Research Article
An Investigation of Genetic Polymorphism In The Rs35521 Serotonin Transporter Gene In Allergic Rhinitis
Abstract
Objective: Allergic rhinitis (AR) is one of the most frequently encountered allergic disorders and has a typical prevalence of between 18 and 40%.The factors which underlie allergic disorders may vary since they are linked to climate, geography, different social conditions and genetic makeup. The objective of our research was to investigate any connections between polymorphism in the serotonin transporter gene and allergic rhinitis.
Methods: This study involved the participation of two groups aged between 15 and 60 years of age who attended the ENT clinic of the Medical Faculty at Erzincan University: 100 individuals with allergic rhinitis plus a control group of 200 individuals who lacked the condition. The AR cases were established on the basis of history, physical examination and skin prick testing. Peripheral blood samples were taken from both groups and subjected to genetic analyses. The analysis utilised a 5-HTT Taqman® primer as genetic probe. The Chi-squared method was utilised for statistical analysis.
Results: 129 of the participants were female (64.5%) and 71 (35.5%) male. The average age of those participating was 34.5 ± 14.6 (range: 20-65) years. In reference to the sex distribution of the patients, 79% of the patients were female. There was a significant difference between the groups according to sex (p <0.01). No significant differences were noted between the patient and control groups when compared according to genetic polymorphism or place of residence. In 61% of the allergic rhinitis sufferers, their symptoms were seasonal. The incidence of AR was higher in both females and in those living in an urban rather than rural setting. When the polymorphism is examined in both the patient and control groups, the most common type is the mutant type. In both the cases and controls, when the polymorphism was investigated, the most frequently seen type was the Mutant variety and no significant difference in frequency was noted according to sex or place of residence.
Conclusion: In this study, when the cases and controls were compared in terms of the polymorphism in the rs35521 serotonin transporter gene, there was no difference at the level of statistical significance between the frequency of occurrence of the mutant or heterozygote form of the gene.
References
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Year 2019,
Volume: 9 Issue: 2, 107 - 114, 08.08.2019
Abstract
References
- 1. Öztürk Ö, Tokmak A, Güçlü E, Yıldızbaş Ş, Gültekin E. Skin Prick Test Results of Patients with Allergic Rhinitis in Düzce. [Article in Turkish] Düzce Tıp Fak Derg 2005;1:11-4.
- 2. Holgate ST. Genetic and environmental interaction in allergy and asthma. J Allergy Clin Immunol 1999;104:1139-46.
- 3. Cogswell JJ, Mitchell EB, Alexander J. Parental smoking, breast feeding, and respiratory infection indevelopment of allergic diseases. Arch Dis Child 1987;62:338-44.
- 4. Zeiger RS, Heller S, Mellon MH, et al. Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: A randomized study. J Allergy Clin Immunol 1989;84:72-89.
- 5. Floistrup H, Swartz J, Bergstrom A, et al. Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol 2006;117:59-66.
- 6. Cingi C, Oğhan F, Ünlü H, Tekat A, Okuyucu Ş. Efficacy of montelukast and desloratadine combination in allergic rhinitis. [Article in Turkish] J Med Updates 2011;1:3-16.
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- 8. Murphy DL, Lerner A, Rudnick G, Lesch KP. Serotonin Transporter: Gene, Genetic Disorders, and Pharmacogenetics. Mol Interv 2004;4:109-23.
- 9. van Cauwenberge P, Bachert C, Passalacqua G, et al. Consensus statement on the treatment of allergic rhinitis. European Academy of Allergology and Clinical Immunology. Allergy 2000;55:116-34.
- 10. Rosenwasser LJ. Treatment of allergic rhinitis. Am J Med 2002;113:17-24.
- 11. Nihlén U, Greiff L, Montnémery P, et al. Incidence and remission of selfreported allergic rhinitis symptoms in adults. Allergy 2006;61:1299-304.
- 12. Bousquet J, Annesi-Maesano I, Carat F, et al. Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group. Clin Exp Allergy 2005;35:728-32.
- 13. Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-31.
- 14. Özkaya M, Doğu O, Sevim S, Çamdeviren H, Yalçınkaya D, Erdal ME. Serotonin transporter (SERT) gene polymorphism in Parkinson’s disease. [Article in Turkish] Turkish J Neurol 2004;10:201-5.
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- 18. Farjadian S, Moghtaderi M, Fakhraei B, Nasiri M, Farjam M. Association between serotonin transporter gene polymorphisms and childhood asthma. J Asthma 2013;50:1031-5.
There are 18 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | August 8, 2019 |
| Submission Date | June 8, 2019 |
| Acceptance Date | July 16, 2019 |
| Published in Issue | Year 2019 Volume: 9 Issue: 2 |
