BibTex RIS Cite

Platelets in preeclampsia: function and role in the inflammation

Year 2014, Volume: 4 Issue: 2, 111 - 116, 15.12.2014

Abstract

Preeclampsia is a hypertensive disease of pregnancy complicating 5-8% of all pregnancies. A growing body of evidence demonstrated that inflammation in microvasculature plays a major role in the pathogenesis of preeclampsia. Although circulating platelets are in rested state, when they are exposed to soluble mediators or microparticles in the inflamed vasculature as in preeclampsia, platelets are activated by engagement of the mediators on surface receptors. Upon activation, platelets degranulate some soluble and adhesion molecules. When soluble mediators released into the local microenvironment, they modulate the interactions between platelets, leukocytes and endothelial cells. Adhesion molecules expressed on the surface may initiate adherence between platelets, leukocytes and endothelial cells. Platelet-leukocyte aggregates promote the recruitment of neutrophils into the inflamed microvasculature. In addition to this, adherent platelets on endothelial cells induce production of inflammatory cytokines thus lead to amplification of inflammatory response. In this review, we mention platelet dysfunction in preeclamptic pregnancies and inflammatory role of platelets in the pathogenesis of preeclampsia.

References

  • ACOG practice bulletin Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol. 2002; 99(1):159-167.
  • Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre- eclampsia. Lancet. 2010; 376(9741): 631-644.
  • Zarbock A, Polanowska-Grabowska RK, Ley K. Platelet-neutrophil- interactions: linking hemostasis and inflammation. Blood Rev. 2007; 21(2): 99-111.
  • Heilmann L, Rath W, Pollow K. Hemostatic abnormalities in patients with severe preeclampsia. Clin Appl Thromb Hemost. 2007; 13(3): 285-291.
  • Konijnenberg A, Stokkers EW, van der Post JA, Schaap MC, Boer K, Bleker OP, Sturk A. Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules. Am J Obstet Gynecol. 1997; 176(2): 461-469.
  • Norris LA, Gleeson N, Sheppard BL, Bonnar J. Whole blood platelet aggregation in moderate and severe pre- eclampsia. Br J Obstet Gynaecol. 1993; 100(7): 684-688.
  • Moncada S, Palmer RM, Higgs EA. The discovery of nitric oxide as the endogenous nitrovasodilator. Hypertension. 1988; 12(4): 365-372.
  • Stokes KY, Granger DN. Platelets: a critical link between inflammation and microvascular dysfunction. J Physiol. 2012; 590(5): 1023-1034.
  • Lyall F, Young A, Greer IA. Nitric oxide concentrations are increased in the fetoplacental circulation in preeclampsia. Am J Obstet Gynecol. 1995; 173(3):714-718.
  • Smarason AK, Allman KG, Young D, Redman CW. Elevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre-eclampsia. Br J Obstet Gynaecol. 1997; 104(5): 538-543.
  • Yoneyama Y, Suzuki S, Sawa R, Yoneyama K, Power GG, Araki T. Increased plasma adenosine concentrations and the severity of preeclampsia. Obstet Gynecol. 2002; 100(6): 1266-1270.
  • Rowland BL, Vermillion ST, Roudebush WE. Elevated circulating concentrations of platelet activating factor in preeclampsia. Am J Obstet Gynecol. 2000; 183(4): 930-932.
  • Gear AR, Camerini D. Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Microcirculation. 2003; 10(3-4): 335-350.
  • Sahin S, Eroglu M, Ozakpinar OB, Tulunay A, Konukcu B, Tetik S. Evaluation of platelet aggregation by aggregometry in preeclamptic women. Zeynep Kamil Tıp Bulteni. 2013; 44: 111-115.
  • O’Brien WF, Saba HJ. Knuppel RA, Scerbo JC. Cohen GK Alterations in platelet concentration and aggregation in normal pregnancy and pre-eclampsia. Am J Obstet Gynecol. 1986;155(3): 486-90.
  • Louden KA, Broughton Pipkin F, Heptinstall S, Fox SC, Mitchell JR, Symonds EM. Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre- eclampsia. Br J Obstet Gynaecol. 1991; 98(12): 1239-1244.
  • Takeuchi T, Yoneyama Y, Suzuki S, Sawa R, Otsubo Y, Araki T. Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia. Gynecol Obstet Invest. 2001; 51(1): 36-39.
  • Peraçoli MT, Menegon FT, Borges VT, de Araşjo Costa RA, Thomazini- Santos IA, Peraçoli JC. Platelet aggregation and TGF-beta(1) plasma levels in pregnant women with preeclampsia. J Reprod Immunol. 2008; 79(1): 79-84.
  • Ahlawat S, Pati HP, Bhatla N, Fatima L, Mittal S Plasma platelet aggregating factor and platelet aggregation studies in pre-eclampsia. Acta Obstet Gynecol Scand. 1996; 75(5): 428-431.
  • Felfernig-Boehm D, Salat A, Vogl SE, Murabito M, Felfernig M, Schmidt D, Mittlboeck M, Husslein P, Mueller MR. Early detection of preeclampsia by determination of platelet aggregability. Thromb Res. 2000; 98(2): 139-146.
  • Csaicsich P, Deutinger J, Tatra G. Platelet specific proteins (beta- thromboglobulin and platelet factor 4) in normal pregnancy and in pregnancy complicated by preeclampsia. Arch Gynecol Obstet. 1989; 244(2): 91-95.
  • Ayhan A, Akkök E, Urman B, Yarali H, Dündar S, Kirazli S. Beta- thromboglobulin and platelet factor 4 levels in pregnancy and preeclampsia. Gynecol Obstet Invest. 1990; 30(1): 12-14.
  • Janes SL, Goodall AH. Flow cytometric detection of circulating activated platelets and platelet hyper-responsiveness in pre- eclampsia and pregnancy. Clin Sci. 1994; 86(6): 731-739.
  • Sahin S, Ozakpinar OB, Tulunay A, Eroglu M, Ciraci E, Uras F, Tetik S. Alterations in platelet functions in pre-eclamptic patients. SGI Summit (2013 September) Turkey abstract book.
  • Holthe MR, Staff AC, Berge LN, Lyberg T. Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women. Am J Obstet Gynecol. 2004; 190(4):1128-1134.
  • Hamburger SA, McEver RP. GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood. 1990; 75(3):550-554.
  • Blanks JE, Moll T, Eytner R, Vestweber D. Stimulation of P- selectin glycoprotein ligand-1 on mouse neutrophils activates beta 2-integrin mediated cell attachment to ICAM-1. Eur J Immunol. 1998; 28(2): 433- 443.
  • Hidari KI, Weyrich AS, Zimmerman GA, McEver RP. Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem. 1997; 272(45): 28750-28756.
  • Mine S, Fujisaki T, Suematsu M, Tanaka Y. Activated platelets and endothelial cell interaction with neutrophils under flow conditions. Intern Med. 2001; 40(11):1085-1092.
  • Xiong Y, Zhou SF, Zhou R, Yang D, Xu ZF, Lou YT, Guo QS, Hu R, Peng T, Ma D, Li XT. Alternations of maternal and cord plasma hemostasis in preeclampsia before and after delivery. Hypertens Pregnancy. 2011; 30(3): 347-358.
  • Laskowska M, Laskowska K, Oleszczuk J. Elevated maternal serum sP-selectin levels in preeclamptic pregnancies with and without intrauterine fetal growth restriction, but not in normotensive pregnancies complicated by isolated IUGR. Med Sci Monit. 2013; 19: 118-124.
  • Chaiworapongsa T, Romero R, Yoshimatsu J, Espinoza J, Kim YM, Park K, Kalache K, Edwin S, Bujold E, Gomez R. Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia. J Matern Fetal Neonatal Med. 2002; 12(1): 19-27.
  • Chavarría ME, Lara-González L, García-Paleta Y, Vital-Reyes VS, Reyes A. Adhesion molecules changes at 20 gestation weeks in pregnancies complicated by preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2008; 137(2): 157-164.
  • Bosio PM, Cannon S, McKenna PJ, O’Herlihy C, Conroy R, Brady H. Plasma P-selectin is elevated in the first trimester in women who subsequently develop pre-eclampsia. BJOG. 2001; 108(7): 709-715.
  • Robb AO, Din JN, Mills NL, Smith IB, Blomberg A, Zikry MN, Raftis JB, Newby DE, Denison FC. The influence of the menstrual cycle, normal pregnancy and pre-eclampsia on platelet activation. Thromb Haemost. 2010; 103(2):372-378.
  • Von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res. 2007; 100(1): 27-40.
  • Freedman JE. CD40-CD40L and platelet function: beyond hemostasis. Circ Res. 2003; 92(9): 944-946.
  • Henn V, Slupsky JR, Gräfe M, Anagnostopoulos I, Förster R, Müller- Berghaus G, Kroczek RA. CD40 ligand on activated platelets triggers an inflammatory reaction of ECs. Nature. 1998; 391(6667): 591-594.
  • Lutgens E, Gorelik L, Daemen MJ, de Muinck ED, Grewal IS, Koteliansky VE, Flavell RA. Requirement for CD154 in the progression of atherosclerosis. Nat Med. 1999; 5(11): 1313-1316.
  • Wagner DD, Burger PC Platelets in inflammation and thrombosis. Arterioscler Thromb Vasc Biol. 2003; 23(12): 2131-2137.
  • Mellembakken JR, Solum NO, Ueland T, Videm V, Aukrust P. Increased concentrations of soluble CD40 ligand, RANTES and GRO-alpha in preeclampsia–possible role of platelet activation. Thromb Haemost. 2001; 86(5): 1272-1276.
  • Lukanov TH, Bojinova SI, Emin AL, Veleva GL, Popova VS, Konova EI. Upregulation of the CD40-CD40 ligand system in pre-eclampsia. Int J Gynaecol Obstet. 2009; 105(3): 257-260.
  • Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res. 2003; 92(9): 1041–1048.
  • Danese S, de la Motte C, Sturm A, Vogel JD, West GA, Strong SA, Katz JA, Fiocchi C. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology. 2003; 124(5): 1249–1264.
  • Bechara C, Chai H, Lin PH, Yao Q, Chen C. Growth related oncogene- alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions. Med Sci Monit. 2007; 13(6): RA87-90.
  • Austgulen R, Lien E, Vince G, Redman CW. Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 1997; 71(1): 53-58.
  • Baviera G, D’Anna R, Corrado F, Ruello A, Buemi M, Jasonni VM. ICAM-1 in maternal serum and amniotic fluid as an early marker of preeclampsia and IUGR. J Reprod Med. 2002; 47(3): 191-193.
  • Spangenberg P, Redlich H, Bergmann I, Losche W, Gotzrath M, Kehrel B. The platelet glycoprotein IIb/IIIa complex is involved in the adhesion of activated platelets to leukocytes. Thromb Haemost. 1993; 70(3): 514–521.
  • Diacovo TG, Roth SJ, Buccola JM, Bainton DF, Springer TA. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood. 1996; 88(1): 146–157.
  • Evangelista V, Manarini S, Rotondo S, Martelli N, Polischuk R, McGregor JL, de Gaetano G, Cerletti C. Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P-selectin and the beta 2 integrin CD11b/CD18. Blood. 1996; 88(11):4183–4194.
  • Simon DI, Chen Z, Xu H, Li CQ, Dong J, McIntire LV, Ballantynec CM, Zhangf L, Furmang MI, Berndth MC, Lopez JA. Platelet glycoprotein Ib alpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/ CD18). J Exp Med. 2000; 192(2): 193–204.
  • Kuijper PH, Gallardo Tores HI, Lammers JW, Sixma JJ, Koenderman L, Zwaginga JJ. Platelet associated fibrinogen and ICAM-2 induce firm adhesion of neutrophils under flow conditions. Thromb Haemost. 1998; 80(3): 443–448.
  • Weber C, Springer TA. Neutrophil accumulation on activated, surface- adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet- activating factor. J Clin Invest. 1997; 100(8): 2085–2093.
  • Silverstein RL, Asch AS, Nachman RL. Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. J Clin Invest. 1989; 84(2): 546–552.
  • Sacks GP, Studena K, Sargent K, Redman CW. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol. 1998; 179(1): 80–86.
  • Barden A, Graham D, Beilin LJ, Ritchie J, Baker R, Walters BN, Michael CA. Neutrophil CD11B expression and neutrophil activation in pre- eclampsia. Clin Sci (Lond). 1997; 92(1): 37-44.
  • Lukanov TH, Bojinova SI, Popova VS, Emin AL, Veleva GL, Gecheva SP, Konova EI. Flow cytometric investigation of CD40-CD40 ligand system in preeclampsia and normal pregnancy Clin Appl Thromb Hemost. 2010;16(3): 306-312.
  • Konijnenberg A, van der Post JA, Mol BW. Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of preeclampsia? A prospective study. Am J Obstet Gynecol. 1997; 177(2): 434–442.
  • Banzola I, Farina A, Concu M, Sekizawa A, Purwosunu Y, Strada I, Arcelli D, Simonazzi G, Caramelli E, Rizzo N. Performance of a panel of maternal serum markers in predicting preeclampsia at 11–15 weeks’ gestation. Prenat Diagn. 2007; 27(11): 1005-1010.

Preeklampside trombositlerin enflamasyondaki rolü ve etkileri

Year 2014, Volume: 4 Issue: 2, 111 - 116, 15.12.2014

Abstract

Preeklampsi tüm gebeliklerin %5-8’ ini komplike eden gebeliğin hipertansif hastalığıdır. Preeklampsi patogenezinde kılcal damar yatağındaki inflamasyon önemli rol oynar. Preeklampside olduğu gibi dolaşımda serbest halde bulunan mikropartiküllerle trombositlerin karşılaşması sonucunda trombositler aktive olurlar. Aktive olan trombositler dolaşıma serbest moleküller salarlar ve hücre yüzeylerindeki adhezyon moleküllerinin artmasına neden olurlar. Serbest moleküller trombosit, lökosit ve endotel hücreleri arasındaki etkileşimleri düzenlerler. Adhezyon molekülleri de trombosit, lökosit ve endotel hücrelerinin birbirlerine bağlanmasına aracılık ederler. Oluşan trombosit-lökosit agregatları nötrofillerin inflamasyonun olduğu damarsal yapılara göçünün artmasına neden olur. Ayrıca, endotel hücrelerine bağlanan trombositler sitokinlerin yapımına ve inflamatuvar yanıtın artmasına neden olur. Bu derlemede, preeklamptik gebelerde trombosit fonksiyon bozuklukları ve trombositlerin preeklampsi patogenezindeki inflamatuvar rolünden bahsedeceğiz.

References

  • ACOG practice bulletin Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol. 2002; 99(1):159-167.
  • Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre- eclampsia. Lancet. 2010; 376(9741): 631-644.
  • Zarbock A, Polanowska-Grabowska RK, Ley K. Platelet-neutrophil- interactions: linking hemostasis and inflammation. Blood Rev. 2007; 21(2): 99-111.
  • Heilmann L, Rath W, Pollow K. Hemostatic abnormalities in patients with severe preeclampsia. Clin Appl Thromb Hemost. 2007; 13(3): 285-291.
  • Konijnenberg A, Stokkers EW, van der Post JA, Schaap MC, Boer K, Bleker OP, Sturk A. Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules. Am J Obstet Gynecol. 1997; 176(2): 461-469.
  • Norris LA, Gleeson N, Sheppard BL, Bonnar J. Whole blood platelet aggregation in moderate and severe pre- eclampsia. Br J Obstet Gynaecol. 1993; 100(7): 684-688.
  • Moncada S, Palmer RM, Higgs EA. The discovery of nitric oxide as the endogenous nitrovasodilator. Hypertension. 1988; 12(4): 365-372.
  • Stokes KY, Granger DN. Platelets: a critical link between inflammation and microvascular dysfunction. J Physiol. 2012; 590(5): 1023-1034.
  • Lyall F, Young A, Greer IA. Nitric oxide concentrations are increased in the fetoplacental circulation in preeclampsia. Am J Obstet Gynecol. 1995; 173(3):714-718.
  • Smarason AK, Allman KG, Young D, Redman CW. Elevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre-eclampsia. Br J Obstet Gynaecol. 1997; 104(5): 538-543.
  • Yoneyama Y, Suzuki S, Sawa R, Yoneyama K, Power GG, Araki T. Increased plasma adenosine concentrations and the severity of preeclampsia. Obstet Gynecol. 2002; 100(6): 1266-1270.
  • Rowland BL, Vermillion ST, Roudebush WE. Elevated circulating concentrations of platelet activating factor in preeclampsia. Am J Obstet Gynecol. 2000; 183(4): 930-932.
  • Gear AR, Camerini D. Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. Microcirculation. 2003; 10(3-4): 335-350.
  • Sahin S, Eroglu M, Ozakpinar OB, Tulunay A, Konukcu B, Tetik S. Evaluation of platelet aggregation by aggregometry in preeclamptic women. Zeynep Kamil Tıp Bulteni. 2013; 44: 111-115.
  • O’Brien WF, Saba HJ. Knuppel RA, Scerbo JC. Cohen GK Alterations in platelet concentration and aggregation in normal pregnancy and pre-eclampsia. Am J Obstet Gynecol. 1986;155(3): 486-90.
  • Louden KA, Broughton Pipkin F, Heptinstall S, Fox SC, Mitchell JR, Symonds EM. Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre- eclampsia. Br J Obstet Gynaecol. 1991; 98(12): 1239-1244.
  • Takeuchi T, Yoneyama Y, Suzuki S, Sawa R, Otsubo Y, Araki T. Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia. Gynecol Obstet Invest. 2001; 51(1): 36-39.
  • Peraçoli MT, Menegon FT, Borges VT, de Araşjo Costa RA, Thomazini- Santos IA, Peraçoli JC. Platelet aggregation and TGF-beta(1) plasma levels in pregnant women with preeclampsia. J Reprod Immunol. 2008; 79(1): 79-84.
  • Ahlawat S, Pati HP, Bhatla N, Fatima L, Mittal S Plasma platelet aggregating factor and platelet aggregation studies in pre-eclampsia. Acta Obstet Gynecol Scand. 1996; 75(5): 428-431.
  • Felfernig-Boehm D, Salat A, Vogl SE, Murabito M, Felfernig M, Schmidt D, Mittlboeck M, Husslein P, Mueller MR. Early detection of preeclampsia by determination of platelet aggregability. Thromb Res. 2000; 98(2): 139-146.
  • Csaicsich P, Deutinger J, Tatra G. Platelet specific proteins (beta- thromboglobulin and platelet factor 4) in normal pregnancy and in pregnancy complicated by preeclampsia. Arch Gynecol Obstet. 1989; 244(2): 91-95.
  • Ayhan A, Akkök E, Urman B, Yarali H, Dündar S, Kirazli S. Beta- thromboglobulin and platelet factor 4 levels in pregnancy and preeclampsia. Gynecol Obstet Invest. 1990; 30(1): 12-14.
  • Janes SL, Goodall AH. Flow cytometric detection of circulating activated platelets and platelet hyper-responsiveness in pre- eclampsia and pregnancy. Clin Sci. 1994; 86(6): 731-739.
  • Sahin S, Ozakpinar OB, Tulunay A, Eroglu M, Ciraci E, Uras F, Tetik S. Alterations in platelet functions in pre-eclamptic patients. SGI Summit (2013 September) Turkey abstract book.
  • Holthe MR, Staff AC, Berge LN, Lyberg T. Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women. Am J Obstet Gynecol. 2004; 190(4):1128-1134.
  • Hamburger SA, McEver RP. GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood. 1990; 75(3):550-554.
  • Blanks JE, Moll T, Eytner R, Vestweber D. Stimulation of P- selectin glycoprotein ligand-1 on mouse neutrophils activates beta 2-integrin mediated cell attachment to ICAM-1. Eur J Immunol. 1998; 28(2): 433- 443.
  • Hidari KI, Weyrich AS, Zimmerman GA, McEver RP. Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem. 1997; 272(45): 28750-28756.
  • Mine S, Fujisaki T, Suematsu M, Tanaka Y. Activated platelets and endothelial cell interaction with neutrophils under flow conditions. Intern Med. 2001; 40(11):1085-1092.
  • Xiong Y, Zhou SF, Zhou R, Yang D, Xu ZF, Lou YT, Guo QS, Hu R, Peng T, Ma D, Li XT. Alternations of maternal and cord plasma hemostasis in preeclampsia before and after delivery. Hypertens Pregnancy. 2011; 30(3): 347-358.
  • Laskowska M, Laskowska K, Oleszczuk J. Elevated maternal serum sP-selectin levels in preeclamptic pregnancies with and without intrauterine fetal growth restriction, but not in normotensive pregnancies complicated by isolated IUGR. Med Sci Monit. 2013; 19: 118-124.
  • Chaiworapongsa T, Romero R, Yoshimatsu J, Espinoza J, Kim YM, Park K, Kalache K, Edwin S, Bujold E, Gomez R. Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia. J Matern Fetal Neonatal Med. 2002; 12(1): 19-27.
  • Chavarría ME, Lara-González L, García-Paleta Y, Vital-Reyes VS, Reyes A. Adhesion molecules changes at 20 gestation weeks in pregnancies complicated by preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2008; 137(2): 157-164.
  • Bosio PM, Cannon S, McKenna PJ, O’Herlihy C, Conroy R, Brady H. Plasma P-selectin is elevated in the first trimester in women who subsequently develop pre-eclampsia. BJOG. 2001; 108(7): 709-715.
  • Robb AO, Din JN, Mills NL, Smith IB, Blomberg A, Zikry MN, Raftis JB, Newby DE, Denison FC. The influence of the menstrual cycle, normal pregnancy and pre-eclampsia on platelet activation. Thromb Haemost. 2010; 103(2):372-378.
  • Von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res. 2007; 100(1): 27-40.
  • Freedman JE. CD40-CD40L and platelet function: beyond hemostasis. Circ Res. 2003; 92(9): 944-946.
  • Henn V, Slupsky JR, Gräfe M, Anagnostopoulos I, Förster R, Müller- Berghaus G, Kroczek RA. CD40 ligand on activated platelets triggers an inflammatory reaction of ECs. Nature. 1998; 391(6667): 591-594.
  • Lutgens E, Gorelik L, Daemen MJ, de Muinck ED, Grewal IS, Koteliansky VE, Flavell RA. Requirement for CD154 in the progression of atherosclerosis. Nat Med. 1999; 5(11): 1313-1316.
  • Wagner DD, Burger PC Platelets in inflammation and thrombosis. Arterioscler Thromb Vasc Biol. 2003; 23(12): 2131-2137.
  • Mellembakken JR, Solum NO, Ueland T, Videm V, Aukrust P. Increased concentrations of soluble CD40 ligand, RANTES and GRO-alpha in preeclampsia–possible role of platelet activation. Thromb Haemost. 2001; 86(5): 1272-1276.
  • Lukanov TH, Bojinova SI, Emin AL, Veleva GL, Popova VS, Konova EI. Upregulation of the CD40-CD40 ligand system in pre-eclampsia. Int J Gynaecol Obstet. 2009; 105(3): 257-260.
  • Inwald DP, McDowall A, Peters MJ, Callard RE, Klein NJ. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res. 2003; 92(9): 1041–1048.
  • Danese S, de la Motte C, Sturm A, Vogel JD, West GA, Strong SA, Katz JA, Fiocchi C. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology. 2003; 124(5): 1249–1264.
  • Bechara C, Chai H, Lin PH, Yao Q, Chen C. Growth related oncogene- alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions. Med Sci Monit. 2007; 13(6): RA87-90.
  • Austgulen R, Lien E, Vince G, Redman CW. Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 1997; 71(1): 53-58.
  • Baviera G, D’Anna R, Corrado F, Ruello A, Buemi M, Jasonni VM. ICAM-1 in maternal serum and amniotic fluid as an early marker of preeclampsia and IUGR. J Reprod Med. 2002; 47(3): 191-193.
  • Spangenberg P, Redlich H, Bergmann I, Losche W, Gotzrath M, Kehrel B. The platelet glycoprotein IIb/IIIa complex is involved in the adhesion of activated platelets to leukocytes. Thromb Haemost. 1993; 70(3): 514–521.
  • Diacovo TG, Roth SJ, Buccola JM, Bainton DF, Springer TA. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood. 1996; 88(1): 146–157.
  • Evangelista V, Manarini S, Rotondo S, Martelli N, Polischuk R, McGregor JL, de Gaetano G, Cerletti C. Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P-selectin and the beta 2 integrin CD11b/CD18. Blood. 1996; 88(11):4183–4194.
  • Simon DI, Chen Z, Xu H, Li CQ, Dong J, McIntire LV, Ballantynec CM, Zhangf L, Furmang MI, Berndth MC, Lopez JA. Platelet glycoprotein Ib alpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/ CD18). J Exp Med. 2000; 192(2): 193–204.
  • Kuijper PH, Gallardo Tores HI, Lammers JW, Sixma JJ, Koenderman L, Zwaginga JJ. Platelet associated fibrinogen and ICAM-2 induce firm adhesion of neutrophils under flow conditions. Thromb Haemost. 1998; 80(3): 443–448.
  • Weber C, Springer TA. Neutrophil accumulation on activated, surface- adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet- activating factor. J Clin Invest. 1997; 100(8): 2085–2093.
  • Silverstein RL, Asch AS, Nachman RL. Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. J Clin Invest. 1989; 84(2): 546–552.
  • Sacks GP, Studena K, Sargent K, Redman CW. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol. 1998; 179(1): 80–86.
  • Barden A, Graham D, Beilin LJ, Ritchie J, Baker R, Walters BN, Michael CA. Neutrophil CD11B expression and neutrophil activation in pre- eclampsia. Clin Sci (Lond). 1997; 92(1): 37-44.
  • Lukanov TH, Bojinova SI, Popova VS, Emin AL, Veleva GL, Gecheva SP, Konova EI. Flow cytometric investigation of CD40-CD40 ligand system in preeclampsia and normal pregnancy Clin Appl Thromb Hemost. 2010;16(3): 306-312.
  • Konijnenberg A, van der Post JA, Mol BW. Can flow cytometric detection of platelet activation early in pregnancy predict the occurrence of preeclampsia? A prospective study. Am J Obstet Gynecol. 1997; 177(2): 434–442.
  • Banzola I, Farina A, Concu M, Sekizawa A, Purwosunu Y, Strada I, Arcelli D, Simonazzi G, Caramelli E, Rizzo N. Performance of a panel of maternal serum markers in predicting preeclampsia at 11–15 weeks’ gestation. Prenat Diagn. 2007; 27(11): 1005-1010.
There are 59 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Sadik Sahin

Ozlem Bingol Ozakpinar This is me

Mustafa Eroglu This is me

Sermin Tetik This is me

Publication Date December 15, 2014
Submission Date December 15, 2014
Published in Issue Year 2014 Volume: 4 Issue: 2

Cite

APA Sahin, S., Bingol Ozakpinar, O., Eroglu, M., Tetik, S. (2014). Preeklampside trombositlerin enflamasyondaki rolü ve etkileri. Clinical and Experimental Health Sciences, 4(2), 111-116. https://doi.org/10.5455/musbed.20140428120946
AMA Sahin S, Bingol Ozakpinar O, Eroglu M, Tetik S. Preeklampside trombositlerin enflamasyondaki rolü ve etkileri. Clinical and Experimental Health Sciences. December 2014;4(2):111-116. doi:10.5455/musbed.20140428120946
Chicago Sahin, Sadik, Ozlem Bingol Ozakpinar, Mustafa Eroglu, and Sermin Tetik. “Preeklampside Trombositlerin Enflamasyondaki Rolü Ve Etkileri”. Clinical and Experimental Health Sciences 4, no. 2 (December 2014): 111-16. https://doi.org/10.5455/musbed.20140428120946.
EndNote Sahin S, Bingol Ozakpinar O, Eroglu M, Tetik S (December 1, 2014) Preeklampside trombositlerin enflamasyondaki rolü ve etkileri. Clinical and Experimental Health Sciences 4 2 111–116.
IEEE S. Sahin, O. Bingol Ozakpinar, M. Eroglu, and S. Tetik, “Preeklampside trombositlerin enflamasyondaki rolü ve etkileri”, Clinical and Experimental Health Sciences, vol. 4, no. 2, pp. 111–116, 2014, doi: 10.5455/musbed.20140428120946.
ISNAD Sahin, Sadik et al. “Preeklampside Trombositlerin Enflamasyondaki Rolü Ve Etkileri”. Clinical and Experimental Health Sciences 4/2 (December 2014), 111-116. https://doi.org/10.5455/musbed.20140428120946.
JAMA Sahin S, Bingol Ozakpinar O, Eroglu M, Tetik S. Preeklampside trombositlerin enflamasyondaki rolü ve etkileri. Clinical and Experimental Health Sciences. 2014;4:111–116.
MLA Sahin, Sadik et al. “Preeklampside Trombositlerin Enflamasyondaki Rolü Ve Etkileri”. Clinical and Experimental Health Sciences, vol. 4, no. 2, 2014, pp. 111-6, doi:10.5455/musbed.20140428120946.
Vancouver Sahin S, Bingol Ozakpinar O, Eroglu M, Tetik S. Preeklampside trombositlerin enflamasyondaki rolü ve etkileri. Clinical and Experimental Health Sciences. 2014;4(2):111-6.

14639   14640