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UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System

Year 2018, Uyku Hastalıkları Özel Sayı, 26 - 33, 27.04.2018

Abstract

ÖZET
Uyku yoksunluğu ve bozulmuş uyku kalitesi bireyin yaşantısını olumsuz yönde etkileyen ve aynı
zamanda ilişkili olduğu klinik antiteler nedeni ile de morbiditesi yüksek olan bir durumdur. Hipertansiyon,
obezite, inme ve kalp hastalığı riskini artırabileceği için popülasyonda genel mortaliteyi
de etkilemektedir. Son yıllarda yapılan çalışmalar, uyku bozuklukları ve gastrointestinal hastalıklar
arasında kuvvetli bir ilişki olduğunu vurgulamaktadır. Tümör nekroz faktörü, interlökin-1 ve
interlökin-6 gibi proinflamatuar sitokinlerin artışı, uyku bozukluğuyla ilişkilendirilmektedir. Bu
sitokinler; gastroözofageal reflü hastalığı, inflamatuar bağırsak hastalığı, karaciğer bozuklukları
ve kolorektal kanser gibi bazı gastrointestinal sistem hastalıklarında da artış göstermektedir.
Hekimlerin ve özellikle de ilgili uzmanların, hastaların hayat kalitesini yükseltebilmek ve daha iyi
bakım sağlayabilmek için uyku bozuklukları ve gastrointestinal hastalıklar arasındaki ilişkinin farkında
olmaları gerekmektedir. Bu makalede, uyku bozuklukları ve bazı gastrointestinal hastalıklar
arasındaki ilişki gözden geçirilecektir.
Anahtar Sözcükler: Gastrointestinal hastalıklar, Obstruktif uyku apne, Sitokinler
ABSTRACT
Sleep deprivation and impaired sleep quality is a condition that affects the individual’s experience
negatively and at the same time has a high morbidity due to the associated clinical conditions.
It can increase risk of hypertension, obesity, stroke and heart disease and also affects general
mortality in the population. Recent studies have emphasized a strong association between
sleep disorders and gastrointestinal disorders. The increase in proinflammatory cytokines, such
as tumor necrosis factor, interleukin-1 and interleukin-6, is associated with sleep disturbances.
These cytokines are increased also in gastroesophageal reflux disease, inflammatory bowel
disease, liver disorders and colorectal cancer. Physicians, and in particular related specialists,
should to be aware of the relationship between sleep disorders and gastrointestinal disorders
in order to improve the quality of life of patients and provide better care. In this article, the
relationship between sleep disturbances and some gastrointestinal diseases will be reviewed.
Keywords: Gastrointestinal Diseases, Obstructive sleep apnea, Cytokines

References

  • C, et al. Transient lower esophageal sphincter relaxations (TLESRs) are the major mechanism of gastroesophageal reflux but are not the cause of reflux disease. Dig Dis Sci. 2005 Jun;50(6):1072-7. 2. Kumar D, Idzikowski C, Wingate DL, Soffer EE, Thompson P, Siderfin C. Relationship between enteric migrating motor complex and the sleep cycle. Am J Physiol. 1990;259(6 pt 1):G983-90. 3. Ferrara A, Pemberton JH, Levin KE, Hanson RB. Relationship between anal canal tone and rectal motor activity. Dis Colon Rectum. 1993;36(4):337-42. 4. Santos RV, Tufik S, De Mello MT. Exercise, sleep and cytokines: is there a relation? Sleep Med Rev. 2007;11(3):231-39. 5. Vgontzas AN, Bixler EO, Lin HM, Prolo IL-6 and its circadian secretion in humans. Neuroimmunomodulation. 2005;12(3):131-40. 6. Vgontzas AN, Zoumakis M, Papanicolaou DA, Bixler EO, Prolo P, Lin HM, et al. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism. 2002;51(7):887-92. 7. Liebregts T, Adam B, Bredack C, Röth A, Heinzel S, Lester S, et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology. 2007;132(3):913-20. 8. Tang Y, Preuss F, Turek FW, Jakate S, Keshavarzian A. Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis. Sleep Med. 2009;10(6):597-603., Trakada G, Chrousos GP.
Year 2018, Uyku Hastalıkları Özel Sayı, 26 - 33, 27.04.2018

Abstract

References

  • C, et al. Transient lower esophageal sphincter relaxations (TLESRs) are the major mechanism of gastroesophageal reflux but are not the cause of reflux disease. Dig Dis Sci. 2005 Jun;50(6):1072-7. 2. Kumar D, Idzikowski C, Wingate DL, Soffer EE, Thompson P, Siderfin C. Relationship between enteric migrating motor complex and the sleep cycle. Am J Physiol. 1990;259(6 pt 1):G983-90. 3. Ferrara A, Pemberton JH, Levin KE, Hanson RB. Relationship between anal canal tone and rectal motor activity. Dis Colon Rectum. 1993;36(4):337-42. 4. Santos RV, Tufik S, De Mello MT. Exercise, sleep and cytokines: is there a relation? Sleep Med Rev. 2007;11(3):231-39. 5. Vgontzas AN, Bixler EO, Lin HM, Prolo IL-6 and its circadian secretion in humans. Neuroimmunomodulation. 2005;12(3):131-40. 6. Vgontzas AN, Zoumakis M, Papanicolaou DA, Bixler EO, Prolo P, Lin HM, et al. Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism. 2002;51(7):887-92. 7. Liebregts T, Adam B, Bredack C, Röth A, Heinzel S, Lester S, et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology. 2007;132(3):913-20. 8. Tang Y, Preuss F, Turek FW, Jakate S, Keshavarzian A. Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis. Sleep Med. 2009;10(6):597-603., Trakada G, Chrousos GP.
There are 1 citations in total.

Details

Primary Language Turkish
Journal Section Original Research
Authors

Zeynep Tuğba Ozan

Hilmi Ataseven This is me

Publication Date April 27, 2018
Published in Issue Year 2018 Uyku Hastalıkları Özel Sayı

Cite

APA Ozan, Z. T., & Ataseven, H. (2018). UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System. Bozok Tıp Dergisi, 8, 26-33.
AMA Ozan ZT, Ataseven H. UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System. Bozok Tıp Dergisi. April 2018;8:26-33.
Chicago Ozan, Zeynep Tuğba, and Hilmi Ataseven. “UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System”. Bozok Tıp Dergisi 8, April (April 2018): 26-33.
EndNote Ozan ZT, Ataseven H (April 1, 2018) UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System. Bozok Tıp Dergisi 8 26–33.
IEEE Z. T. Ozan and H. Ataseven, “UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System”, Bozok Tıp Dergisi, vol. 8, pp. 26–33, 2018.
ISNAD Ozan, Zeynep Tuğba - Ataseven, Hilmi. “UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System”. Bozok Tıp Dergisi 8 (April 2018), 26-33.
JAMA Ozan ZT, Ataseven H. UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System. Bozok Tıp Dergisi. 2018;8:26–33.
MLA Ozan, Zeynep Tuğba and Hilmi Ataseven. “UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System”. Bozok Tıp Dergisi, vol. 8, 2018, pp. 26-33.
Vancouver Ozan ZT, Ataseven H. UYKU BOZUKLUKLARI VE GASTROİNTESTİNAL SİSTEM Sleep Disorders and the Gastrointestinal System. Bozok Tıp Dergisi. 2018;8:26-33.
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