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Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients

Year 2022, Volume: 6 Issue: 1, 21 - 25, 22.04.2022
https://doi.org/10.46332/aemj.900116

Abstract

Purpose: Psoriasis has been accepted as a T-cell mediated systemic disease and systemic inflammation may also cause immune-mediated hearing loss. We aimed to evaluate cochlear function with otoacoustic emission (OAE) measurement in psoriasis pa-tients and to evaluate whether there is a relationship between duration and severity of the disease and OAEs.
Materials and Methods: Forty-four patients diagnosed with psoriasis were included in the study. The control group consisted of 35 healthy volunteers. The patients' age, gender, onset age, family history, disease duration, and additional diseases were ques-tioned, and psoriasis area severity index (PASI) was calculated. Audiological and otological evaluations were performed. Distor-tion Product Otoacoustic Emission (DPOAE) were measured at 500, 1000, 2,000, 4,000, 6000, 8000 and 10000 Hz frequencies.
Results: There was no significant difference in DPOAE values at 500, 1000, 2000, 4000, 6000, 8000, and 10000 Hz between healthy volunteers and psoriasis patients. There was a significant difference between PASI score and SNR value at 1000 Hz (p=0.031), disease duration, and DPAOE values at 4000 and 6000 Hz (p=0.033, p=0.038 respectively)
Conclusion: Considering that psoriasis is a long-term, chronic systemic disease, patients should be follow-up closely even if they do not have hearing complaints in the early period, and as the duration and severity of the disease increases, the hearing of the patients may be affected. 

References

  • 1. Van de Kerkhof PCM, Nestlé FO. Psoriasis. In: Bolognia JL, Jorizzo JL, Schaffer JV, Editors. Dermatology. 3st Ed. USA: Elsevier Saunders; 2012:135-156.
  • 2. Augustin M, Radtke MA. Quality of life in psoriasis patients. Expert Rev Pharmacoecon Outcomes Res. 2014;14(4):559-568.
  • 3. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361(17):496-509.
  • 4. Kim J, Krueger JG. The immunopathogenesis of psoriasis. Dermatol Clin. 2015;33(1):13-23.
  • 5. Kemp DT. Stimulated acoustic emissions from within the human auditory system. J Acoust Soc Am. 1978;64(5):1386-1391.
  • 6. Kemp DT. Otoacoustic emissions, their origin in cochlear function, and use. Br Med Bull. 2002;63(1):223-241.
  • 7. Lehnhardt E. Sudden hearing disorders occurring simultaneously or successively on both sides. Z Laryngol Rhinol Otol. 1958;37(1):1-16.
  • 8. Tsai TF, Wang TS, Hung ST, et al. Epidemiology and comorbidities of psoriasis patients in a national database in Tai-wan. J Dermatol Sci. 2011;63(1):40-46.
  • 9. Karabulut H, Karadag AS, Dagli M, et al. Investigation of hearing and outer hair cell function of cochlea in patients with psoriasis. J Int Adv Otol. 2010; 6(2):239-244.
  • 10. Pariser DM, Bagel J, Gelfand JM, et al. National psoriasis foundation clinical consensus on disease severity. Arch Dermatol. 2007;143(2):239-242.
  • 11. Dornhoffer JL, Arenberg IK. Immune mechanisms in Meniere's syndrome. Otolaryngol Clin North Am. 1997;30(6):1017-1026.
  • 12. Halligan CS, Bauch CD, Brey RH, et al. Hearing loss in rheumatoid arthritis. Laryngoscope. 2006;116(11):2044-2049.
  • 13. Dagli M, Sivas Acar F, Karabulut H, Eryilmaz A, Erkol Inal E. Evaluation of hearing and cochlear function by DPOAE and audiometric tests in patients with ankylosing spondilitis. Rheumatol Int. 2007;27(6):511-516.
  • 14. Eryilmaz A, Dagli M, Karabulut H, Sivas Acar F, Erkol Inal E, Gocer C. Evaluation of hearing loss in patients with an-kylosing spondylitis. J Laryngol Otol. 2007;121(9):845-849.
  • 15. Bayazit YA, Yilmaz M, Gunduz B, et al. Distortion product otoacoustic emission findings in Behçet's disease and rheumatoid arthritis. ORL J Otorhinolaryngol Relat Spec. 2007;69(4):233-238.
  • 16. Dagli M, Eryilmaz A, Tanrikulu S, et al. Evaluation of cochlear involvement by distortion product otoacoustic emission in Behçet's disease. Auris Nasus Larynx. 2008;35(3):333-337.
  • 17. Hatzopoulos S, Amoroso C, Aimoni C, Lo Monaco A, Govoni M, Martini A. Hearing loss evaluation of Sjögren's syn-drome using distortion product otoacoustic emissions. Acta Otolaryngol Suppl. 2002;122(5):20-25.
  • 18. Karatas E, Onat AM, Durucu C, et al. Audiovestibular disturbance in patients with systemic lupus erythematosus. Oto-laryngol Head Neck Surg. 2007;136(1):82-86.
  • 19. Yen YC, Lin YS, Weng SF, Lai FJ. Risk of sudden sensorineural hearing loss in patients with psoriasis: a retrospective cohort study. Am J Clin Dermatol. 2015;16(3):213-220.
  • 20. Gunes A, Gundogdu I, Mutlu M, Ozturk EA, Cakci A, Akin I. Functions of the inner ear in psoriatic arthritis. Auris Nasus Larynx. 2016;43(6):626-631.
  • 21. Vir D, Sharma P, Mahajan R, Dogra S, Bakshi J, Panda NK. Investigation of high-frequency hearing loss and outer hair cell function of the cochlea in patients with psoriasis: a case-control study. Clin Exp Dermatol. 2019;44(5):520-523.
  • 22. Dikici O, Muluk NB, Tosun AK, Unlusoy I. Subjective audiological tests and transient evoked otoacoustic emissions in patients with rheumatoid arthritis: analysis of the factors affecting hearing levels. Eur Arch Otorhinolaryngol. 2009;266(11):1719-1726.

Psöriazis Hastalarında Koklear Dış Tüy Hücre Fonksiyonunun Araştırılması

Year 2022, Volume: 6 Issue: 1, 21 - 25, 22.04.2022
https://doi.org/10.46332/aemj.900116

Abstract

Amaç: Psöriazis, T hücre aracılı sistemik bir hastalık olarak kabul edilmektedir ve sistemik inflamatur yanıt immun sistem aracılı işitme kaybına neden olabilir. Çalışmamızda, psoriazis hastalarında koklear fonksiyonunun göstergesi olan otoakustik emisyon (OAE) ölçümü ile hastalık süre ve şiddeti ile arasında bir ilişki olup olmadığını değerlendirmeyi amaçladık.
Araçlar ve Yöntem: Çalışmaya psoriasis tanılı 44 hasta dahil edildi. Kontrol grubu 35 sağlıklı gönüllüden oluşturuldu. Hastaların yaşı, cinsiyeti, hastalık başlangıç yaşı ve süresi, aile öyküsü ve ek hastalıkları sorgulandı ve psoriazis alan şiddet indeksi (PASI) hesaplandı. Odyolojik ve otolojik değerlendirmeler yapıldı. Distortion Product Otoakustik Emisyon (DPOAE) 500, 1000, 2000, 4000, 6000, 8000 ve 10000 Hz frekanslarında ölçüldü.
Bulgular: 500, 1000, 2000, 4000, 6000, 8000 ve 10000 Hz'deki DPOAE değerleri karşılaştırıldığında hasta grubu ile sağlıklı gönüllüler arasında anlamlı fark yoktu. PASI skoru ile 1000 Hz'deki SNR değeri arasında (p=0.031) ve hastalık süresi ile 4000 ve 6000 Hz'deki DPAOE değerleri arasında (sırasıyla p=0.033, p=0.038 anlamlı fark bulundu.
Sonuç: Psöriazisin uzun süreli, kronik sistemik bir hastalık olduğu göz önüne alındığında, hastaların erken dönemde işitme yakınmaları olmasa dahi yakından takip edilmesi önemlidir ve hastalığın süresi ve şiddeti arttıkça hastaların işitme duyusu etkilenebilir.

References

  • 1. Van de Kerkhof PCM, Nestlé FO. Psoriasis. In: Bolognia JL, Jorizzo JL, Schaffer JV, Editors. Dermatology. 3st Ed. USA: Elsevier Saunders; 2012:135-156.
  • 2. Augustin M, Radtke MA. Quality of life in psoriasis patients. Expert Rev Pharmacoecon Outcomes Res. 2014;14(4):559-568.
  • 3. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361(17):496-509.
  • 4. Kim J, Krueger JG. The immunopathogenesis of psoriasis. Dermatol Clin. 2015;33(1):13-23.
  • 5. Kemp DT. Stimulated acoustic emissions from within the human auditory system. J Acoust Soc Am. 1978;64(5):1386-1391.
  • 6. Kemp DT. Otoacoustic emissions, their origin in cochlear function, and use. Br Med Bull. 2002;63(1):223-241.
  • 7. Lehnhardt E. Sudden hearing disorders occurring simultaneously or successively on both sides. Z Laryngol Rhinol Otol. 1958;37(1):1-16.
  • 8. Tsai TF, Wang TS, Hung ST, et al. Epidemiology and comorbidities of psoriasis patients in a national database in Tai-wan. J Dermatol Sci. 2011;63(1):40-46.
  • 9. Karabulut H, Karadag AS, Dagli M, et al. Investigation of hearing and outer hair cell function of cochlea in patients with psoriasis. J Int Adv Otol. 2010; 6(2):239-244.
  • 10. Pariser DM, Bagel J, Gelfand JM, et al. National psoriasis foundation clinical consensus on disease severity. Arch Dermatol. 2007;143(2):239-242.
  • 11. Dornhoffer JL, Arenberg IK. Immune mechanisms in Meniere's syndrome. Otolaryngol Clin North Am. 1997;30(6):1017-1026.
  • 12. Halligan CS, Bauch CD, Brey RH, et al. Hearing loss in rheumatoid arthritis. Laryngoscope. 2006;116(11):2044-2049.
  • 13. Dagli M, Sivas Acar F, Karabulut H, Eryilmaz A, Erkol Inal E. Evaluation of hearing and cochlear function by DPOAE and audiometric tests in patients with ankylosing spondilitis. Rheumatol Int. 2007;27(6):511-516.
  • 14. Eryilmaz A, Dagli M, Karabulut H, Sivas Acar F, Erkol Inal E, Gocer C. Evaluation of hearing loss in patients with an-kylosing spondylitis. J Laryngol Otol. 2007;121(9):845-849.
  • 15. Bayazit YA, Yilmaz M, Gunduz B, et al. Distortion product otoacoustic emission findings in Behçet's disease and rheumatoid arthritis. ORL J Otorhinolaryngol Relat Spec. 2007;69(4):233-238.
  • 16. Dagli M, Eryilmaz A, Tanrikulu S, et al. Evaluation of cochlear involvement by distortion product otoacoustic emission in Behçet's disease. Auris Nasus Larynx. 2008;35(3):333-337.
  • 17. Hatzopoulos S, Amoroso C, Aimoni C, Lo Monaco A, Govoni M, Martini A. Hearing loss evaluation of Sjögren's syn-drome using distortion product otoacoustic emissions. Acta Otolaryngol Suppl. 2002;122(5):20-25.
  • 18. Karatas E, Onat AM, Durucu C, et al. Audiovestibular disturbance in patients with systemic lupus erythematosus. Oto-laryngol Head Neck Surg. 2007;136(1):82-86.
  • 19. Yen YC, Lin YS, Weng SF, Lai FJ. Risk of sudden sensorineural hearing loss in patients with psoriasis: a retrospective cohort study. Am J Clin Dermatol. 2015;16(3):213-220.
  • 20. Gunes A, Gundogdu I, Mutlu M, Ozturk EA, Cakci A, Akin I. Functions of the inner ear in psoriatic arthritis. Auris Nasus Larynx. 2016;43(6):626-631.
  • 21. Vir D, Sharma P, Mahajan R, Dogra S, Bakshi J, Panda NK. Investigation of high-frequency hearing loss and outer hair cell function of the cochlea in patients with psoriasis: a case-control study. Clin Exp Dermatol. 2019;44(5):520-523.
  • 22. Dikici O, Muluk NB, Tosun AK, Unlusoy I. Subjective audiological tests and transient evoked otoacoustic emissions in patients with rheumatoid arthritis: analysis of the factors affecting hearing levels. Eur Arch Otorhinolaryngol. 2009;266(11):1719-1726.
There are 22 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Articles
Authors

Ozlem Yagiz Aghayarov 0000-0002-8455-4400

Esra İnan Doğan 0000-0002-9539-334X

Publication Date April 22, 2022
Published in Issue Year 2022 Volume: 6 Issue: 1

Cite

APA Yagiz Aghayarov, O., & İnan Doğan, E. (2022). Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients. Ahi Evran Medical Journal, 6(1), 21-25. https://doi.org/10.46332/aemj.900116
AMA Yagiz Aghayarov O, İnan Doğan E. Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients. Ahi Evran Med J. April 2022;6(1):21-25. doi:10.46332/aemj.900116
Chicago Yagiz Aghayarov, Ozlem, and Esra İnan Doğan. “Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients”. Ahi Evran Medical Journal 6, no. 1 (April 2022): 21-25. https://doi.org/10.46332/aemj.900116.
EndNote Yagiz Aghayarov O, İnan Doğan E (April 1, 2022) Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients. Ahi Evran Medical Journal 6 1 21–25.
IEEE O. Yagiz Aghayarov and E. İnan Doğan, “Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients”, Ahi Evran Med J, vol. 6, no. 1, pp. 21–25, 2022, doi: 10.46332/aemj.900116.
ISNAD Yagiz Aghayarov, Ozlem - İnan Doğan, Esra. “Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients”. Ahi Evran Medical Journal 6/1 (April 2022), 21-25. https://doi.org/10.46332/aemj.900116.
JAMA Yagiz Aghayarov O, İnan Doğan E. Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients. Ahi Evran Med J. 2022;6:21–25.
MLA Yagiz Aghayarov, Ozlem and Esra İnan Doğan. “Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients”. Ahi Evran Medical Journal, vol. 6, no. 1, 2022, pp. 21-25, doi:10.46332/aemj.900116.
Vancouver Yagiz Aghayarov O, İnan Doğan E. Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients. Ahi Evran Med J. 2022;6(1):21-5.

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