Year 2013,
Volume: 18 Issue: 3, 123 - 126, 02.02.2013
Abstract
BACKGROUND AND AIMS
Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the genus hepacivirus in the family Flaviviridae. HCV causes chronic infection in more than 80% of cases. It is resposible for more than 50% of liver transplantation among adults in developed countries. Approximately 200 million pepople are infected with HCV entire the world. Africa and many parts of Asia are the major endemic areas for HCV infection.
Although hepatitis C virus (HCV) is one of the most common cause of chronic liver disease in middle-east, its epidemiology remains unclear around the Lake Van region. We therefore assessed the prevalance of HCV infection in individuals who live in rural areas of eastern part of Turkey.
METHODS
We prospectively analysed 1062 ( 405 male, 657 female) patients who admitted to Gastroenterology clinic of Yuzuncuyil University Faculty of Medicine between January 2011-October 2011. Patients with prior HCV infection and with acute HCV infection were excluded. Presence of HCV infection was assessed by the routine ELISA method. All data was recorded on SPSS and was analysed by simple statistical methods.
RESULTS
The mean age was 46.1 ±17.9 years in males and was 42.5±17 years in females. 3 men and 6 women had anti-HCV antibody. Total Anti-HCV seropositivity was 0.8%.
DISCUSSION
Interestingly, HCV infection is not a serious health problem in eastern part of Turkey. It may be due to low prevalence of intravenous drug users and homosexuals as well as to strict traditional rules. Further analyses may require to establish this phenomenon particularly in eastern part of Turkey which is located on the main cross-road of the world narcotic trade.
Keywords
References
- Rosen HR. Clinical practice. Chronic hepatitis C infection. N Engl J Med 2011; 364:2429-2438. Armstrong GL, Wasley A, Simard EP, et al. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med 2006; 144:705-714.
- Wang CC, Krantz E, Klarquist J, et al. Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. J Infect Dis 2007; 196:1474-1482.
- Baldo V, Baldovin T, Trivello R, Floreani A. Epidemiology of HCV infection. Curr Pharm Des 2008; 14:1646-1654.
- Akcam FZ, Uskun E, Avsar K, Songur Y. Hepatitis B virus and hepatitis C virus seroprevalence in rural areas of the southwestern region of Turkey. Int J Infect Dis 2009; 13:274-284.
- Dursun M, Ozekinci T, Ertem M, et al. Prevalence of Hepatitis C in adults in the south-eastern region of Anatolia: a community-based study. Hepatol Res 2004; 29:75-80.
- Yildirim B, Barut S, Bulut Y, et al. Seroprevalence of hepatitis B and C viruses in the province of Tokat in the Black Sea region of Turkey: A population-based study. Turk J Gastroenterol 2009; 20:27-30.
- Maher L, Li J, Jalaludin B, et al. Impact of a reduction in heroin availability on patterns of drug use, risk behaviour and incidence of hepatitis C virus infection in injecting drug users in New South Wales, Australia. Drug Alcohol Depend 2007; 89:244-250.
- Burt RD, Hagan H, Garfein RS, et al. J Trends in hepatitis B virus, hepatitis C virus, and human immunodeficiency virus prevalence, risk behaviors, and preventive measures among Seattle injection drug users aged 18-30 years, 1994-2004. Urban Health 2007; 84:436-454.
- Negro F, Alberti A. The global health burden of hepatitis C virus infection. Liver Int 2011; 31:1-3.
- Porto-Espinoza L, Cuadra-Sanchez C, Moronta R, Monsalve-Castillo F, Callejas-Valero D. Immune evasion mechanisms of hepatitis C virus. Invest Clin 2006; 47:71-82.
- Cooper C. Hepatitis C Treatment Highlights from AASLD 2011. Clin Infect Dis. 2012; Apr 4. [Epub ahead of print]
- Muhlberger N, Schwarzer R, Lettmeier B, et al. HCVrelated burden of disease in Europe: a systematic assessment of incidence, prevalence, morbidity, and mortality. BMC Public Health 2009; 9:34.
- Krekulova L, Rehak V, Strunecky O, Nemecek V. Current situation and trends in the hepatitis C virus genotype distribution among injecting drug users in the Czech Republic. Epidemiol Mikrobiol Imunol 2009; 58:84-89.
Year 2013,
Volume: 18 Issue: 3, 123 - 126, 02.02.2013
Abstract
References
- Rosen HR. Clinical practice. Chronic hepatitis C infection. N Engl J Med 2011; 364:2429-2438. Armstrong GL, Wasley A, Simard EP, et al. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med 2006; 144:705-714.
- Wang CC, Krantz E, Klarquist J, et al. Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. J Infect Dis 2007; 196:1474-1482.
- Baldo V, Baldovin T, Trivello R, Floreani A. Epidemiology of HCV infection. Curr Pharm Des 2008; 14:1646-1654.
- Akcam FZ, Uskun E, Avsar K, Songur Y. Hepatitis B virus and hepatitis C virus seroprevalence in rural areas of the southwestern region of Turkey. Int J Infect Dis 2009; 13:274-284.
- Dursun M, Ozekinci T, Ertem M, et al. Prevalence of Hepatitis C in adults in the south-eastern region of Anatolia: a community-based study. Hepatol Res 2004; 29:75-80.
- Yildirim B, Barut S, Bulut Y, et al. Seroprevalence of hepatitis B and C viruses in the province of Tokat in the Black Sea region of Turkey: A population-based study. Turk J Gastroenterol 2009; 20:27-30.
- Maher L, Li J, Jalaludin B, et al. Impact of a reduction in heroin availability on patterns of drug use, risk behaviour and incidence of hepatitis C virus infection in injecting drug users in New South Wales, Australia. Drug Alcohol Depend 2007; 89:244-250.
- Burt RD, Hagan H, Garfein RS, et al. J Trends in hepatitis B virus, hepatitis C virus, and human immunodeficiency virus prevalence, risk behaviors, and preventive measures among Seattle injection drug users aged 18-30 years, 1994-2004. Urban Health 2007; 84:436-454.
- Negro F, Alberti A. The global health burden of hepatitis C virus infection. Liver Int 2011; 31:1-3.
- Porto-Espinoza L, Cuadra-Sanchez C, Moronta R, Monsalve-Castillo F, Callejas-Valero D. Immune evasion mechanisms of hepatitis C virus. Invest Clin 2006; 47:71-82.
- Cooper C. Hepatitis C Treatment Highlights from AASLD 2011. Clin Infect Dis. 2012; Apr 4. [Epub ahead of print]
- Muhlberger N, Schwarzer R, Lettmeier B, et al. HCVrelated burden of disease in Europe: a systematic assessment of incidence, prevalence, morbidity, and mortality. BMC Public Health 2009; 9:34.
- Krekulova L, Rehak V, Strunecky O, Nemecek V. Current situation and trends in the hepatitis C virus genotype distribution among injecting drug users in the Czech Republic. Epidemiol Mikrobiol Imunol 2009; 58:84-89.
There are 13 citations in total.
Details
| Primary Language | English |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | February 2, 2013 |
| Published in Issue | Year 2013 Volume: 18 Issue: 3 |