Research Article
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Year 2019, Volume: 5 Issue: 1, 94 - 97, 04.01.2019
https://doi.org/10.18621/eurj.379970

Abstract

References

  • [1] Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet 2007;369:1287-301.
  • [2] Chebib FT, Torres VE. Autosomal dominant polycystic kidney disease: core curriculum 2016. Am J Kidney Dis 2016;67:792-810.
  • [3] Luciano RL, Dahl NK. Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management. Nephrol Dial Transplant 2014;29:247-54.
  • [4] Leung GK, Fan YW. Chronic subdural haematoma and arachnoid cyst in autosomal dominant polycystic kidney disease (ADPKD). J Clin Neurosci 2005;12:817-9.
  • [5] Belz MM, Fick-Brosnahan GM, Hughes RL, Rubinstein D, Chapman AB, Johnson AM, et al. Recurrence of intracranial aneurysms in autosomal-dominant polycystic kidney disease. Kidney Int 2003;63:1824-30.
  • [6] Pei Y, Obaji J, Dupuis A, Paterson AD, Magistroni R, Dicks E, et al. Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol 2009;20:205-12.
  • [7] Xu HW, Yu SQ, Mei CL, Li MH. Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease. Stroke 2011;42:204-6.
  • [8] Cagnazzo F, Gambacciani C, Morganti R, Perrini P. Intracranial aneurysms in patients with autosomal dominant polycystic kidney disease: prevalence, risk of rupture, and management. A systematic review. Acta Neurochir (Wien) 2017;159:811-21.
  • [9] Schrier RW, Belz MM, Johnson AM, Kaehny WD, Hughes RL, Rubinstein D, et al. Repeat imaging for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease with initially negative studies: a prospective ten-year follow-up. J Am Soc Nephrol 2004;15:1023-8.

Neurological findings in autosomal dominant polycystic kidney disease

Year 2019, Volume: 5 Issue: 1, 94 - 97, 04.01.2019
https://doi.org/10.18621/eurj.379970

Abstract

Objective: Autosomal dominant polycystic kidney disease (ADPKD)
mainly affects the kidneys, but other abnormalities like intracranial aneurysms
(ICAs) are not uncommon. In this study, we aimed to investigate retrospectively
frequency of ICA and other neurological abnormalities in ADPKD patients.

Methods: One hundred and forty patients with ADPKD who did not receive replacement
therapy and followed-up at outpatient clinic were evaluated.

Results: The mean age of the patients was 43.4 ± 13 years and mean glomerular filtration
rate was 87 ± 15 ml/min. ICA was detected in four (2.8%) patients. Three patients were from the same family. Thirteen (9.3%)
patients had magnetic resonance angiography due to their family stories, but
aneurysm was not seen in them.

Conclusion: Individuals with ADPKD who
have a history of aneurysm or hemorrhage in their family should be screened for
aneurysm due to mortality and risk of recurrent rupture. 

References

  • [1] Torres VE, Harris PC, Pirson Y. Autosomal dominant polycystic kidney disease. Lancet 2007;369:1287-301.
  • [2] Chebib FT, Torres VE. Autosomal dominant polycystic kidney disease: core curriculum 2016. Am J Kidney Dis 2016;67:792-810.
  • [3] Luciano RL, Dahl NK. Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management. Nephrol Dial Transplant 2014;29:247-54.
  • [4] Leung GK, Fan YW. Chronic subdural haematoma and arachnoid cyst in autosomal dominant polycystic kidney disease (ADPKD). J Clin Neurosci 2005;12:817-9.
  • [5] Belz MM, Fick-Brosnahan GM, Hughes RL, Rubinstein D, Chapman AB, Johnson AM, et al. Recurrence of intracranial aneurysms in autosomal-dominant polycystic kidney disease. Kidney Int 2003;63:1824-30.
  • [6] Pei Y, Obaji J, Dupuis A, Paterson AD, Magistroni R, Dicks E, et al. Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol 2009;20:205-12.
  • [7] Xu HW, Yu SQ, Mei CL, Li MH. Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease. Stroke 2011;42:204-6.
  • [8] Cagnazzo F, Gambacciani C, Morganti R, Perrini P. Intracranial aneurysms in patients with autosomal dominant polycystic kidney disease: prevalence, risk of rupture, and management. A systematic review. Acta Neurochir (Wien) 2017;159:811-21.
  • [9] Schrier RW, Belz MM, Johnson AM, Kaehny WD, Hughes RL, Rubinstein D, et al. Repeat imaging for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease with initially negative studies: a prospective ten-year follow-up. J Am Soc Nephrol 2004;15:1023-8.
There are 9 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Demet Yıldız 0000-0003-0807-8980

Abdülmecit Yıldız 0000-0001-5941-9103

Publication Date January 4, 2019
Submission Date January 17, 2018
Acceptance Date February 12, 2018
Published in Issue Year 2019 Volume: 5 Issue: 1

Cite

AMA Yıldız D, Yıldız A. Neurological findings in autosomal dominant polycystic kidney disease. Eur Res J. January 2019;5(1):94-97. doi:10.18621/eurj.379970

e-ISSN: 2149-3189 


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