Abstract
Amaç: Bu çalışmanın amacı ayaktan tedavi ve takip alan hastalarda uzamış COVID-19 semptomlarını tanımlamaktır.
Gereç ve Yöntem: Bu prospektif, gözlemsel, tanımlayıcı çalışma, Şubat-Mayıs 2022'de bir üniversite hastanesinin COVID-19 kliniğinde gerçekleştirildi. Polikliniğe ayaktan başvuran ve tanıları polimeraz zincir reaksiyonu (PCR) testi ile doğrulanan hastalar çalışmaya alındı. Hastalar 12 haftalık bir süre boyunca uzamış COVID-19 semptomları açısından takip edildi. Uzamış COVID-19 semptom sıklığı ile cinsiyet, yaş ve kan grubu arasındaki ilişki araştırıldı.
Bulgular: Çalışmaya alınan 7139 hastanın 1701'inde (%23,8) en az bir uzamış COVID semptomu gözlendi. Ayaktan takip edilen tüm COVID-19 hastalarında en sık görülen semptom miyaljiydi (%4,33). Cinsiyete göre semptomlar incelendiğinde, öksürük ve tat/koku kaybının kadınlarda ve baş dönmesinin erkeklerde en sık görülen uzun süreli COVID semptomu olduğu izlendi Vücut kitle indeksi ile ilişkisi incelendiğinde, en belirgin değişkenlik gösteren semptomların periferik nöropati ve kulak çınlaması olduğu, en az değişkenlik gösterenlerin ise tat/koku kaybı, anksiyete ve depresyon olduğu görüldü.
Sonuç: Bu çalışmada ayaktan tedavi gören COVID-19 hastalarında uzun süreli COVID semptomları yaygın olarak saptanmıştır. Yaş, cinsiyet, VKİ ve kan grubu, hastalarda gelişen uzun süreli COVID semptomlarını etkileyen faktörler olabilir.
References
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- Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Health. 2020;25:278-80.
- Seyed Hosseini E, Riahi Kashani N, Nikzad H, Azadbakht J, Hassani Bafrani H, Haddad Kashani H. The novel coronavirus Disease-2019 (COVID-19): Mechanism of action, detection and recent therapeutic strategies. Virology. 2020;551:1-9.
- Li YD, Chi WY, Su JH, Ferrall L, Hung CF, Wu TC. Coronavirus vaccine development: from SARS and MERS to COVID-19. J Biomed Sci. 2020;27:104.
- Meo SA, Bukhari IA, Akram J, Meo AS, Klonoff DC. COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. Eur Rev Med Pharmacol Sci. 2021;25:1663-69.
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- Mitrani RD, Dabas N, Goldberger JJ. COVID-19 cardiac injury: Implications for long-term surveillance and outcomes in survivors. Heart Rhythm. 2020;17:1984–90.
- Callard F, Perego E. How and why patients made Long Covid. Soc Sci Med. 2020;113426.
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- Ceban F, Ling S, Lui LMW, Lee Y, Gill H, Teopiz KM et al. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain Behav Immun 2022;101:93-135.
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Abstract
Purpose: The purpose of this study is to describe long COVID-19 symptoms in patients receiving outpatient treatment.
Materials and Methods: This prospective, observational, descriptive study was conducted in the COVID-19 clinic of a university hospital in February-May 2022. Patients who applied to the outpatient clinic and were diagnosed with COVID-19 were included in the study. Patients were follow up for prolonged COVID-19 symptoms for a 12-week period. It was investigated whether there was a relationship between long COVID-19 symptoms frequency and gender, age and blood type.
Results: At least one long COVID symptom was observed in 23% of 7139 patients included in the study. Myalgia was the most common symptom detected in 4.33% of all patients. Cough and loss of taste/smell were the most common symptoms in women, and dizziness in men. The frequency of 26 of 29 symptoms varied with age. While the symptoms most affected by the Body Mass Index were peripheral neuropathy and tinnitus, the least affected symptoms were loss of taste/smell, anxiety and depression.
Conclusion: Long COVID symptoms were widely detected in COVID-19 outpatients. Age, gender and BMI may be factors affecting long COVID symptoms.
References
- Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res 2020;7:11.
- Sohrabi C, Alsafi Z, O'Neill N, Khan M, Kerwan A, Al-Jabir A et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020:71-6.
- Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020;91:157-60.
- Velavan TP, Meyer CG. The COVID-19 epidemic. Trop Med Int Health. 2020;25:278-80.
- Seyed Hosseini E, Riahi Kashani N, Nikzad H, Azadbakht J, Hassani Bafrani H, Haddad Kashani H. The novel coronavirus Disease-2019 (COVID-19): Mechanism of action, detection and recent therapeutic strategies. Virology. 2020;551:1-9.
- Li YD, Chi WY, Su JH, Ferrall L, Hung CF, Wu TC. Coronavirus vaccine development: from SARS and MERS to COVID-19. J Biomed Sci. 2020;27:104.
- Meo SA, Bukhari IA, Akram J, Meo AS, Klonoff DC. COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. Eur Rev Med Pharmacol Sci. 2021;25:1663-69.
- Arnold DT, Hamilton FW, Milne A, Morley AJ, Viner J, Attwood M et al. Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort. Thorax. 2021;76:399-401.
- Mitrani RD, Dabas N, Goldberger JJ. COVID-19 cardiac injury: Implications for long-term surveillance and outcomes in survivors. Heart Rhythm. 2020;17:1984–90.
- Callard F, Perego E. How and why patients made Long Covid. Soc Sci Med. 2020;113426.
- NICE. COVID-19 rapid guideline: managing the long-term effects of COVID-19. London, National Institute for Health and Care Excellence. (NICE); 2020.
- Daher A, Balfanz P, Cornelissen C, Müller A, Bergs I, Marx N et al. Follow up of patients with severe coronavirus disease 2019 (COVID-19): Pulmonary and extrapulmonary disease sequelae. Respir Med. 2020;174:1061-97.
- Goërtz YMJ, Van Herck M, Delbressine JM, Vaes AW, Meys R, Machado FVC et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? ERJ Open Res. 2020;6:00542-2020.
- Ceban F, Ling S, Lui LMW, Lee Y, Gill H, Teopiz KM et al. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain Behav Immun 2022;101:93-135.
- Davis HE, Assaf GS, McCorkell L, Wei H, Low RJ, Re'em Y et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EclinicalMedicine. 2021;38:1010-9.
- Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC et al. Attributes and predictors of long COVID. Nat Med. 2021;27:626-31.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research |
| Authors | |
| Publication Date | March 31, 2023 |
| Acceptance Date | March 11, 2023 |
| Published in Issue | Year 2023 Volume: 48 Issue: 1 |
