Research Article
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The Incidence of Pericolonic Tumor Deposits in Colorectal Cancer

Year 2016, Volume: 21 Issue: 3, 169 - 172, 01.09.2016
https://doi.org/10.21673/anadoluklin.254214

Abstract

Aim: Currently, the primary method for assessing the prognostic differences among patients is the tumor-node-metastasis (TNM) staging system developed by the American Joint Committee on Cancer (AJCC). Our aim was to evaluate the incidence of the presence of pericolonic tumor deposits in patients operated on for colorectal cancer, and to demonstrate its relation with tumor stages.

Materials and Methods: The pathological findings of a total number of 190 patients who underwent surgical resections for colorectal cancer were evaluated retrospectively. Staging was carried out according to the 7th edition of the AJCC staging manual.

Results: Among all 190 colorectal cancer patients, a total of 30 (15.8%) patients were detected to harbor pericolonic tumor deposits. In the final pathology reports, 66.6% of the patients were reported as T3, and 46.6% were reported as N1c. Thus, 56.6% of the patients were reported as Stage IIIB.

Discussion and Conclusion: In the absence of other evidence of lymph node involvement, the presence of pericolonic tumor deposits results in the reclassification of the disease from StageII to Stage III. The fact that Stage III disease necessitates adjuvant treatment puts forth an emphasis on the importance of upstaging due to the presence of tumor deposits.


References

  • 1. Global Burden of Disease Cancer Collaboration.
  • The Global Burden of Cancer 2013. JAMA Oncol.
  • 2015;1(4):505–27.
  • 2. American Joint Committee on Cancer. Manual for Staging
  • of Cancer. Philadelphia: Lippincott-Raven; 1998.
  • 3. Gabriel WB, Dukes CE, Bussy HJR. Lymphatic spread in
  • cancer of the rectum. Br J Surg. 1935;23(90):395–413.
  • 4. Jass JR, Morson BC. Reporting colorectal cancer. J Clin
  • Pathol. 1987;40:1016–23.

Kolorektal Kanserlerde Perikolonik Tümör Depozitlerinin Sıklığı

Year 2016, Volume: 21 Issue: 3, 169 - 172, 01.09.2016
https://doi.org/10.21673/anadoluklin.254214

Abstract

Amaç: Güncel olarak, hastalar arasında prognostik farklılıkları değerlendirmek için Amerikan Kanser Ortak Komitesi (American Joint Committee on Cancer—AJCC) tarafından geliştirilenTümör-Nodül-Metastaz (TNM) Evreleme Sistemi kullanılmaktadır. Amacımız kolorektal kansernedeniyle ameliyat olan hastalarda perikolonik tümör depozitlerinin görülme sıklığını değerlendirmekve tümör evreleri ile ilişkisini göstermektir.

Gereç ve Yöntemler: Kolorektal kanser için cerrahi rezeksiyon yapılan toplam 190 hastanın patolojikbulguları retrospektif olarak değerlendirildi. Evreleme, Amerikan Kanser Ortak Komitesikanser evreleme kılavuzunun yedinci edisyonuna uygun olarak gerçekleştirildi.

Bulgular: 190 kolorektal kanserli hastanın 30’unda (%15,8) perikolonik tümör depoziti saptandı.Patoloji sonuçlarına göre hastaların %66,6’sı T3, %46,6’sı ise N1c evresinde idi. Ayrıca %56,6olgu Evre IIIB olarak rapor edildi.

Tartışma ve Sonuç: Lenf nodu tutulumunun diğer kanıtları yok ise perikolonik tümör depozitlerininvarlığı hastalığın Evre II’den Evre III’e yeniden sınıflandırılmasını sağlar. Evre III’teki hastalardaadjuvan tedavi gerekmesi nedeniyle tümör depozitlerinin varlığından dolayı ortaya çıkan üstevreye kayma önemlidir.

References

  • 1. Global Burden of Disease Cancer Collaboration.
  • The Global Burden of Cancer 2013. JAMA Oncol.
  • 2015;1(4):505–27.
  • 2. American Joint Committee on Cancer. Manual for Staging
  • of Cancer. Philadelphia: Lippincott-Raven; 1998.
  • 3. Gabriel WB, Dukes CE, Bussy HJR. Lymphatic spread in
  • cancer of the rectum. Br J Surg. 1935;23(90):395–413.
  • 4. Jass JR, Morson BC. Reporting colorectal cancer. J Clin
  • Pathol. 1987;40:1016–23.
There are 9 citations in total.

Details

Subjects Health Care Administration
Journal Section ORIGINAL ARTICLE
Authors

Orhan Alimoğlu

Tunç Eren This is me

Kerem Tolan This is me

Ali Kılıç This is me

Tamador Shamaileh This is me

Gürhan Baş This is me

Publication Date September 1, 2016
Acceptance Date May 12, 2016
Published in Issue Year 2016 Volume: 21 Issue: 3

Cite

Vancouver Alimoğlu O, Eren T, Tolan K, Kılıç A, Shamaileh T, Baş G. The Incidence of Pericolonic Tumor Deposits in Colorectal Cancer. Anatolian Clin. 2016;21(3):169-72.

13151 This Journal licensed under a CC BY-NC (Creative Commons Attribution-NonCommercial 4.0) International License.