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Acute histopathological effects of cryotherapy on lung tissue

Year 2016, Volume: 1 Issue: 1, 1 - 5, 29.12.2016

Banu Yoldaş Alpaslan Çakan Ufuk Çağırıcı Kutsal Turhan Volkan Ertuğrul Ali Veral Fatma Aşkar

Abstract

Background: Cryotherapy is an actual treatment and diagnostic method in many fields of medicine. We aimed to evaluate the acute histopathological effects of cryotherapy application on lung tissue.


Materials and Methods: In this study 10 male rabbits were used. After providing single lung ventilation of the rabbits, clamshell incision was performed for exploration. Four different cryotherapy applications were performed to determine the different histopathologic changes on atelectatic and ventilated lung, also the difference between one versus two-cycle applications. After all applications, firstly, air leak was checked, then specimens were taken to analyze the acute histopathologic effects.


Results: After cryotherapy application, no air leak was detected on ventilated rabbit lung with a pressure of 30 cmH2O. There was no bleeding from lung tissue, but macroscopic parenchymal hematoma developed. The depth of necrosis in lung tissue was evaluated with histopathological analysis. In all samples, alveolar edema and congestion were observed but there was no statistical difference between the depth of necrosis regarding with different cryotherapy applications.


Conclusions: This study indicated that different applications of cryotherapy on lung parenchyma is a safe method and do not affect the depth of necrosis in a statistically significant degree.


Keywords

Experimental model lung cryotherapy

References

  • Polascik TJ, Nosnik I, Mayes JM, Mouraviev V. Short-term cancer control after primary cryosurgical ablation for clinically localized prostate cancer using third-generation cryotechnology. Urology 2007; 70: 117-21.
  • Chin JL, Lim D, Abdelhady M. Review of primary and salvage cryoablation for prostate cancer. Cancer Control 2007; 14: 231-7.
  • Nakada SY, Jerde TJ, Warner T, Lee FT. Comparison of cryotherapy and nephrectomy in treating implanted VX-2 carcinoma in rabbit kidneys. Investig Urol 2004; 94: 632-6.
  • Janzen NK, Perry KT, Han KR, Kristo B, Raman S, Said JW, et al. The effects of intentional cryoablation and radiofrequency ablation of renal tissue involving the collecting system in a porcine model. J Urol 2007; 173: 1368-74.
  • Ng KK, Lam CM, Poon RT, Shek TW, To JY, Wo YH, et al. Comparison of systemic responses of radiofrequency ablation cryotherapy and surgical resection in a porcine liver model. Ann Surg Oncol 2004; 11: 650-7.
  • Permpongkosol S, Nicol TL, Link RE, Varkarakis I, Khurana H, Zhai QJ, et al. Differences in ablation size in porcine kidney, liver and lung after cryoablation using the same ablation protocol. Am J Roentgenol 2007; 188: 1028-32.
  • Cakan A, Yoldas B, Samancilar O, Ertugrul V, Turhan K, Cagirici U, et al. Ligasure vessel sealing system versus harmonic scalpel for sutureless nonanatomical pulmonary resections in a rabbit model. Eur Surg Res 2009; 43: 24-8.
  • Izumi Y, Oyama T, Ikeda E, Kawamura M, Kobayashi K. The acute effects of transthoracic cryoablation on normal lung evaluated in a porcine model. Ann Thorac Surg 2005; 79: 318-22.
  • Wang H, Littrup PJ, Duan Y, Zhang Y, Feng H, Nie Z. Thoracic masses treated with percutaneous cryotherapy: initial experience with more than 200 procedures. Radiology 2005; 235: 289-98.
  • Maiwand MO, Asimakopoulos G. Cryosurgery for lung cancer: clinical results and technical aspects. Technol Cancer Res Treat 2004; 3: 143-50.
  • Thurer RJ. Cryotherapy in early lung cancer. Chest 2001; 120: 3-5.
  • Mathur PN, Edell E, Sutedja T, Vergnon JM. Treatment of early stage non-small lung cancer. Chest 2003; 123: 176-80.
  • Simoff MJ. Endobronchial management of advanced lung cancer. Cancer Control 2001; 8: 337-43.
  • Vergnon JM, Schmitt T, Alamartine E, Barthelemy JC, Fournel P, Emonot A. Initial combined cryotherapy and irradiation for unresectable non-small cell lung cancer. Chest 1992; 102: 1436-40.
  • Deygas N, Froudarakis M, Ozenne G, Vergnon JM. Cryotherapy in early superficial bronchogenic carcinoma. Chest 2001; 120: 26-31.
  • Asimakopoulos G, Beeson J, Evans J, Maiwand MO. Cryosurgery for malignant endobronchial tumors: analysis of outcome. Chest 2005; 127: 2007-14.
  • Maiwand MO, Evans JM, Beeson JE. The application of cryosurgery in the treatment of lung cancer. Cryobiology 2004; 48: 55-61.
  • Maiwand MO, Zehr KJ, Dyke CM, Peralta M, Tadjkarimi S, Khagani A, et al. The role of cryotherapy for airway complications after lung and heart-lung transplantation. Eur J Cardiothorac Surg 1997; 12: 549-54.
  • Moorjani N, Beeson JE, Evans JM, Maiwand MO. Cryosurgery for the treatment of benign tracheo-bronchial lesions. Interact Cardiovasc Thorac Surg 2004; 3: 547-50.
  • Babiak A, Hetzel J, Krishna G, Fritz P, Moeller P, Balli T, et al. Transbronchial cryobiopsy: a new tool for lung biopsies. Respiration 2009; 78: 203-8.
  • Ganganah O, Guo SL, Chiniah M, Li YS. Efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours: A systematic review and meta-analysis. Respirology 2016; 21: 834-41.
  • Hagmeyer L, Theegarten D, Wohlschläger J, Treml M, Matthes S, Priegnitz C, et al. The role of transbronchial cryobiopsy and surgical lung biopsy in the diagnostic algorithm of interstitial lung disease. Clin Respir J 2016; 10: 589-95.
  • Cascante JA, Cebollero P, Herrero S, Yagüe A, Echegoyen A, Elizalde J, et al. Transbronchial cryobiopsy in ILD: are we on the right path? J Bronchology Interv Pulmonol 2016; 23: 204-9.
  • Izumi Y, Tsukada N, Ikeda E, Kawamura M, Kobayashi K. Superficial contact cryoablation attenuates experimentally created lung air leakage. Cryobiology 2005; 51: 306-10.

Year 2016, Volume: 1 Issue: 1, 1 - 5, 29.12.2016

Banu Yoldaş Alpaslan Çakan Ufuk Çağırıcı Kutsal Turhan Volkan Ertuğrul Ali Veral Fatma Aşkar

Abstract

References

  • Polascik TJ, Nosnik I, Mayes JM, Mouraviev V. Short-term cancer control after primary cryosurgical ablation for clinically localized prostate cancer using third-generation cryotechnology. Urology 2007; 70: 117-21.
  • Chin JL, Lim D, Abdelhady M. Review of primary and salvage cryoablation for prostate cancer. Cancer Control 2007; 14: 231-7.
  • Nakada SY, Jerde TJ, Warner T, Lee FT. Comparison of cryotherapy and nephrectomy in treating implanted VX-2 carcinoma in rabbit kidneys. Investig Urol 2004; 94: 632-6.
  • Janzen NK, Perry KT, Han KR, Kristo B, Raman S, Said JW, et al. The effects of intentional cryoablation and radiofrequency ablation of renal tissue involving the collecting system in a porcine model. J Urol 2007; 173: 1368-74.
  • Ng KK, Lam CM, Poon RT, Shek TW, To JY, Wo YH, et al. Comparison of systemic responses of radiofrequency ablation cryotherapy and surgical resection in a porcine liver model. Ann Surg Oncol 2004; 11: 650-7.
  • Permpongkosol S, Nicol TL, Link RE, Varkarakis I, Khurana H, Zhai QJ, et al. Differences in ablation size in porcine kidney, liver and lung after cryoablation using the same ablation protocol. Am J Roentgenol 2007; 188: 1028-32.
  • Cakan A, Yoldas B, Samancilar O, Ertugrul V, Turhan K, Cagirici U, et al. Ligasure vessel sealing system versus harmonic scalpel for sutureless nonanatomical pulmonary resections in a rabbit model. Eur Surg Res 2009; 43: 24-8.
  • Izumi Y, Oyama T, Ikeda E, Kawamura M, Kobayashi K. The acute effects of transthoracic cryoablation on normal lung evaluated in a porcine model. Ann Thorac Surg 2005; 79: 318-22.
  • Wang H, Littrup PJ, Duan Y, Zhang Y, Feng H, Nie Z. Thoracic masses treated with percutaneous cryotherapy: initial experience with more than 200 procedures. Radiology 2005; 235: 289-98.
  • Maiwand MO, Asimakopoulos G. Cryosurgery for lung cancer: clinical results and technical aspects. Technol Cancer Res Treat 2004; 3: 143-50.
  • Thurer RJ. Cryotherapy in early lung cancer. Chest 2001; 120: 3-5.
  • Mathur PN, Edell E, Sutedja T, Vergnon JM. Treatment of early stage non-small lung cancer. Chest 2003; 123: 176-80.
  • Simoff MJ. Endobronchial management of advanced lung cancer. Cancer Control 2001; 8: 337-43.
  • Vergnon JM, Schmitt T, Alamartine E, Barthelemy JC, Fournel P, Emonot A. Initial combined cryotherapy and irradiation for unresectable non-small cell lung cancer. Chest 1992; 102: 1436-40.
  • Deygas N, Froudarakis M, Ozenne G, Vergnon JM. Cryotherapy in early superficial bronchogenic carcinoma. Chest 2001; 120: 26-31.
  • Asimakopoulos G, Beeson J, Evans J, Maiwand MO. Cryosurgery for malignant endobronchial tumors: analysis of outcome. Chest 2005; 127: 2007-14.
  • Maiwand MO, Evans JM, Beeson JE. The application of cryosurgery in the treatment of lung cancer. Cryobiology 2004; 48: 55-61.
  • Maiwand MO, Zehr KJ, Dyke CM, Peralta M, Tadjkarimi S, Khagani A, et al. The role of cryotherapy for airway complications after lung and heart-lung transplantation. Eur J Cardiothorac Surg 1997; 12: 549-54.
  • Moorjani N, Beeson JE, Evans JM, Maiwand MO. Cryosurgery for the treatment of benign tracheo-bronchial lesions. Interact Cardiovasc Thorac Surg 2004; 3: 547-50.
  • Babiak A, Hetzel J, Krishna G, Fritz P, Moeller P, Balli T, et al. Transbronchial cryobiopsy: a new tool for lung biopsies. Respiration 2009; 78: 203-8.
  • Ganganah O, Guo SL, Chiniah M, Li YS. Efficacy and safety of cryobiopsy versus forceps biopsy for interstitial lung diseases and lung tumours: A systematic review and meta-analysis. Respirology 2016; 21: 834-41.
  • Hagmeyer L, Theegarten D, Wohlschläger J, Treml M, Matthes S, Priegnitz C, et al. The role of transbronchial cryobiopsy and surgical lung biopsy in the diagnostic algorithm of interstitial lung disease. Clin Respir J 2016; 10: 589-95.
  • Cascante JA, Cebollero P, Herrero S, Yagüe A, Echegoyen A, Elizalde J, et al. Transbronchial cryobiopsy in ILD: are we on the right path? J Bronchology Interv Pulmonol 2016; 23: 204-9.
  • Izumi Y, Tsukada N, Ikeda E, Kawamura M, Kobayashi K. Superficial contact cryoablation attenuates experimentally created lung air leakage. Cryobiology 2005; 51: 306-10.
There are 24 citations in total.

Details

Journal Section How to do ıt
Authors

Banu Yoldaş

Alpaslan Çakan This is me

Ufuk Çağırıcı This is me

Kutsal Turhan This is me

Volkan Ertuğrul This is me

Ali Veral This is me

Fatma Aşkar This is me

Publication Date December 29, 2016
Published in Issue Year 2016 Volume: 1 Issue: 1

Cite

APA Yoldaş, B., Çakan, A., Çağırıcı, U., Turhan, K., et al. (2016). Acute histopathological effects of cryotherapy on lung tissue. CURRENT THORACIC SURGERY, 1(1), 1-5.
AMA Yoldaş B, Çakan A, Çağırıcı U, Turhan K, Ertuğrul V, Veral A, Aşkar F. Acute histopathological effects of cryotherapy on lung tissue. CTS. December 2016;1(1):1-5.
Chicago Yoldaş, Banu, Alpaslan Çakan, Ufuk Çağırıcı, Kutsal Turhan, Volkan Ertuğrul, Ali Veral, and Fatma Aşkar. “Acute Histopathological Effects of Cryotherapy on Lung Tissue”. CURRENT THORACIC SURGERY 1, no. 1 (December 2016): 1-5.
EndNote Yoldaş B, Çakan A, Çağırıcı U, Turhan K, Ertuğrul V, Veral A, Aşkar F (December 1, 2016) Acute histopathological effects of cryotherapy on lung tissue. CURRENT THORACIC SURGERY 1 1 1–5.
IEEE B. Yoldaş, “Acute histopathological effects of cryotherapy on lung tissue”, CTS, vol. 1, no. 1, pp. 1–5, 2016.
ISNAD Yoldaş, Banu et al. “Acute Histopathological Effects of Cryotherapy on Lung Tissue”. CURRENT THORACIC SURGERY 1/1 (December 2016), 1-5.
JAMA Yoldaş B, Çakan A, Çağırıcı U, Turhan K, Ertuğrul V, Veral A, Aşkar F. Acute histopathological effects of cryotherapy on lung tissue. CTS. 2016;1:1–5.
MLA Yoldaş, Banu et al. “Acute Histopathological Effects of Cryotherapy on Lung Tissue”. CURRENT THORACIC SURGERY, vol. 1, no. 1, 2016, pp. 1-5.
Vancouver Yoldaş B, Çakan A, Çağırıcı U, Turhan K, Ertuğrul V, Veral A, Aşkar F. Acute histopathological effects of cryotherapy on lung tissue. CTS. 2016;1(1):1-5.