis was considered in the patient whose liver enzymes were increased and other etiological factors were excluded. Liver biopsy was performed and the biopsy was compatible with toxic hepatitis. The drug was discontinued and supportive treatment was initiated. At follow up liver enzymes regressed and patient discharged. Although didrogesterone is known to be a safe drug, drug-induced toxic hepatitis should be considered in cases of jaundice.
Keywords
References
- 1. Coelingh Bennink HJ, Boerrigter PJ. Use of dydrogesterone as a progestogen for oral contraception. Steroids. 2003;68(10-13):927-929.
- 2. Altintaş E, Oğuz D, Kaçar S, Ozderin Y, Sezgin O, Zengin NI. Dydrogesterone-induced hepatitis and autoimmune hemolytic anemia. Turk J Gastroenterol. 2004;15(1):49-52.
- 3. Franco Hidalgo S, Prieto de Paula JM, Salado Valdivieso I. Toxic hepatitis associated with the use of medroxyprogesterone. Gastroenterol Hepatol. 2009;32(1):72-73.
- 4. Arıcı S. Toksik Hepatit. Pamukkale Tıp Dergisi. 2008;1(2):113-119.
- 5. Chitturi S. Farrell G.C. Drug Induced Liver Injury. In Schiff ER, Sorrell MF, Maddrey WC. Schiff's Diseases of Liver. 10th ed. United States: John Wiley and Sons, Inc; 2011:923–1003.
- 6. Hee L, Kettner LO, Vejtorp M. Continuous use of oral contraceptives: an overview of effects and side-effects. Acta Obstet Gynecol Scand. 2013;92(2):125-136.
- 7. Choudhary NS, Bodh V, Chaudhari S, Saraf N, Saigal S. Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases. J Clin Exp Hepatol. 2017;7(3):266-268.
- 8. Andrade RJ, Chalasani N, Björnsson ES, ve ark. Drug-induced liver injury. Nat Rev Dis Primers. 2019;5(1):58.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | April 23, 2020 |
| Published in Issue | Year 2020 Volume: 4 Issue: 1 |
Cite
Ahi Evran Medical Journal is indexed in ULAKBIM TR Index, Turkish Medline, DOAJ, Index Copernicus, EBSCO and Turkey Citation Index. Ahi Evran Medical Journal is periodical scientific publication. Can not be cited without reference. Responsibility of the articles belong to the authors.
