Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki

Mehmet Özdin

doi:10.33716/bmedj.760653

Research Article

Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki

Year 2020, Volume: 4 Issue: 3, 1 - 6, 27.11.2020

Mehmet Özdin

https://doi.org/10.33716/bmedj.760653

Cited By: 4

Abstract

Amaç: Bu çalışmada amacımız; Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi (SÜEAH) Pediatrik Dermatoloji Polikliniklerine müracaat eden pediatrik yaş grubunda Atopik Dermatit (AD) hastalarında, periferik kandan ölçülebilen nötrofil lenfosit oranı (NLO), trombosit lenfosit oranı (TLO), eozinofil lenfosit oranı (ELO) ile serum total immün globobülin E (T-IgE) değerleri ve kan eozinofil sayısını tespit etmek AD ile bu parametreler arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntemler: Çalışmaya dahil ettiğimiz hastalara ait veriler 01.01.2018 ile 31.10.2019 tarihleri arasında müracaat eden AD hastalarından hastane bilgi yönetimi sistemi (HBYS) üzerinden retrospektif olarak elde edildi. Kontrol grubuna alerjik hastalığı, enfeksiyonu veya kronik bir hastalığı olanlar dahil edilmedi.
Bulgular: Çalışma kriterlerine uyan 30 AD hastasının 8 kız, 22 erkek olup, yaş ortalaması 9.33±5.84 olarak tespit edildi. Kontrol grubunda 30 olgunun 12’si kız, 18’i erkek olmak üzere yaş ortalaması 10.69±4.69 olarak belirlendi. AD hastalarının T-IgE değerleri 304.48±25.81 IU/mL, eozinofil düzeyleri ortalama 1.39±0.29 K/uL, NLO 2.23±1.19, TLO 123.69±41.99, ELO 0.133±0.111 olarak tespit edildi. Kontrol grubunun T-IgE değerleri 41.03±6.18 IU/mL, eozinofil düzeyleri ortalama 0.39±0.09 K/uL, NLO 1.73±0.61, 107.66±35.30, ELO 0.071±0.049 olarak tespit edildi. AD hastaları ile kontrol grubu istatistiksel olarak karşılaştırıldığında T-IgE, Eozinofil, NLO, ELO değerleri arasında (p<0.05), TLO değerleri ise (p>0.05) olarak tespit edildi.
Sonuç: Çalışmamızda AD hastalarında NLO, TLO, ELO ile T-IgE değerleri ile kan eozinofil düzeyleri yüksek bulunmuştur. Bu parametrelerin bu hastalığın teşhis ve takibinde önemli olduğunu ortaya koymaktadır. Bu değerlerin yüksek saptanması, daha sonraki çalışmalarda bu değerlerin referans olarak alınabilmesine katkı sağlayacaktır

Keywords

atopik dermatit;, total IgE değerleri;, nötrofil lenfosit oranı

Supporting Institution

Herhangi bir kurum tarafından desteklenmemiştir

Project Number

Thanks

Kolaylıklar diliyor, ilginize teşekkür ediyorum.

References

1. Boguniewicz M, Leung DY. Atopic dermatitis. In: Adkinson NF, Bochner BS, Busse WW. Middleton’s allergy: Principles and practice. 7th ed. Philadelphia: Mosby Elsevier. 2009:1083-9.
2. Hanifin JM. Atopic dermatitis in infants and children. Ped Clin North Am 1991;4:763.
3. Leung DYM. Atopic dermatitis and the immune system: The role of superantigens and bacteria. J Am Acad Dermatol. 2001; 45:13-15.
4. Herrick CA, Xu L, McKenzie AN, Tigelaar RE, Bottomly K. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J Immunol 2003;170:2488-95.
5. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9.
6. Elberling J, Linneberg A, Dirksen A, Johansen JD, Frolund L, Madsen F. Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity. Clin Exp Allergy 2005;35:75-81.
7. Lee CH, Chuang HY, Shih CC, Jee SH, Wang LF, Chiu HC. Correlation of serum total IgE, eosinophil granule cationic proteins, sensitized allergens and family aggregation in atopic dermatitis patients with or without rhinitis. J Dermatol 2004;31:784-93.
8. Woerly G, Loiseau S, Loyens M, Schoch C, Capron M. Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils: consequences for allergic eye diseases. Allergy 2003;58:397-406.
9. Czech W, Krutmann J, Schopf E, Kapp A. Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis. Br J Dermatol 1992;126:351-5.
10. Schultz Larsen FV, Holm NV. Atopic dermatitis in a population based twin series: Concordance rates and heritability estimation. Acta Derm Venereol Suppl 1985;114:159.
11. Yuksel H, Can D, Reisli I, Uzuner N, Orhan F, Cevit O.Characteristics and prognosis of childhood atopic dermatitis: A multicenter study in Turkey. Int Arch Allergy Immunol 2010;152(4):362-7.
12. Nishimoto M, Numahara T, Nakashima K, Yoshida T. Peripheral eosinophil counts relates the improvement of the skin lesions of atopic dermatitis patients more sensitive thanserum eosinophil cationic protein levels. Arerugi 1998;47:591-6.
13. Kagi MK, Joller-Jemelka H, Wuthrich B. Correlation ofeosinophils, eosinophil cationic protein, and soluble interleukin-2 receptor with the clinical activity of atopic dermatitis. Dermatology 1992;185:88-92.
14. Gu H, You LP, Liu YS. Survey on the prevalance of childhood atopic dermatitis in ten cities of China. Chin J Dermatol 2004;37:29-31.
15. Nationale Eczema Society 2003. Diet and Eczema in Children. www.eczema.org/ 10/9/20046.
16. Ben-Gashir MA, Sedd PT. Hy RJ. Quality of life and disease severity are correlated in children with atopic dermatitis. Br J Dermatol 2004;150:284-90.
17. Wollenberg A, Wetzel S, Burgdorf WHC, Haas J. Viral infections in atopic dermatitis: pathogenic aspects and clinical management. J Allergy Clin Immunol 2003;112:667-674.
18. Laske N, Niggemann B. Does the severity of atopic dermatitis correlate with serum Ig E levels? Pediatr Allergy Immunol 2004;15:86-8.
19. Deniz Özçeker, Cansu Durak, Aslı Derya Kardelen, Nermin Güler, Zeynep Tamay. Çocuklarda Atopik Dermatit: Ne Kadar Atopik? Asthma Allergy Immunol. 2017;15:135-139.
20. Belgin Aktaş, Yakup Canıtez, Nihat Sapan. Atopik dermatit tanı yaşının ek alerjik hastalık gelişimi üzerine etkisi. Türk Ped Arfl 2011;46:308-12.
21. Frigas E, Gleich GJ. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol 1986;77:527-37.
22. Kayabaşı S, Gül F. Pfapa sendromunda yeni öngörücü parametreler: nötrofil lenfosit oranı ve trombosit lenfosit oranı. Ortadogu Tıp Derg 2019;11(3):231-234.
23. Bucak A, Ulu S, Oruc S, Yucedag F, Tekin MS, Karakaya F. Neutrophil-to-lymphocyte ratio as a novelpotential marker for predicting prognosis of Bell palsy. Laryngoscope 2014;124:1678-81.
24. Doğan Atan, Kürşat Murat Özcan, Sabri Köseoğlu, Aykut İkincioğulları, Mehmet Ali Çetin, Serdar Ensari. Nazal polipte yeni öngörücü parametreler: Nötrofil lenfosit oranı ve trombosit lenfosit oranı. Kulak Burun Bogaz Ihtis Derg 2015;25(2):97-101.
25. Utku Oflazoğlu, Ahmet Alacacıoğlu, Işıl Somalı, Melike Yüce1, Abdullah Murat Buyruk, Umut Varol. Nötrofil/Lenfosit Oranı, Trombosit/Lenfosit Oranı ve Ortalama Trombosit Hacminin Kolorektal Karsinomlu Hastalardaki Prognostik Değeri Acta oncologia turcica. 2017;50(1):1-6
26. Gülşah Şiranlı, Cuma Mertoğlu, Alevtina Ersoy, Yücel Karakurt, Adalet Özçiçek. Diyabetik mikrovasküler komplikasyonlarda nötrofil lenfosit oranı ve ortalama trombosit hacmi. Ulusal 2. Kalıtsal Metabolik Hastalıklar laboratuvar Sempozyumu. 2019;PS-04.

The Relationship Between Hematological and Allergic Values in Children with Atopic Dermatitis

Year 2020, Volume: 4 Issue: 3, 1 - 6, 27.11.2020

Mehmet Özdin

https://doi.org/10.33716/bmedj.760653

Cited By: 4

Abstract

Aim: Our aim in this study; In Atopic Dermatitis (AD), patients in the pediatric age group who applied to the Pediatric Dermatology Polyclinics of Sakarya University Training and Research Hospital (SUTRH), to determine neutrophil lymphocyte ratio (NLO), platelet lymphocyte ratio (TLO), eosinophil lymphocyte ratio (ELO) and serum total immune globobulin E (T-IgE) values and blood eosinophil count to investigate the relationship between AD and these parameters.
Materials and Methods: The data of the patients we included in the study were obtained retrospectively from the AD patients who applied between 01.01.2018 and 31.10.2019 through the hospital information management system (HIMS). Those with allergic disease, infection or chronic disease were not included in the control group.
Results: Of the 30 AD patients who met the study criteria, 8 were girls and 22 were boys, with an average age of 9.33 ± 5.84. In the control group, the average age of the patients was 12.6 girls and 18 boys, 10.69 ± 4.69. T-IgE values of AD patients were determined as 304.48±25.81 IU / mL, eosinophil levels were 1.39 ± 0.29 K / uL, NLO 2.23±1.19, TLO 123.69±41.99, ELO 0.133±0.111. T-IgE values of the control group were determined as 41.03±6.18 IU / mL, eosinophil levels on average 0.39±0.09 K / uL, NLO 1.73±0.61, 107.66±35.30, ELO 0.071±0.049. When AD patients and control groups were compared statistically, T-IgE, Eosinophil, NLO, ELO values were determined as (p <0.05) and TLO values as (p> 0.05).
Conclusion: In our study, NLR, TLR, ELR and T-IgE values and blood eosinophil levels were found high in AD patients. It reveals that these parameters are important in the diagnosis and follow-up of this disease. High determination of these values will contribute to the reference of these values in future studies.

Keywords

atopic dermatitis, total IgE levels, neutrophil lymphocyte ratio

Project Number

References

1. Boguniewicz M, Leung DY. Atopic dermatitis. In: Adkinson NF, Bochner BS, Busse WW. Middleton’s allergy: Principles and practice. 7th ed. Philadelphia: Mosby Elsevier. 2009:1083-9.
2. Hanifin JM. Atopic dermatitis in infants and children. Ped Clin North Am 1991;4:763.
3. Leung DYM. Atopic dermatitis and the immune system: The role of superantigens and bacteria. J Am Acad Dermatol. 2001; 45:13-15.
4. Herrick CA, Xu L, McKenzie AN, Tigelaar RE, Bottomly K. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J Immunol 2003;170:2488-95.
5. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9.
6. Elberling J, Linneberg A, Dirksen A, Johansen JD, Frolund L, Madsen F. Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity. Clin Exp Allergy 2005;35:75-81.
7. Lee CH, Chuang HY, Shih CC, Jee SH, Wang LF, Chiu HC. Correlation of serum total IgE, eosinophil granule cationic proteins, sensitized allergens and family aggregation in atopic dermatitis patients with or without rhinitis. J Dermatol 2004;31:784-93.
8. Woerly G, Loiseau S, Loyens M, Schoch C, Capron M. Inhibitory effects of ketotifen on eotaxin-dependent activation of eosinophils: consequences for allergic eye diseases. Allergy 2003;58:397-406.
9. Czech W, Krutmann J, Schopf E, Kapp A. Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis. Br J Dermatol 1992;126:351-5.
10. Schultz Larsen FV, Holm NV. Atopic dermatitis in a population based twin series: Concordance rates and heritability estimation. Acta Derm Venereol Suppl 1985;114:159.
11. Yuksel H, Can D, Reisli I, Uzuner N, Orhan F, Cevit O.Characteristics and prognosis of childhood atopic dermatitis: A multicenter study in Turkey. Int Arch Allergy Immunol 2010;152(4):362-7.
12. Nishimoto M, Numahara T, Nakashima K, Yoshida T. Peripheral eosinophil counts relates the improvement of the skin lesions of atopic dermatitis patients more sensitive thanserum eosinophil cationic protein levels. Arerugi 1998;47:591-6.
13. Kagi MK, Joller-Jemelka H, Wuthrich B. Correlation ofeosinophils, eosinophil cationic protein, and soluble interleukin-2 receptor with the clinical activity of atopic dermatitis. Dermatology 1992;185:88-92.
14. Gu H, You LP, Liu YS. Survey on the prevalance of childhood atopic dermatitis in ten cities of China. Chin J Dermatol 2004;37:29-31.
15. Nationale Eczema Society 2003. Diet and Eczema in Children. www.eczema.org/ 10/9/20046.
16. Ben-Gashir MA, Sedd PT. Hy RJ. Quality of life and disease severity are correlated in children with atopic dermatitis. Br J Dermatol 2004;150:284-90.
17. Wollenberg A, Wetzel S, Burgdorf WHC, Haas J. Viral infections in atopic dermatitis: pathogenic aspects and clinical management. J Allergy Clin Immunol 2003;112:667-674.
18. Laske N, Niggemann B. Does the severity of atopic dermatitis correlate with serum Ig E levels? Pediatr Allergy Immunol 2004;15:86-8.
19. Deniz Özçeker, Cansu Durak, Aslı Derya Kardelen, Nermin Güler, Zeynep Tamay. Çocuklarda Atopik Dermatit: Ne Kadar Atopik? Asthma Allergy Immunol. 2017;15:135-139.
20. Belgin Aktaş, Yakup Canıtez, Nihat Sapan. Atopik dermatit tanı yaşının ek alerjik hastalık gelişimi üzerine etkisi. Türk Ped Arfl 2011;46:308-12.
21. Frigas E, Gleich GJ. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol 1986;77:527-37.
22. Kayabaşı S, Gül F. Pfapa sendromunda yeni öngörücü parametreler: nötrofil lenfosit oranı ve trombosit lenfosit oranı. Ortadogu Tıp Derg 2019;11(3):231-234.
23. Bucak A, Ulu S, Oruc S, Yucedag F, Tekin MS, Karakaya F. Neutrophil-to-lymphocyte ratio as a novelpotential marker for predicting prognosis of Bell palsy. Laryngoscope 2014;124:1678-81.
24. Doğan Atan, Kürşat Murat Özcan, Sabri Köseoğlu, Aykut İkincioğulları, Mehmet Ali Çetin, Serdar Ensari. Nazal polipte yeni öngörücü parametreler: Nötrofil lenfosit oranı ve trombosit lenfosit oranı. Kulak Burun Bogaz Ihtis Derg 2015;25(2):97-101.
25. Utku Oflazoğlu, Ahmet Alacacıoğlu, Işıl Somalı, Melike Yüce1, Abdullah Murat Buyruk, Umut Varol. Nötrofil/Lenfosit Oranı, Trombosit/Lenfosit Oranı ve Ortalama Trombosit Hacminin Kolorektal Karsinomlu Hastalardaki Prognostik Değeri Acta oncologia turcica. 2017;50(1):1-6
26. Gülşah Şiranlı, Cuma Mertoğlu, Alevtina Ersoy, Yücel Karakurt, Adalet Özçiçek. Diyabetik mikrovasküler komplikasyonlarda nötrofil lenfosit oranı ve ortalama trombosit hacmi. Ulusal 2. Kalıtsal Metabolik Hastalıklar laboratuvar Sempozyumu. 2019;PS-04.

There are 26 citations in total.

Details

Primary Language	Turkish
Subjects	Clinical Sciences
Journal Section	MAKALELER
Authors	Mehmet Özdin 0000-0003-3077-7171
Project Number	-
Publication Date	November 27, 2020
Published in Issue	Year 2020 Volume: 4 Issue: 3

Cite

APA	Özdin, M. (2020). Atopik Dermatiti Olan Çocuklarda Hematolojik ve Alerjik Değerler Arasındaki İlişki. Balıkesir Medical Journal, 4(3), 1-6. https://doi.org/10.33716/bmedj.760653