Analysis of Factors that Influence the Outcomes of Labor Induction with Intravenous Synthetic Oxytocin Infusion in Term Pregnancy with Favourable Bishop Score
Abstract
Purpose: To investigate the factors that influence the success of labor induction with synthetic intravenous oxytocin infusion in term pregnancies with favourable Bishop score. Material and Methods: 150 pregnant women with completed 37 weeks of gestation and Bishop score>6 who had single and cephalic presentation of pregnancy and were decided to underwent labor induction with intravenous oxytocin infusion were included in the study. Labor induction was considered unsuccessful if a vaginal delivery did not occur within 24 hours after the onset of loxytocin infusion or a cesarean section was performed during oxytocin infusion due to foetal distress, cephalopelvic disproportion or failure to progress in labor. Multivariable regression were used to identify odds of induction success. Results: Out of 150 women, induction of labor was unsuccessful in 23 (15.3%). Multivariate analysis demonstrated that nulliparity, shorter gestation period, persistent occiput posterior presentation and greater birth weight were independent risk factors for the induction failure. ROC curve analysis stated that gestation period of <270 days predict induction failure with a sensitivity of 60.9% and a spesificity of 92.9% while value of >3445-gram-birth weight has a sensitivity of 82.6% and a spesificity of 71.7% for the prediction of failure. Conclusion: Nulliparity, shorter gestation period, persistent occiput posterior presentation and greater birth weight increase the failure risk of labor induction with intravenous synthetic oxytocin infusion
References
- ACOG Practice Bulletin no 107. Induction of labor. Obstet Gynecol. 2009;114:386-97.
- Ashton DM. Elective delivery at less than 39 weeks. Curr Opin Obstet Gynecol. 2010;22:506-10.
- Guerra GV, Cecatti JG, Souza JP, Faşndes A, Morais SS, Gülmezoglu AM, et al. World Health Organisation 2005 Global Survey on Maternal and Perinatal Health Research Group. Factors and outcomes associated with the induction of labour in Latin America. BJOG. 2009;116:1762-72.
- Seitchik J, Amico J, Robinson AG, Castillo M. Oxytocin augmentation of dysfunctional labor. 4. Oxytocin pharmacokinetics. Am J Obstet Gynecol. 1984;150:225.
- Alfirevic Z, Kelly AJ, Dowswell T. Intravenous oxytocin alone for cervical ripening and induction of labour. Cochrane Database Syst Rev. 2009;7:CD003246.
- Smith JG, Merrill DC. Oxytocin for Induction of Labor. Clinical Obstetrics and Gynecology. 2006;49:594- 608.
- Doyran GD, Özdemir İ, Somunkıran A, Gül ÖK,
- Demirci F, Yücel O. İndüksiyon öncesi transperineal ultrasonografik servikal uzunluk ve Bishop skorunun indüksiyon-doğum süresine etkisi Zeynep Kamil Tıp Bülteni. 2005;3:99-104.
- Rane SM, Guirgis RR, Higgins B, Nicolaides KH. Models for the prediction of successful induction of labor based on pre-induction sonographic measurement of cervical length. J Matern Fetal Neonatal Med. 2005;17:315-22.
- Crane JM. Factors predicting labor induction success: a critical analysis. Clin Obstet Gynecol. 2006;49:573-84.
- Kavanagh J, Kelly AJ, Thomas J. Hyaluronidase for cervical ripening and induction of labour. Cochrane Database Syst Rev. 2006;19:CD003097.
- Grobman WA. Predictors of induction success. Semin Perinatol. 2012;36:344-7.
- Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z. The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents. - Int J Endocrinol. 2011;2011:350546.
- Tandoğan B, Gürleyiğ E, Uçar U, Ayvacı H, Dayıcıoğlu V. Oksiput posterior prezantasyonun obstetrik prognoz ve postpartum nörogelişimsel sürece etkisi Zeynep Kamil Tıp Bülteni. 2008;39:45-9.
- Ponkey SE, Cohen AP, Heffner LJ, Lieberman E. Persistent fetal occiput posterior position: obstetric outcomes. Obstet Gynecol. 2003;101:915-20.
- Cheng YW, Shaffer BL, Caughey AB. The association between persistent occiput posterior position and neonatal outcomes. Obstet Gynecol. 2006;107:837-44.
- Rane SM, Guigis RR, Higgins B, Nicolaides KH. The value of ultrasound in the prediction of successful induction of labor. Ultrasound Obstet Gynecol. 2004;24:538-49.
- Ingemarsson E, Ingemarsson I, Solum T, Westgren M. Influence of occiput posterior position on the fetal heart rate pattern. Obstet Gynecol. 1980;55:301-4.
- Vrouenraets FP, Roumen FJ, Dehing CJ, van den
Term Gebelikte ve Uygun Bishop Skoru Varlığında Intravenöz Sentetik Oksitosin Infüzyonu ile Doğum Indüksiyonu Sonucuna Etki Eden Faktörlerin Analizi
Abstract
Amaç: Uygun Bishop skoruna sahip term gebeliklerde intravenöz sentetik oksitosin indüksiyon başarısını etkileyen faktörleri incelemek Materyal ve Metod: 37. gebelik haftasını tamamlamış ve intravenöz oksitosin infüzyonu ile doğum induksiyonuna karar verilen, bishop skoru>6 olan, tekil ve sefalik prezantasyona sahip 150 gebe çalışmaya dahil edildi. Doğumun 24 saat içerisinde olmaması, fetal distres, sefalopelvik uyumsuzluk ya da ilerlemeyen doğum eylemi nedeniyle sezaryen ile doğum eyleminin sonuçlanması başarısız doğum induksiyonu olarak tanımlandı. İndüksiyon sonucuna etki edebilecek faktörler lojistik regresyon modeli ile analiz edildi. Araştırma Makalesi / Research Article 317 Kokanalı ve ark. Cukurova Medical Journal Bulgular: 150 gebenin 23 (15.3%) tanesinde doğum indüksiyonu başarısız oldu. Lojistik regresyon modelinde, nulliparite varlığı, uzamış gebelik süresi, persiste oksiput posterior pozisyonu ve artmış yenidoğan kilosu indüksiyon başarısını olumsuz etkileyebilecek faktörler olarak bulundu. ROC analizi ile 270 günlük gebelik süresi eşik alındığında %60.9’luk duyarlılık ve %92.9’luk özgüllük ile indüksiyon başarısızlığı öngörülebildiği, diğer taraftan 3445 gramlık yenidoğan kilosu eşik değerinin ise indüksiyon başarısızlığı öngörmede %82.6’lık duyarlılığa ve %71.7’lik özgüllüğe sahip olduğu bulundu. Sonuçlar: Term gebeliklerde uygun Bishop skoru varlığında nulliparite, kısa gebelik süresi, persistan oksiput posterior pozisyonu ve fazla yenidoğan doğum kilosu başarısız senteik oksitosin indüksiyon olasılığını arttırmaktadır
References
- ACOG Practice Bulletin no 107. Induction of labor. Obstet Gynecol. 2009;114:386-97.
- Ashton DM. Elective delivery at less than 39 weeks. Curr Opin Obstet Gynecol. 2010;22:506-10.
- Guerra GV, Cecatti JG, Souza JP, Faşndes A, Morais SS, Gülmezoglu AM, et al. World Health Organisation 2005 Global Survey on Maternal and Perinatal Health Research Group. Factors and outcomes associated with the induction of labour in Latin America. BJOG. 2009;116:1762-72.
- Seitchik J, Amico J, Robinson AG, Castillo M. Oxytocin augmentation of dysfunctional labor. 4. Oxytocin pharmacokinetics. Am J Obstet Gynecol. 1984;150:225.
- Alfirevic Z, Kelly AJ, Dowswell T. Intravenous oxytocin alone for cervical ripening and induction of labour. Cochrane Database Syst Rev. 2009;7:CD003246.
- Smith JG, Merrill DC. Oxytocin for Induction of Labor. Clinical Obstetrics and Gynecology. 2006;49:594- 608.
- Doyran GD, Özdemir İ, Somunkıran A, Gül ÖK,
- Demirci F, Yücel O. İndüksiyon öncesi transperineal ultrasonografik servikal uzunluk ve Bishop skorunun indüksiyon-doğum süresine etkisi Zeynep Kamil Tıp Bülteni. 2005;3:99-104.
- Rane SM, Guirgis RR, Higgins B, Nicolaides KH. Models for the prediction of successful induction of labor based on pre-induction sonographic measurement of cervical length. J Matern Fetal Neonatal Med. 2005;17:315-22.
- Crane JM. Factors predicting labor induction success: a critical analysis. Clin Obstet Gynecol. 2006;49:573-84.
- Kavanagh J, Kelly AJ, Thomas J. Hyaluronidase for cervical ripening and induction of labour. Cochrane Database Syst Rev. 2006;19:CD003097.
- Grobman WA. Predictors of induction success. Semin Perinatol. 2012;36:344-7.
- Vrachnis N, Malamas FM, Sifakis S, Deligeoroglou E, Iliodromiti Z. The oxytocin-oxytocin receptor system and its antagonists as tocolytic agents. - Int J Endocrinol. 2011;2011:350546.
- Tandoğan B, Gürleyiğ E, Uçar U, Ayvacı H, Dayıcıoğlu V. Oksiput posterior prezantasyonun obstetrik prognoz ve postpartum nörogelişimsel sürece etkisi Zeynep Kamil Tıp Bülteni. 2008;39:45-9.
- Ponkey SE, Cohen AP, Heffner LJ, Lieberman E. Persistent fetal occiput posterior position: obstetric outcomes. Obstet Gynecol. 2003;101:915-20.
- Cheng YW, Shaffer BL, Caughey AB. The association between persistent occiput posterior position and neonatal outcomes. Obstet Gynecol. 2006;107:837-44.
- Rane SM, Guigis RR, Higgins B, Nicolaides KH. The value of ultrasound in the prediction of successful induction of labor. Ultrasound Obstet Gynecol. 2004;24:538-49.
- Ingemarsson E, Ingemarsson I, Solum T, Westgren M. Influence of occiput posterior position on the fetal heart rate pattern. Obstet Gynecol. 1980;55:301-4.
- Vrouenraets FP, Roumen FJ, Dehing CJ, van den
Details
| Primary Language | English |
|---|---|
| Journal Section | Research |
| Authors | |
| Publication Date | September 28, 2015 |
| Published in Issue | Year 2015 Volume: 40 Issue: 2 |
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