Research Article
Year 2019,
Volume: 46 Issue: 3, 575 - 581, 16.09.2019
Abstract
ABSTRACT
Background: intradermal nevi are benign tumors of the skin and may be accompanied by different histopathological findings.
Objective:The
aim of this study was to assess co-existing unusual histopathological findings
in specimens resected with a preliminary diagnosis of an intradermal nevus.
Design: Retrospective
study
Setting: Education
and research hospital
Subject and Methods:We
retrospectively examined demographic and histopathological data of 2640 cases
resected with a preliminary diagnosis of an intradermal nevus between January
2010 and April 2018.
Results:A
total of 1973 women and 667 men with an age range of 2.8 to 94 years were
enrolled. Among cases having a histopathological diagnosis of intradermal
nevus, 46 cases had unusual histopathological findings, which included 21 osseous
metaplasia, 8 epidermal cysts, 4 folliculitidis, 1 seborrheic keratosis, 1
verruca vulgaris, 1 cavernous hemangioma-intravascular papillary endothelial
hyperplasia, 1 trichofollicoma, 1 sebaceous hyperplasia, 1 pilonidal sinus, 1
granulomaous inflammation, 1 basal cell carcinoma, 4 foreign body reactions,
and 1 Demodex spp.
Conclusion:
Although unusual histopathological findings were observed in a minority of
cases with intradermal nevi, it was noted that problems with differential
diagnosis may arise in some cases. Intradermal nevi need to be carefully
examined for potential co-existing neoplastic lesions.
Keywords
References
- REFERENCESReference 1. Sasaki S, Mitsuhashi Y, Ito Y. Osteo-nevus of Nanta: a case report and review of the Japanese literature. J Dermatol. 1999; 26: 183-8. Reference 2. Burgdorf W, Nasemann T. Cutaneous osteomas: a clinical and histopathologic review. Arch Dermatol Res. 1977; 260: 121-35.Reference 3. Conlin PA, Jimenez-Quintero LP, Rapini RP. Osteomas of the skin revisited: a clinicopathologic review of 74 cases. Am J Dermatopathol. 2002; 24: 479-83.Reference 4. Keida T, Hayashi N, Kawakami M, Kawashima M. Transforming growth factor beta and connective tissue growth factor are involved in the evolution of nevus of Nanta. J Dermatol. 2005; 32:442–5.Reference 5. Al-Daraji W. Osteo-nevus of Nanta (osseous metaplasia in a benign intradermal melanocytic nevus): an uncommon phenomenon. Dermatol Online J. 2007; 13:16. Reference 6. Elders DE, Elenitsas R, Murphy GF, Xu X. Benign Pigmented Lesions and Malignant Melanoma.İn: Elders DE, Elenitsas R, editors. Lever’s Histopathology of Skin. Philadelphia: Lippincott Williams and Wilkins; 2009.p.699-791.Reference 7. Freeman RG, Knox JM. Epidermal cysts associated with pigmented naevi. Arch Dermatol. 1962; 85:72-6.Reference 8. Kurokawa I, Kusumoto K, Sensaki H, Shikata N, Tsubura A, Nishijima S. Trichofolliculoma: Case report with immunohistochemical study of cytokeratins. Br J Dermatol. 2003; 148:597-8. Reference 9. Schulz T, Hartschuh W. The trichofolliculoma undergoes changes corresponding to the regressing normal hair follicle in its cycle. J Cutan Pathol. 1998; 25:341-53.Reference 10. Stern JB, Stout DA. Trichofolliculoma showing perineural invasion. Trichofolliculocarcinoma? Arch Dermatol. 1979; 115:1003-4. Reference 11. Bolte C, Cullen R, Sazunic I. Collision Tumor between Trichofolliculoma and Melanocytic Nevus. 2017; 9:181-3.Reference 12. Tognetti L, Cinotti E, Perrot JL, Campoli M, Fimiani M, Rubegni P. Benign and malignant collision tumors of melanocytic skin lesions with hemangioma: Dermoscopic and reflectance confocal microscopy features. Skin Res Technol. 2018;24:313-7.Reference13. Sener S, Karaman U, Colak C, Aydin NE, Sasmaz S, Iraz M. Positivity of Demodex spp. in biopsy specimens of nevi. Tropical Biomedicine. 2009; 26: 51–6 Reference 14. Park YW, Yoon SY, Paik SH, Hwang EJ, Jin SP, Park HS. Verruca vulgaris on top of a melanocyte nevus simulating melanoma. Korean J Dermatol 2012; 50: 923-4.Reference 15. Boyd AS, Rapini RP. Cutaneous collision tumors. An analysis of 69 cases and review of the literature. Am J Dermatopathol. 1994; 16:253– 7.Reference 16. Chong Y, Song DH, Jang KT, Park KH, Lee EJ. Concurrent Occurrence of Seborrheic Keratosıs and Melanocytıc Nevus ın the Same Lesion. Nasza Dermatologia Online. 2014; 5: 179-82.
Year 2019,
Volume: 46 Issue: 3, 575 - 581, 16.09.2019
Abstract
References
- REFERENCESReference 1. Sasaki S, Mitsuhashi Y, Ito Y. Osteo-nevus of Nanta: a case report and review of the Japanese literature. J Dermatol. 1999; 26: 183-8. Reference 2. Burgdorf W, Nasemann T. Cutaneous osteomas: a clinical and histopathologic review. Arch Dermatol Res. 1977; 260: 121-35.Reference 3. Conlin PA, Jimenez-Quintero LP, Rapini RP. Osteomas of the skin revisited: a clinicopathologic review of 74 cases. Am J Dermatopathol. 2002; 24: 479-83.Reference 4. Keida T, Hayashi N, Kawakami M, Kawashima M. Transforming growth factor beta and connective tissue growth factor are involved in the evolution of nevus of Nanta. J Dermatol. 2005; 32:442–5.Reference 5. Al-Daraji W. Osteo-nevus of Nanta (osseous metaplasia in a benign intradermal melanocytic nevus): an uncommon phenomenon. Dermatol Online J. 2007; 13:16. Reference 6. Elders DE, Elenitsas R, Murphy GF, Xu X. Benign Pigmented Lesions and Malignant Melanoma.İn: Elders DE, Elenitsas R, editors. Lever’s Histopathology of Skin. Philadelphia: Lippincott Williams and Wilkins; 2009.p.699-791.Reference 7. Freeman RG, Knox JM. Epidermal cysts associated with pigmented naevi. Arch Dermatol. 1962; 85:72-6.Reference 8. Kurokawa I, Kusumoto K, Sensaki H, Shikata N, Tsubura A, Nishijima S. Trichofolliculoma: Case report with immunohistochemical study of cytokeratins. Br J Dermatol. 2003; 148:597-8. Reference 9. Schulz T, Hartschuh W. The trichofolliculoma undergoes changes corresponding to the regressing normal hair follicle in its cycle. J Cutan Pathol. 1998; 25:341-53.Reference 10. Stern JB, Stout DA. Trichofolliculoma showing perineural invasion. Trichofolliculocarcinoma? Arch Dermatol. 1979; 115:1003-4. Reference 11. Bolte C, Cullen R, Sazunic I. Collision Tumor between Trichofolliculoma and Melanocytic Nevus. 2017; 9:181-3.Reference 12. Tognetti L, Cinotti E, Perrot JL, Campoli M, Fimiani M, Rubegni P. Benign and malignant collision tumors of melanocytic skin lesions with hemangioma: Dermoscopic and reflectance confocal microscopy features. Skin Res Technol. 2018;24:313-7.Reference13. Sener S, Karaman U, Colak C, Aydin NE, Sasmaz S, Iraz M. Positivity of Demodex spp. in biopsy specimens of nevi. Tropical Biomedicine. 2009; 26: 51–6 Reference 14. Park YW, Yoon SY, Paik SH, Hwang EJ, Jin SP, Park HS. Verruca vulgaris on top of a melanocyte nevus simulating melanoma. Korean J Dermatol 2012; 50: 923-4.Reference 15. Boyd AS, Rapini RP. Cutaneous collision tumors. An analysis of 69 cases and review of the literature. Am J Dermatopathol. 1994; 16:253– 7.Reference 16. Chong Y, Song DH, Jang KT, Park KH, Lee EJ. Concurrent Occurrence of Seborrheic Keratosıs and Melanocytıc Nevus ın the Same Lesion. Nasza Dermatologia Online. 2014; 5: 179-82.
There are 1 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Articles |
| Authors | |
| Publication Date | September 16, 2019 |
| Submission Date | May 24, 2019 |
| Published in Issue | Year 2019 Volume: 46 Issue: 3 |