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Year 2021, Volume: 3 Issue: 1, 36 - 38, 15.04.2021

Mehmet Özgür Arslanoğlu Ebru Kaçmaz Gürkan Bozan Ener Cagri Dınleyıcı Burak Özkan Sabiha Sahin

Abstract

References

  • 1.Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol. 2002; 40(6): 789-801.
  • 2.Andersen GO, Ritland S. Life threatening intoxication with sodium valproate. J Toxicol Clin Toxicol. 1995; 33(3): 279-284.
  • 3.Nau H, Loscher W. Valproic acid and metabolites: pharmacological and toxicological studies. Epilepsia. 1984; 25 Suppl 1:S14-22.
  • 4.Lheureux PE, Penaloza A, Zahir S, Gris M. Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? Crit Care. 2005; 9(5): 431-40.
  • 5.Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol (Phila). 2009; 47(2): 101-11.
  • 6.Katiyar A, Aaron C. Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity. J Med Toxicol. 2007; 3(3): 129-38.
  • 7.Ingels M, Beauchamp J, Clark RF, Williams SR. Delayed valproic acid toxicity: a retrospective case series. Ann Emerg Med. 2002;39(6): 616-21
  • 8.Ghannoum M, Laliberté M, Nolin TD, MacTier R, Lavergne V, Hoffman RS, Gosselin S; EXTRIP Workgroup. Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015; 53(5): 454-65.
  • 9.Ishikura H, Matsuo N, Matsubara M, Ishihara T, Takeyama N, Tanaka T. Valproic acid overdose and L-carnitine therapy. J Anal Toxicol. 1996; 20(1): 55-8.

L-Carnitine treatment in a child with valproic acid intoxication

Year 2021, Volume: 3 Issue: 1, 36 - 38, 15.04.2021

Mehmet Özgür Arslanoğlu Ebru Kaçmaz Gürkan Bozan Ener Cagri Dınleyıcı Burak Özkan Sabiha Sahin

Abstract

With its growing application in neurological and psychiatric diseases, valproic acid overdose due to acute and chronic use has been causing emergency admission. Asymptomatic cases of hyperammonemia may be found in valproic acid poisoning ranging from central nervous system depression to coma. While supportive therapy is adequate, in most cases active charcoal, levocarnitine supplementation, and treatment with naloxane and hemodialysis, when needed, can also be used. In the case study reported in this paper, we aimed to focus at bringing awareness to the use of levocarnitine in asymptomatic patients with valproic acid poisoning accompanied by hyperammonemia.

Keywords

hyperammonemia intoxication L-carinitine valproik acid

References

  • 1.Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol. 2002; 40(6): 789-801.
  • 2.Andersen GO, Ritland S. Life threatening intoxication with sodium valproate. J Toxicol Clin Toxicol. 1995; 33(3): 279-284.
  • 3.Nau H, Loscher W. Valproic acid and metabolites: pharmacological and toxicological studies. Epilepsia. 1984; 25 Suppl 1:S14-22.
  • 4.Lheureux PE, Penaloza A, Zahir S, Gris M. Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? Crit Care. 2005; 9(5): 431-40.
  • 5.Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol (Phila). 2009; 47(2): 101-11.
  • 6.Katiyar A, Aaron C. Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity. J Med Toxicol. 2007; 3(3): 129-38.
  • 7.Ingels M, Beauchamp J, Clark RF, Williams SR. Delayed valproic acid toxicity: a retrospective case series. Ann Emerg Med. 2002;39(6): 616-21
  • 8.Ghannoum M, Laliberté M, Nolin TD, MacTier R, Lavergne V, Hoffman RS, Gosselin S; EXTRIP Workgroup. Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015; 53(5): 454-65.
  • 9.Ishikura H, Matsuo N, Matsubara M, Ishihara T, Takeyama N, Tanaka T. Valproic acid overdose and L-carnitine therapy. J Anal Toxicol. 1996; 20(1): 55-8.
There are 9 citations in total.

Details

Primary Language English
Subjects Intensive Care
Journal Section Case Reports
Authors

Mehmet Özgür Arslanoğlu 0000-0003-3798-0260

Ebru Kaçmaz This is me 0000-0002-7136-9441

Gürkan Bozan 0000-0001-5041-8892

Ener Cagri Dınleyıcı 0000-0002-0339-0134

Burak Özkan This is me 0000-0002-7738-9347

Sabiha Sahin 0000-0003-0759-4158

Publication Date April 15, 2021
Submission Date December 25, 2020
Acceptance Date January 4, 2021
Published in Issue Year 2021 Volume: 3 Issue: 1

Cite

APA Arslanoğlu, M. Ö., Kaçmaz, E., Bozan, G., Dınleyıcı, E. C., et al. (2021). L-Carnitine treatment in a child with valproic acid intoxication. Eurasian Journal of Critical Care, 3(1), 36-38.
AMA Arslanoğlu MÖ, Kaçmaz E, Bozan G, Dınleyıcı EC, Özkan B, Sahin S. L-Carnitine treatment in a child with valproic acid intoxication. Eurasian j Crit Care. April 2021;3(1):36-38.
Chicago Arslanoğlu, Mehmet Özgür, Ebru Kaçmaz, Gürkan Bozan, Ener Cagri Dınleyıcı, Burak Özkan, and Sabiha Sahin. “L-Carnitine Treatment in a Child With Valproic Acid Intoxication”. Eurasian Journal of Critical Care 3, no. 1 (April 2021): 36-38.
EndNote Arslanoğlu MÖ, Kaçmaz E, Bozan G, Dınleyıcı EC, Özkan B, Sahin S (April 1, 2021) L-Carnitine treatment in a child with valproic acid intoxication. Eurasian Journal of Critical Care 3 1 36–38.
IEEE M. Ö. Arslanoğlu, E. Kaçmaz, G. Bozan, E. C. Dınleyıcı, B. Özkan, and S. Sahin, “L-Carnitine treatment in a child with valproic acid intoxication”, Eurasian j Crit Care, vol. 3, no. 1, pp. 36–38, 2021.
ISNAD Arslanoğlu, Mehmet Özgür et al. “L-Carnitine Treatment in a Child With Valproic Acid Intoxication”. Eurasian Journal of Critical Care 3/1 (April 2021), 36-38.
JAMA Arslanoğlu MÖ, Kaçmaz E, Bozan G, Dınleyıcı EC, Özkan B, Sahin S. L-Carnitine treatment in a child with valproic acid intoxication. Eurasian j Crit Care. 2021;3:36–38.
MLA Arslanoğlu, Mehmet Özgür et al. “L-Carnitine Treatment in a Child With Valproic Acid Intoxication”. Eurasian Journal of Critical Care, vol. 3, no. 1, 2021, pp. 36-38.
Vancouver Arslanoğlu MÖ, Kaçmaz E, Bozan G, Dınleyıcı EC, Özkan B, Sahin S. L-Carnitine treatment in a child with valproic acid intoxication. Eurasian j Crit Care. 2021;3(1):36-8.
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