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Helicobacter pylori eradikasyon tedavisinin tam kan sayımı ve inflamatuvar parametrelere etkisi

Year 2022, Volume: 21 Issue: 2, 53 - 58, 25.08.2022
https://doi.org/10.17941/agd.1106356

Abstract

Giriş ve amaç: Helicobacter pylori (H. pylori) enfeksiyonun inflamatuvar ve tam kan sayımı parametrelerinde değişikliklere neden olduğu daha önce bildirilmiştir. Ancak eradikasyon tedavisi sonrasında bu parametrelerdeki değişiklikler yeterince incelenmemişti. Bu çalışmanın amacı eradikasyonunun, inflamatuar belirteçler ve tam kan sayımı parametreleri üzerine etkisinini belirlemektir. Gereç ve yöntem: Bu tek merkezli gözlemsel çalışma Temmuz 2021 ile Ocak 2022 tarihleri arasında iç hastalıkları polikliniğine dispeptik yakınmaları nedeniyle başvuran ve üst gis endoskopisi uygulanan hastalardan Helicobacter pylori testi pozitif saptananlarla yapıldı. Tedaviden 8 hafta sonra yapılan kontrolde eradikasyonu başarılı olan hastalar çalışmaya alındı. Tedavi öncesi ve tedavi sonrası laboratuvar parametreleri kıyaslandı. Bulgular: Hastaların ortalama yaşı 43.84±12.59 idi. Tedavi sonrası C- reaktif protein (CRP), trombosit lenfosit oranı (PLR) ve nötrofil lenfosit oranı (NLR) değerinde anlamlı azalma olduğu saptandı. Trombosit sayısı ve ortalama trombosit hacmi (MPV) değerleri tedavi öncesi ve sonrasında farklılık bulunmadı. Sonuç: Helicobacter pylori eradikasyonu yapılan hastalarda CRP, PLR ve NLR gibi inflamatuar belirteçler tedavi öncesine göre anlamlı olarak azalmaktadır. Bunlar Helicobacter pylori enfeksiyonunun değerlendirilmesinde kullanılabilecek, ucuz invaziv olmayan paramatreler olabilir.

References

  • Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther. 1995;9(suppl 2):33‐39.
  • Goni E, Franceschi F. Helicobacter pylori and extragastric diseases. Helicobacter. 2016;21 Suppl 1:45-48. doi:10.1111/hel.12340.
  • Kim TJ, Pyo JH, Lee H, et al. Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults. Korean J Gastroenterol. 2018;72(1):21-27. doi:10.4166/kjg.2018.72.1.21.
  • Umit H, Umit EG. Helicobacter pylori and mean platelet volume: a relation way before immune thrombocytopenia?. Eur Rev Med Pharmacol Sci. 2015;19(15):2818-2823.
  • Kaplan M, Ates I, Yuksel M, et al. The role of the PLR-NLR combination in the prediction of the presence of Helicobacter pylori and its associated complications. Saudi J Gastroenterol. 2018 Sep-Oct;24(5):294-300. doi:10.4103/sjg.SJ _29_18.
  • Matsukawa Y, Kitamura N, Iwamoto M, et al. Helicobacter pylori upregulates peripheral platelet counts mainly in female patients. Acta Haematol. 2011;126(3):172-5. doi: 10.1159/000329011.
  • Altun Ö, Özcan M. Helikobakter Pilori Eradike Edilen Hastaların Takibinde, Trombosit Sayısı, PDW ve MPV Değerinin Önemi. Bosphorus Med J 2020:7(2),45-50.
  • Erre GL, Paliogiannis P, Castagna F, et al. Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis. Eur J Clin Invest. 2019;49(1):e13037. doi:10.1111/eci.13037.
  • Farah R, Hamza H, Khamisy-Farah R. A link between platelet to lymphocyte ratio and Helicobacter pylori infection. J Clin Lab Anal. 2018 Jan;32(1):e22222. doi: 10.1002/jcla.22222.
  • Guclu M, Faruq Agan A. Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume. Euroasian J Hepatogastroenterol. 2017;7(1):11-16. doi:10.5005/jp-journals-10018-1204.
  • Balta S, Ozturk C. The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets. 2015;26(7):680-681. doi:10.3109/09537104.2014.979340.
  • McColl KE. Clinical practice. Helicobacter pylori infection. N Engl J Med. 2010;362(17):1597-1604. doi:10.1056/NEJMcp1001110.
  • Elizalde JI, Gomez J, Panes J, et al. Platelet activation In mice and human Helicobacter pylori infection. J Clin Invest. 1997;100(5):996-1005. doi:10.1172/JCI119650.
  • Altun Ö. Özcan M. The Importance of Platelet Count, PDW and MPV Value in the Follow-up of Patients with Helicobacter Pylori Eradication. Bosphorus Medical Journal, 7(2), 45-50.
  • Pellicano R, Oliaro E, Fagoonee S, et al. Clinical and biochemical parameters related to cardiovascular disease after Helicobacter pylori eradication. Int Angiol. 2009;28(6):469-473.
  • Matsukawa Y, Iwamoto M, Kato K, et al. Long term changes in platelet counts after H. pylori eradication in non-ITP patients. Platelets. 2010;21(8):628-31. doi: 10.3109/09537104.2010.510894.
  • Topal F, Karaman K, Akbulut S, et al. The relationship between mean platelet volume levels and the inflammation in Helicobacter pylori gastritis. J Natl Med Assoc. 2010;102(8):726-730. doi:10.1016/s0027-9684(15)30659-3.
  • Beyan C, Beyan E. Relationship between mean platelet volume and C-reactive protein. Proc (Bayl Univ Med Cent). 2020;33(3):476-477. Published 2020 Jul 6. doi:10.1080/08998280.2020.1768781.

Effect of eradication treatment for Helicobacter pylori on complete blood count and inflammatory parameters

Year 2022, Volume: 21 Issue: 2, 53 - 58, 25.08.2022
https://doi.org/10.17941/agd.1106356

Abstract

Background and aims: Previously Helicobacter pylori (H. Pylori) infection was held responsible for changes in complete blood count and inflammatory parameters. But changes in these parameters after eradication treatment was not entirely evaluated. This study was designed to evaluate the effect of eradication threatment for H. pylori infection on inflammatory markers and complete blood count parameters. Materials and method: This single center observational study enrolled participants who came to internal medicine outpatient clinics because of dyspeptic complaints and who were diagnosed to have H. pylori infection after endoscopic evaluation, between July 2021 and January 2022. Participants who were tested negative for H. pylori stool antigen test eight weeks after eradication treatment were included. Complete blood count and infammatory parameters before and after eradication treatment were compared. Results: Mean participant age was 43.84±12.59 years. There were significant decreases in C-reactive protein (CRP), platelet to lymphocyte ratio (PLR) and neutrophile to lymphocyte ratio (NLR) after eradication. Changes in platelet counts and mean platelet volumes (MPV) were insignificant. Conclusion: CRP, PLR and NLR were significantly lower after eradication for H. pylori. These parameters may be useful, simple, available and non-invasive tests that may be used in evaluation of eradication treatment for H. pylori.

References

  • Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther. 1995;9(suppl 2):33‐39.
  • Goni E, Franceschi F. Helicobacter pylori and extragastric diseases. Helicobacter. 2016;21 Suppl 1:45-48. doi:10.1111/hel.12340.
  • Kim TJ, Pyo JH, Lee H, et al. Lack of Association between Helicobacter pylori Infection and Various Markers of Systemic Inflammation in Asymptomatic Adults. Korean J Gastroenterol. 2018;72(1):21-27. doi:10.4166/kjg.2018.72.1.21.
  • Umit H, Umit EG. Helicobacter pylori and mean platelet volume: a relation way before immune thrombocytopenia?. Eur Rev Med Pharmacol Sci. 2015;19(15):2818-2823.
  • Kaplan M, Ates I, Yuksel M, et al. The role of the PLR-NLR combination in the prediction of the presence of Helicobacter pylori and its associated complications. Saudi J Gastroenterol. 2018 Sep-Oct;24(5):294-300. doi:10.4103/sjg.SJ _29_18.
  • Matsukawa Y, Kitamura N, Iwamoto M, et al. Helicobacter pylori upregulates peripheral platelet counts mainly in female patients. Acta Haematol. 2011;126(3):172-5. doi: 10.1159/000329011.
  • Altun Ö, Özcan M. Helikobakter Pilori Eradike Edilen Hastaların Takibinde, Trombosit Sayısı, PDW ve MPV Değerinin Önemi. Bosphorus Med J 2020:7(2),45-50.
  • Erre GL, Paliogiannis P, Castagna F, et al. Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis. Eur J Clin Invest. 2019;49(1):e13037. doi:10.1111/eci.13037.
  • Farah R, Hamza H, Khamisy-Farah R. A link between platelet to lymphocyte ratio and Helicobacter pylori infection. J Clin Lab Anal. 2018 Jan;32(1):e22222. doi: 10.1002/jcla.22222.
  • Guclu M, Faruq Agan A. Association of Severity of Helicobacter pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume. Euroasian J Hepatogastroenterol. 2017;7(1):11-16. doi:10.5005/jp-journals-10018-1204.
  • Balta S, Ozturk C. The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets. 2015;26(7):680-681. doi:10.3109/09537104.2014.979340.
  • McColl KE. Clinical practice. Helicobacter pylori infection. N Engl J Med. 2010;362(17):1597-1604. doi:10.1056/NEJMcp1001110.
  • Elizalde JI, Gomez J, Panes J, et al. Platelet activation In mice and human Helicobacter pylori infection. J Clin Invest. 1997;100(5):996-1005. doi:10.1172/JCI119650.
  • Altun Ö. Özcan M. The Importance of Platelet Count, PDW and MPV Value in the Follow-up of Patients with Helicobacter Pylori Eradication. Bosphorus Medical Journal, 7(2), 45-50.
  • Pellicano R, Oliaro E, Fagoonee S, et al. Clinical and biochemical parameters related to cardiovascular disease after Helicobacter pylori eradication. Int Angiol. 2009;28(6):469-473.
  • Matsukawa Y, Iwamoto M, Kato K, et al. Long term changes in platelet counts after H. pylori eradication in non-ITP patients. Platelets. 2010;21(8):628-31. doi: 10.3109/09537104.2010.510894.
  • Topal F, Karaman K, Akbulut S, et al. The relationship between mean platelet volume levels and the inflammation in Helicobacter pylori gastritis. J Natl Med Assoc. 2010;102(8):726-730. doi:10.1016/s0027-9684(15)30659-3.
  • Beyan C, Beyan E. Relationship between mean platelet volume and C-reactive protein. Proc (Bayl Univ Med Cent). 2020;33(3):476-477. Published 2020 Jul 6. doi:10.1080/08998280.2020.1768781.
There are 18 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Recep Alanlı 0000-0003-4663-1898

Murat Bülent Küçükay 0000-0003-3657-6565

Publication Date August 25, 2022
Published in Issue Year 2022 Volume: 21 Issue: 2

Cite

APA Alanlı, R., & Küçükay, M. B. (2022). Effect of eradication treatment for Helicobacter pylori on complete blood count and inflammatory parameters. Akademik Gastroenteroloji Dergisi, 21(2), 53-58. https://doi.org/10.17941/agd.1106356

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