Abstract
Amaç: Bu çalışmada amacımız, Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi (SÜEAH) Nöroloji ve Beyin Cerrahisi polikliniğine müracaat eden Migren hastalarında lipit düzeylerini tespit etmek ve Migren ile lipit düzeyleri arasındaki bu ilişkiyi araştırmaktır.
Gereç ve Yöntemler: Çalışmamıza dahil ettiğimiz veriler 01.01.2018-30.09.2019 tarihleri arasındaki müracaat eden ve 20 yaş üzerindeki Migren hastalarından hastane bilgi yönetimi sistemi (HBYS) üzerinden retrospektif olarak elde edildi. Hasta ve kontrol grubu aralarındaki ilişki ve farklar araştırıldı. Hasta ve kontrol grubuna diyabet ve hipertansiyon lipit düzeylerini olumsuz etkileyecek durumlar ile malignite ve kronik nörolojik hastalığı olanlar alınmadı.
Bulgular: Çalışma kriterlerine uyan 48 migren hastasının 36 kadın, 12 erkek olup, yaş ortalaması 42.17±11.24 olarak tespit edildi. Kontrol grubunda 48 olgunun 15’i erkek, 33’ü kadın olmak üzere yaş ortalaması 47.15±17.04 yıl olarak belirlendi. Çalışmada; total kolesterol (TK), trigliserid (TG), düşük dansiteli lipoprotein (LDL) ve yüksek dansiteli lipoprotein (HDL) düzeyleri tespit edildi. Migren hastalarının ortalama lipit değerleri (mg/dl olarak), TK 213.38±38.50, TG 238.31±66.49, LDL 164.38±24.06 düzeyleri yüksek değerlerde iken, HDL 52±9 düzeyleri düşük değerlerde saptandı. Kontrol grubunun ortalama lipit değerleri (mg/dl olarak), TK 169.52±51.55, TG 103.29±38.15, LDL 126.98±35.58 ve HDL 54.52±7.31 olarak saptandı. Migren hastaları ile kontrol grubu istatistiksel olarak TK, TG, LDL ve HDL için karşılaştırıldığında istatistiksel olarak anlamlı (p<0.05) olduğu saptandı.
Sonuç: Migren hastalarında lipit profilleri olumsuz etkilenmektedir. Lipit profillerinin düzeltilmesi ve önleyici tedbirlerin alınması, klinik bulguların daha hafif seyretmesine ve hasta şikâyetlerini en aza inmesine katkı sağlayacaktır.
Supporting Institution
Herhangi bir kurum tarafından desteklenmemiştir
Project Number
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References
- 1. Demirkaya M. Migrenli kadın hastalarda atak sırasında ve ataklar arası dönemde seks hormonu düzeyleri. Uzmanlık Tezi 2006.
- 2. Selekler M. Yaşamı Olumsuz Etkileyen Baş Ağrısı: MİGREN.
- 3. Özön Ö, Bolay H. Primer Baş Ağrılarında Tanı ve Tedavi Yaklaşımları. Türk Nöroşirürji Dergisi 2003;13:97-112.
- 4. The World Health Report. Mental Health: New Understanding New Hope. 2001.
- 5. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 2009;339:b3914.
- 6. Silva FA, Rueda-Clausen CF, Silva SY, Zarruk JG, Guzmán JC, Morillo CA, Vesga B, Pradilla G, Flórez M, López-Jaramillo P. Endothelial function in patients with migraine during the interictal period. Headache 2007;47:45-51.
- 7. Hamed SA. The vascular risk associations with migraine: relation to migraine susceptibility and progression. Atherosclerosis 2009;205:15-22.
- 8. Yıldırım S, Akar S, Kuyucu M, Yıldırım A, Dane S, Aygül R. Paraoxonase 1 gene polymorphisms, paraoxonase/arylesterase activities and oxidized low-density lipoprotein levels in patients with migraine. Cell Biochem Funct 2011;29:549-554.
- 9. Yilmaz N, Aydin O, Yegin A, Tiltak A, Eren E. Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs. Clin Biochem 2011;44:832-837.
- 10. Monastero R, Pipia C, Cefalù AB, Liveri ET, Rosano R, Camarda R, Camarda C. Association between plasma lipid levels and migraine in subjects aged > or =50 years: preliminary data from the Zabùt Aging Project. Neurol Sci 2008;29:179-181.
- 11. Gruber HJ, Bernecker C, Pailer S, Lechner A, Horejsi R, Möller R, Fazekas F, Truschnig-Wilders M. Lipid profile in normal weight migraineurs - evidence for cardiovascular risk. Eur J Neurol 2010;17:419-425.
- 12. Kurth T, Schürks M, Logroscino G, Gaziano JM, Buring JE. Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ 2008;337:a636.
- 13. Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ. Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 2005;64:614-620.
- 14 Rist PM, Tzourio C, Kurth T. Associations between lipid levels and migraine: cross-sectional analysis in the epidemiology of vascular ageing study. Cephalalgia 2011;31:1459-1465.
- 15. Saberi A, Hatamian HR, Kazemnejad E, Ghorbannejad N. Hyperlipidemia in migraine: Is it more frequent in migraineurs? Iran J Neurol 2011;10:46-50.
- 16. Kurth T. Migraine a marker of vascular health? Cephalalgia 2013; 33: 226-227.
- 17. Funda Yıldırım Baş, Seden Demirci, Bahriye Arslan, Zeliha Salman. Hiperlipidemili hastalarda baş ağrısı. Tepecik Eğit. ve Araşt. Hast. Dergisi 2015;25(3):186-190.
- 18. Hamed SA. The vascular risk associations with migraine: Relation to migraine susceptibility and progression. Atherosclerosis 2009;205:15-22.
- 19. Sener A, Ozsavci D, Oba R, et al. Do platelet apoptosis, activation, aggregation, lipid peroxidation and platelet–leukocyte aggregate formation occur simultaneously in hyperlipidemia? Clinical Biochemistry 2005;38:1081-1087.
- 20. Boes CJ, Capobianco D J, Ctrer FM, et al. Headache and Other Craniofacial Pain. In Bradley WG, Daroff RB, Fenichel GM, Jankovic J. Neurology in clinical practice. 5th ed Butterworth, Heinemann 2008;2026-42.
- 21. Harel Z, Gascon G, Riggs S, et al. Supplementation with omega-3 polyunsaturated fatty acids in the management of recurrent migraines in adolescents. Journal of Adolescent Health 2002;31:154-161.
- 22. Monastero R, Pipia C, Cefalù AB, et al. Association between plasma lipid levels and migraine in subjects aged > or =50 years: preliminary data from the Zabùt Aging Project. Neurol Sci 2008;29:179-181.
- 23. Gokce N, Duffy SJ, Hunter LM, et al. Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults. American Journal of Cardiology 2001;88:153-159.
- 24. Saberi A, Hatamian HR, Kazemnejad E, Ghorbannejad N. Hyperlipidemia in migraine: Is it more frequent in migraineurs? Ir J Neurol 2011;10(3-4):46-50.
- 25. M. Rist P, Tzourio C, Kurth T. Associations Between Lipid Levels and Migraine: Crosssectional Analysis in the EVA Cephalalgia 2011;31(14):1459-1465.
- 26. Bic Z, Blix GG, Hopp HP, Leslie FM, Schell MJ. Th e infl uence of a low fat-diet on incidence and severity of migraine headaches. J Women’s Heath Gender Based Med 1999;8:623-630.
Abstract
Aim: The aim of this study was to determine the lipid levels of migraine patients who applied to the Neurology and Neurosurgery outpatient clinic of Sakarya University Training and Research Hospital (SÜEAH) and to investigate this relationship between migraine and lipid levels.
Materials and Methods: The data included in our study were obtained retrospectively from the hospital information management system (HIS) of migraine patients over 20 years of age who applied between 01.01.2018-30.09.2019. The relationship and differences between the patient and control groups were investigated. Patients and controls were not included in conditions that would adversely affect the lipid levels of diabetes and hypertension, and those with malignancy and chronic neurological disease.
Results: Of the 48 migraine patients who met the study criteria, 36 were female and 12 were male. The mean age was 42.17±11.24 years. The mean age was 47.15±17.04 years in the control group, of which 15 were male and 33 were female. Study; Total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) levels were determined. The mean lipid values (mg / dl), TC 213.38±38.50, TG 238.31±66.49, LDL 164.38±24.06, and HDL 52 ± 9 levels of migraine patients were found to be low. The mean lipid values (mg / dl) of the control group were TC 169.52±51.55, TG 103.29±38.15, LDL 126.98 ± 35.58 and HDL 54.52±7.31. Migraine patients and control groups were statistically significant (p <0.05) when compared to TC, TG, LDL and HDL.
Conclusion: Lipid profiles are negatively affected in migraine patients. Correcting lipid profiles and taking preventive measures will contribute to the milder clinical findings and to minimize patient complaints.
Project Number
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References
- 1. Demirkaya M. Migrenli kadın hastalarda atak sırasında ve ataklar arası dönemde seks hormonu düzeyleri. Uzmanlık Tezi 2006.
- 2. Selekler M. Yaşamı Olumsuz Etkileyen Baş Ağrısı: MİGREN.
- 3. Özön Ö, Bolay H. Primer Baş Ağrılarında Tanı ve Tedavi Yaklaşımları. Türk Nöroşirürji Dergisi 2003;13:97-112.
- 4. The World Health Report. Mental Health: New Understanding New Hope. 2001.
- 5. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 2009;339:b3914.
- 6. Silva FA, Rueda-Clausen CF, Silva SY, Zarruk JG, Guzmán JC, Morillo CA, Vesga B, Pradilla G, Flórez M, López-Jaramillo P. Endothelial function in patients with migraine during the interictal period. Headache 2007;47:45-51.
- 7. Hamed SA. The vascular risk associations with migraine: relation to migraine susceptibility and progression. Atherosclerosis 2009;205:15-22.
- 8. Yıldırım S, Akar S, Kuyucu M, Yıldırım A, Dane S, Aygül R. Paraoxonase 1 gene polymorphisms, paraoxonase/arylesterase activities and oxidized low-density lipoprotein levels in patients with migraine. Cell Biochem Funct 2011;29:549-554.
- 9. Yilmaz N, Aydin O, Yegin A, Tiltak A, Eren E. Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs. Clin Biochem 2011;44:832-837.
- 10. Monastero R, Pipia C, Cefalù AB, Liveri ET, Rosano R, Camarda R, Camarda C. Association between plasma lipid levels and migraine in subjects aged > or =50 years: preliminary data from the Zabùt Aging Project. Neurol Sci 2008;29:179-181.
- 11. Gruber HJ, Bernecker C, Pailer S, Lechner A, Horejsi R, Möller R, Fazekas F, Truschnig-Wilders M. Lipid profile in normal weight migraineurs - evidence for cardiovascular risk. Eur J Neurol 2010;17:419-425.
- 12. Kurth T, Schürks M, Logroscino G, Gaziano JM, Buring JE. Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ 2008;337:a636.
- 13. Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ. Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 2005;64:614-620.
- 14 Rist PM, Tzourio C, Kurth T. Associations between lipid levels and migraine: cross-sectional analysis in the epidemiology of vascular ageing study. Cephalalgia 2011;31:1459-1465.
- 15. Saberi A, Hatamian HR, Kazemnejad E, Ghorbannejad N. Hyperlipidemia in migraine: Is it more frequent in migraineurs? Iran J Neurol 2011;10:46-50.
- 16. Kurth T. Migraine a marker of vascular health? Cephalalgia 2013; 33: 226-227.
- 17. Funda Yıldırım Baş, Seden Demirci, Bahriye Arslan, Zeliha Salman. Hiperlipidemili hastalarda baş ağrısı. Tepecik Eğit. ve Araşt. Hast. Dergisi 2015;25(3):186-190.
- 18. Hamed SA. The vascular risk associations with migraine: Relation to migraine susceptibility and progression. Atherosclerosis 2009;205:15-22.
- 19. Sener A, Ozsavci D, Oba R, et al. Do platelet apoptosis, activation, aggregation, lipid peroxidation and platelet–leukocyte aggregate formation occur simultaneously in hyperlipidemia? Clinical Biochemistry 2005;38:1081-1087.
- 20. Boes CJ, Capobianco D J, Ctrer FM, et al. Headache and Other Craniofacial Pain. In Bradley WG, Daroff RB, Fenichel GM, Jankovic J. Neurology in clinical practice. 5th ed Butterworth, Heinemann 2008;2026-42.
- 21. Harel Z, Gascon G, Riggs S, et al. Supplementation with omega-3 polyunsaturated fatty acids in the management of recurrent migraines in adolescents. Journal of Adolescent Health 2002;31:154-161.
- 22. Monastero R, Pipia C, Cefalù AB, et al. Association between plasma lipid levels and migraine in subjects aged > or =50 years: preliminary data from the Zabùt Aging Project. Neurol Sci 2008;29:179-181.
- 23. Gokce N, Duffy SJ, Hunter LM, et al. Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults. American Journal of Cardiology 2001;88:153-159.
- 24. Saberi A, Hatamian HR, Kazemnejad E, Ghorbannejad N. Hyperlipidemia in migraine: Is it more frequent in migraineurs? Ir J Neurol 2011;10(3-4):46-50.
- 25. M. Rist P, Tzourio C, Kurth T. Associations Between Lipid Levels and Migraine: Crosssectional Analysis in the EVA Cephalalgia 2011;31(14):1459-1465.
- 26. Bic Z, Blix GG, Hopp HP, Leslie FM, Schell MJ. Th e infl uence of a low fat-diet on incidence and severity of migraine headaches. J Women’s Heath Gender Based Med 1999;8:623-630.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | MAKALELER |
| Authors | |
| Project Number | - |
| Publication Date | March 9, 2020 |
| Published in Issue | Year 2020 Volume: 4 Issue: 1 |
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