Research Article
BibTex RIS Cite

Comparison of efficacy of intraarticular polyacrylamide hydrogel and methylprednisolone acetate in patients with knee osteoarthritis

Year 2018, Volume: 43 Number: Supplement 1, 124 - 128, 29.12.2018
https://doi.org/10.17826/cumj.403372

Abstract

Purpose: The aim of this study was to compare and evaluate the efficacy of intraarticular methylprednisolone acetate and an intra-articular polyacrylamide hydrogel in patients with different stages of knee osteoarthritis. 

Materials and Methods: Patients with symptomatic knee osteoarthritis and history of failed pharmacotherapy or physiotherapy interventions were included in this study. The first 64 consecutive patients got intra-articular polyacrylamide hydrogel, the latter 79 consecutive patients got intra-articular methylprednisolone acetate. Patients were evaluated by WOMAC score and self-assessment questions. 

Results: There was no statistically significance difference between groups when WOMAC scores and answers of self-assessment questions were compared. 

Conclusion: Intra-articular use of polyacrylamide hydrogel was not superior to methylprednisolone acetate, for patients with knee osteoarthritis. 


References

  • 1. Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 2012;64(6):1697-707.
  • 2. Neustadt DH. Intra-articular injections for osteoarthritis of the knee. Cleve Clin J Med. 2006 Oct;73(10):897-8, 901-4, 906-11. Review.
  • 3. Jüni P, Hari R, Rutjes AW, Fischer R, Silletta MG, Reichenbach S, da Costa BR. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015 Oct 22;(10):CD005328.
  • 4. Raynauld JP, Buckland-Wright C, Ward R, Choquette D, Haraoui B, Martel-Pelletier J, et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2003 Feb;48(2):370-7.
  • 5. Yavuz U, Sökücü S, Albayrak A, Oztürk K. Efficacy comparisons of the intraarticular steroidal agents in the patients with knee osteoarthritis. Rheumatol Int. 2012 Nov;32(11):3391-6.
  • 6. Leighton R, Akermark C, Therrien R, Richardson JB, Andersson M, Todman MG, et al. NASHA hyaluronic acid vs. methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial. Osteoarthritis Cartilage. 2014 Jan;22(1):17-25.
  • 7. Patrick T. Polyacrylamide gel in cosmetic procedures: experience with Aquamid. Semin Cutan Med Surg. 2004 Dec;23(4):233-5. Review.
  • 8. King DJ, Noss RR. Toxicity of polyacrylamide and acrylamide monomer. Rev Environ Health. 1989 Jan-Dec;8(1-4):3-16. Review.
  • 9. Zar VV, Zagorodniy NV, Martinov DV. Effectiveness and safety of injectable endoprosthetics of synovial fluid by cross-linked polymer NOLTREX for treatment OA knee. European Journal of Musculoskeletal Diseases 2012;1(1):23–32.
  • 10. Bodugoz-Senturk H, Macias CE, Kung JH, Muratoglu OK. Poly(vinyl alcohol)-acrylamide hydrogels as load-bearing cartilage substitute. Biomaterials. 2009 Feb;30(4):589-96.
  • 11. Korkmaz M, Erdoğan Y, Okur A, Göçmen AY, Günaydın İ. Comparison of the effects of intraarticular hyaluronic acid and antiinflammatory drug treatments on the surgical intervention rates in patients with gonarthrosis. Turk J Med Sci 2013; 43:222-226.
  • 12. Yildiz SK, Özkan FÜ, Aktaş I, Silte AD, Kaysin MY, Badur NB. The effectiveness of ultrasound treatment for the management of knee osteoarthritis: a randomized, placebo-controlled, double-blind study. Turk J Med Sci. 2015;45(6):1187-91.
  • 13. Zhang W, Robertson J, Jones AC, Dieppe PA, Doherty M. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis. 2008 Dec;67(12):1716-23.
  • 14. Ravaud P, Moulinier L, Giraudeau B, Ayral X, Guerin C, Noel E, et al. Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: results of a multicenter, randomized, controlled trial. Arthritis Rheum. 1999 Mar;42(3):475-82.
  • 15. Arden NK, Reading IC, Jordan KM, Thomas L, Platten H, Hassan A, et al. A randomised controlled trial of tidal irrigation vs corticosteroid injection in knee osteoarthritis: the KIVIS Study. Osteoarthritis Cartilage. 2008 Jun;16(6):733-9.
  • 16. Tonbul M, Adas M, Bekmezci T, Kara AD. Intra-articular polyacrylamide hydrogel injections are not innocent. Case Rep Orthop. 2014;2014:150709.

Diz osteoartriti olan hastalarda eklem içi poliakrilamid hidrojel ve metilprednizolon asetatın etkinliğinin karşılaştırılması

Year 2018, Volume: 43 Number: Supplement 1, 124 - 128, 29.12.2018
https://doi.org/10.17826/cumj.403372

Abstract

Amaç: Bu çalışmanın amacı, farklı evrelerde diz osteoartriti olan hastalarda eklem içi metilprednizolon asetat ve eklem içi poliakrilamid hidrojelin etkinliğini karşılaştırmak ve değerlendirmektir.

Gereç ve Yöntem: Semptomatik diz osteoartriti olan ilaç veya fizik tedaviden fayda görmemiş hastalar çalışmaya dahil edildi. İlk 64 hasta eklem içi poliakrilamid hidrojel tedavisi aldı, sonraki 79 hasta ise eklem içi metilprednizolon asetat tedavisi aldı. Hastalar WOMAC skoru ve özdeğerlendirme soruları ile değerlendirildi. 

Bulgular: WOMAC skorları ve özdeğerlendirme sorularının cevapları karşılaştırıldığında gruplar arasında istatistiksel olarak anlamlı bir fark yoktu.

Sonuç: Diz osteoartriti olan hastalarda, eklem içi poliakrilamid hidrojelin kullanımı metilprednizolon asetata göre üstün değildir.


References

  • 1. Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 2012;64(6):1697-707.
  • 2. Neustadt DH. Intra-articular injections for osteoarthritis of the knee. Cleve Clin J Med. 2006 Oct;73(10):897-8, 901-4, 906-11. Review.
  • 3. Jüni P, Hari R, Rutjes AW, Fischer R, Silletta MG, Reichenbach S, da Costa BR. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015 Oct 22;(10):CD005328.
  • 4. Raynauld JP, Buckland-Wright C, Ward R, Choquette D, Haraoui B, Martel-Pelletier J, et al. Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2003 Feb;48(2):370-7.
  • 5. Yavuz U, Sökücü S, Albayrak A, Oztürk K. Efficacy comparisons of the intraarticular steroidal agents in the patients with knee osteoarthritis. Rheumatol Int. 2012 Nov;32(11):3391-6.
  • 6. Leighton R, Akermark C, Therrien R, Richardson JB, Andersson M, Todman MG, et al. NASHA hyaluronic acid vs. methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial. Osteoarthritis Cartilage. 2014 Jan;22(1):17-25.
  • 7. Patrick T. Polyacrylamide gel in cosmetic procedures: experience with Aquamid. Semin Cutan Med Surg. 2004 Dec;23(4):233-5. Review.
  • 8. King DJ, Noss RR. Toxicity of polyacrylamide and acrylamide monomer. Rev Environ Health. 1989 Jan-Dec;8(1-4):3-16. Review.
  • 9. Zar VV, Zagorodniy NV, Martinov DV. Effectiveness and safety of injectable endoprosthetics of synovial fluid by cross-linked polymer NOLTREX for treatment OA knee. European Journal of Musculoskeletal Diseases 2012;1(1):23–32.
  • 10. Bodugoz-Senturk H, Macias CE, Kung JH, Muratoglu OK. Poly(vinyl alcohol)-acrylamide hydrogels as load-bearing cartilage substitute. Biomaterials. 2009 Feb;30(4):589-96.
  • 11. Korkmaz M, Erdoğan Y, Okur A, Göçmen AY, Günaydın İ. Comparison of the effects of intraarticular hyaluronic acid and antiinflammatory drug treatments on the surgical intervention rates in patients with gonarthrosis. Turk J Med Sci 2013; 43:222-226.
  • 12. Yildiz SK, Özkan FÜ, Aktaş I, Silte AD, Kaysin MY, Badur NB. The effectiveness of ultrasound treatment for the management of knee osteoarthritis: a randomized, placebo-controlled, double-blind study. Turk J Med Sci. 2015;45(6):1187-91.
  • 13. Zhang W, Robertson J, Jones AC, Dieppe PA, Doherty M. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis. 2008 Dec;67(12):1716-23.
  • 14. Ravaud P, Moulinier L, Giraudeau B, Ayral X, Guerin C, Noel E, et al. Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: results of a multicenter, randomized, controlled trial. Arthritis Rheum. 1999 Mar;42(3):475-82.
  • 15. Arden NK, Reading IC, Jordan KM, Thomas L, Platten H, Hassan A, et al. A randomised controlled trial of tidal irrigation vs corticosteroid injection in knee osteoarthritis: the KIVIS Study. Osteoarthritis Cartilage. 2008 Jun;16(6):733-9.
  • 16. Tonbul M, Adas M, Bekmezci T, Kara AD. Intra-articular polyacrylamide hydrogel injections are not innocent. Case Rep Orthop. 2014;2014:150709.
There are 16 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research
Authors

Ahmet Issın 0000-0002-3084-0372

Nizamettin Koçkara 0000-0003-1780-0074

İsmet Yalkın Çamurcu 0000-0002-3900-5162

Publication Date December 29, 2018
Acceptance Date July 3, 2018
Published in Issue Year 2018 Volume: 43 Number: Supplement 1

Cite

MLA Issın, Ahmet et al. “Comparison of Efficacy of Intraarticular Polyacrylamide Hydrogel and Methylprednisolone Acetate in Patients With Knee Osteoarthritis”. Cukurova Medical Journal, vol. 43, no. Ek 1, 2018, pp. 124-8, doi:10.17826/cumj.403372.