Research Article
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Year 2017, Volume: 3 Issue: 3, 214 - 219, 04.11.2017
https://doi.org/10.18621/eurj.316421

Abstract

References

  • [1] Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancerstatistics. CA Cancer J Clin 2011;61:69-90.
  • [2] Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 2012;62:220-41.
  • [3] Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-45.
  • [4] Swiderska M, Choromańska B, Dąbrowska E, Konarzewska-Duchnowska E, Choromańska K, Szczurko G, et al. The diagnostics of colorectal cancer. Contemp Oncol (Pozn) 2014;18:1-6.
  • [5] Ong SL, Garcea G, Thomasset SC, Mann CD, Neal CP, Abu Amara M, et al. Surrogate markers of resectability in patients undergoing exploration of potentially resectable pancreatic adenocarcinoma. J Gastrointest Surg 2008;12:1068-73.
  • [6] Chang H, Gao J, Xu BQ, Guo SP, Lu RB, Li G, et al. Haemoglobin, neutrophil to lymphocyte ratio, and platelet count improve prognosis prediction of the TNM staging system in nasopharyngeal carcinoma: development and validation in 3237 patients from a single institution. Clin Oncol (R Coll Radiol) 2013;25:639-46.
  • [7] Roxburgh CS, Salmond JM, Horgan PG, Oien KA, McMillan DC. Comparison of the prognostic value of inflammation-based pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer. Ann Surg 2009;249:788-93.
  • [8] Rizzo A, Pallone F, Monteleone G, Fantini MC. Intestinal inflammation and colorectal cancer: a double-edged sword. World J Gastroenterol 2011;17:3092-100.
  • [9] Roxburgh CS, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 2010;6:149-63.
  • [10] Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005;91:181-4.
  • [11] Malietzis G, Giacometti M, Askari A, Nachiappan S, Kennedy RH, Faiz OD, et al. A preoperative neutrophil to lymphocyte ratio of 3 predicts disease-free survival after curative elective colorectal cancer surgery. Ann Surg 2014;260:287-92.
  • [12] Ding PR, An X, Zhang RX, Fang YJ, Li LR, Chen G, et al. Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA coloncancer. Int J Colorectal Dis 2010;25:1427-33.
  • [13] He W, Yin C, Guo G, Jiang C, Wang F, Qiu H, et al. Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol 2013;30:439.
  • [14] Absenger G, Szkandera J, Stotz M, Postlmayr U, Pichler M, Ress AL, et al. Preoperative neutrophil to lymphocyte ratio predicts clinical outcome in patients with stage II and III coloncancer. Anticancer Res 2013;33:4591-4.
  • [15] Briggs C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol 2009;31:277-97.
  • [16] Shen J, Ran ZH, Zhang Y, Cai Q, Yin HM, Zhou XT, et al. Biomarkers of altered coagulation and fibrinolysis as measures of disease activity in active inflammatory bowel disease: a gender-stratified, cohort analysis. Thromb Res 2009;123:604-11.
  • [17] Karaman K, Bostanci EB, Aksoy E, Kurt M, Celep B, Ulas M, et al. The predictive value of mean platelet volume in differential diagnosis of non-functional pancreatic neuroendocrine tumors from pancreatic adenocarcinomas. Eur J Intern Med 2011;22:e95-8.
  • [18] Kurt M, Onal IK, Sayilir AY, Beyazit Y, Oztas E, Kekilli M. The role of mean platelet volume in the diagnosis of hepatocellular carcinoma in patients with chronic liver disease. Hepatogastroenterology 2012;59:1580-2.
  • [19] Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 2002;22:913-22.
  • [20] Borsig L. The role of platelet activation in tumor metastasis. Expert Rev Anticancer Ther 2008;8:1247-55.
  • [21] Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med 2005;142:233-9.
  • [22] Suzuki K, Aiura K, Ueda M, Kitajima M. The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents. Pancreas 2004;29:132-40.
  • [23] Zhou X, Du Y, Huang Z, Xu J, Qiu T, Wang J, et al. Prognostic value of PLR in various cancers: a meta-analysis. PLoS One 2014;9:101119.
  • [24] Jia J, Zheng X, Chen Y, Wang L, Lin L, Ye X, et al. Stage-dependent changes of preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in colorectal cancer. Tumour Biol 2015;36:9319-25.
  • [25] Szkandera J, Pichler M, Absenger G, Stotz M, Arminger F, Weissmueller M, et al. The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients. Am J Surg 2014;208:210-4.
  • [26] Kwon HC, Kim SH, Oh SY, Lee S, Lee JH, Choi HJ, et al. Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers 2012;17:216-22.

Importance of preoperative hematological parameters in patients undergoing surgical resection for colorectal cancer

Year 2017, Volume: 3 Issue: 3, 214 - 219, 04.11.2017
https://doi.org/10.18621/eurj.316421

Abstract

Objectives. Colorectal cancer has a high prevalence worldwide, and
new predictive and prognostic factors are needed for its early diagnosis,
treatment, and follow-up. In this study, we have investigated the relationship
between colorectal cancer and neutrophil to lymphocyte ratio
(NLR), mean platelet volume (MPV), and platelet to
lymphocyte ratio (PLR) values. Methods. Data from 71 patients
admitted to our hospital between May 2013 and May 2015, who underwent surgical resection
for colorectal cancer, and met the criteria of the study, was evaluated
retrospectively. NLR, MPV and PLR data detected in the preoperative period was
noted. Demographic data, the presence of comorbidity, colonic localization of
the tumor, colonoscopic findings, and surgical resection type and method were
compared with the data of morbidity and mortality, lymphovascular and
perineural invasion, lymph node and distant metastasis and stage of the
disease. Results. No statistical significance was detected between
preoperative NLR, MPV, and PLR, demographical data, the presence of
comorbidity, colonic localization of the tumor, colonoscopic findings, surgical
resection type and method and morbidity, lymph node and distant metastasis,
lymphovascular invasion, or stage of the disease. However, a statistically
significant relationship was detected between mortality development and NLR and
PLR values (p=0.030; p=0.043; respectively). There was also a
statistically significant relationship between the presence of perineural
invasion and PLR (p=0.031). Conclusion.
Hematological parameters (NLR, MPV, and PLR) evaluated in preoperative period
in patients who have been applied surgical resection for colorectal cancer may
help clinical and pathological staging.

References

  • [1] Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancerstatistics. CA Cancer J Clin 2011;61:69-90.
  • [2] Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 2012;62:220-41.
  • [3] Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-45.
  • [4] Swiderska M, Choromańska B, Dąbrowska E, Konarzewska-Duchnowska E, Choromańska K, Szczurko G, et al. The diagnostics of colorectal cancer. Contemp Oncol (Pozn) 2014;18:1-6.
  • [5] Ong SL, Garcea G, Thomasset SC, Mann CD, Neal CP, Abu Amara M, et al. Surrogate markers of resectability in patients undergoing exploration of potentially resectable pancreatic adenocarcinoma. J Gastrointest Surg 2008;12:1068-73.
  • [6] Chang H, Gao J, Xu BQ, Guo SP, Lu RB, Li G, et al. Haemoglobin, neutrophil to lymphocyte ratio, and platelet count improve prognosis prediction of the TNM staging system in nasopharyngeal carcinoma: development and validation in 3237 patients from a single institution. Clin Oncol (R Coll Radiol) 2013;25:639-46.
  • [7] Roxburgh CS, Salmond JM, Horgan PG, Oien KA, McMillan DC. Comparison of the prognostic value of inflammation-based pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer. Ann Surg 2009;249:788-93.
  • [8] Rizzo A, Pallone F, Monteleone G, Fantini MC. Intestinal inflammation and colorectal cancer: a double-edged sword. World J Gastroenterol 2011;17:3092-100.
  • [9] Roxburgh CS, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 2010;6:149-63.
  • [10] Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005;91:181-4.
  • [11] Malietzis G, Giacometti M, Askari A, Nachiappan S, Kennedy RH, Faiz OD, et al. A preoperative neutrophil to lymphocyte ratio of 3 predicts disease-free survival after curative elective colorectal cancer surgery. Ann Surg 2014;260:287-92.
  • [12] Ding PR, An X, Zhang RX, Fang YJ, Li LR, Chen G, et al. Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA coloncancer. Int J Colorectal Dis 2010;25:1427-33.
  • [13] He W, Yin C, Guo G, Jiang C, Wang F, Qiu H, et al. Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol 2013;30:439.
  • [14] Absenger G, Szkandera J, Stotz M, Postlmayr U, Pichler M, Ress AL, et al. Preoperative neutrophil to lymphocyte ratio predicts clinical outcome in patients with stage II and III coloncancer. Anticancer Res 2013;33:4591-4.
  • [15] Briggs C. Quality counts: new parameters in blood cell counting. Int J Lab Hematol 2009;31:277-97.
  • [16] Shen J, Ran ZH, Zhang Y, Cai Q, Yin HM, Zhou XT, et al. Biomarkers of altered coagulation and fibrinolysis as measures of disease activity in active inflammatory bowel disease: a gender-stratified, cohort analysis. Thromb Res 2009;123:604-11.
  • [17] Karaman K, Bostanci EB, Aksoy E, Kurt M, Celep B, Ulas M, et al. The predictive value of mean platelet volume in differential diagnosis of non-functional pancreatic neuroendocrine tumors from pancreatic adenocarcinomas. Eur J Intern Med 2011;22:e95-8.
  • [18] Kurt M, Onal IK, Sayilir AY, Beyazit Y, Oztas E, Kekilli M. The role of mean platelet volume in the diagnosis of hepatocellular carcinoma in patients with chronic liver disease. Hepatogastroenterology 2012;59:1580-2.
  • [19] Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 2002;22:913-22.
  • [20] Borsig L. The role of platelet activation in tumor metastasis. Expert Rev Anticancer Ther 2008;8:1247-55.
  • [21] Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med 2005;142:233-9.
  • [22] Suzuki K, Aiura K, Ueda M, Kitajima M. The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents. Pancreas 2004;29:132-40.
  • [23] Zhou X, Du Y, Huang Z, Xu J, Qiu T, Wang J, et al. Prognostic value of PLR in various cancers: a meta-analysis. PLoS One 2014;9:101119.
  • [24] Jia J, Zheng X, Chen Y, Wang L, Lin L, Ye X, et al. Stage-dependent changes of preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in colorectal cancer. Tumour Biol 2015;36:9319-25.
  • [25] Szkandera J, Pichler M, Absenger G, Stotz M, Arminger F, Weissmueller M, et al. The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients. Am J Surg 2014;208:210-4.
  • [26] Kwon HC, Kim SH, Oh SY, Lee S, Lee JH, Choi HJ, et al. Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers 2012;17:216-22.
There are 26 citations in total.

Details

Subjects Health Care Administration
Journal Section Original Articles
Authors

Haci Murat Cayci

Umut Eren Erdogdu

Publication Date November 4, 2017
Submission Date May 27, 2017
Acceptance Date July 12, 2017
Published in Issue Year 2017 Volume: 3 Issue: 3

Cite

AMA Cayci HM, Erdogdu UE. Importance of preoperative hematological parameters in patients undergoing surgical resection for colorectal cancer. Eur Res J. November 2017;3(3):214-219. doi:10.18621/eurj.316421

e-ISSN: 2149-3189 


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