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Musculoskeletal System Status, Sleep and Quality of Life of Children with Acute Lymphoblastic Lymphoma During Hospitalization: A Descriptive Pilot Study

Year 2018, Volume: 2 Issue: 1, 31 - 38, 17.01.2018

Abstract

Aim: The aim of this study is to analyze and present the
status about muscle strength, gross motor function, functional mobility, sleep
and quality of life of children with
Acute Lymphoblastic Lymphoma (ALL) during
hospitalization.

Methods:
Children
diagnosed as ALL, between 4-18 ages, having medical treatment at hospital were
included in this study. Children with any other neurologic or metabolic
diseases and children whose cancer reoccurred didn’t include. For all of the
children information recorded about age (year), height (cm), body mass (kg),
gender, exercise background, recurrent of the cancer and medical treatment.
Assessment scales that are used in this study were; Gross Motor Functions
Measurement (GMFM), Timed Up and Go (TUG) test,
sit-to-stand test,
1 minute walk test (1 MWT), Functional
Independence Measure for Children (WeFIM), Impact on Family Scale (IPFAM), Pediatric Quality of Life Inventory (
PedsQL) (Cancer Module) Parent Proxy Report and Children’s
Sleep Habits Questionnaire Short Form (CSHQ)
. We presented descriptive analyses as minimums,
maximums, means and standard deviations for continuous variables and minimums,
maximums, medians and standard errors for categorical variables. We set the
level of significance at p<0.05.

Results:
We included 7
children (5 girls and two boys) and parents in this study. Mean age of the
children was 6.86 ±4.48.  In our sample mean value of GMFM-66 was
67.65±15.57, TUG was 11.69±5.10, 1 MWT was 55.81±23.81, sit-to-stand test was
23.69±6.81, IPFAM total score was 72.71±4.34, CSHQ total score was 48.71±2.87, WeeFIM
total score was 100.57±7.27 and PedsQL total
score was 64.29±19.17







Conclusion:
According to the
study ALL affects musculoskeletal status, quality of life, family impairment
and sleep habits of the children. We think muscle strengthening exercises and
activity focused interventions could be effective and should be studied in new
research in the rehabilitation of ALL.

References

  • 1. Kaatsch P. Epidemiology of childhood cancer. Cancer treatment reviews. 2010;36(4):277-85. 2. Ness KK, Kaste SC, Zhu L, Pui C-H, Jeha S, Nathan PC, et al. Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia. Leukemia & lymphoma. 2015;56(4):1004-11. 3. Rosen GM, Shor AC, Geller TJ. Sleep in children with cancer. Current opinion in pediatrics. 2008;20(6):676-81. 4. Rosen G, Brand SR. Sleep in children with cancer: case review of 70 children evaluated in a comprehensive pediatric sleep center. Supportive Care in Cancer. 2011;19(7):985-94. 5. Wang T-H, Liao H-F, Peng Y-C. Reliability and validity of the five-repetition sit-to-stand test for children with cerebral palsy. Clinical rehabilitation. 2012;26(7):664-71. 6. Russell DJ, Rosenbaum PL, Avery LM, Lane M. Gross motor function measure (GMFM-66 and GMFM-88) user's manual: Cambridge University Press; 2002. 7. Williams EN, Carroll SG, Reddihough DS, Phillips BA, Galea MP. Investigation of the timed ‘up & go’test in children. Developmental Medicine & Child Neurology. 2005;47(8):518-24. 8. McDowell BC, Kerr C, Parkes J, Cosgrove A. Validity of a 1 minute walk test for children with cerebral palsy. Developmental medicine & child neurology. 2005;47(11):744-8. 9. Hamilton B, Granger C. Functional Independence Measure for Children (WeeFIM). Buffalo, NY: Research Foundation of the State University of New York. 1991. 10. Bek N, Simsek IE, Erel S, Yakut Y, Uygur F. Turkish version of impact on family scale: a study of reliability and validity. Health and quality of life outcomes. 2009;7(1):4. 11. Varni JW, Burwinkle TM, Katz ER, Meeske K, Dickinson P. The PedsQL™ in pediatric cancer. Cancer. 2002;94(7):2090-106. 12. Fiş NP, Arman A, Ay P, TOPUZOĞLU A, GÜLER AS, İMREN SG, et al. Çocuk Uyku Alışkanlıkları Anketinin Türkçe geçerliliği ve güvenilirliği. Anadolu Psikiyatri Dergisi. 2010;11:151-60. 13. Hoffman MC, Mulrooney DA, Steinberger J, Lee J, Baker KS, Ness KK. Deficits in physical function among young childhood cancer survivors. Journal of clinical oncology. 2013;31(22):2799-805. 14. Ness KK, Baker KS, Dengel DR, Youngren N, Sibley S, Mertens AC, et al. Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia. Pediatric blood & cancer. 2007;49(7):975-81. 15. Reinders-Messelink H, Schoemaker M, Snijders T, Göeken L, van den Briel M, Bökkerink J, et al. Motor performance of children during treatment for acute lymphoblastic leukemia. Medical and pediatric oncology. 1999;33(6):545-50. 16. Wright MJ, Halton JM, Martin RF, Barr RD. Long‐term gross motor performance following treatment for acute lymphoblastic leukemia. Medical and pediatric oncology. 1998;31(2):86-90. 17. Nicolini‐Panisson RDA, Donadio MV. Normative values for the Timed ‘Up and Go’test in children and adolescents and validation for individuals with Down syndrome. Developmental Medicine & Child Neurology. 2014;56(5):490-7. 18. Gocha Marchese V, Chiarello LA, Lange BJ. Strength and functional mobility in children with acute lymphoblastic leukemia. Medical and pediatric oncology. 2003;40(4):230-2. 19. Zupanec S, Jones H, Stremler R. Sleep habits and fatigue of children receiving maintenance chemotherapy for ALL and their parents. Journal of Pediatric Oncology Nursing. 2010;27(4):217-28. 20. Gordijn MS, van Litsenburg RR, Gemke RJ, Huisman J, Bierings MB, Hoogerbrugge PM, et al. Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatric blood & cancer. 2013;60(3):479-85. 21. Eiser C, Eiser JR, Stride CB. Quality of life in children newly diagnosed with cancer and their mothers. Health and quality of life outcomes. 2005;3(1):1. 22. Patterson JM, Holm KE, Gurney JG. The impact of childhood cancer on the family: a qualitative analysis of strains, resources, and coping behaviors. Psycho‐Oncology. 2004;13(6):390-407.  

AKUT LENFOBLASTİK LENFOMA'LI ÇOCUKLARDA HOSPİTALİZASYON SÜRECİNDE KAS İSKELET SİSTEMİNİN DURUMU, UYKU VE YAŞAM KALİTESİ: TANIMLAYICI PİLOT ÇALIŞMA

Year 2018, Volume: 2 Issue: 1, 31 - 38, 17.01.2018

Abstract

Amaç: Bu çalışmanın amacı Akut Lenfoblastik Lenfoma'lı (ALL)
çocuklarda hospitalizasyon sürecinde kas kuvveti,
kaba motor fonksiyon, fonksiyonel
mobilite, uyku ve yaşam kalitesi ile ilgili durumları analiz etmek ve
sunmaktır.

Metod: Bu çalışmaya, ALL teşhisi konulan 4-18 yaşlar
arasında, hastanede tıbbi tedavi gören çocuklar dâhil edildi. Başka bir
nörolojik veya metabolik hastalığı olan çocuklar ile kanseri tekrarlayan
çocuklar dâhil edilmedi. Tüm çocuklar için; yaş (yıl), boy (cm), vücut ağırlığı
(kg), cinsiyet, egzersiz geçmişi, kanserin tekrarlayıp tekrarlamadığı ve tıbbi
tedavileri hakkında bilgiler kaydedildi. Bu çalışmada kullanılan değerlendirme
ölçekleri; Kaba Motor Fonksiyon Ölçümü (GMFM), Zamanlı Kalk Yürü Testi (TUG),
Otur-Kalk Testi, 1 Dakikalık Yürüme Testi (1 MWT), Çocuklar için Fonksiyonel
Bağımsızlık Ölçeği (WeFIM), Aile Etkilenim Ölçeği (IPFAM), Pediatrik Yaşam
Kalitesi Envanteri Ebeveyn Raporu (
PedsQL) (Kanser Modülü) ve Çocuk Uyku Alışkanlıkları Anketi Kısa
Formu'ydu (CSHQ).
Tanımlayıcı analizler;
sürekli değişkenler için minimum, maksimum, ortalama ve standart sapma ve
kategorik değişkenler için minimum, maksimum, medyan ve standart hata olarak
sunuldu. İstatistiksel anlamlılık seviyesi olarak p <0.05'i belirlendi.

Bulgular: Çalışmaya 7 çocuk (5 kız, iki erkek) ve anne-baba dâhil edildi. Çocukların yaş ortalaması 6.86 ± 4.48 idi. Örneklemden elde edilen ortalama değerler; GMFM-66: 67.65 ± 15.57, TUG: 11.69 ± 5.10, 1 MWT: 55.81 ± 23.81, Otur-Kalk Testi: 23.69 ± 6.81, IPFAM toplam puanı: 72.71 ± 4.34, CSHQ toplam puanı: 48.71 ± 2.87, WeeFIM toplam puanı: 100.57 ± 7.27 ve PedsQL toplam puanı: 64.29 ± 19.17 şeklindeydi.







Sonuç:
Çalışmamızın sonuçlarına göre, ALL; hospitalizasyon sürecinde
kas iskelet sistemini, yaşam kalitesini, aile etkilenimini ve çocukların uyku
alışkanlıklarını etkilemektedir. Kas güçlendirme egzersizleri ve aktiviteye
odaklı müdahalelerin ALL'nin rehabilitasyonunda etkili olabileceğini, yeni
çalışmalarda araştırılması gerektiğini düşünüyoruz.

References

  • 1. Kaatsch P. Epidemiology of childhood cancer. Cancer treatment reviews. 2010;36(4):277-85. 2. Ness KK, Kaste SC, Zhu L, Pui C-H, Jeha S, Nathan PC, et al. Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia. Leukemia & lymphoma. 2015;56(4):1004-11. 3. Rosen GM, Shor AC, Geller TJ. Sleep in children with cancer. Current opinion in pediatrics. 2008;20(6):676-81. 4. Rosen G, Brand SR. Sleep in children with cancer: case review of 70 children evaluated in a comprehensive pediatric sleep center. Supportive Care in Cancer. 2011;19(7):985-94. 5. Wang T-H, Liao H-F, Peng Y-C. Reliability and validity of the five-repetition sit-to-stand test for children with cerebral palsy. Clinical rehabilitation. 2012;26(7):664-71. 6. Russell DJ, Rosenbaum PL, Avery LM, Lane M. Gross motor function measure (GMFM-66 and GMFM-88) user's manual: Cambridge University Press; 2002. 7. Williams EN, Carroll SG, Reddihough DS, Phillips BA, Galea MP. Investigation of the timed ‘up & go’test in children. Developmental Medicine & Child Neurology. 2005;47(8):518-24. 8. McDowell BC, Kerr C, Parkes J, Cosgrove A. Validity of a 1 minute walk test for children with cerebral palsy. Developmental medicine & child neurology. 2005;47(11):744-8. 9. Hamilton B, Granger C. Functional Independence Measure for Children (WeeFIM). Buffalo, NY: Research Foundation of the State University of New York. 1991. 10. Bek N, Simsek IE, Erel S, Yakut Y, Uygur F. Turkish version of impact on family scale: a study of reliability and validity. Health and quality of life outcomes. 2009;7(1):4. 11. Varni JW, Burwinkle TM, Katz ER, Meeske K, Dickinson P. The PedsQL™ in pediatric cancer. Cancer. 2002;94(7):2090-106. 12. Fiş NP, Arman A, Ay P, TOPUZOĞLU A, GÜLER AS, İMREN SG, et al. Çocuk Uyku Alışkanlıkları Anketinin Türkçe geçerliliği ve güvenilirliği. Anadolu Psikiyatri Dergisi. 2010;11:151-60. 13. Hoffman MC, Mulrooney DA, Steinberger J, Lee J, Baker KS, Ness KK. Deficits in physical function among young childhood cancer survivors. Journal of clinical oncology. 2013;31(22):2799-805. 14. Ness KK, Baker KS, Dengel DR, Youngren N, Sibley S, Mertens AC, et al. Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemia. Pediatric blood & cancer. 2007;49(7):975-81. 15. Reinders-Messelink H, Schoemaker M, Snijders T, Göeken L, van den Briel M, Bökkerink J, et al. Motor performance of children during treatment for acute lymphoblastic leukemia. Medical and pediatric oncology. 1999;33(6):545-50. 16. Wright MJ, Halton JM, Martin RF, Barr RD. Long‐term gross motor performance following treatment for acute lymphoblastic leukemia. Medical and pediatric oncology. 1998;31(2):86-90. 17. Nicolini‐Panisson RDA, Donadio MV. Normative values for the Timed ‘Up and Go’test in children and adolescents and validation for individuals with Down syndrome. Developmental Medicine & Child Neurology. 2014;56(5):490-7. 18. Gocha Marchese V, Chiarello LA, Lange BJ. Strength and functional mobility in children with acute lymphoblastic leukemia. Medical and pediatric oncology. 2003;40(4):230-2. 19. Zupanec S, Jones H, Stremler R. Sleep habits and fatigue of children receiving maintenance chemotherapy for ALL and their parents. Journal of Pediatric Oncology Nursing. 2010;27(4):217-28. 20. Gordijn MS, van Litsenburg RR, Gemke RJ, Huisman J, Bierings MB, Hoogerbrugge PM, et al. Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatric blood & cancer. 2013;60(3):479-85. 21. Eiser C, Eiser JR, Stride CB. Quality of life in children newly diagnosed with cancer and their mothers. Health and quality of life outcomes. 2005;3(1):1. 22. Patterson JM, Holm KE, Gurney JG. The impact of childhood cancer on the family: a qualitative analysis of strains, resources, and coping behaviors. Psycho‐Oncology. 2004;13(6):390-407.  
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Ayşe Numanoğlu Akbaş

Muhammet Fatih Uysal This is me

Nuriye Özengin

Publication Date January 17, 2018
Published in Issue Year 2018 Volume: 2 Issue: 1

Cite

APA Numanoğlu Akbaş, A., Uysal, M. F., & Özengin, N. (2018). AKUT LENFOBLASTİK LENFOMA’LI ÇOCUKLARDA HOSPİTALİZASYON SÜRECİNDE KAS İSKELET SİSTEMİNİN DURUMU, UYKU VE YAŞAM KALİTESİ: TANIMLAYICI PİLOT ÇALIŞMA. Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 2(1), 31-38.