BibTex RIS Cite

“The Relationship of Mean Platelet Volume with Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’

Year 2014, Volume: 19 Issue: 1, 28 - 32, 29.04.2014

Nilgün Güdücü Salih Kutay Güliz Sidar Uzay Görmüş Zehra Kavak İlkkan Dünder

Abstract

ABSTRACT

Aims: Evaluation of the relationship among mean platelet volume (MPV) and endogenous sex hormones and cardiovascular (CV) risk parameters

Methods: We designed a retrospective study in postmenopausal women. Patient charts were reviewed for the results of mean platelet volume, hormonal and biochemical parameters.

Results: MPV correlated only with white blood cell and platelet counts(r = -0.270, p = 0.023) and platelet count (r = -0.558, p = 0.001). There was no statistically significant difference in MPV of patients with and without metabolic syndrome.

Conclusion: There was no relationship between MPV and endogenous sex hormones and parameters indicating higher CV risk.

Keywords

Endogenous sex hormones postmenopausal women mean platelet volume cardiovascular disease

References

  • Stampfer MJ, Willett WC, Colditz GA, et al. A prospective study of postmenopausal estrogen therapy and coronary artery disease. N Engl J Med 1985; 313: 1044-1049.
  • Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002; 288: 321-333.
  • Thaulow E, Erikssen J, Sandvik L, Stormorken H, Cohn PF. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation 1991; 84: 6136
  • Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and metaanalysis. J Thromb Haemost 2010; 8: 148-156.
  • Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983; 32: 443-460.
  • Khetwat G, Farday N, Nealen MI, et al. Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression. Blood 2000; 95: 2289-2296.
  • Nagata Y, Yoshikawa J, Hashimoto A, et al. Proplatelet formation of megakaryocytes is triggered by autocrine estradiol. Genes Dev 2003; 17: 286428
  • Goodrow GJ, L’Hommedieu GD, Gannon B, Sites CK. Predictors of worsening insulin sensitivity in postmenopausal women. Am J Obstet Gynecol 2006; 194: 355-361.
  • Ranganath LR, Christofides J, Semple MJ. Increased mean platelet volume after oestrogen replacement therapy. Ann Clin Biochem 1996; 33: 555-560.
  • Thijs A, van Baal WM, van der Mooren MJ, et al. Effects of hormone replacement therapy on blood platelets. Eur J Clin Invest 2002; 32: 613-618.
  • Libby P. Molecular bases of the acute coronary syndromes. Circulation 1996; 91: 2844-2850.
  • Wu KK, Thiagarajan P. Role of endothelium in thrombosis and hemostasis. Annu Rev Med 1996; 47: 315-3
  • Santimone I, Di Castelnuovo A, De Curtis A, et al. White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLISANI project Haematologica 2011; 96: 1180-1188.
  • Suzuki S, Matsuno K, Kondoh M. Primary hemostasis during women's life cycle measured by Thrombostat 4000. Semin Thromb Hemost 1995; 21: 103Rank A, Nieuwland R, Nikolajek K, et al. Hormone replacement therapy leads to increased plasma levels of platelet derived microparticles in postmenopausal women Arch Gynecol Obstet 2012; 285: 1035-1041.
  • Karagöz B, Bilgi O, Alacacıoğlu A, et al. Mean platelet volume increase after tamoxifen, but not after anastrazole in adjuvant therapy of breast cancer. Med Oncol 2009; 27:199-192.
  • Teede HJ, McGrath BP, Turner A, Majewski H. Effects of oral combined hormone replacement therapy on platelet aggregation in postmenopausal women. Clin Sci (Lond) 2001; 100: 207-213.
  • Poller L. Oral contraceptives, blood clotting and thrombosis. Br Med Bull 1978; 34: 151-156.
  • Johnson M, Ramey E, Ramwell PW. Sex and age differences in human platelet aggregation. Nature 1975; 253: 253-355.
  • Wattel E, Cambier N, Caulier MT, et al. Androgen therapy in myelodysplastic syndromes with thrombocytopenia: a report on 20 cases. Br J Haematol 1994; 87: 205.
  • Sullivan PS, Jackson CW, McDonald TP. Castration decreases thrombocytopoiesis and testosterone restores platelet production in castrated BALB/c mice: evidence that testosterone acts on a bipotential hematopoietic precursor cell. J Lab Clin Med 1995; 125: 326-333.
  • Kebapcilar L, Taner CE, Kebapcilar AG, Sari I. High mean platelet volume, low-grade systemic coagulation and fibrinolytic activation are associated with androgen and insulin levels in polycystic ovary syndrome. Arch Gynecol Obstet 2009; 280: 187-193.
  • Martina V, Benso A, Gigliardi VR, et al. Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects. Clin Endocrinol (Oxf) 2006; 64: 260-264.
  • Li S, Li X, Li J, et al. Experimental arterial thrombosis regulated by androgen and its receptor via modulation of platelet activation. Thromb Res 2007; 121: 127-134.
  • Munoz YC, Gomez GI, Moreno M, et al. Dehydroepiandrosterone prevents the aggregation of platelets obtained from postmenopausal women with type 2 diabetes mellitus through the activation of the PKC/eNOS/NO pathway. Horm Metab Res 2012; 44: 625-6

Year 2014, Volume: 19 Issue: 1, 28 - 32, 29.04.2014

Nilgün Güdücü Salih Kutay Güliz Sidar Uzay Görmüş Zehra Kavak İlkkan Dünder

Abstract

References

  • Stampfer MJ, Willett WC, Colditz GA, et al. A prospective study of postmenopausal estrogen therapy and coronary artery disease. N Engl J Med 1985; 313: 1044-1049.
  • Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002; 288: 321-333.
  • Thaulow E, Erikssen J, Sandvik L, Stormorken H, Cohn PF. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation 1991; 84: 6136
  • Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and metaanalysis. J Thromb Haemost 2010; 8: 148-156.
  • Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983; 32: 443-460.
  • Khetwat G, Farday N, Nealen MI, et al. Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression. Blood 2000; 95: 2289-2296.
  • Nagata Y, Yoshikawa J, Hashimoto A, et al. Proplatelet formation of megakaryocytes is triggered by autocrine estradiol. Genes Dev 2003; 17: 286428
  • Goodrow GJ, L’Hommedieu GD, Gannon B, Sites CK. Predictors of worsening insulin sensitivity in postmenopausal women. Am J Obstet Gynecol 2006; 194: 355-361.
  • Ranganath LR, Christofides J, Semple MJ. Increased mean platelet volume after oestrogen replacement therapy. Ann Clin Biochem 1996; 33: 555-560.
  • Thijs A, van Baal WM, van der Mooren MJ, et al. Effects of hormone replacement therapy on blood platelets. Eur J Clin Invest 2002; 32: 613-618.
  • Libby P. Molecular bases of the acute coronary syndromes. Circulation 1996; 91: 2844-2850.
  • Wu KK, Thiagarajan P. Role of endothelium in thrombosis and hemostasis. Annu Rev Med 1996; 47: 315-3
  • Santimone I, Di Castelnuovo A, De Curtis A, et al. White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLISANI project Haematologica 2011; 96: 1180-1188.
  • Suzuki S, Matsuno K, Kondoh M. Primary hemostasis during women's life cycle measured by Thrombostat 4000. Semin Thromb Hemost 1995; 21: 103Rank A, Nieuwland R, Nikolajek K, et al. Hormone replacement therapy leads to increased plasma levels of platelet derived microparticles in postmenopausal women Arch Gynecol Obstet 2012; 285: 1035-1041.
  • Karagöz B, Bilgi O, Alacacıoğlu A, et al. Mean platelet volume increase after tamoxifen, but not after anastrazole in adjuvant therapy of breast cancer. Med Oncol 2009; 27:199-192.
  • Teede HJ, McGrath BP, Turner A, Majewski H. Effects of oral combined hormone replacement therapy on platelet aggregation in postmenopausal women. Clin Sci (Lond) 2001; 100: 207-213.
  • Poller L. Oral contraceptives, blood clotting and thrombosis. Br Med Bull 1978; 34: 151-156.
  • Johnson M, Ramey E, Ramwell PW. Sex and age differences in human platelet aggregation. Nature 1975; 253: 253-355.
  • Wattel E, Cambier N, Caulier MT, et al. Androgen therapy in myelodysplastic syndromes with thrombocytopenia: a report on 20 cases. Br J Haematol 1994; 87: 205.
  • Sullivan PS, Jackson CW, McDonald TP. Castration decreases thrombocytopoiesis and testosterone restores platelet production in castrated BALB/c mice: evidence that testosterone acts on a bipotential hematopoietic precursor cell. J Lab Clin Med 1995; 125: 326-333.
  • Kebapcilar L, Taner CE, Kebapcilar AG, Sari I. High mean platelet volume, low-grade systemic coagulation and fibrinolytic activation are associated with androgen and insulin levels in polycystic ovary syndrome. Arch Gynecol Obstet 2009; 280: 187-193.
  • Martina V, Benso A, Gigliardi VR, et al. Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects. Clin Endocrinol (Oxf) 2006; 64: 260-264.
  • Li S, Li X, Li J, et al. Experimental arterial thrombosis regulated by androgen and its receptor via modulation of platelet activation. Thromb Res 2007; 121: 127-134.
  • Munoz YC, Gomez GI, Moreno M, et al. Dehydroepiandrosterone prevents the aggregation of platelets obtained from postmenopausal women with type 2 diabetes mellitus through the activation of the PKC/eNOS/NO pathway. Horm Metab Res 2012; 44: 625-6
There are 24 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Nilgün Güdücü

Salih Kutay This is me

Güliz Sidar This is me

Uzay Görmüş This is me

Zehra Kavak This is me

İlkkan Dünder This is me

Publication Date April 29, 2014
Published in Issue Year 2014 Volume: 19 Issue: 1

Cite

APA Güdücü, N., Kutay, S., Sidar, G., Görmüş, U., et al. (2014). “The Relationship of Mean Platelet Volume with Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’. EASTERN JOURNAL OF MEDICINE, 19(1), 28-32.
AMA Güdücü N, Kutay S, Sidar G, Görmüş U, Kavak Z, Dünder İ. “The Relationship of Mean Platelet Volume with Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’. EASTERN JOURNAL OF MEDICINE. April 2014;19(1):28-32.
Chicago Güdücü, Nilgün, Salih Kutay, Güliz Sidar, Uzay Görmüş, Zehra Kavak, and İlkkan Dünder. ““The Relationship of Mean Platelet Volume With Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’”. EASTERN JOURNAL OF MEDICINE 19, no. 1 (April 2014): 28-32.
EndNote Güdücü N, Kutay S, Sidar G, Görmüş U, Kavak Z, Dünder İ (April 1, 2014) “The Relationship of Mean Platelet Volume with Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’. EASTERN JOURNAL OF MEDICINE 19 1 28–32.
IEEE N. Güdücü, S. Kutay, G. Sidar, U. Görmüş, Z. Kavak, and İ. Dünder, ““The Relationship of Mean Platelet Volume with Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’”, EASTERN JOURNAL OF MEDICINE, vol. 19, no. 1, pp. 28–32, 2014.
ISNAD Güdücü, Nilgün et al. ““The Relationship of Mean Platelet Volume With Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’”. EASTERN JOURNAL OF MEDICINE 19/1 (April 2014), 28-32.
JAMA Güdücü N, Kutay S, Sidar G, Görmüş U, Kavak Z, Dünder İ. “The Relationship of Mean Platelet Volume with Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’. EASTERN JOURNAL OF MEDICINE. 2014;19:28–32.
MLA Güdücü, Nilgün et al. ““The Relationship of Mean Platelet Volume With Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’”. EASTERN JOURNAL OF MEDICINE, vol. 19, no. 1, 2014, pp. 28-32.
Vancouver Güdücü N, Kutay S, Sidar G, Görmüş U, Kavak Z, Dünder İ. “The Relationship of Mean Platelet Volume with Endogenous Sex Hormones and Cardiovascular Risk Parameters In Postmenopausal Women ‘’. EASTERN JOURNAL OF MEDICINE. 2014;19(1):28-32.