Kolorektal Kanserde Endoskopik Özelliklerler Tümör Patolojisini ve Tümör Evresini Predikte Edebilir mi?
Abstract
Giriş ve Amaç: Kolorektal kanserli hastalarımızın demografik
özelliklerini ve tanı anındaki endoskopik özelliklerinin kolorektal kanserin
patolojik özellikleri ile olan ilişkisini incelemeyi hedefledik. Gereç ve Yöntem: Hastanemiz Endoskopi Ünitesinde Ocak 2010-Ekim 2017
tarihleri arasında kolonoskopi esnasında kolorektal kanser ön tanısı ile
biyopsi alınan ve patolojileri kolorektal kanser gelen hastalar çalışmaya dahil
edildi. Tümöre bağlı lüminal obstrüksiyon, tümörün makroskopik özellikleri gibi
endoskopik özellikler ve kolorektal kanserin patolojik özellikleri retrospektif
olarak incelendi. Bulgular: Çalışmamıza 168 hasta dahil edildi. Hastaların en
sık başvuru şikayeti kabızlık olup kolonda kanserin en sık izlendiği yer
sigmoid kolondu. Hematokezya sol kolon yerleşimli kanserlerde diğer
bölgelerdekine göre anlamlı olarak daha sık izlendi (p=0.02). Cinsiyetler
arasında başvuru şekli, kanser lokalizasyonu ve endoskopik obstrüksiyon
farklılık göstermedi. Endoskopik obstrüksiyonu olan hastalarda kolorektal
kanserin kötü diferansiasyonu anlamlı olarak daha fazlaydı (p=0.015). Sonuç: Endoskopun geçemeyeceği şekilde lüminal obstrüksiyonu
olan hastaların yakından izlenmeleri, ameliyatlarının geciktirilmeden yapılması
ve ameliyat sonrası daha kısa aralıklarla takibi bu hastaların sağkalımları üzerine
etkili olabilir.
References
- 1- Araujo SE, Alves PR, Habr-Gama A. Role of colonoscopy in colorectal cancer. Rev Hosp Clin Fac Med Sau Paulo 2011;56:25-35.
- 2- Patil PS, Saklani A, Gambhire P, et al. Colorectal cancer in India: An audit from a tertiary center in a low prevalence area. Indian J Surg Oncol 2017;8:484-90.
- 3- Huang JJ, Huang JL. Challenges to the adoption of risk algorithms for colorectal cancer screening programmes: perspectives for future research. Hong Kong Med J 2017;23:661-3
- 4- Gallo G, Sammarco G, Chiriatti AP, et al. The role of self-expandable metallic stents as "bridge to surgery" for the treatment of acute malignant colorectal obstruction. Our experience. Ann Ital Chir 2017;6:418-24.
- 5- Weng W, Feng J, Qin H, Ma Y. Molecular therapy of colorectal cancer: progress and future directions. Int J Cancer 2014;136:493-502.
- 6- Özkan ÖF, Kaya Ü, Güner A, et al. Bir eğitim ve araştırma hastanesinde kolorektal kanser hastalarının demografik dağılımı ve hastalık özellikleri. Pam Tıp Derg 2012;5:132-5.
- 7- Baer C, Menon R, Bastawrous S, Bastawrous A. Emergency presentations of colorectal cancer. Surg Clin North Am 2017;97:529-45.
- 8- Wilson MJ, Dekker JWT, Harlaar JJ, et al. The role of preoperative iron deficiency in colorectal cancer patients: prevalence and treatment. Int J Colorectal Dis 2017;32:1617-24.
- 9- İnce AT, Baysal B, Kayar Y, et al. Comparison of tomographic and colonoscopic diagnoses in the presence of colonic wall thickening. Int J Clin Exp Med 2014;7:4413-9.
- 10- Dickerson EC, Chong ST, Ellis JH, et al. Recurrence of colonic diverticulitis: identifying predictive CT findings-retrospective cohort study. Radiology 2017;285:850-8.
- 11- Mohd Suan MA, Tan WL, Soelar SA, et al. Intestinal obstruction: predictor of poor prognosis in colorectal carcinoma? Epidemiol Health 2015;37:e2015017.
- 12- Rasool A, Bari S, Rashid S, et al. Outcome of patients with acute intestinal obstruction due to colorectal carcinoma. Internet J Surg 2008;20:1.
- 13- Chalieopanyarwong V, Boonpipattanapong T, Prechawittayakul P, Sangkhathat S. Endoscopic obstruction is associated with higher risk of acute events requiring emergency operation in colorectal cancer patients. World J Emerg Surg 2013;8:34.
- 14- Ballian N, Mahvi DM, Kennedy GD. Colonoscopic findings and tumor site do not predict bowel obstruction during medical treatment of stage IV colorectal cancer. Oncologist 2009;14:580-5.
- 15- Dai W, Li Y, Meng X, et al. Does tumor size have its prognostic role in colorectal cancer? Re-evaluating its value incolorectal adenocarcinoma with different macroscopic growth pattern. Int J Surg 2017;45:105-12.
Abstract
Background and Aims: Our aim was to evaluate the
demographic features of our colorectal cancer patients and assess the
association between endoscopic and pathologic features in those patients. Materials and Methods: In this study, we retrospectively evaluated the medical
records of patients who were diagnosed with colorectal cancer through biopsy taken by colonoscopy in the endoscopy
unit of our hospital between January 2010 and October 2017. We analyzed endoscopic
features of colorectal cancer such as luminal obstruction, macroscopic
appearance, and histological features. Results: We obtained data from 168 patients for this study.
The most common symptom was constipation and the most common cancer location
was the sigmoid colon. Hematochezia was found to be significantly higher in
cancers located in the left colon (p = 0.02). Symptoms, cancer location, and endoscopic
obstruction were not significantly different between genders. Poor histological
differentiation was significantly higher in the endoscopic obstruction group (p
= 0.015). Conclusion: Immediate surgery and close
follow-up in patients with endoscopic obstruction can impact their survival.
References
- 1- Araujo SE, Alves PR, Habr-Gama A. Role of colonoscopy in colorectal cancer. Rev Hosp Clin Fac Med Sau Paulo 2011;56:25-35.
- 2- Patil PS, Saklani A, Gambhire P, et al. Colorectal cancer in India: An audit from a tertiary center in a low prevalence area. Indian J Surg Oncol 2017;8:484-90.
- 3- Huang JJ, Huang JL. Challenges to the adoption of risk algorithms for colorectal cancer screening programmes: perspectives for future research. Hong Kong Med J 2017;23:661-3
- 4- Gallo G, Sammarco G, Chiriatti AP, et al. The role of self-expandable metallic stents as "bridge to surgery" for the treatment of acute malignant colorectal obstruction. Our experience. Ann Ital Chir 2017;6:418-24.
- 5- Weng W, Feng J, Qin H, Ma Y. Molecular therapy of colorectal cancer: progress and future directions. Int J Cancer 2014;136:493-502.
- 6- Özkan ÖF, Kaya Ü, Güner A, et al. Bir eğitim ve araştırma hastanesinde kolorektal kanser hastalarının demografik dağılımı ve hastalık özellikleri. Pam Tıp Derg 2012;5:132-5.
- 7- Baer C, Menon R, Bastawrous S, Bastawrous A. Emergency presentations of colorectal cancer. Surg Clin North Am 2017;97:529-45.
- 8- Wilson MJ, Dekker JWT, Harlaar JJ, et al. The role of preoperative iron deficiency in colorectal cancer patients: prevalence and treatment. Int J Colorectal Dis 2017;32:1617-24.
- 9- İnce AT, Baysal B, Kayar Y, et al. Comparison of tomographic and colonoscopic diagnoses in the presence of colonic wall thickening. Int J Clin Exp Med 2014;7:4413-9.
- 10- Dickerson EC, Chong ST, Ellis JH, et al. Recurrence of colonic diverticulitis: identifying predictive CT findings-retrospective cohort study. Radiology 2017;285:850-8.
- 11- Mohd Suan MA, Tan WL, Soelar SA, et al. Intestinal obstruction: predictor of poor prognosis in colorectal carcinoma? Epidemiol Health 2015;37:e2015017.
- 12- Rasool A, Bari S, Rashid S, et al. Outcome of patients with acute intestinal obstruction due to colorectal carcinoma. Internet J Surg 2008;20:1.
- 13- Chalieopanyarwong V, Boonpipattanapong T, Prechawittayakul P, Sangkhathat S. Endoscopic obstruction is associated with higher risk of acute events requiring emergency operation in colorectal cancer patients. World J Emerg Surg 2013;8:34.
- 14- Ballian N, Mahvi DM, Kennedy GD. Colonoscopic findings and tumor site do not predict bowel obstruction during medical treatment of stage IV colorectal cancer. Oncologist 2009;14:580-5.
- 15- Dai W, Li Y, Meng X, et al. Does tumor size have its prognostic role in colorectal cancer? Re-evaluating its value incolorectal adenocarcinoma with different macroscopic growth pattern. Int J Surg 2017;45:105-12.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | December 28, 2018 |
| Published in Issue | Year 2018 Volume: 26 Issue: 3 |