Abstract
References
- Vale ECSD, Garcia LC. Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects. An Bras Dermatol. 2023;98(3):355-372.
- Niebel D, de Vos L, Fetter T, Brägelmann C, Wenzel J. Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions. Am J Clin Dermatol. 2023;24(4):521-540.
- Lu Q, Long H, Chow S, et al. Guideline for the diagnosis, treatment and long-term management of cutaneous lupus erythematosus. J Autoimmun. 2021;123:102707.
- Avilés Izquierdo JA, Cano Martínez N, Lázaro Ochaita P. Epidemiological characteristics of patients with cutaneous lupus erythematosus. Actas Dermosifiliogr. 2014;105(1):69-73.
- Cardinali C, Caproni M, Bernacchi E, Amato L, Fabbri P. The spectrum of cutaneous manifestations in lupus erythematosus--the Italian experience. Lupus. 2000;9(6):417-423.
- Durosaro O, Davis MD, Reed KB, Rohlinger AL. Incidence of cutaneous lupus erythematosus, 1965-2005: a population-based study. Arch Dermatol. 2009;145(3):249-253.
- Biazar C, Sigges J, Patsinakidis N, et al. Cutaneous lupus erythematosus: first multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE). Autoimmun Rev. 2013;12(3):444-454.
- Chong BF, Song J, Olsen NJ. Determining risk factors for developing systemic lupus erythematosus in patients with discoid lupus erythematosus. Br J Dermatol. 2012;166(1):29-35.
- Filotico R, Mastrandrea V. Cutaneous lupus erythematosus: clinico-pathologic correlation. G Ital Dermatol Venereol. 2018;153(2):216-229.
- Lin TL, Wu CY, Juan CK, et al. Long-Term Risk of Autoimmune Diseases other than Systemic Lupus Erythematosus in Cutaneous Lupus Erythematosus-Alone Patients: A 10-Year Nationwide Cohort Study. Dermatology. 2022;238(1):92-100.
- Singh AG, Crowson CS, Singh S, et al. Cancer risk in cutaneous lupus erythematosus: a population-based cohort study. Rheumatology (Oxford). 2016;55(11):2009-2013.
- Westermann R, Zobbe K, Cordtz R, Haugaard JH, Dreyer L. Increased cancer risk in patients with cutaneous lupus erythematosus and systemic lupus erythematosus compared with the general population: A Danish nationwide cohort study. Lupus. 2021;30(5):752-761.
- Yavuz GO, Yavuz IH, Bayram I, Aktar R, Bilgili SG. Clinic experience in discoid lupus erythematosus: a retrospective study of 132 cases. Postepy Dermatol Alergol. 2019;36(6):739-743.
- Uva L, Miguel D, Pinheiro C, Freitas JP, Marques Gomes M, Filipe P. Cutaneous manifestations of systemic lupus erythematosus. Autoimmune Dis. 2012;2012:834291.
- Cooper EE, Pisano CE, Shapiro SC. Cutaneous Manifestations of "Lupus": Systemic Lupus Erythematosus and Beyond. Int J Rheumatol. 2021;2021:6610509.
- Zhou W, Wu H, Zhao M, Lu Q. New insights into the progression from cutaneous lupus to systemic lupus erythematosus. Expert Rev Clin Immunol. 2020;16(8):829-837.
- Al-Saif FM, Al-Balbeesi AO, Al-Samary AI, et al. Discoid lupus erythematosus in a Saudi population: Clinical and histopathological study. JSSDDS. 2012;16:9-12.
- Tang WYM, Chan LY, Lo KK. Discoid lupus erythematosus in Hongkong Chinese: a review of 12 cases. HKMJ. 1996;2(3):239-245.
- Cenk H, Gökşin Ş, İmren IG. Diskoid Lupus Eritematozus Hastalarının Klinikoepidemiyolojik Profili ve Sistemik Hastalıklarla İlişkisi.Turk J Clin Lab. 2022;13(2):207-214.
Abstract
Objective: Cutaneous Lupus Erythematosus (CLE) is a chronic inflammatory disease with different subtypes that exhibit variations in clinical, immunological, and prognostic features. This study aims to investigate the demographic and clinical characteristics of patients with CLE, the frequency of observed subtypes, antibody levels, the rate of co-occurrence with systemic lupus erythematosus (SLE), and the treatments administered.
Methods: The data of 56 patients diagnosed with CLE between November 2021 and December 2023 were retrospectively analyzed in this study. Demographic features, clinical findings, comorbidities, antinuclear antibody (ANA) and anti-dsDNA results, and treatments administered were recorded from patient files.
Results: The study included 38 females (67.9%) and 18 males (32.1%) with a mean age of 42.3±14.3 years. The most common clinical subtype was Chronic CLE (CCLE) (85.7%). Within CCLE, discoid lupus erythematosus (DLE) constituted 76.8%. The most frequently affected anatomic region was the face. SLE was present in 16.1% of the patients. Among patients with Acute CLE (ACLE), 100% had SLE, while this ratio was 66.7% for Subacute CLE (SCLE) and 6.9% for DLE. ANA was positive in 42.9% of all patients and 32.6% of DLE patients.
Conclusion: In this study, it was observed that the most common clinical subtype was DLE, lesions most frequently occurred in the facial region, the highest risk of SLE was associated with ACLE, and the most commonly administered treatment was topical calcineurin inhibitors. Identifying the subtypes of CLE, initiating appropriate treatment, and regular monitoring of patients are crucial in the management of patients with CLE.
Keywords
cutaneous lupus erythematosus discoid lupus erythematosus systemic lupus erythematosus antinuclear antibody
Ethical Statement
The present study was conducted according to the Declaration of Helsinki and approved by the Clinical Research and Ethics Committee of Giresun Training and Research Hospital (Approval number: 24, date: 18.12.2023).
References
- Vale ECSD, Garcia LC. Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects. An Bras Dermatol. 2023;98(3):355-372.
- Niebel D, de Vos L, Fetter T, Brägelmann C, Wenzel J. Cutaneous Lupus Erythematosus: An Update on Pathogenesis and Future Therapeutic Directions. Am J Clin Dermatol. 2023;24(4):521-540.
- Lu Q, Long H, Chow S, et al. Guideline for the diagnosis, treatment and long-term management of cutaneous lupus erythematosus. J Autoimmun. 2021;123:102707.
- Avilés Izquierdo JA, Cano Martínez N, Lázaro Ochaita P. Epidemiological characteristics of patients with cutaneous lupus erythematosus. Actas Dermosifiliogr. 2014;105(1):69-73.
- Cardinali C, Caproni M, Bernacchi E, Amato L, Fabbri P. The spectrum of cutaneous manifestations in lupus erythematosus--the Italian experience. Lupus. 2000;9(6):417-423.
- Durosaro O, Davis MD, Reed KB, Rohlinger AL. Incidence of cutaneous lupus erythematosus, 1965-2005: a population-based study. Arch Dermatol. 2009;145(3):249-253.
- Biazar C, Sigges J, Patsinakidis N, et al. Cutaneous lupus erythematosus: first multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE). Autoimmun Rev. 2013;12(3):444-454.
- Chong BF, Song J, Olsen NJ. Determining risk factors for developing systemic lupus erythematosus in patients with discoid lupus erythematosus. Br J Dermatol. 2012;166(1):29-35.
- Filotico R, Mastrandrea V. Cutaneous lupus erythematosus: clinico-pathologic correlation. G Ital Dermatol Venereol. 2018;153(2):216-229.
- Lin TL, Wu CY, Juan CK, et al. Long-Term Risk of Autoimmune Diseases other than Systemic Lupus Erythematosus in Cutaneous Lupus Erythematosus-Alone Patients: A 10-Year Nationwide Cohort Study. Dermatology. 2022;238(1):92-100.
- Singh AG, Crowson CS, Singh S, et al. Cancer risk in cutaneous lupus erythematosus: a population-based cohort study. Rheumatology (Oxford). 2016;55(11):2009-2013.
- Westermann R, Zobbe K, Cordtz R, Haugaard JH, Dreyer L. Increased cancer risk in patients with cutaneous lupus erythematosus and systemic lupus erythematosus compared with the general population: A Danish nationwide cohort study. Lupus. 2021;30(5):752-761.
- Yavuz GO, Yavuz IH, Bayram I, Aktar R, Bilgili SG. Clinic experience in discoid lupus erythematosus: a retrospective study of 132 cases. Postepy Dermatol Alergol. 2019;36(6):739-743.
- Uva L, Miguel D, Pinheiro C, Freitas JP, Marques Gomes M, Filipe P. Cutaneous manifestations of systemic lupus erythematosus. Autoimmune Dis. 2012;2012:834291.
- Cooper EE, Pisano CE, Shapiro SC. Cutaneous Manifestations of "Lupus": Systemic Lupus Erythematosus and Beyond. Int J Rheumatol. 2021;2021:6610509.
- Zhou W, Wu H, Zhao M, Lu Q. New insights into the progression from cutaneous lupus to systemic lupus erythematosus. Expert Rev Clin Immunol. 2020;16(8):829-837.
- Al-Saif FM, Al-Balbeesi AO, Al-Samary AI, et al. Discoid lupus erythematosus in a Saudi population: Clinical and histopathological study. JSSDDS. 2012;16:9-12.
- Tang WYM, Chan LY, Lo KK. Discoid lupus erythematosus in Hongkong Chinese: a review of 12 cases. HKMJ. 1996;2(3):239-245.
- Cenk H, Gökşin Ş, İmren IG. Diskoid Lupus Eritematozus Hastalarının Klinikoepidemiyolojik Profili ve Sistemik Hastalıklarla İlişkisi.Turk J Clin Lab. 2022;13(2):207-214.
Details
| Primary Language | English |
|---|---|
| Subjects | Dermatology, Rheumatology and Arthritis |
| Journal Section | Research Article |
| Authors | |
| Early Pub Date | February 29, 2024 |
| Publication Date | January 31, 2024 |
| Submission Date | December 31, 2023 |
| Acceptance Date | January 10, 2024 |
| Published in Issue | Year 2024 Volume: 1 Issue: 1 |
