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Surgical Treatment of Male Infertility

Year 2022, Volume: 24 Issue: Special Issue, 30 - 35, 30.10.2022

Selahittin Çayan

https://doi.org/10.18678/dtfd.1186146

Abstract

Male infertility may occur due to obstructive and non-obstructive reasons, and some pathologies may be corrected with surgical and medical treatment. Such treatment may increase the possibility of spontaneous pregnancy, the success of assisted reproductive technology, and also testicular sperm retrieval rate. This review will focus on surgical treatment alternatives in infertile males. Although treatment options for varicocele in infertile men include open surgical, radiologic, and laparoscopic approaches; microsurgical varicocele repair has the highest improvement in postoperative sperm parameters with lower complication rates. Recent advances in microsurgical anastomosis techniques have increased the patency rate for proximal epididymal obstruction. Although treatment options for distal ejaculatory duct obstruction include endoscopic resection, balloon dilatation, and laser incision/excision, transurethral resection of the ejaculatory duct (TURED), is still the primary gold standard treatment of distal ejaculatory duct obstruction. The testicular sperm retrieval rate has increased with the management of correctable pathologies in men with non-obstructive azoospermia. In case of treatment failure of correctable or uncorrectable pathologies of male factor infertility, surgical sperm obtained from the urogenital tract may necessary for assisted reproductive technology. Surgical success rates for male infertility and the success of surgical sperm obtained procedures have increased dramatically over the last decades attributable to the development of microsurgical techniques and endoscopic equipment, instrumentation, and techniques.

Keywords

Male infertility varicocele obstructive azoospermia surgical treatment

References

  • Assidi M. Infertility in men: Advances towards a comprehensive and integrative strategy for precision theranostics. Cells. 2022;11(10):1711.
  • Çayan S, Erdemir F, Özbey I, Turek PJ, Kadioğlu A, et al. Can varicocelectomy significantly change the way couples use assisted reproductive technologies? J Urol. 2002;167(4):1749-52.
  • Çayan S, Turek PJ. How useful are the various techniques for sperm retrieval and assisted reproductive technologies in helping couples with an ejaculation? Fertil Steril. 2001;76(3, Suppl 1):S244-5.
  • Çayan S, Kadioğlu TC, Tefekli A, Kadioglu A, Tellaloglu S. Comparison of results and complications of high ligation surgery and microsurgical high inguinal varicocelectomy in the treatment of varicocele. Urology. 2000;55(5):750-4.
  • Tefekli A, Çayan S, Uluocak N, Poyanli A, Alp T, Kadioğlu A. Is selective internal spermatic venography necessary in detecting recurrent varicocele after surgical repair? Eur Urol. 2001;40(4):404-8.
  • Minhas S, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. European association of urology guidelines on male sexual and reproductive health: 2021 update on male infertility. Eur Urol. 2021;80(5):603-20.
  • Çayan S, Orhan İ, Altay B, Aşcı R, Akbay E, Ayas B, et al. Fertility outcomes and predictors for successful sperm retrieval and pregnancy in 327 azoospermic men with a history of cryptorchidism who underwent microdissection testicular sperm extraction. Andrology. 2021;9(1):253-9.
  • Çayan S, Hernandez A, Turek PJ. The pattern of semen quality recovery after three different types of vasectomy reversal procedures. Fertil Steril. 2000;74(3, Suppl 1):S238.
  • Kadioglu A, Cayan S, Tefekli A, Orhan I, Engin G, Turek PJ. Does response to treatment of ejaculatory duct obstruction in infertile men vary with pathology? Fertil Steril. 2001;76(1):138-42.
  • Efesoy O, Çayan S, Akbay E. The efficacy of recombinant human follicle-stimulating hormone in the treatment of various types of male factor infertility at a single university hospital. J Androl. 2009;30(6):679-84.
  • Saylam B, Efesoy O, Çayan S. The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men. Fertil Steril. 2011;95(2):809-11.
  • Çayan S, Lee D, Black LD, Reijo Pera RA, Turek PJ. Response to varicocelectomy in oligospermic men with and without defined genetic infertility. Urology. 2001;57(3):530-5.
  • Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ, et al. Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I. Fertil Steril. 2021;115(1):54-61.
  • Giwercman A, Giwercman YL. Epidemiology of male reproductive disorders. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2013. 2000.
  • Velasquez M, Tanrikut C. Surgical management of male infertility: an update. Transl Androl Urol. 2014;3(1):64-76.
  • Penson DF, Paltiel AD, Krumholz HM, Palter S. The cost-effectiveness of treatment for varicocele related infertility. J Urol. 2002;168(6):2490-4.
  • Schlegel PN. Is assisted reproduction the optimal treatment for varicocele-associated male infertility? A cost-effectiveness analysis. Urology. 1997;49(1):83-90.
  • Orhan I, Onur R, Çayan S, Koksal IT, Kadioglu A. Seminal vesicle sperm aspiration in the diagnosis of ejaculatory duct obstruction. BJU Int. 1999;84(9):1050-3.
  • Çayan S, Lee D, Conaghan J, Givens CA, Ryan IP, Schriock ED, et al. A comparison of ICSI outcomes with fresh and cryopreserved epididymal spermatozoa from the same couples. Hum Reprod. 2001;16(3):495-9.
  • Kadioglu A, Tefekli A, Çayan S, Kandirali, E, Erdemir F, Tellaloglu S. Microsurgical inguinal varicocele repair in azoospermic men. Urology. 2001;57(2):328-33.
  • de Kretser DM. Male infertility. Lancet. 1997;349(9054):787-90.
  • Gupta R, Gupta A, Aggarwal N. Variations of gonadal veins: embryological prospective and clinical significance. J Clin Diagn Res. 2015;9(2):AC08-10.
  • Vanlangenhove P, Dhondt E, Maele GV, Van Waesberghe S, Delanghe E, Defreyne L. Internal spermatic vein insufficiency in varicoceles: a different entity in adults and adolescents. AJR Am J Roentgenol. 2015;205(3):667-75.
  • Najari BB; Katz MJ, Schulster ML, Lee DJ, Li PS, Goldstein M. Increased body mass index in men with varicocele is associated with larger spermatic vein diameters when supine. Urology. 2016;89:40-4.
  • Ficarra V, Cerruto MA, Liguori G, Mazzoni G, Minucci S, Tracia A, et al. Treatment of varicocele in subfertile men: The Cochrane Review--a contrary opinion. Eur Urol. 2006;49(2):258-63.
  • Marmar JL, Agarwal A, Prabakaran S, Agarwal R, Short RA, Benoff S, et al. Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis. Fertil Steril. 2007;88(3):639-48.
  • Cayan S, Kadioglu A, Orhan I, Kandirali E, Tefekli A, Tellaloglu S. The effect of microsurgical varicocelectomy on serum follicle stimulating hormone, testosterone and free testosterone levels in infertile men with varicocele. BJU Int. 1999;84(9):1046-9.
  • Çayan S, Akbay E. Fate of recurrent or persistent varicocele in the era of assisted reproduction technology: microsurgical subinguinal redo varicocelectomy versus observation. Urology. 2018;117:64-9.
  • Çayan S, Shavakhabov S, Kadioğlu A. Treatment of palpable varicocele in infertile men: A meta-analysis to define the best technique. J Androl. 2009;30(1):33-40.
  • Çayan S, Orhan İ, Akbay E, Kadıoğlu A. Systematic review of treatment methods for recurrent varicoceles to compare post-treatment sperm parameters, pregnancy and complication rates. Andrologia. 2019;51(11):e13419.
  • Jargiello T, Drelich-Zbroja A, Falkowski A, Sojka M, Pyra K, Szczerbo-Trojanowska M. Endovascular transcatheter embolization of recurrent postsurgical varicocele: anatomic reasons for surgical failure. Acta Radiol. 2015;56(1):63-9.
  • Halpern J, Mittal S, Pereira K, Bhatia S, Ramasamy R. Percutaneous embolization of varicocele: technique, indications, relative contraindications, and complications. Asian J Androl. 2016;18(2):234-8.
  • Goldstein M, Tanrikut C. Microsurgical management of male infertility. Nat Clin Pract Urol. 2006;3(7):381-91.
  • Lv KL, Zhuang JT, Zhao L, Wan Z, Zhang YD, Gao Y, et al. Varicocele anatomy during subinguinal microsurgical varicocelectomy in Chinese men. Andrologia. 2015;47(10):1190-5.
  • Kamal KM, Jarvi KJ, Zini A. Microsurgical varicocelectomy in the era of assisted reproductive technology: influence of initial semen quality on pregnancy rates. Fertil Steril. 2001;75(5):1013-6.
  • Agarwal A, Esteves SC. Varicocele and male infertility: current concepts and future perspectives. Asian J Androl. 2016;18(2):161-2.
  • Goluboff ET, Stifelman MD, Fisch H. Ejaculatory duct obstruction in the infertile male. Urology. 1995;45(6):925-31.
  • Lee R, Li PS, Schlegel PN, Goldstein M. Reassessing reconstruction in the management of obstructive azoospermia: reconstruction or sperm acquisition? Urol Clin North Am. 2008;35(2):289-301.
  • Lopes LS, Cury VN, Cha JD, Lampa Junior VM, Marques JL, Mizrahi FE, et al. Do assisted reproduction outcomes differ according to aetiology of obstructive azoospermia? Andrologia. 2020;52(1):e13425.
  • Berger RE. Triangulation end-to-side vasoepididymostomy. J Urol. 1998;159(6):1951-3.
  • Shiraishi K, Matsuyama H. Outcomes of partial intussusception and endo-to-side vasoepididymostomy in men with epididymal obstructive azoospermia. Int J Urol. 2020;27(12):1124-9.
  • Dubin JM, White J, Ory J, Ramasamy R. Vasectomy reversal vs. sperm retrieval with in vitro fertilization: a contemporary, comparative analysis. Fertil Steril. 2021;115(6):1377-83.
  • Darves-Bornoz A, Panken E, Brannigan RE, Halpern JA. Robotic surgery in male infertility. Urol Clin North Am. 2021;48(1):127-35.
  • Vahidi S, Horoki AZ, Talkhooncheh MH, Jambarsang S, Marvast LD, Sadeghi A, et al. Success rate and ART outcome of microsurgical sperm extraction in non obstructive azoospermia: A retrospective study. Int J Reprod Biomed. 2021;19(9):781-8.
  • Hanson BM, Kohn TP, Pastuszak AW, Scott RT Jr, Cheng PJ, Hotaling JM. Round spermatid injection into human oocytes: a systematic review and meta-analysis. Asian J Androl. 2021;23(4):363-9.

Erkek İnfertilitesinin Cerrahi Tedavisi

Year 2022, Volume: 24 Issue: Special Issue, 30 - 35, 30.10.2022

Selahittin Çayan

https://doi.org/10.18678/dtfd.1186146

Abstract

Erkek infertilitesi obstrüktif ve obstrüktif olmayan sebeplerle oluşabilir ve bunların bazıları cerrahi ve medikal tedavi ile düzeltilebilir. Bu tedavi yöntemleri çiftlerde spontan gebelik şansını artırabildiği gibi bu tedaviler ile üremeye yardımcı tedavi yöntemleri başarısı ve testiküler sperm bulma şansı artabilir. Bu derlemede infertil erkeklerde cerrahi tedavi yöntemleri irdelenecektir. Varikoselli infertil erkeklerde tedavi opsiyonları açık ve laparoskopik cerrahi ve radyolojik tedavi olmakla birlikte, mikrocerrahi varikoselektomi postoperatif sperm parametrelerinde en yüksek artış oranı ve en düşük komplikasyon oranlarına sahiptir. Proksimal epididimal obstrüksiyonların cerrahi tedavisinde mikrocerrahi anastomoz yöntemlerindeki ilerlemeler kanalın açılma başarısını artırmaktadır. Distal ejakülatör kanal tıkanıklığının cerrahi tedavisinde endoskopik rezeksiyon, balon dilatasyon, lazerle insizyon/eksizyon yöntemleri bulunmakla beraber, transüretral ejakülatör kanal rezeksiyonu (transurethral resection of the ejaculatory duct, TURED) hala altın standart tedavi yöntemidir. Nonobstrüktif azospermide düzeltilebilir patolojilerin giderilmesiyle testiküler sperm elde etme oranlarında artış gösterilmiştir. Düzeltilebilir veya düzeltilemez patolojilere bağlı erkek infertilitesinde tedavi başarısızlığı durumunda yardımcı üreme teknolojisi için ürogenital sistemden cerrahi olarak sperm elde etmek gerekli olabilir. Erkek infertilitesi cerrahi tedavilerinin başarı oranları ve cerrahi olarak sperm elde etme başarı oranları, mikro cerrahi tekniklerinin, endoskopik ekipman, enstrümantasyon ve tekniklerin gelişmesine bağlı olarak son dekatlarda çarpıcı bir şekilde artmıştır.

Keywords

Erkek infertilitesi varikosel obstrüktif azospermi cerrahi tedavi

References

  • Assidi M. Infertility in men: Advances towards a comprehensive and integrative strategy for precision theranostics. Cells. 2022;11(10):1711.
  • Çayan S, Erdemir F, Özbey I, Turek PJ, Kadioğlu A, et al. Can varicocelectomy significantly change the way couples use assisted reproductive technologies? J Urol. 2002;167(4):1749-52.
  • Çayan S, Turek PJ. How useful are the various techniques for sperm retrieval and assisted reproductive technologies in helping couples with an ejaculation? Fertil Steril. 2001;76(3, Suppl 1):S244-5.
  • Çayan S, Kadioğlu TC, Tefekli A, Kadioglu A, Tellaloglu S. Comparison of results and complications of high ligation surgery and microsurgical high inguinal varicocelectomy in the treatment of varicocele. Urology. 2000;55(5):750-4.
  • Tefekli A, Çayan S, Uluocak N, Poyanli A, Alp T, Kadioğlu A. Is selective internal spermatic venography necessary in detecting recurrent varicocele after surgical repair? Eur Urol. 2001;40(4):404-8.
  • Minhas S, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. European association of urology guidelines on male sexual and reproductive health: 2021 update on male infertility. Eur Urol. 2021;80(5):603-20.
  • Çayan S, Orhan İ, Altay B, Aşcı R, Akbay E, Ayas B, et al. Fertility outcomes and predictors for successful sperm retrieval and pregnancy in 327 azoospermic men with a history of cryptorchidism who underwent microdissection testicular sperm extraction. Andrology. 2021;9(1):253-9.
  • Çayan S, Hernandez A, Turek PJ. The pattern of semen quality recovery after three different types of vasectomy reversal procedures. Fertil Steril. 2000;74(3, Suppl 1):S238.
  • Kadioglu A, Cayan S, Tefekli A, Orhan I, Engin G, Turek PJ. Does response to treatment of ejaculatory duct obstruction in infertile men vary with pathology? Fertil Steril. 2001;76(1):138-42.
  • Efesoy O, Çayan S, Akbay E. The efficacy of recombinant human follicle-stimulating hormone in the treatment of various types of male factor infertility at a single university hospital. J Androl. 2009;30(6):679-84.
  • Saylam B, Efesoy O, Çayan S. The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men. Fertil Steril. 2011;95(2):809-11.
  • Çayan S, Lee D, Black LD, Reijo Pera RA, Turek PJ. Response to varicocelectomy in oligospermic men with and without defined genetic infertility. Urology. 2001;57(3):530-5.
  • Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, Lamb DJ, et al. Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I. Fertil Steril. 2021;115(1):54-61.
  • Giwercman A, Giwercman YL. Epidemiology of male reproductive disorders. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2013. 2000.
  • Velasquez M, Tanrikut C. Surgical management of male infertility: an update. Transl Androl Urol. 2014;3(1):64-76.
  • Penson DF, Paltiel AD, Krumholz HM, Palter S. The cost-effectiveness of treatment for varicocele related infertility. J Urol. 2002;168(6):2490-4.
  • Schlegel PN. Is assisted reproduction the optimal treatment for varicocele-associated male infertility? A cost-effectiveness analysis. Urology. 1997;49(1):83-90.
  • Orhan I, Onur R, Çayan S, Koksal IT, Kadioglu A. Seminal vesicle sperm aspiration in the diagnosis of ejaculatory duct obstruction. BJU Int. 1999;84(9):1050-3.
  • Çayan S, Lee D, Conaghan J, Givens CA, Ryan IP, Schriock ED, et al. A comparison of ICSI outcomes with fresh and cryopreserved epididymal spermatozoa from the same couples. Hum Reprod. 2001;16(3):495-9.
  • Kadioglu A, Tefekli A, Çayan S, Kandirali, E, Erdemir F, Tellaloglu S. Microsurgical inguinal varicocele repair in azoospermic men. Urology. 2001;57(2):328-33.
  • de Kretser DM. Male infertility. Lancet. 1997;349(9054):787-90.
  • Gupta R, Gupta A, Aggarwal N. Variations of gonadal veins: embryological prospective and clinical significance. J Clin Diagn Res. 2015;9(2):AC08-10.
  • Vanlangenhove P, Dhondt E, Maele GV, Van Waesberghe S, Delanghe E, Defreyne L. Internal spermatic vein insufficiency in varicoceles: a different entity in adults and adolescents. AJR Am J Roentgenol. 2015;205(3):667-75.
  • Najari BB; Katz MJ, Schulster ML, Lee DJ, Li PS, Goldstein M. Increased body mass index in men with varicocele is associated with larger spermatic vein diameters when supine. Urology. 2016;89:40-4.
  • Ficarra V, Cerruto MA, Liguori G, Mazzoni G, Minucci S, Tracia A, et al. Treatment of varicocele in subfertile men: The Cochrane Review--a contrary opinion. Eur Urol. 2006;49(2):258-63.
  • Marmar JL, Agarwal A, Prabakaran S, Agarwal R, Short RA, Benoff S, et al. Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis. Fertil Steril. 2007;88(3):639-48.
  • Cayan S, Kadioglu A, Orhan I, Kandirali E, Tefekli A, Tellaloglu S. The effect of microsurgical varicocelectomy on serum follicle stimulating hormone, testosterone and free testosterone levels in infertile men with varicocele. BJU Int. 1999;84(9):1046-9.
  • Çayan S, Akbay E. Fate of recurrent or persistent varicocele in the era of assisted reproduction technology: microsurgical subinguinal redo varicocelectomy versus observation. Urology. 2018;117:64-9.
  • Çayan S, Shavakhabov S, Kadioğlu A. Treatment of palpable varicocele in infertile men: A meta-analysis to define the best technique. J Androl. 2009;30(1):33-40.
  • Çayan S, Orhan İ, Akbay E, Kadıoğlu A. Systematic review of treatment methods for recurrent varicoceles to compare post-treatment sperm parameters, pregnancy and complication rates. Andrologia. 2019;51(11):e13419.
  • Jargiello T, Drelich-Zbroja A, Falkowski A, Sojka M, Pyra K, Szczerbo-Trojanowska M. Endovascular transcatheter embolization of recurrent postsurgical varicocele: anatomic reasons for surgical failure. Acta Radiol. 2015;56(1):63-9.
  • Halpern J, Mittal S, Pereira K, Bhatia S, Ramasamy R. Percutaneous embolization of varicocele: technique, indications, relative contraindications, and complications. Asian J Androl. 2016;18(2):234-8.
  • Goldstein M, Tanrikut C. Microsurgical management of male infertility. Nat Clin Pract Urol. 2006;3(7):381-91.
  • Lv KL, Zhuang JT, Zhao L, Wan Z, Zhang YD, Gao Y, et al. Varicocele anatomy during subinguinal microsurgical varicocelectomy in Chinese men. Andrologia. 2015;47(10):1190-5.
  • Kamal KM, Jarvi KJ, Zini A. Microsurgical varicocelectomy in the era of assisted reproductive technology: influence of initial semen quality on pregnancy rates. Fertil Steril. 2001;75(5):1013-6.
  • Agarwal A, Esteves SC. Varicocele and male infertility: current concepts and future perspectives. Asian J Androl. 2016;18(2):161-2.
  • Goluboff ET, Stifelman MD, Fisch H. Ejaculatory duct obstruction in the infertile male. Urology. 1995;45(6):925-31.
  • Lee R, Li PS, Schlegel PN, Goldstein M. Reassessing reconstruction in the management of obstructive azoospermia: reconstruction or sperm acquisition? Urol Clin North Am. 2008;35(2):289-301.
  • Lopes LS, Cury VN, Cha JD, Lampa Junior VM, Marques JL, Mizrahi FE, et al. Do assisted reproduction outcomes differ according to aetiology of obstructive azoospermia? Andrologia. 2020;52(1):e13425.
  • Berger RE. Triangulation end-to-side vasoepididymostomy. J Urol. 1998;159(6):1951-3.
  • Shiraishi K, Matsuyama H. Outcomes of partial intussusception and endo-to-side vasoepididymostomy in men with epididymal obstructive azoospermia. Int J Urol. 2020;27(12):1124-9.
  • Dubin JM, White J, Ory J, Ramasamy R. Vasectomy reversal vs. sperm retrieval with in vitro fertilization: a contemporary, comparative analysis. Fertil Steril. 2021;115(6):1377-83.
  • Darves-Bornoz A, Panken E, Brannigan RE, Halpern JA. Robotic surgery in male infertility. Urol Clin North Am. 2021;48(1):127-35.
  • Vahidi S, Horoki AZ, Talkhooncheh MH, Jambarsang S, Marvast LD, Sadeghi A, et al. Success rate and ART outcome of microsurgical sperm extraction in non obstructive azoospermia: A retrospective study. Int J Reprod Biomed. 2021;19(9):781-8.
  • Hanson BM, Kohn TP, Pastuszak AW, Scott RT Jr, Cheng PJ, Hotaling JM. Round spermatid injection into human oocytes: a systematic review and meta-analysis. Asian J Androl. 2021;23(4):363-9.
There are 45 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Invited Review
Authors

Selahittin Çayan 0000-0003-4784-2208

Publication Date October 30, 2022
Submission Date June 24, 2022
Published in Issue Year 2022 Volume: 24 Issue: Special Issue

Cite

APA Çayan, S. (2022). Surgical Treatment of Male Infertility. Duzce Medical Journal, 24(Special Issue), 30-35. https://doi.org/10.18678/dtfd.1186146
AMA Çayan S. Surgical Treatment of Male Infertility. Duzce Med J. October 2022;24(Special Issue):30-35. doi:10.18678/dtfd.1186146
Chicago Çayan, Selahittin. “Surgical Treatment of Male Infertility”. Duzce Medical Journal 24, no. Special Issue (October 2022): 30-35. https://doi.org/10.18678/dtfd.1186146.
EndNote Çayan S (October 1, 2022) Surgical Treatment of Male Infertility. Duzce Medical Journal 24 Special Issue 30–35.
IEEE S. Çayan, “Surgical Treatment of Male Infertility”, Duzce Med J, vol. 24, no. Special Issue, pp. 30–35, 2022, doi: 10.18678/dtfd.1186146.
ISNAD Çayan, Selahittin. “Surgical Treatment of Male Infertility”. Duzce Medical Journal 24/Special Issue (October 2022), 30-35. https://doi.org/10.18678/dtfd.1186146.
JAMA Çayan S. Surgical Treatment of Male Infertility. Duzce Med J. 2022;24:30–35.
MLA Çayan, Selahittin. “Surgical Treatment of Male Infertility”. Duzce Medical Journal, vol. 24, no. Special Issue, 2022, pp. 30-35, doi:10.18678/dtfd.1186146.
Vancouver Çayan S. Surgical Treatment of Male Infertility. Duzce Med J. 2022;24(Special Issue):30-5.
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