Research Article
Year 2018,
Volume: 1 Issue: 2, 32 - 36, 10.09.2018
Abstract
Amaç: Bu çalışmanın amacı, D vitamini eksikliği olan
kadınlarda, cinsel işlevleri araştırmaktır.
Gereç ve yöntemler: Vitamin D eksikliği saptanmış olan, 25-40 yaş aralığında
255 kadın, hasta grubu ve vitamin D seviyeleri normal aralıkta saptanan 255
kadın kontrol grubu olarak çalışmaya alındı. Her iki gruptaki katılımcılar
cinsel yönden aktifti ve herhangi bir iletişim bozukluğu ya da zekâ geriliği
yoktu. Seksüel fonksiyonlara etkisi olabilecek ürojinekolojik operasyon
geçirenler, gebe veya emziren kadınlar, seksüel olarak aktif olmayan kadınlar,
akut veya kronik hastalığı olanlar çalışma dışı bırakıldı. Beck Depresyon
Envanteri (BDE), Beck Anksiyete Envanteri (BAE) ve Kadın Seksüel Fonksiyon
İndeksi (KSFİ) skorları belirlendi. Vitamin D seviyeleri serum 25 - hidroksi-vitamin
D düzeyleri ölçülerek belirlendi.
Bulgular: Hasta ve kontrol gruplarında yaş ve vücut kitle indeksi
değerleri benzer idi (p> 0.05). D vitamini düzeyleri düşük kadınlarda BDE ve
BAE skorlarının daha yüksek olduğu bulundu (p <0.05). D vitamini eksikliği
bulunan kadınların toplam FSFI skorları kontrol grubuna göre anlamlı olarak
düşüktü (p <0.05). D vitamini eksikliği olan kadınların KSFI alt
gruplarından libido, uyarılma, lubrikasyon, orgazm, memnuniyet ve ağrı
skorlarının kontrol grubu ile karşılaştırıldığında düşük olduğu kaydedildi (p
<0.05).
Sonuç: D vitamini üzerine birçok çalışma olmasına rağmen, D
vitamini eksikliğinin cinsel fonksiyon üzerindeki etkilerini araştıran sadece
bir çalışma vardır. Cinsel işlev bozukluğu olan hastalar için D vitamini
düzeyleri tanı ve takip üzerine düşünülmeli ve ölçülmelidir.
Keywords
References
- 1.Piovezan RD, Hirotsu C, Feres MC, et al. Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency. PloS one2017;12:e0180901.
- 2. Yagiz AE, Ustun N, Paksoy H, et al. Association of Vitamin D with Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis Romatoid Artrit ve Ankilozan Spondilitte Vitamin D’nin Hastalık Aktivitesi ile İlişkisi. J Clin Anal Med2015;6:486-9.
- 3. Hightower JM, Dalessandri KM. Low 25-Hydroxyvitamin D and Myofascial Pain: Association of Cancer, Colon Polyps, and Tendon Rupture. 2017:1-7.
- 4.Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004;80:1678- 1688.
- 5.Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 2005;289:F8–F28.
- 6. Karahan AY, Hüner B, Kuran B, ve ark. Vitamin D düzeyi ile Özgül Olmayan Kas İskelet Sistemi Ağrıları Arasındaki İlişkinin Değerlendirilmesi: Çok merkezli retrospektif bir çalışma. Türk Osteoporoz dergisi 2017;23: 61-66.
- 7.Anderson PH, Lam NN, Turner AG, et al. The pleiotropic effects of vitamin D in bone. J Steroid Biochem Mol Biol 2013;136:190–194.
- 8.Lai YH, Fang TC. The pleiotropic effect of vitamin D. ISRN Nephrol 2013;2013:898125.
- 9.Ingraham BA, Bragdon B, Nohe A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin 2008;24:139–149.
- 10.Teegarden D, Donkin SS. Vitamin D: emerging new roles in insulin sensitivity. Nutr Res Rev 2009;22:82–92.
- 11.Guillot X, Semerano L, Saidenberg-Kermanach N, Falgarone G, Boissier MC. Vitamin D and inflammation. Joint Bone Spine 2010;77:552–557.
- 12.Haussler MR. Vitamin D receptors: nature and function. Annu Rev Nutr 1986;6:527–562.
- 13.Pilz S, Grübler M, Gaksch M, et al. Vitamin D and mortality. Anticancer Res 2016;36:1379–1387.
- 14.Kıdır V. Cardiovascular and metabolic effects of vitamin D. J Clin Exp Invest 2013;4:398-404 .
- 15.Yılmaz M, Yılmaz N. The role of vitamin D in the brain and related neurological diseases. J Clin Exp Invest 2013;4:411-415.
- 16.Zittermann A, Prokop S. The role of vitamin D for cardiovascular disease and overall mortality. Adv Exp Med Biol 2014;810:106–119.
- 17.Cutolo M, Pizzorni C, Sulli A. Vitamin D endocrine system involvement in autoimmune rheumatic diseases. Autoimmun Rev 2011;11:84–87.
- 18.Colonese F, Laganà AS, Colonese E, et al. The pleiotropic effects of vitamin D in gynecological and obstetric diseases: an overview on a hot topic. Biomed Res Int 2015;2015:986281.
- 19.Caretta N, de Kreutzenberg SV, Valente U, et al. Hypovitaminosis D is associated with erectile dysfunction in type 2 diabetes. Endocrine 2016 (January (12)) [Epub ahead of print].
- 20.Krysiak R, Gilowska M, Okopien B. Sexual function and depressive symptoms in young women with low vitamin D status: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2016; 204:108-112.
- 21.Wiegel M, Meston C, Rosen R. The Female Sexual Function Index (FSFI): cross- 277 validation and development of clinical cut-off scores. J Sex Marital Ther 2005;31:1–20.
- 22. E. Öksüz, S. Malhan, “Prevalence and risk factors for female sexual dysfunction in turkish women”, The Journal of Urology 175: 654-658, (2006).
- 23.Beck AT, Steer RA, Brown GK. BDI-II: Beck Depression Inventory manual. 2nd 278 ed. San Antonio: Psychological Corporation; 1996.
- 24.Hisli N. Beck Depresyon Envanteri'nin geçerliliği üzerine bir çalışma. Psikoloji Dergisi 1988;6:118-22.
- 25.Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: Psychometric properties. J Consult Clin Psychol 1998;56: 893-97.
- 26.Ulusoy M, Şahin NH, Erkmen H. Turkish version of the Beck Anxiety Inventory: Psychometric properties. J Cogn Psychother, 1998;12:163-172.
- 27.Berk M, Sanders KM, Pasco JA, et al. Vitamin D deficiency may play a role in depression. Med Hypotheses 2007;69:1316–9.
- 28.Bertone-Johnson ER. Vitamin D and the occurrence of depression: causal association or circumstantial evidence. Nutr Rev 2009;67:481–492.
- 29.Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1alpha-hydroxylase in human brain. J Chem Neuroanat 2005;29:21–30.
- 30.Barassi A, Pezzilli R, Colpi GM, Corsi Romanelli MM, Melzi d’Eril GV. Vitamin D and erectile dysfunction. J Sex Med 2014;11:2792–2800.
- 31.Pilz S, Verheyen N, Grübler MR, Tomaschitz A, März W. Vitamin D and 266 cardio vascular disease prevention. Nat Rev Cardiol 2016(May (6))
- 32.Zittermann A, Prokop S. The role of vitamin D for cardiovascular disease and 268 ov erall mortality. Adv Exp Med Biol 2014;810:106–119.
- 33.Martínez-Miguel P, Valdivielso JM, Medrano-Andrés D, et al. The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and 285 nitric oxide in cultured endothelial cells. Am J Physiol Endocrinol Metab 2014; 286 307 :E1085–96.
- 34.Andrukhova O, Slavic S, Zeitz U, et al. Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Mol Endocrinol 2014;28:53–56.
- 35.Molinari C, Uberti F, Grossini E, et al. 1a,25-Dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem 2011;27:661–668.
- 36.Davis SR, Wahlin-Jacobsen S. Testosterone in women—the clinical significance. Lancet Diabetes Endocrinol 2015;3:980–992.
- 37.Chang EM, Kim YS, Won HJ, Yoon TK, Lee WS. Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab 2014;99:2526–2532.
Year 2018,
Volume: 1 Issue: 2, 32 - 36, 10.09.2018
Abstract
References
- 1.Piovezan RD, Hirotsu C, Feres MC, et al. Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency. PloS one2017;12:e0180901.
- 2. Yagiz AE, Ustun N, Paksoy H, et al. Association of Vitamin D with Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis Romatoid Artrit ve Ankilozan Spondilitte Vitamin D’nin Hastalık Aktivitesi ile İlişkisi. J Clin Anal Med2015;6:486-9.
- 3. Hightower JM, Dalessandri KM. Low 25-Hydroxyvitamin D and Myofascial Pain: Association of Cancer, Colon Polyps, and Tendon Rupture. 2017:1-7.
- 4.Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004;80:1678- 1688.
- 5.Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 2005;289:F8–F28.
- 6. Karahan AY, Hüner B, Kuran B, ve ark. Vitamin D düzeyi ile Özgül Olmayan Kas İskelet Sistemi Ağrıları Arasındaki İlişkinin Değerlendirilmesi: Çok merkezli retrospektif bir çalışma. Türk Osteoporoz dergisi 2017;23: 61-66.
- 7.Anderson PH, Lam NN, Turner AG, et al. The pleiotropic effects of vitamin D in bone. J Steroid Biochem Mol Biol 2013;136:190–194.
- 8.Lai YH, Fang TC. The pleiotropic effect of vitamin D. ISRN Nephrol 2013;2013:898125.
- 9.Ingraham BA, Bragdon B, Nohe A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin 2008;24:139–149.
- 10.Teegarden D, Donkin SS. Vitamin D: emerging new roles in insulin sensitivity. Nutr Res Rev 2009;22:82–92.
- 11.Guillot X, Semerano L, Saidenberg-Kermanach N, Falgarone G, Boissier MC. Vitamin D and inflammation. Joint Bone Spine 2010;77:552–557.
- 12.Haussler MR. Vitamin D receptors: nature and function. Annu Rev Nutr 1986;6:527–562.
- 13.Pilz S, Grübler M, Gaksch M, et al. Vitamin D and mortality. Anticancer Res 2016;36:1379–1387.
- 14.Kıdır V. Cardiovascular and metabolic effects of vitamin D. J Clin Exp Invest 2013;4:398-404 .
- 15.Yılmaz M, Yılmaz N. The role of vitamin D in the brain and related neurological diseases. J Clin Exp Invest 2013;4:411-415.
- 16.Zittermann A, Prokop S. The role of vitamin D for cardiovascular disease and overall mortality. Adv Exp Med Biol 2014;810:106–119.
- 17.Cutolo M, Pizzorni C, Sulli A. Vitamin D endocrine system involvement in autoimmune rheumatic diseases. Autoimmun Rev 2011;11:84–87.
- 18.Colonese F, Laganà AS, Colonese E, et al. The pleiotropic effects of vitamin D in gynecological and obstetric diseases: an overview on a hot topic. Biomed Res Int 2015;2015:986281.
- 19.Caretta N, de Kreutzenberg SV, Valente U, et al. Hypovitaminosis D is associated with erectile dysfunction in type 2 diabetes. Endocrine 2016 (January (12)) [Epub ahead of print].
- 20.Krysiak R, Gilowska M, Okopien B. Sexual function and depressive symptoms in young women with low vitamin D status: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2016; 204:108-112.
- 21.Wiegel M, Meston C, Rosen R. The Female Sexual Function Index (FSFI): cross- 277 validation and development of clinical cut-off scores. J Sex Marital Ther 2005;31:1–20.
- 22. E. Öksüz, S. Malhan, “Prevalence and risk factors for female sexual dysfunction in turkish women”, The Journal of Urology 175: 654-658, (2006).
- 23.Beck AT, Steer RA, Brown GK. BDI-II: Beck Depression Inventory manual. 2nd 278 ed. San Antonio: Psychological Corporation; 1996.
- 24.Hisli N. Beck Depresyon Envanteri'nin geçerliliği üzerine bir çalışma. Psikoloji Dergisi 1988;6:118-22.
- 25.Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: Psychometric properties. J Consult Clin Psychol 1998;56: 893-97.
- 26.Ulusoy M, Şahin NH, Erkmen H. Turkish version of the Beck Anxiety Inventory: Psychometric properties. J Cogn Psychother, 1998;12:163-172.
- 27.Berk M, Sanders KM, Pasco JA, et al. Vitamin D deficiency may play a role in depression. Med Hypotheses 2007;69:1316–9.
- 28.Bertone-Johnson ER. Vitamin D and the occurrence of depression: causal association or circumstantial evidence. Nutr Rev 2009;67:481–492.
- 29.Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1alpha-hydroxylase in human brain. J Chem Neuroanat 2005;29:21–30.
- 30.Barassi A, Pezzilli R, Colpi GM, Corsi Romanelli MM, Melzi d’Eril GV. Vitamin D and erectile dysfunction. J Sex Med 2014;11:2792–2800.
- 31.Pilz S, Verheyen N, Grübler MR, Tomaschitz A, März W. Vitamin D and 266 cardio vascular disease prevention. Nat Rev Cardiol 2016(May (6))
- 32.Zittermann A, Prokop S. The role of vitamin D for cardiovascular disease and 268 ov erall mortality. Adv Exp Med Biol 2014;810:106–119.
- 33.Martínez-Miguel P, Valdivielso JM, Medrano-Andrés D, et al. The active form of vitamin D, calcitriol, induces a complex dual upregulation of endothelin and 285 nitric oxide in cultured endothelial cells. Am J Physiol Endocrinol Metab 2014; 286 307 :E1085–96.
- 34.Andrukhova O, Slavic S, Zeitz U, et al. Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice. Mol Endocrinol 2014;28:53–56.
- 35.Molinari C, Uberti F, Grossini E, et al. 1a,25-Dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem 2011;27:661–668.
- 36.Davis SR, Wahlin-Jacobsen S. Testosterone in women—the clinical significance. Lancet Diabetes Endocrinol 2015;3:980–992.
- 37.Chang EM, Kim YS, Won HJ, Yoon TK, Lee WS. Association between sex steroids, ovarian reserve, and vitamin D levels in healthy nonobese women. J Clin Endocrinol Metab 2014;99:2526–2532.
There are 37 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Original Investigation |
| Authors | |
| Publication Date | September 10, 2018 |
| Acceptance Date | October 2, 2018 |
| Published in Issue | Year 2018 Volume: 1 Issue: 2 |
