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Comparison of carotid elasticity and distensibility between patients with end-stage renal disease and healthy volunteers

Year 2020, Volume: 45 Issue: 1, 208 - 214, 31.03.2020
https://doi.org/10.17826/cumj.644489

Abstract

Purpose: The incidence of cardiovascular events increased in patients with end-stage renal disease, but it is not clear how renal failure affects carotid arteries. The aim of this study is to evaluate this affect. For this purpose, the elasticity and distensibility which are markers of subclinical carotid atherosclerosis were measured and compared in patients with end-stage renal disease and healthy population.
Materials and Methods: The study was planned as cross-sectional. A total of 119 subjects (61 patients and 58 control) were enrolled into the study. Carotid elasticity and distensibility were measured and compared between the groups. In addition, we investigated whether there was a significant correlation between the duration of dialysis and carotid elasticity and distensibility.
Results: Carotid elasticity and distensibility were significantly lower in the patient group than in the control group (0.12±0.02 vs. 0.23±0.04, p < 0.001, and 7.47±0.51 vs. 9.42±0.73, p < 0.001, respectively). Correlation analysis revealed a significant positive correlation between the duration of dialysis and carotid elasticity and distensibility (r = -0.783, p < 0.001 ve r = -0.385, p = 0.002, respectively).
Conclusion: Carotid elasticity and distensibility decreased in patients with end-stage renal disease. These results may suggest an increased risk of subclinical atherosclerosis in the carotid arteries in this patient group and may indirectly suggest that the increase in the risk of cerebrovascular event is caused by atherosclerosis in the carotid arteries.

References

  • 1. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet 2013; 382:260–72.
  • 2. Saran R, Robinson B, Abbott KC, Agodoa LYC, Bragg-Gresham J, Balkrishnan R, et al. US Renal Data System 2018 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2019 Mar;73(3S1):A7-A8.
  • 3. Toyoda K, Ninomiya T. Stroke and cerebrovascular diseases in patients with chronic kidney disease. Lancet Neurol. 2014;13:823-33.
  • 4. Boesen ME, Singh D, Menon BK, Frayne R. A systematic literature review of the effect of carotid atherosclerosis on local vessel stiffness and elasticity. Atherosclerosis. 2015;243:211-22.
  • 5. Qaseem A, Hopkins RH Jr, Sweet DE, Starkey M, Shekelle P; Clinical Guidelines Committee of the American College of Physicians. Screening, Monitoring, and Treatment of Stage 1 to 3 Chronic Kidney Disease: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med 2013;159:835-47.
  • 6. Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, et al; American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008;21:93–111.
  • 7. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis 2012;34:290–6.
  • 8. Marlatt KL, Kelly AS, Steinberger J, Dengel DR. The influence of gender on carotid artery compliance and distensibility in children and adults. J Clin Ultrasound 2013;41:340–6.
  • 9. Koivistoinen T, Virtanen M, Hutri-Kähönen N, Lehtimäki T, Jula A, Juonala M, et al. Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey. Atherosclerosis 2012;220:387–93.
  • 10. Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JS, Raitakari OT. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 2005;112:1486–93.
  • 11. Ninomiya T. Risk of stroke in kidney disease. Contrib Nephrol 2013; 179: 58–66.
  • 12. Lee M, Saver JL, Chang KH, Liao HW, Chang SC, Ovbiagele B. Low glomerular filtration rate and risk of stroke: meta-analysis. BMJ 2010; 341: c4249.
  • 13. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 2003;108:2154–69.
  • 14. Gansevoort RT, Correa-Rotter R, Hemmelgarn BR, Jafar TH, Heerspink HJ, Mann JF, et al. Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention. Lancet 2013;382:339–52.
  • 15. Moe SM. Klotho: a master regulator of cardiovascular disease? Circulation 2012; 125: 2181–83.
  • 16. Boccardo P, Remuzzi G, Galbusera M. Platelet dysfunction in renal failure. Semin Thromb Hemost. 2004;30:579-89.
  • 17. Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, et al. FSR Investigators. Proteinuria and clinical outcomes after ischemic stroke. Neurology. 2012;78:1909-15.
  • 18. Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, et al. ; American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Epidemiology and Prevention; Council for High Blood Pressure Research,; Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:517-84.
  • 19. Shakeri A, Abdi M, Khosroshahi HT, Fouladi RF. Common carotid artery intima-media thickness and atherosclerotic plaques in carotid bulb in patients with chronic kidney disease on hemodialysis: a case-control study. Pak J Biol Sci. 2011;14:844-8.
  • 20. Pang Y, Sang Y, Ballew SH, Grams ME, Heiss G, Coresh J, et al. Carotid Intima-Media Thickness and Incident ESRD: The Atherosclerosis Risk in Communities (ARIC) Study. Clin J Am Soc Nephrol. 2016;11:1197–205.
  • 21. Wu Y, Hou J, Li J, Luo Y, Wu S. Correlation between Carotid Intima–Media Thickness and Early-Stage Chronic Kidney Disease: Results from Asymptomatic Polyvascular Abnormalities in Community Study. J Stroke Cerebrovasc Dis. 2016;25:259-65
  • 22. Lawal OM, Balogun MO, Akintomide AO, Ayoola OO, Mene-Afejuku TO, Ogunlade O, et al. Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients. Clin Med Insights Cardiol. 2019;13 1179546819852941.
  • 23. Hsu S, Rifkin DE, Criqui MH, Suder NC, Garimella P, Ginsberg C, et al. Relationship of Femoral Artery Ultrasound Measures of Atherosclerosis with Chronic Kidney Disease. Vasc Surg. 2018;67:1855–63.e1.
  • 24. Atalay, M.K. Cardiothoracic Imaging a report by Cardiac Magnetic Resonance Imaging and Computed Tomography—State of the Art. 2019. Available online: https://www.researchgate.net/publication/267825158_Cardiothoracic_Imaging_a_report_by_Cardiac_Magnetic_Resonance_Imaging_and_Computed_Tomography-_State_of_the_Art (accessed on 31 October 2019).

Karotis elastisite ve distensibilitesinin son dönem böbrek yetmezliği olan hastalar ve sağlıklı gönüllüler arasında karşılaştırılması

Year 2020, Volume: 45 Issue: 1, 208 - 214, 31.03.2020
https://doi.org/10.17826/cumj.644489

Abstract

Amaç: Son dönem böbrek yetmezliği olan kronik böbrek hastalarında kardiyovasküler olayların sıklığının artığı bilinmektedir ancak böbrek yetmezliğinin karotis arterler üzerinde nasıl bir etki gösterdiği net değildir. Bu çalışmanın amacı bunu değerlendirmektir. Bu amaçla subklinik karotis aterosklerozu ve hasarını gösteren elastisite ve distensibilite son dönem böbrek yetmezliği olan hastalar ve sağlıklı populasyonda ölçülerek karşılaştırılmıştır.
Gereç ve Yöntem: Çalışma kesitsel olarak planlandı. Son dönem böbrek yetmezliği olan 61 hasta ve 58 sağlıklı gönüllünün karotis elastisitesi ve distensibilitesi ölçülerek aralarında istatistiksel anmalı fark olup olmadığı değerlendirildi. Ayrıca hasta grubundaki bireylerin diyalize girme süreleri ile karotis elastisitesi ve distensibilitesi arasında anlamlı korelasyon olup olmadığı araştırıldı.
Bulgular: Hasta grubundahem karotis elastisitesi hem de distensibilitesi istatistiksel anlamlı olarak daha düşüktü (0,12±0,02 vs. 0,23±0,04, p < 0,001, ve 7,47±0,51 vs. 9,42±0,73, p < 0,001, sırasıyla). Diyaliz süresi ile hem karotis elastisitesi hem de karotis distensibilitesi arasında istatistiksel anlamlı negatif yönlü korelasyon bulundu (r = -0,783, p < 0,001 ve r = -0,385, p = 0,002, sırasıyla).
Sonuç: Son dönem böbrek yetmezliği olan hastalarda karotis elastisitesi ve distensibilitesi azalmıştır. Bu sonuçları bize bu hasta grubunda karotis arterlerde subklinik ateroskleroz riskinin arttığını düşündürebilir, ayrıca serebrovasküler olay riskindeki artışın sebebinin karotis arterlerdeki ateroskleroz olduğunu da indirekt olarak düşündürebilir.

References

  • 1. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet 2013; 382:260–72.
  • 2. Saran R, Robinson B, Abbott KC, Agodoa LYC, Bragg-Gresham J, Balkrishnan R, et al. US Renal Data System 2018 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2019 Mar;73(3S1):A7-A8.
  • 3. Toyoda K, Ninomiya T. Stroke and cerebrovascular diseases in patients with chronic kidney disease. Lancet Neurol. 2014;13:823-33.
  • 4. Boesen ME, Singh D, Menon BK, Frayne R. A systematic literature review of the effect of carotid atherosclerosis on local vessel stiffness and elasticity. Atherosclerosis. 2015;243:211-22.
  • 5. Qaseem A, Hopkins RH Jr, Sweet DE, Starkey M, Shekelle P; Clinical Guidelines Committee of the American College of Physicians. Screening, Monitoring, and Treatment of Stage 1 to 3 Chronic Kidney Disease: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med 2013;159:835-47.
  • 6. Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, et al; American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008;21:93–111.
  • 7. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, et al. Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011. Cerebrovasc Dis 2012;34:290–6.
  • 8. Marlatt KL, Kelly AS, Steinberger J, Dengel DR. The influence of gender on carotid artery compliance and distensibility in children and adults. J Clin Ultrasound 2013;41:340–6.
  • 9. Koivistoinen T, Virtanen M, Hutri-Kähönen N, Lehtimäki T, Jula A, Juonala M, et al. Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey. Atherosclerosis 2012;220:387–93.
  • 10. Juonala M, Järvisalo MJ, Mäki-Torkko N, Kähönen M, Viikari JS, Raitakari OT. Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 2005;112:1486–93.
  • 11. Ninomiya T. Risk of stroke in kidney disease. Contrib Nephrol 2013; 179: 58–66.
  • 12. Lee M, Saver JL, Chang KH, Liao HW, Chang SC, Ovbiagele B. Low glomerular filtration rate and risk of stroke: meta-analysis. BMJ 2010; 341: c4249.
  • 13. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 2003;108:2154–69.
  • 14. Gansevoort RT, Correa-Rotter R, Hemmelgarn BR, Jafar TH, Heerspink HJ, Mann JF, et al. Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention. Lancet 2013;382:339–52.
  • 15. Moe SM. Klotho: a master regulator of cardiovascular disease? Circulation 2012; 125: 2181–83.
  • 16. Boccardo P, Remuzzi G, Galbusera M. Platelet dysfunction in renal failure. Semin Thromb Hemost. 2004;30:579-89.
  • 17. Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, et al. FSR Investigators. Proteinuria and clinical outcomes after ischemic stroke. Neurology. 2012;78:1909-15.
  • 18. Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, et al. ; American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Epidemiology and Prevention; Council for High Blood Pressure Research,; Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:517-84.
  • 19. Shakeri A, Abdi M, Khosroshahi HT, Fouladi RF. Common carotid artery intima-media thickness and atherosclerotic plaques in carotid bulb in patients with chronic kidney disease on hemodialysis: a case-control study. Pak J Biol Sci. 2011;14:844-8.
  • 20. Pang Y, Sang Y, Ballew SH, Grams ME, Heiss G, Coresh J, et al. Carotid Intima-Media Thickness and Incident ESRD: The Atherosclerosis Risk in Communities (ARIC) Study. Clin J Am Soc Nephrol. 2016;11:1197–205.
  • 21. Wu Y, Hou J, Li J, Luo Y, Wu S. Correlation between Carotid Intima–Media Thickness and Early-Stage Chronic Kidney Disease: Results from Asymptomatic Polyvascular Abnormalities in Community Study. J Stroke Cerebrovasc Dis. 2016;25:259-65
  • 22. Lawal OM, Balogun MO, Akintomide AO, Ayoola OO, Mene-Afejuku TO, Ogunlade O, et al. Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients. Clin Med Insights Cardiol. 2019;13 1179546819852941.
  • 23. Hsu S, Rifkin DE, Criqui MH, Suder NC, Garimella P, Ginsberg C, et al. Relationship of Femoral Artery Ultrasound Measures of Atherosclerosis with Chronic Kidney Disease. Vasc Surg. 2018;67:1855–63.e1.
  • 24. Atalay, M.K. Cardiothoracic Imaging a report by Cardiac Magnetic Resonance Imaging and Computed Tomography—State of the Art. 2019. Available online: https://www.researchgate.net/publication/267825158_Cardiothoracic_Imaging_a_report_by_Cardiac_Magnetic_Resonance_Imaging_and_Computed_Tomography-_State_of_the_Art (accessed on 31 October 2019).
There are 24 citations in total.

Details

Primary Language Turkish
Subjects Radiology and Organ Imaging
Journal Section Research
Authors

Aylin Güneşli 0000-0002-8337-6905

Nihan Tekkarışmaz Törer This is me 0000-0001-7631-7395

Publication Date March 31, 2020
Acceptance Date January 2, 2020
Published in Issue Year 2020 Volume: 45 Issue: 1

Cite

MLA Güneşli, Aylin and Nihan Tekkarışmaz Törer. “Karotis Elastisite Ve Distensibilitesinin Son dönem böbrek yetmezliği Olan Hastalar Ve sağlıklı gönüllüler arasında karşılaştırılması”. Cukurova Medical Journal, vol. 45, no. 1, 2020, pp. 208-14, doi:10.17826/cumj.644489.