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Akut anterior ST segment miyokard infarktüsü sonrası GRACE risk skorunun sol ventrikül ejeksiyon fraksiyonundaki prediktif değeri

Year 2019, Volume: 44 Issue: 3, 819 - 828, 30.09.2019
https://doi.org/10.17826/cumj.459500

Abstract

Amaç: Bu çalışmanın amacı, akut anteriyor segment miyokard infarktüsü (AMI) sonrası sol ventrikül ejeksiyon fraksiyonu (LVEF) için GRACE skorunun prediktif değerini araştırmaktır. Akut miyokard enfarktüsünde (AMI) hızlı ve tam reperfüzyona rağmen, sol ventrikül fonksiyonunun yetersiz düzelmesi LVEF'de azalmaya neden olabilir.

Yöntemler: AMİ ile başvuran 710 hasta retrospektif olarak incelendi ve 290 hasta çalışmaya alındı. Hastalar LVEF'ye göre iki gruba ayrıldı ve LVEF <%50 olanlar deprese EF grubu (grup 1) olarak tanımlandı, >% 50 olanlar ise korunmuş EF grubu (grup 2) olarak tanımlandı. Tüm hastaların GRACE risk skorları hesaplandı.

Bulgular: Grup 1'e 132 hasta dahil edildi, 158 hasta grup 2'ye dahil edildi. Hastane içi ölüm GRACE risk skoru ve hastane içi ölüm / MI GRACE risk skoru grup 1'de daha yüksek bulundu. Risk skorlaro ve LVEF arasında anlamlı negatif korelasyon bulundu. Çok değişkenli regresyon analizinde hastane içi ölüm risk skoru ve hastane içi ölüm / MI risk skorunun depresif LVEF'nin bağımsız olarak öngördürücüsü olduğu bulunmuştur.

Sonuçlar: GRACE risk skoru, primer PKG ile tedavi edilen akut ön segment AMI hastalarında depresif LVEF'yi öngörmede klinik olarak önemli bir role sahiptir.

References

  • 1. Sanderson JE, Tse TF. Heart failure: a global disease requiring a global response. Heart. 2003;89:585-6.
  • 2. Hung J, Teng TH, Finn J, Knuiman M, Briffa T, Stewart S et al. Trends from 1996 to 2007 in incidence and mortality outcomes of heart failure after acute myocardial infarction: a population-based study of 20,812 patients with first acute myocardial infarction in western Australia. J Am Heart Assoc. 2013;2:e000172.
  • 3. Jhund PS, McMurray JJ. Heart failure after acute myocardial infarction: a lost battle in the war on heart failure. Circulation. 2008;118:2019-21.
  • 4. Bigger Jr JT, Fleiss JL, Kleiger R, Miller JP, Rolnitzky LM. The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation. 1984;69:250-58.
  • 5. Jneid H, Anderson JL, Wright RS, Adams CD, Bridges CR, Casey DE et al. 2012 ACCF/AHA Focused Update of the Guideline or the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Diretrizes 2012 Writing Committee Members. Circulation. 2012;126:875-910.
  • 6. Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST segment elevation of the European Society of Cardiology. Eur Heart J. 2011;32:2999-3054.
  • 7. Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163:2345-53.
  • 8. Gibson CM, Cannon CP, Daley WL, Dodge Jr JT, Alexander Jr B, Marble SJ et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93:879-88.
  • 9. Gheorghiade M, Sopko G, De Luca L, Velazquez EJ, Parker JD, Binkley PF et al. Navigating the crossroads of coronary artery disease and heart failure. Circulation. 2006;114:1202-13.
  • 10. Nestico PF, Hakki AH, Iskandrian AS. Left ventricular dilatation. Prognostic value in severe left ventricular dysfunction secondary to coronary artery disease. Chest. 1985;88:215-20.
  • 11. Cohn PF, Herman MV, Gorlin R. Ventricular dysfunction in coronary artery disease. Am J Cardiol. 1974;33:307-10.
  • 12. Lopez-Jimenez F, Goraya TY, Hellermann JP, Jacobsen SJ, Reeder GS, Weston SA et al. Measurement of ejection fraction after myocardial infarction in the population. Chest. 2004;125:397-403.
  • 13. Mukherjee Jayanta T. In hospital measurement of left ventricular ejection fraction and one-year outcomes in acute coronary syndromes: results from the IMMEDIATE Trial Diss. Sackler School of Graduate Biomedical Sciences (tufts University). 2015:14;1-29
  • 14. Lewis EF. Beyond the p value: the quest for improving health status in patients with ischemic heart disease. Circulation. 2010;122:1664-6.
  • 15. Butler J, Chirovsky D, Phatak H, McNeill A, Cody R. Renal function, health outcomes, and resource utilization in acute heart failure: a systematic review. Circ Heart Fail. 2010;3:726-45
  • 16. Foraker RE, Rose KM, Suchindran CM, Chang PP, McNeill AM, Rosamond WD. Socioeconomic status, medicaid coverage, clinical comorbidity, and rehospitalization or death after an incident heart failure hospitalization: Atherosclerosis Risk in Communities cohort (1987 to 2004). Circ Heart Fail. 2011;4:308-16.
  • 17. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bo hm M, Dickstein K et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail.2012;14:803-69.
  • 18. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey Jr DE, Drazner MH et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62:147-239.
  • 19. Abu-Assi E, Garcia-Acuna JM, Pena-Gil C, Gonzalez-Juanatey JR. Validation of the GRACE risk score for predicting death within 6 months of follow-up in a contemporary cohort of patients with acute coronary syndrome. Rev Esp Cardiol. 2010;63:640-8.
  • 20. Tang EW, Wong CK, Herbison P. Global Registry of Acute Coronary Events (GRACE) hospital discharge risk score accurately predicts long-term mortality post-acute coronary syndrome. Am Heart J. 2007;153:29-35.
  • 21. Raposeiras-Roubín S, Abu-Assi E, López-López A, Bouzas-Cruz N, Castiñeira-Busto M, Cambeiro-González C et al. Risk stratification for the development of heart failure after acute coronary syndrome at the time of hospital discharge: Predictive ability of GRACE risk score. J Cardiol. 2015;66:224-31.
  • 22. Goff DC Jr, Lloyd-Jones DM, Bennett G, Teixeira R, Baptista R, Jorge E et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63:2935-59.
  • 23. Antonio N, Monteiro S, Lourenco C, de Boer MJ, Hoorntje JC, Dambrink JH et al. Left ventricular systolic dysfunction after acute coronary syndromes: incidence; prognosis and risk predictors. Eur J Heart Fail Suppl. 2008;7(Suppl 1):S133.
  • 24. De Luca G, Suryapranata H, van’t Hof AW, Przybycień K, Gorący J, Kornacewicz-Jach Z. Prognostic assessment of patients with acute myocardial infarction treated with primary angioplasty: implications for early discharge. Circulation. 2004;109:2737-43.

The predictive value of GRACE risk score on the left ventricular ejection fraction after acute anterior ST-segment myocardial infarction

Year 2019, Volume: 44 Issue: 3, 819 - 828, 30.09.2019
https://doi.org/10.17826/cumj.459500

Abstract

Purpose: The aim of the study is to investigate the predictive value of GRACE score for left ventricular ejection fraction (LVEF) after acute anterior segment acute myocardial infarction (AMI). Despite rapid and complete reperfusion in AMI, inadequate recovery of left ventricular function may result in a decrease in LVEF.

Materials and Methods: We retrospectively analyzed 712 patients presented with AMI and 290 patients were included. Patients were divided into two groups according to LVEF and a value <50% was defined as depressed EF group (group 1), a value ≥50% was defined as preserved EF group (group 2). The GRACE risk scores of all patients were calculated.

Results: 132 patients were included in the group 1, 158 patients were included in the group 2. In-hospital death GRACE risk score and in-hospital death/MI GRACE risk score were higher in group 1. A significant negative correlation was found between risk scores and LVEF. In multivariate regression analysis, in-hospital death risk score, and in-hospital death/MI risk score were found to be independently predictors of depressed LVEF.

Conclusion: GRACE risk score has a clinically important role predicting depressed LVEF in acute anterior segment AMI patients treated with primary PCI. 


References

  • 1. Sanderson JE, Tse TF. Heart failure: a global disease requiring a global response. Heart. 2003;89:585-6.
  • 2. Hung J, Teng TH, Finn J, Knuiman M, Briffa T, Stewart S et al. Trends from 1996 to 2007 in incidence and mortality outcomes of heart failure after acute myocardial infarction: a population-based study of 20,812 patients with first acute myocardial infarction in western Australia. J Am Heart Assoc. 2013;2:e000172.
  • 3. Jhund PS, McMurray JJ. Heart failure after acute myocardial infarction: a lost battle in the war on heart failure. Circulation. 2008;118:2019-21.
  • 4. Bigger Jr JT, Fleiss JL, Kleiger R, Miller JP, Rolnitzky LM. The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation. 1984;69:250-58.
  • 5. Jneid H, Anderson JL, Wright RS, Adams CD, Bridges CR, Casey DE et al. 2012 ACCF/AHA Focused Update of the Guideline or the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Diretrizes 2012 Writing Committee Members. Circulation. 2012;126:875-910.
  • 6. Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST segment elevation of the European Society of Cardiology. Eur Heart J. 2011;32:2999-3054.
  • 7. Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163:2345-53.
  • 8. Gibson CM, Cannon CP, Daley WL, Dodge Jr JT, Alexander Jr B, Marble SJ et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93:879-88.
  • 9. Gheorghiade M, Sopko G, De Luca L, Velazquez EJ, Parker JD, Binkley PF et al. Navigating the crossroads of coronary artery disease and heart failure. Circulation. 2006;114:1202-13.
  • 10. Nestico PF, Hakki AH, Iskandrian AS. Left ventricular dilatation. Prognostic value in severe left ventricular dysfunction secondary to coronary artery disease. Chest. 1985;88:215-20.
  • 11. Cohn PF, Herman MV, Gorlin R. Ventricular dysfunction in coronary artery disease. Am J Cardiol. 1974;33:307-10.
  • 12. Lopez-Jimenez F, Goraya TY, Hellermann JP, Jacobsen SJ, Reeder GS, Weston SA et al. Measurement of ejection fraction after myocardial infarction in the population. Chest. 2004;125:397-403.
  • 13. Mukherjee Jayanta T. In hospital measurement of left ventricular ejection fraction and one-year outcomes in acute coronary syndromes: results from the IMMEDIATE Trial Diss. Sackler School of Graduate Biomedical Sciences (tufts University). 2015:14;1-29
  • 14. Lewis EF. Beyond the p value: the quest for improving health status in patients with ischemic heart disease. Circulation. 2010;122:1664-6.
  • 15. Butler J, Chirovsky D, Phatak H, McNeill A, Cody R. Renal function, health outcomes, and resource utilization in acute heart failure: a systematic review. Circ Heart Fail. 2010;3:726-45
  • 16. Foraker RE, Rose KM, Suchindran CM, Chang PP, McNeill AM, Rosamond WD. Socioeconomic status, medicaid coverage, clinical comorbidity, and rehospitalization or death after an incident heart failure hospitalization: Atherosclerosis Risk in Communities cohort (1987 to 2004). Circ Heart Fail. 2011;4:308-16.
  • 17. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bo hm M, Dickstein K et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail.2012;14:803-69.
  • 18. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey Jr DE, Drazner MH et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62:147-239.
  • 19. Abu-Assi E, Garcia-Acuna JM, Pena-Gil C, Gonzalez-Juanatey JR. Validation of the GRACE risk score for predicting death within 6 months of follow-up in a contemporary cohort of patients with acute coronary syndrome. Rev Esp Cardiol. 2010;63:640-8.
  • 20. Tang EW, Wong CK, Herbison P. Global Registry of Acute Coronary Events (GRACE) hospital discharge risk score accurately predicts long-term mortality post-acute coronary syndrome. Am Heart J. 2007;153:29-35.
  • 21. Raposeiras-Roubín S, Abu-Assi E, López-López A, Bouzas-Cruz N, Castiñeira-Busto M, Cambeiro-González C et al. Risk stratification for the development of heart failure after acute coronary syndrome at the time of hospital discharge: Predictive ability of GRACE risk score. J Cardiol. 2015;66:224-31.
  • 22. Goff DC Jr, Lloyd-Jones DM, Bennett G, Teixeira R, Baptista R, Jorge E et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63:2935-59.
  • 23. Antonio N, Monteiro S, Lourenco C, de Boer MJ, Hoorntje JC, Dambrink JH et al. Left ventricular systolic dysfunction after acute coronary syndromes: incidence; prognosis and risk predictors. Eur J Heart Fail Suppl. 2008;7(Suppl 1):S133.
  • 24. De Luca G, Suryapranata H, van’t Hof AW, Przybycień K, Gorący J, Kornacewicz-Jach Z. Prognostic assessment of patients with acute myocardial infarction treated with primary angioplasty: implications for early discharge. Circulation. 2004;109:2737-43.
There are 24 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research
Authors

Veysel Tosun 0000-0001-7629-2108

Necmettin Korucuk This is me 0000-0002-2059-6126

Ali Yaşar Kılınç This is me

Ünal Güntekin 0000-0002-1344-6250

Publication Date September 30, 2019
Acceptance Date January 6, 2019
Published in Issue Year 2019 Volume: 44 Issue: 3

Cite

MLA Tosun, Veysel et al. “The Predictive Value of GRACE Risk Score on the Left Ventricular Ejection Fraction After Acute Anterior ST-Segment Myocardial Infarction”. Cukurova Medical Journal, vol. 44, no. 3, 2019, pp. 819-28, doi:10.17826/cumj.459500.