Comparison of the Effects on the Postoperative Analgesia of Bupivacaine or Ropivacaine Application on Intraperitoneal and Incisional Line during Ovariohysterectomy in Dogs
Abstract
In
this study, it was aimed to compare the effect of postoperative analgesia of
bupivacaine and ropivacaine locally applied on intraperitoneal or incisional line
under general anesthesia in dogs undergoing ovariohysterectomy. Dogs
which were operated ovariohysterectomy under xylazine-ketamine general
anesthesia were divided two groups, 8 animals in each. During the operation, in the first
group (BG, n = 8) bupivacaine was administered to three different points,
namely the incision line between the corpus and cervix uteri (I),
intraperitoneal (II) and muscle incision line (III). In the other group (RG, n
= 8), ropivacaine was applied to these three points in a similar manner and the
operation was routinely completed. Pulse, respiratory rate and body temperature
measurements were performed at 2th, 4th, 6th,
8th, 12th and 24th hours postoperatively.
Similarly, at the same time each dog was evaluated using Simple Descriptive
Pain Scale (SDS), Melbourne pain scale and Glaskow composite pain scales.
Pulse, respiratory rate and body temperature values were among the reference
limits, although there were statistical differences especially among the groups
in terms of pulse. According to the evaluation results of SDS and Melbourne
pain scale, a statistical difference was found between BG and RG at
postoperative 4th and 6th hours (P<0.001, P=0.003). The results of the Glaskow
composite pain scale showed a statistically significant difference (P<0.001).
between the groups at 4th hour. As a result,
when the data obtained without study were evaluated together, it was concluded
that bupivacaine, a long-acting local anesthetic, is more potent than
ropivacaine in postoperative analgesic effect of incisional and intraperitoneal
use in ovariohysterectomy operations in dogs.
Keywords
References
- 1. Benito J, Monteiro BP, Beaudry F, Lavoie AM, Lascelles BDX, Steagall PV. Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy. AJVR 2016; 77 (6): 641-5.
- 2. Benito J, Monteiro B, Lavoie AM, Beauchamp G, Lascelles BDX, Steagall PV. Analgesic efficacy of intraperitoneal administration of bupivacaine in cats. J Feline Med Surg 2016; 18 (11): 906-12.
- 3. Campagnol D, Teixeira-Neto FJ, Monteiro EM, Restitutti F, Minto BW. Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs. Vet Anaest Analg 2012; 39 (4): 426-30.
- 4. Fitzpatrick CL, Weir HL, Monnet E. Effects of infiltration of the incision site with bupivacaine on postoperative pain and incisional healing in dogs undergoing ovariohysterectomy. JAVMA 2010; 237 (4): 395-401.
- 5. Flecknell P. Advances in the assessment and alleviation of pain in laboratory and domestic animals. J Vet Anesth 1994; 21 (2): 98-105.
- 6. Guerrero KSK, Campagna I, Bruhl-Day R, Hegamin-Younger C. Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy. Vet Anaest Analg 2016; 43 (5): 571-8.
- 7. Gültekin Ç. Tümör cerrahisi uygulanan köpeklerde morfin ve tramadol’ün analjezik etkilerinin karşılaştırılması. Doktora Tezi, Ankara Üniv Sağ Bil Ens, Ankara 2012; s. 18-35.
- 8. Hellyer P, Rodan I, Brunt J, Downing R, Hagedorn JE, Robertson SA. AAHA/AAFP pain management guidelines for dogs & cats. J Am Anim Hosp Assoc 2007; 43 (5): 235-48.
- 9. Kim YK, Lee SS, Suh EH, Lee L, Lee HC, Lee HJ, Yeon SC. Sprayed intraperitoneal bupivacaine reduces early postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy in dogs. Vet J 2012; 191 (2): 188-92.
- 10. Kuzucu O. Köpeklerde karprofen ve fluniksin’in postoperatif analjezik etkinliklerinin karşılaştırılması. Doktora Tezi, Ankara Üniv Sağ Bil Ens, Ankara 2005; s. 10,40.
- 11. Mich PM, Hellyer PW. Objective, categoric methods for assessing pain and analgesia. Gaynor JS, Muir III, WW. eds. In: Handbook of Veterinary Pain Management. 2nd. Missouri: Mosby, 2009; pp. 78-109.
- 12. Saritas ZK, Korkmaz M, Yilmaz O. The effect of intravenously given dexketoprofen trometamol on postoperative pain in ovariohysterectomized dogs. Eurasian J Vet Sci 2014; 30: 5-10.
- 13. Savvas I, Papazoglou LG, Kazakos G, Anagnostou T, Tsioli V, Raptopoulos D. Incisional block with bupivacaine for analgesia after celiotomy in dogs. J Am Anim Hosp Assoc 2008; 44 (2): 60-6.
- 14. Schuszler L, Igna C, Sala A, Brudiu I, Sabau M, Dascalu R. Intraoperative analgesic effect of butarphanol for ovariohysterectomy in bitches: a dose titration study. Lucrari Ştiintifice Med Vet 2009; 42 (2), 160-3.
- 15. Winkler KP, Greenfield CL, Benson GJ. The effect of wound irrigation with bupivacaine on postoperative analgesia of the feline onychectomy patient. J Am Anim Hosp Assoc 1997; 33: 346-52.
Köpeklerde Ovariohisterektomi Sırasında İntraperitoneal ve Ensizyon Hattına Bupivacaine veya Ropivacaine Uygulamasının Postoperatif Analjezi Üzerine Etkilerinin Karşılaştırılması
Abstract
Bu
çalışmada köpeklerde genel anestezi altında gerçekleştirilen ovariohisterektomi
sırasında intraperitoneal ya da ensiyon hattına lokal olarak uygulanan
bupivacaine ve ropivacainin postoperatif analjezi üzerine etkisinin karşılaştırmalı
olarak değerlendirilmesi amaçlandı. Ksilazin-ketamin genel anestezisi altında
ovariohisterektomi yapılan köpekler, her birinde 8 hayvan olacak şekilde 2
gruba ayrıldı. İlk gruba (BG, n=8) operasyon sırasında korpus uteri ile serviks
uteri arasına yapılan ensiyon hattına (I), intraperitoneal (II) olarak ve kas
üzerindeki ensizyon hattı (III) olmak üzere farklı üç noktaya bupivacaine diğer
grubta (RG, n=8) ise benzer şekilde bu
üç noktaya ropivacaine uygulaması yapıldı ve operasyon rutin bir şekilde
tamamlandı. Operasyondan sonraki 2., 4., 6., 8., 12. ve 24. saatlerde nabız,
solunum sayısı ve vücut sıcaklığı ölçümleri yapıldı. Benzer şekilde aynı
saatlerde her bir köpek basit ağrı tanımlama (SDS) skalası, Melbourne
ağrı skalası ve Glaskow kompozit ağrı skalaları kullanılarak değerlendirildi. Özellikle nabız bakımından gruplar
arasında istatistiksel farklar bulunsa da nabız, solunum sayısı ve vücut sıcaklığı
değerleri referans sınırlar arasında idi. SDS ve Melbourne ağrı skalasının
değerlendirme sonuçlarına göre postoperatif 4. ve 6. saatlerde BG ve RG
arasında istatistiksel bir fark belirlendi (P<0.001, P=0.003). Glaskow
kompozit ağrı skalasının sonuçları 4. saatte gruplar arasında istatistiksel
olarak anlamlı bir fark bulundu (P<0.001). Sonuç olarak çalışmadan elde
edilen veriler bir arada değerlendirildiğinde uzun etkili bir lokal anestezik
olan bupivacainin köpeklerde ovariohisterektomi operasyonlarında ensizyonel ve
intraperitoneal kullanımının postoperatif analjezik etkisinin ropivacaine göre
daha güçlü olduğu sonucuna varıldı.
Keywords
References
- 1. Benito J, Monteiro BP, Beaudry F, Lavoie AM, Lascelles BDX, Steagall PV. Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy. AJVR 2016; 77 (6): 641-5.
- 2. Benito J, Monteiro B, Lavoie AM, Beauchamp G, Lascelles BDX, Steagall PV. Analgesic efficacy of intraperitoneal administration of bupivacaine in cats. J Feline Med Surg 2016; 18 (11): 906-12.
- 3. Campagnol D, Teixeira-Neto FJ, Monteiro EM, Restitutti F, Minto BW. Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs. Vet Anaest Analg 2012; 39 (4): 426-30.
- 4. Fitzpatrick CL, Weir HL, Monnet E. Effects of infiltration of the incision site with bupivacaine on postoperative pain and incisional healing in dogs undergoing ovariohysterectomy. JAVMA 2010; 237 (4): 395-401.
- 5. Flecknell P. Advances in the assessment and alleviation of pain in laboratory and domestic animals. J Vet Anesth 1994; 21 (2): 98-105.
- 6. Guerrero KSK, Campagna I, Bruhl-Day R, Hegamin-Younger C. Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy. Vet Anaest Analg 2016; 43 (5): 571-8.
- 7. Gültekin Ç. Tümör cerrahisi uygulanan köpeklerde morfin ve tramadol’ün analjezik etkilerinin karşılaştırılması. Doktora Tezi, Ankara Üniv Sağ Bil Ens, Ankara 2012; s. 18-35.
- 8. Hellyer P, Rodan I, Brunt J, Downing R, Hagedorn JE, Robertson SA. AAHA/AAFP pain management guidelines for dogs & cats. J Am Anim Hosp Assoc 2007; 43 (5): 235-48.
- 9. Kim YK, Lee SS, Suh EH, Lee L, Lee HC, Lee HJ, Yeon SC. Sprayed intraperitoneal bupivacaine reduces early postoperative pain behavior and biochemical stress response after laparoscopic ovariohysterectomy in dogs. Vet J 2012; 191 (2): 188-92.
- 10. Kuzucu O. Köpeklerde karprofen ve fluniksin’in postoperatif analjezik etkinliklerinin karşılaştırılması. Doktora Tezi, Ankara Üniv Sağ Bil Ens, Ankara 2005; s. 10,40.
- 11. Mich PM, Hellyer PW. Objective, categoric methods for assessing pain and analgesia. Gaynor JS, Muir III, WW. eds. In: Handbook of Veterinary Pain Management. 2nd. Missouri: Mosby, 2009; pp. 78-109.
- 12. Saritas ZK, Korkmaz M, Yilmaz O. The effect of intravenously given dexketoprofen trometamol on postoperative pain in ovariohysterectomized dogs. Eurasian J Vet Sci 2014; 30: 5-10.
- 13. Savvas I, Papazoglou LG, Kazakos G, Anagnostou T, Tsioli V, Raptopoulos D. Incisional block with bupivacaine for analgesia after celiotomy in dogs. J Am Anim Hosp Assoc 2008; 44 (2): 60-6.
- 14. Schuszler L, Igna C, Sala A, Brudiu I, Sabau M, Dascalu R. Intraoperative analgesic effect of butarphanol for ovariohysterectomy in bitches: a dose titration study. Lucrari Ştiintifice Med Vet 2009; 42 (2), 160-3.
- 15. Winkler KP, Greenfield CL, Benson GJ. The effect of wound irrigation with bupivacaine on postoperative analgesia of the feline onychectomy patient. J Am Anim Hosp Assoc 1997; 33: 346-52.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | August 8, 2019 |
| Submission Date | January 17, 2018 |
| Acceptance Date | October 4, 2018 |
| Published in Issue | Year 2019 Volume: 16 Issue: 2 |
Cite
https://dergipark.org.tr/tr/download/journal-file/20610
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