The effect of antibiotherapy used against the PSA increase in serum PSA levels

Ayhan Karaköse; Mehmet Yüksel; Necip Pirinççi; Sacit Görgel; Yusuf Ateşçi; Bilal Gümüş

The effect of antibiotherapy used against the PSA increase in serum PSA levels

Year 2015, Volume: 20 Issue: 1, 30 - 33, 02.06.2015

Ayhan Karaköse Mehmet Yüksel Necip Pirinççi Sacit Görgel Yusuf Ateşçi Bilal Gümüş

Abstract

Aim.To evaluatethe effect of antibiotics in patients with PSA value high than 4 ng / ml ontPSA, fPSA and fPSA / tPSA ratio.Methods.A total of96 patients included the study withdetected high level than 4 ng / ml serum PSA. Patients were divided into 2groups according to the high level of PSA value. Group 1 included 49 patients with PSA level between 4-10ng/ml. Group 2 included 47 patients with PSA level high than 10 ng/ml. Patientswere treated with Ciprofloxacin (500mgb.i.d.) orally for 2 weeks. All patients' PSA levels were evaluated and analyzed before and afterantibiotic treatment. Statistical analyses were performed with SPSS version 18.A p value <0.05 was considered significant.Results.The meanage was 61.6 ±5.7 (51-75) years in group 1 and 63.1 ±8.7 (55-74) years in group2. Suspicious DRE findings were significantly high in group 2. The mean tPSA values were6.82±0.42 and 5.93±0.36 before and after antibiotic treatment in group 1respectively. There was no significant differences tPSA value before and afterantibiotic treatment in group 1. Themean tPSA values were 32.53±8.23 and 11.72±5.61 before and after antibiotictreatment in group 2 respectively. The mean tPSA value decreased significantlyafter antibiotic treatment in group 2. Prostate cancer was detected in 32 patients after TRUS guided prostatebiopsy. Prostate cancer was identifiedin 13 patients in gruop 1 and 19 patients in group 2. Conclusıons.Antibiotic treatment in patients with PSA levels high than 10 ng/ml iseffective on prostate biopsy decision and antibiotic treatment can preventunnecessary prostate biopsies.

Keywords

Prostate, cancer, PSA, biopsy

References

Bulbul MA, Wassan W, Hijaz A, et al. The effect of
antibiotics on elevated serum prostate-specific antigen
in patients with urinary symptoms and negative digital
rectal examination: a pilot study. J Med Liban 2002; 50: 23-25. 9.
Tan YH, Tan KY, Foo KT. The role of a trial of
antibiotics in asymptomatic patients with elevated
prostate-specifi c antigen – an Asian perspective. BJU Int 2000; 86: 104.
Erol H, Beder N, Calişkan T, et al. Can the effect of antibiotherapy and anti-inflammatory therapy on serum PSA levels discriminate between benign and malign prostatic pathologies? Urol Int 2006; 76: 20- 26.
Dai B, Ye DW, Kong YY, et al. Individualized prostate biopsy strategy for Chinese patients with different prostate-specific antigen levels. Asian J Androl 2008; 10: 325-331.
Raaijmakers R, Wildhagen MF, Ito K, et al. Prostate- specific antigen change in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam. Urology 2004; 63: 316-320.
Kaygisiz O, Ugurlu O, Kosan M, et al. Effects of antibacterial therapy on PSA change in the presence and absence of prostatic inflammation in patients with PSA levels between 4 and 10 ng/mL. Prostate Cancer Prostatic Dis 2006; 9: 235-238.

Year 2015, Volume: 20 Issue: 1, 30 - 33, 02.06.2015

Ayhan Karaköse Mehmet Yüksel Necip Pirinççi Sacit Görgel Yusuf Ateşçi Bilal Gümüş

Abstract

References

Bulbul MA, Wassan W, Hijaz A, et al. The effect of
antibiotics on elevated serum prostate-specific antigen
in patients with urinary symptoms and negative digital
rectal examination: a pilot study. J Med Liban 2002; 50: 23-25. 9.
Tan YH, Tan KY, Foo KT. The role of a trial of
antibiotics in asymptomatic patients with elevated
prostate-specifi c antigen – an Asian perspective. BJU Int 2000; 86: 104.
Erol H, Beder N, Calişkan T, et al. Can the effect of antibiotherapy and anti-inflammatory therapy on serum PSA levels discriminate between benign and malign prostatic pathologies? Urol Int 2006; 76: 20- 26.
Dai B, Ye DW, Kong YY, et al. Individualized prostate biopsy strategy for Chinese patients with different prostate-specific antigen levels. Asian J Androl 2008; 10: 325-331.
Raaijmakers R, Wildhagen MF, Ito K, et al. Prostate- specific antigen change in the European Randomized Study of Screening for Prostate Cancer, section Rotterdam. Urology 2004; 63: 316-320.
Kaygisiz O, Ugurlu O, Kosan M, et al. Effects of antibacterial therapy on PSA change in the presence and absence of prostatic inflammation in patients with PSA levels between 4 and 10 ng/mL. Prostate Cancer Prostatic Dis 2006; 9: 235-238.

There are 11 citations in total.

Details

Primary Language	English
Journal Section	Articles
Authors	Ayhan Karaköse Mehmet Yüksel Necip Pirinççi Sacit Görgel This is me Yusuf Ateşçi This is me Bilal Gümüş
Publication Date	June 2, 2015
Published in Issue	Year 2015 Volume: 20 Issue: 1

Cite

APA	Karaköse, A., Yüksel, M., Pirinççi, N., Görgel, S., et al. (2015). The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE, 20(1), 30-33.
AMA	Karaköse A, Yüksel M, Pirinççi N, Görgel S, Ateşçi Y, Gümüş B. The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE. June 2015;20(1):30-33.
Chicago	Karaköse, Ayhan, Mehmet Yüksel, Necip Pirinççi, Sacit Görgel, Yusuf Ateşçi, and Bilal Gümüş. “The Effect of Antibiotherapy Used Against the PSA Increase in Serum PSA Levels”. EASTERN JOURNAL OF MEDICINE 20, no. 1 (June 2015): 30-33.
EndNote	Karaköse A, Yüksel M, Pirinççi N, Görgel S, Ateşçi Y, Gümüş B (June 1, 2015) The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE 20 1 30–33.
IEEE	A. Karaköse, M. Yüksel, N. Pirinççi, S. Görgel, Y. Ateşçi, and B. Gümüş, “The effect of antibiotherapy used against the PSA increase in serum PSA levels”, EASTERN JOURNAL OF MEDICINE, vol. 20, no. 1, pp. 30–33, 2015.
ISNAD	Karaköse, Ayhan et al. “The Effect of Antibiotherapy Used Against the PSA Increase in Serum PSA Levels”. EASTERN JOURNAL OF MEDICINE 20/1 (June 2015), 30-33.
JAMA	Karaköse A, Yüksel M, Pirinççi N, Görgel S, Ateşçi Y, Gümüş B. The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE. 2015;20:30–33.
MLA	Karaköse, Ayhan et al. “The Effect of Antibiotherapy Used Against the PSA Increase in Serum PSA Levels”. EASTERN JOURNAL OF MEDICINE, vol. 20, no. 1, 2015, pp. 30-33.
Vancouver	Karaköse A, Yüksel M, Pirinççi N, Görgel S, Ateşçi Y, Gümüş B. The effect of antibiotherapy used against the PSA increase in serum PSA levels. EASTERN JOURNAL OF MEDICINE. 2015;20(1):30-3.