Abstract
Aim: Vitamin D is effective in calcium absorbtion and bone metabolism. Also, decreased vitamin D levels are associated with most of the chronic diseases such as DM, HT, cancer and otoimmune diseases. In this study, we aimed to investigate vitamin D levels that is carried out in our laboratory between January and December in 2012.
Materials and Methods: A total of 4168 patients between January and December in 2012 were evaluated and age, sex and vitamin D levels classified by month.
Results: In our study, 3242 (77,8 %) female and 926 (22,2 %) male were included. Mean vitamin D levels were 22,80±13,27 ng/mL, 22,49±13,88 ng/mL in female patients, 23,75±10,57 ng/mL in male patients. 47 % of patients (50 % in female 38 % in male) have vitamin D levels under < 20 ng/mL (cut-off for vitamin D defiency).
Conclusion: Our results showed that there was an important difference between vitamin D levels when patients compared according to sex, age and months. These variations may be important in clinical desicion because vitamin D levels were evaulated according to defiency cut-off and this cut-off is not different for sex and seasons.
Keywords
References
- Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003;88(2):296-307.
- Holick MF. Vitamin D deficiency. N Engl J Med 2007;357(3): 266-81.
- Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87(4):1080S-6S.
- Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med 2002;112(8):659-62.
- Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Hassan Murad M, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911-30.
- Dimitri P, Bishop N. Rickets: new insights into a re- emerging problem. Curr Opin Orthop 2007;18(5):486- 93.
- Kuroda T, Shiraki M, Tanaka S, Ohta H. Contributions of 25-hydroxyvitamin D, co-morbidities and bone mass to mortality in Japanese postmenapausal women. Bone 2009;44(1):168-72.
- Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF. The role of vitamin D in cancer prevention. Am J Public Health 2006;96(2):252-61.
- Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007;7(9):684-700.
- Forman JP, Curhan GC, Taylor EN. Plasma 25- Hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension 2008;52(5):828-32.
- Kurt M, Cömertoğlu İ, Sarp Ü, Yalçın P, Dinçer G. Osteoporozlu hastalarda D vitamini düzeyleri. Türk Osteoporoz Dergisi 2011; 17(3):68-70.
- Hekimsoy Z, Dinç G, Kafesciler S, Onur E, Güvenç Y, Pala T, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health 2010;10(1):782.
- Bolland MJ, Grey AB, Ames RW, Mason BH, Horne AM, Gamble GD, Reid IR. The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. Am J Clin Nutr 2007;86(4):959-64.
- Kanan RM, Al Saleh YM, Fakhoury HM, Adham M, Aljaser S, Tamimi W. Year-round vitamin D deficiency among Saudi female out-patients. Public Health Nutr 2013;16(3):544-8.
- Vuceljic M, Ilic-Stojanovic O, Lazovic M, Grajic M. Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women. Vojnosanit Pregl 2012;69(3):243-8.
- van den Quweland JM, Beijers AM, Demacker PM, van Daal HM. Measurement of 25-OH-vitamin D in human serum using liquid chromatography tandem-mass spectrometry with comparison to radioimmunoassay and automated immunoassay. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878(15-16):1163-8.
- Chen H, McCoy LF, Schleicher RL, Pfeiffer CM. Measurement of 25(OH)D3 and 25(OH)D2 in human serum using liquid chromatography-tandem mass spectrometry and its comparison a radioimmunassay method. Clin Chem Acta 2008;391(1-2):6-12.
Abstract
Amaç: D vitamini, kalsiyum absorbsiyonu ve kemik metabolizmasında etkilidir. Ayrıca düşük D vitamini düzeyleri DM, HT, kanser ve otoimmun hastalıkların yer aldığı çoğu kronik hastalık ile de ilişkilidir. Bu çalışmada laboratuvarımızda 2012 yılı Ocak-Aralık ayları arasında çalışılan D vitamini düzeylerinin incelenmesi amaçlandı.
Materyal ve Metod: 2012 yılında Ocak-Aralık ayları arasındaki 4168 hasta değerlendirildi ve yaş, cinsiyet ve D vitamini düzeyleri aylara göre gruplara ayrıldı.
Bulgular: Çalışmamızda 3242 (% 77,8) kadın ve 926 (%22,2) erkek yer aldı. Hastaların D vitamini düzeyleri ortalaması 22,80±13,27 ng/mL, kadınlarda 22,49±13,88 ng/mL, erkeklerde 23,75±10,57 ng/mL idi. Hastaların % 47’inde (kadınlarda % 50, erkeklerde %38) < 20 ng/mL D vitamini seviyeleri vardı (D vitamin yetersizliği için cut-off). D vitamini yetersizliğinde mevsimsel değişiklikleri incelemek için ortalama D vitamini düzeyleri karşılaştırıldığında tüm gruplar arasında istatiksel olarak anlamlı fark bulundu ( p<0,001).
Sonuç: Bizim sonuçlarımız, hastalar cinsiyet, yaş ve aylara göre karşılaştırıldığında, D vitamini düzeyleri arasında önemli bir fark olduğunu göstermiştir. Bu varyasyonlar klinik kararda önemli olabilir çünkü D vitamini düzeyleri cut-off’a göre değerlendirilmektedir ve bu cut-off cinsiyet ve mevsim açısından farklı değildir.
Keywords
References
- Holick MF. Vitamin D: A millenium perspective. J Cell Biochem 2003;88(2):296-307.
- Holick MF. Vitamin D deficiency. N Engl J Med 2007;357(3): 266-81.
- Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87(4):1080S-6S.
- Tangpricha V, Pearce EN, Chen TC, Holick MF. Vitamin D insufficiency among free-living healthy young adults. Am J Med 2002;112(8):659-62.
- Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Hassan Murad M, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911-30.
- Dimitri P, Bishop N. Rickets: new insights into a re- emerging problem. Curr Opin Orthop 2007;18(5):486- 93.
- Kuroda T, Shiraki M, Tanaka S, Ohta H. Contributions of 25-hydroxyvitamin D, co-morbidities and bone mass to mortality in Japanese postmenapausal women. Bone 2009;44(1):168-72.
- Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF. The role of vitamin D in cancer prevention. Am J Public Health 2006;96(2):252-61.
- Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007;7(9):684-700.
- Forman JP, Curhan GC, Taylor EN. Plasma 25- Hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension 2008;52(5):828-32.
- Kurt M, Cömertoğlu İ, Sarp Ü, Yalçın P, Dinçer G. Osteoporozlu hastalarda D vitamini düzeyleri. Türk Osteoporoz Dergisi 2011; 17(3):68-70.
- Hekimsoy Z, Dinç G, Kafesciler S, Onur E, Güvenç Y, Pala T, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health 2010;10(1):782.
- Bolland MJ, Grey AB, Ames RW, Mason BH, Horne AM, Gamble GD, Reid IR. The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. Am J Clin Nutr 2007;86(4):959-64.
- Kanan RM, Al Saleh YM, Fakhoury HM, Adham M, Aljaser S, Tamimi W. Year-round vitamin D deficiency among Saudi female out-patients. Public Health Nutr 2013;16(3):544-8.
- Vuceljic M, Ilic-Stojanovic O, Lazovic M, Grajic M. Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women. Vojnosanit Pregl 2012;69(3):243-8.
- van den Quweland JM, Beijers AM, Demacker PM, van Daal HM. Measurement of 25-OH-vitamin D in human serum using liquid chromatography tandem-mass spectrometry with comparison to radioimmunoassay and automated immunoassay. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878(15-16):1163-8.
- Chen H, McCoy LF, Schleicher RL, Pfeiffer CM. Measurement of 25(OH)D3 and 25(OH)D2 in human serum using liquid chromatography-tandem mass spectrometry and its comparison a radioimmunassay method. Clin Chem Acta 2008;391(1-2):6-12.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Articles |
| Authors | |
| Publication Date | May 2, 2015 |
| Published in Issue | Year 2015 Volume: 15 Issue: 1 |