Abstract
BACKGROUND:
Hypoxemia related conditions is associated with an increased risk of gastric damage. Helicobacter pylori (H.pylori) infection also causes gastric damage and affects approximately 40 million individuals in Turkey. Obstructive sleep apnea syndrome (OSAS) is a sleep disorder and is characterized by episodic upper airway obstruction during sleep. It is associated with oxyhemoglobin desaturations, hypoxemia and discontinuation of sleep. However, there are a few data in the field of H.pylori prevalence among patients with OSAS which is linked to tissue hypoxemia. The aim of the current study was to investigate the link between H.pylori infection and OSAS.
METHODS:
Between February 2011 and February 2012, faeces was collected from OSAS patients ( n=24; 12 female) and healthy individuals (n=100, 50 female) and analysed using the Helicobacter pylori Stool Antigen Test. OSAS was detected with polysomnography in connection with disease symptoms and findings. All data was recorded on SPSS and analysed with chi-square test.
RESULTS:
Among 24 patients with OSAS, 12 (50%) of them had a positive result for H.pylori fecal test. In control group (100 subjects), H.pylori fecoprevalance was only 15%. H.pylori antibody seropositivity was significantly higher in patients with OSAS compared to control patients (p<0.001). Consistent with recent epidemiologic studies to date, seroprevalence of H.pylori was found higher than normal subjects.
CONCLUSIONS:
Seroprevalance of H.pylori detected with fecal test were significantly higher in patients with OSAS. OSAS is related to presence of H.pylori. A positive correlation between the H.pylori infection and OSAS might be hypothesized. This may be due to gastric damage due to OSAS-related hypoxemia.
Keywords: OSAS, H.pylori, Stool Antigen Test.
Keywords
References
- Silva JM, Villares CA, Monteiro Mdo S, et al. Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection. Rev Inst Med Trop Sao Paulo 2010; 52: 125-128.
- Goodwin CS, Mendall MM, Northfield TC. Helicobacter pylori infection. Lancet 1997; 349: 2652
- Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993; 328: 1230-1235.
- Ferretti A, Giampiccolo P, Cavalli A, et al, Expiratory flow limitation and orthopnea in massively obese subjects. Chest 2001; 119: 1401-1408.
- Newman AB, Foster G, Givelber R, et al. Progression and regression of sleep-disordered breathing with changes in weight: The Sleep Heart Health Study. Arch Intern Med 2005; 165: 2408-2413.
- Vgontzas AN, Papanicolaou DA, Bixler EO, et al. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: Role of sleep disturbance and obesity. J Clin Endocrinol Metab 1997; 82: 1313-1316.
- Wessendorf TE, Thilman AF, Wang YM, et al. Fibrinogen levels and obstructive sleep apnea in ischemic stroke. Am J Respir Crit Care Med 2000; 162: 2039-2042.
- Geiser T, Buck F, Meyer BJ, et al. In vivo platelet activation is increased during sleep in patients with obstructive sleep apnea syndrome. Respiration 2002; 69: 229-234.
- Sanner BM, Konermann M, Tepel M, et al. Platelet function in patients with obstructive sleep apnoea syndrome. Eur Respir J 2000; 16: 648-652.
- Guardiola JJ, Matheson PJ, Clavijo LC, et al. Hypercoagulability in patients with obstructive sleep apnea. Sleep Med 2001; 2: 517-523.
- Parra O. Sleep-disordered breathing and stroke: Is there a rationale for treatment? Eur Respir J 2001; 18: 619-6
- Kamada T, Sato N, Kawano S, et al. Gastric mucosal hemodynamics after thermal or head injury. A clinical application of reflactance spectrofotometry. Gastroenterology 1982; 83: 535-40.
- Sato N, Kawano S, Kamada T, et al. Hemodynamics of the gastric mucosa and gastric ulcer. Dig. Dis Sci 1986; 31: 35-41.
- Arias MA, Garcia F, Fernandez AA, et al. Obstructive Sleep Apnea Syndrome Affects Left Ventricular Diastolic Function. Eur Respir J 2002; 20: 1239-1245.
- Nieto FJ, Young TB, Lind Bk, et al. Association of sleep disordered breathing, sleep apnea, and hypertension in alarge community-based study. Sleep Heart Health Study. JAMA 2000; 283: 1829-1836.
- Talwar V, de Caestecker JS. What is the relationship between gastro-oesophageal reflux and obstructive sleep apnea? Dig Liver Dis 2006; 38: 82-84.
- Unal M, Oztürk L, Oztürk C, et al. The seroprevalence of Helicobacter pylori infection in patients with obstructive sleep apnoea: a preliminary study. Clin Otolaryngol Allied Sci 2003; 28: 100-102.
- Ye XW, Xiao J, Qiu T, et al. Helicobacter pylori seroprevalence in patients with obstructive sleep apnea syndrome among a Chinese population. Saudi Med J 2009; 30: 693-697.
Abstract
References
- Silva JM, Villares CA, Monteiro Mdo S, et al. Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection. Rev Inst Med Trop Sao Paulo 2010; 52: 125-128.
- Goodwin CS, Mendall MM, Northfield TC. Helicobacter pylori infection. Lancet 1997; 349: 2652
- Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993; 328: 1230-1235.
- Ferretti A, Giampiccolo P, Cavalli A, et al, Expiratory flow limitation and orthopnea in massively obese subjects. Chest 2001; 119: 1401-1408.
- Newman AB, Foster G, Givelber R, et al. Progression and regression of sleep-disordered breathing with changes in weight: The Sleep Heart Health Study. Arch Intern Med 2005; 165: 2408-2413.
- Vgontzas AN, Papanicolaou DA, Bixler EO, et al. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: Role of sleep disturbance and obesity. J Clin Endocrinol Metab 1997; 82: 1313-1316.
- Wessendorf TE, Thilman AF, Wang YM, et al. Fibrinogen levels and obstructive sleep apnea in ischemic stroke. Am J Respir Crit Care Med 2000; 162: 2039-2042.
- Geiser T, Buck F, Meyer BJ, et al. In vivo platelet activation is increased during sleep in patients with obstructive sleep apnea syndrome. Respiration 2002; 69: 229-234.
- Sanner BM, Konermann M, Tepel M, et al. Platelet function in patients with obstructive sleep apnoea syndrome. Eur Respir J 2000; 16: 648-652.
- Guardiola JJ, Matheson PJ, Clavijo LC, et al. Hypercoagulability in patients with obstructive sleep apnea. Sleep Med 2001; 2: 517-523.
- Parra O. Sleep-disordered breathing and stroke: Is there a rationale for treatment? Eur Respir J 2001; 18: 619-6
- Kamada T, Sato N, Kawano S, et al. Gastric mucosal hemodynamics after thermal or head injury. A clinical application of reflactance spectrofotometry. Gastroenterology 1982; 83: 535-40.
- Sato N, Kawano S, Kamada T, et al. Hemodynamics of the gastric mucosa and gastric ulcer. Dig. Dis Sci 1986; 31: 35-41.
- Arias MA, Garcia F, Fernandez AA, et al. Obstructive Sleep Apnea Syndrome Affects Left Ventricular Diastolic Function. Eur Respir J 2002; 20: 1239-1245.
- Nieto FJ, Young TB, Lind Bk, et al. Association of sleep disordered breathing, sleep apnea, and hypertension in alarge community-based study. Sleep Heart Health Study. JAMA 2000; 283: 1829-1836.
- Talwar V, de Caestecker JS. What is the relationship between gastro-oesophageal reflux and obstructive sleep apnea? Dig Liver Dis 2006; 38: 82-84.
- Unal M, Oztürk L, Oztürk C, et al. The seroprevalence of Helicobacter pylori infection in patients with obstructive sleep apnoea: a preliminary study. Clin Otolaryngol Allied Sci 2003; 28: 100-102.
- Ye XW, Xiao J, Qiu T, et al. Helicobacter pylori seroprevalence in patients with obstructive sleep apnea syndrome among a Chinese population. Saudi Med J 2009; 30: 693-697.
Details
| Primary Language | English |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | April 29, 2014 |
| Published in Issue | Year 2014 Volume: 19 Issue: 1 |