ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi
Abstract
ABSTRACT
Objective: Age-related macular degeneration (AMD) is the most common cause of advanced visual loss in
developed societies. ANXA3 contributes to tumor development by affecting cell signaling pathways, cell
profiling, invasion, metastasis and cell apoptosis. The aim of this study was to compare serum ANXA3 levels
in wet type and dry type macular degeneration patients with the control group and to investigate whether
there is a significant difference between the groups.
Material and Methods: A total of 78 patients (39 patients with wet AMD, 39 patients with dry AMD diagnosed
at the same time period and 39 healthy controls without any previous diagnosis of macular degeneration)
were enrolled in this study. ANXA3 levels were determined by enzyme-linked immunosorbent assay
(ELISA).
Results: Serum ANXA3 levels were found to be significantly higher in wet AMD than in the control group
(p=0.005). In addition, the difference between serum ANXA3 levels of wet and dry AMD patients was found
to be significant. It was observed that there was a significant increase in wet type AMD patients (p=0.004).
However, no significant difference was found in ANXA3 levels in dry type AMD compared to the control
group (p=0.444).
Conclusion: These findings suggest that ANXA3 protein may play an important role in age-related macular
degeneration.
Keywords
ASSOCIATION OF SERUM ANNEXIN A3 (ANXA3) LEVELS WITH AGE-RELATED MACULAR DEGENERATION Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (Anxa3) Düzeylerinin İlişkisi
References
- 1.Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018;392(10153):1147-59.
- 2. Abraham JR, Jaffe GJ, Kaiser PK, et al. Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry Age-Related Macular Degeneration: The Importance of Outer Retinal Integrity. Ophthalmol Retina. 2022;6(11):1019-27.
- 3. Hobbs SD, Pierce K. Wet Age-Related Macular Degeneration (Wet AMD). In: StatPearls. Treasure Island (FL): StatPearls Publishing; November 7, 2022.
- 4. Chaudhuri M, Hassan Y, Bakka Vemana PPS, Bellary Pattanashetty MS, Abdin ZU, Siddiqui HF. Age-Related Macular Degeneration: An Exponentially Emerging Imminent Threat of Visual Impairment and Irreversible Blindness. Cureus. 2023;15(5):e39624.
- 5. Zhang H, Zhang Z, Guo T, et al. Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer. Front Cell Dev Biol. 2023;11:1141331.
- 6. Shao G, Zhou H, Zhang Q, Jin Y, Fu C. Advancements of Annexin A1 in inflammation and tumorigenesis. Onco Targets Ther. 2019;12:3245-54.
- 7. Ozturk A. Role of annexin A3 in breast cancer (Review). Mol Clin Oncol. 2022;16(6):111.
- 8. Mussunoor S, Murray GI. The role of annexins in tumour development and progression. J Pathol. 2008;216(2):131-40.
- 9. Gerke V, Moss SE. Annexins: from structure to function. Physiol Bozok Tıp Derg 2023;13(3):52-57 Bozok Med J 2023;13(3):52-57 OZTURK et al. ANXA3 and macular degeneration Rev. 2002;82(2):331-71.
- 10. Lee SH, Lee PH, Kim BG, Hong J, Jang AS. Annexin A5 Protein as a Potential Biomarker for the Diagnosis of Asthma. Lung. 2018;196(6):681-9.
Abstract
References
- 1.Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018;392(10153):1147-59.
- 2. Abraham JR, Jaffe GJ, Kaiser PK, et al. Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry Age-Related Macular Degeneration: The Importance of Outer Retinal Integrity. Ophthalmol Retina. 2022;6(11):1019-27.
- 3. Hobbs SD, Pierce K. Wet Age-Related Macular Degeneration (Wet AMD). In: StatPearls. Treasure Island (FL): StatPearls Publishing; November 7, 2022.
- 4. Chaudhuri M, Hassan Y, Bakka Vemana PPS, Bellary Pattanashetty MS, Abdin ZU, Siddiqui HF. Age-Related Macular Degeneration: An Exponentially Emerging Imminent Threat of Visual Impairment and Irreversible Blindness. Cureus. 2023;15(5):e39624.
- 5. Zhang H, Zhang Z, Guo T, et al. Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer. Front Cell Dev Biol. 2023;11:1141331.
- 6. Shao G, Zhou H, Zhang Q, Jin Y, Fu C. Advancements of Annexin A1 in inflammation and tumorigenesis. Onco Targets Ther. 2019;12:3245-54.
- 7. Ozturk A. Role of annexin A3 in breast cancer (Review). Mol Clin Oncol. 2022;16(6):111.
- 8. Mussunoor S, Murray GI. The role of annexins in tumour development and progression. J Pathol. 2008;216(2):131-40.
- 9. Gerke V, Moss SE. Annexins: from structure to function. Physiol Bozok Tıp Derg 2023;13(3):52-57 Bozok Med J 2023;13(3):52-57 OZTURK et al. ANXA3 and macular degeneration Rev. 2002;82(2):331-71.
- 10. Lee SH, Lee PH, Kim BG, Hong J, Jang AS. Annexin A5 Protein as a Potential Biomarker for the Diagnosis of Asthma. Lung. 2018;196(6):681-9.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Ophthalmology and Optometry (Other) |
| Journal Section | Original Research |
| Authors | |
| Publication Date | September 15, 2023 |
| Published in Issue | Year 2023 Volume: 13 Issue: 3 |
