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Evaluation of Helicobacter pylori prevalence in celiac disease

Year 2018, Volume: 17 Issue: 1, 12 - 17, 24.04.2018
https://doi.org/10.17941/agd.366411

Abstract

Background and Aims: Although studies have reported a protective role of Helicobacter pylori against celiac disease, some studies have shown an increased prevalence of Helicobacter pylori in celiac disease. We aimed to detect the prevalence of Helicobacter pylori at the time of the diagnosis of celiac disease and compared it with an age-matched control group in our clinic. Materials and Methods: In this study, 41 celiac and 82 control patients, with similar age and sex, who underwent an upper gastrointestinal endoscopy for dyspeptic symptoms were included. Results: Helicobacter pylori was detected in 20 (48.8%) of the 41 celiac patients and in 70 (85.4%) of the 82 control subjects. The prevalence of Helicobacter pylori was lower in celiac patients than in the general population. Conclusion: Multicenter studies including a larger number of patients are needed to assess the role of Helicobacter pylori in the pathogenesis of celiac disease.

References

  • REFERANSLAR 1-Green PH, Cellier C. Celiac disease. N Engl J Med 2007;357:1731-43. 2- Biagi F, Klersy C, Balduzzi D, Corazza GR. Are we not over-estimating the prevalence of coeliac disease in the general population? Ann Med 2010;42:557-61. 3- Kochhar GS, Singh T, Gill A, Kirby DF. Celiac disease: Managing a multisystem disorder. Cleve Clin J Med. 2016 Mar;83(3):217-27. 4- Sergi C, Shen F, Bouma G. Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease). World J Gastroenterol. 2017 Jan 28;23(4):573-589. 5-Harris LA, Park JY, Voltaggio L, Lam-Himlin D. Celiac disease: clinical, endoscopic, and histopathologic review. Gastrointest Endosc 2012;76:625-40. 6- Ford AC, Axon ATR. Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter 2010; 15 Suppl 1: 1-6. 7- Smyk DS, Koutsoumpas AL, Mytilinaiou MG, et al. Helicobacter pylori and autoimmune disease: cause or by stander. World J Gastroenterol 2014; 20: 613-29. 8-Broide E, Sandbank J, Scapa E, Kimchi NA, Shap-iro M, Lerner A. The immunohistochemistry profle of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and infammation. Mediators Infamm 2007;2007:81838. 9- Konturek PC, Karczewska E, Dieterich W, et al. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2000; 95: 3682-3. 10. Aydogdu S, Cakir M, Yuksekkaya HA, et al. Helicobacter pylori infection in children with celiac disease. Scand J Gastroenterol 2008; 43: 1088-93. 11. Ciacci C, Squillante A, Rendina D, et al. Helicobacter pylori infection and peptic disease in coeliac disease. Eur J Gastroenterol Hepatol 2000; 12: 1283-7. 12. Lebwohl B, Blaser MJ, Ludvigsson JF, et al. Decreased risk of celiac disease in patients with Helicobacter pylori colonization. Am J Epidemiol 2013; 178: 1721-30. 13. Luzza F, Mancuso M, Imeneo M, et al. Helicobacter pylori infection in children with celiac disease: prevalence and clinicopathologic features. J Pediatr Gastr Nutr 1999; 28: 143-6. 14. Diamanti A, Maino C, Niveloni S, et al. Characterization of gastric mucosal lesions in patients with celiac disease: a prospective controlled study. Am J Gastroenterol 1999; 94: 1313-9. 15. Rostami-Nejad M, Villanacci V, Mashayakhi R, et al. Celiac disease and Hp infection association in Iran. Rev Esp Enferm Dig 2009; 101: 850-4. 16. Rostami Nejad M, Rostami K, Yamaoka Y, et al. Clinical and histological presentation of Helicobacter pylori and gluten related gastroenteropathy. Arch Iran Med 2011; 14: 115-8. 17. Jozefczuk J, Bancerz B, Walkowiak M, et al. Prevalence of Helicobacter pylori infection in pediatric celiac disease. Eur Rev Med Pharmacol Sci. 2015;19(11):2031-5. 18. Villanacci V, Bassotti G, Liserre B, et al. Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2006; 101: 1880-5. 19. Narang M, Puri AS, Sachdeva S, Singh J, Kumar A, Saran RK. Celiac disease and Helicobacter pylori infection in children: Is there any Association? J Gastroenterol Hepatol. 2017 Jun;32(6):1178-1182. 20. Arnold IC, Dehzad N, Reuter S, Martin H, Becher B, Taube C, Müller A. Heli¬cobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest. 2011;121(8):3088-93. 21. Chen Y, Segers S, Blaser MJ. Association between Helicobacter pylori and mor¬tality in the NHANES III study. Gut. 2013;62(9):1262-9.

Çölyak hastalığında Helicobacter pylori prevalansının değerlendirilmesi

Year 2018, Volume: 17 Issue: 1, 12 - 17, 24.04.2018
https://doi.org/10.17941/agd.366411

Abstract

Giriş ve Amaç: Helicobacter pylori’nin çölyak hastalığına karşı koruyucu rolü olabileceğini gösteren çalışmaların yanı sıra; çölyak hastalığında Helicobacter pylori prevalansının arttığını gösteren çalışmalar da mevcuttur. Biz çalışmamızda; kliniğimizde çölyak hastalığı tanısı almış hastalarda tanı anında Helicobacter pylori prevalansını saptamayı ve yaş uyumlu kontrol grubu ile karşılaştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya 41 çölyak hastası, yaş ve cinsiyet uyumlu dispeptik şikayetleri nedeni ile üst gastrointestinal sistem endoskopisi yapılmış 82 kontrol hastası dahil edildi. Bulgular: Helicobacter pylori 41 çölyak hastasının 20’sinde (48,8%), 82 kontrol hastasının 70’inde (85.4%) tespit edildi. Helicobacter pylori prevalansı çölyak hastalarında genel popülasyondan daha az saptandı. Sonuç: Çölyak hastalığının patogenezinde Helicobacter pylori’nin rolünü değerlendirmek için çok sayıda hasta içeren çok merkezli çalışmalara ihtiyaç vardır.

References

  • REFERANSLAR 1-Green PH, Cellier C. Celiac disease. N Engl J Med 2007;357:1731-43. 2- Biagi F, Klersy C, Balduzzi D, Corazza GR. Are we not over-estimating the prevalence of coeliac disease in the general population? Ann Med 2010;42:557-61. 3- Kochhar GS, Singh T, Gill A, Kirby DF. Celiac disease: Managing a multisystem disorder. Cleve Clin J Med. 2016 Mar;83(3):217-27. 4- Sergi C, Shen F, Bouma G. Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease). World J Gastroenterol. 2017 Jan 28;23(4):573-589. 5-Harris LA, Park JY, Voltaggio L, Lam-Himlin D. Celiac disease: clinical, endoscopic, and histopathologic review. Gastrointest Endosc 2012;76:625-40. 6- Ford AC, Axon ATR. Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter 2010; 15 Suppl 1: 1-6. 7- Smyk DS, Koutsoumpas AL, Mytilinaiou MG, et al. Helicobacter pylori and autoimmune disease: cause or by stander. World J Gastroenterol 2014; 20: 613-29. 8-Broide E, Sandbank J, Scapa E, Kimchi NA, Shap-iro M, Lerner A. The immunohistochemistry profle of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and infammation. Mediators Infamm 2007;2007:81838. 9- Konturek PC, Karczewska E, Dieterich W, et al. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2000; 95: 3682-3. 10. Aydogdu S, Cakir M, Yuksekkaya HA, et al. Helicobacter pylori infection in children with celiac disease. Scand J Gastroenterol 2008; 43: 1088-93. 11. Ciacci C, Squillante A, Rendina D, et al. Helicobacter pylori infection and peptic disease in coeliac disease. Eur J Gastroenterol Hepatol 2000; 12: 1283-7. 12. Lebwohl B, Blaser MJ, Ludvigsson JF, et al. Decreased risk of celiac disease in patients with Helicobacter pylori colonization. Am J Epidemiol 2013; 178: 1721-30. 13. Luzza F, Mancuso M, Imeneo M, et al. Helicobacter pylori infection in children with celiac disease: prevalence and clinicopathologic features. J Pediatr Gastr Nutr 1999; 28: 143-6. 14. Diamanti A, Maino C, Niveloni S, et al. Characterization of gastric mucosal lesions in patients with celiac disease: a prospective controlled study. Am J Gastroenterol 1999; 94: 1313-9. 15. Rostami-Nejad M, Villanacci V, Mashayakhi R, et al. Celiac disease and Hp infection association in Iran. Rev Esp Enferm Dig 2009; 101: 850-4. 16. Rostami Nejad M, Rostami K, Yamaoka Y, et al. Clinical and histological presentation of Helicobacter pylori and gluten related gastroenteropathy. Arch Iran Med 2011; 14: 115-8. 17. Jozefczuk J, Bancerz B, Walkowiak M, et al. Prevalence of Helicobacter pylori infection in pediatric celiac disease. Eur Rev Med Pharmacol Sci. 2015;19(11):2031-5. 18. Villanacci V, Bassotti G, Liserre B, et al. Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2006; 101: 1880-5. 19. Narang M, Puri AS, Sachdeva S, Singh J, Kumar A, Saran RK. Celiac disease and Helicobacter pylori infection in children: Is there any Association? J Gastroenterol Hepatol. 2017 Jun;32(6):1178-1182. 20. Arnold IC, Dehzad N, Reuter S, Martin H, Becher B, Taube C, Müller A. Heli¬cobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest. 2011;121(8):3088-93. 21. Chen Y, Segers S, Blaser MJ. Association between Helicobacter pylori and mor¬tality in the NHANES III study. Gut. 2013;62(9):1262-9.
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Evrim Kahramanoğlu Aksoy 0000-0001-8887-3428

Ferdane Sapmaz 0000-0003-1278-110X

Muhammet Yener Akpınar 0000-0003-0903-4664

Metin Uzman 0000-0002-5412-8523

Publication Date April 24, 2018
Published in Issue Year 2018 Volume: 17 Issue: 1

Cite

APA Kahramanoğlu Aksoy, E., Sapmaz, F., Akpınar, M. Y., Uzman, M. (2018). Çölyak hastalığında Helicobacter pylori prevalansının değerlendirilmesi. Akademik Gastroenteroloji Dergisi, 17(1), 12-17. https://doi.org/10.17941/agd.366411

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