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Year 2019, Volume: 5 Issue: 1, 14 - 19, 04.01.2019
https://doi.org/10.18621/eurj.410990

Abstract

References

  • [1] de Bold AJ. Atrial natriuretic factor: a hormone produced by the heart. Science. 1985;230:767-70.
  • [2] Nosadini R, Semplicini A, Fioretto P, Lusiani L, Trevisan R, Donadon V, et al. Sodium-lithium countertransport and cardiorenal abnormalities in essential hypertension. Hypertension 1991;18:191-8.
  • [3] Fine LG, Badie-Dezfooly B, Lowe AG, Hamzeh A, Wells J, Salehmoghaddam S. Stimulation of Na+/H+ antiport is an early event in hypertrophy of renal proximal tubular cells. Proc Natl Acad Sci U S A 1985;82:1736-40.
  • [4] Wang TJ, Larson MG, Levy D, Benjamin EJ, Leip EP, Wilson PW, et al. Impact of obesity on plasma natriuretic peptide levels. Circulation 2004;109:594-600.
  • [5] Nannipieri M, Seghieri G, Catalano C, Prontera T, Baldi S, Ferrannini E. Defective regulation and action of atrial natriuretic peptide in type 2 diabetes. Horm Metab Res 2002;34:265-70.
  • [6] Moro C, Berlan M. Cardiovascular and metabolic effects of natriuretic peptides. Fundam Clin Pharmacol 2006;20:41-9.
  • [7] Boyuk B, Atalay H, Degirmencioglu S, Altay M, Guzel S, Celebi A, et al. Is there a relation between serum vitamin D level and microvascular comlications in type 2 diabetes? Eurasian J Med Oncol 2017;1:190-6.
  • [8] Jacobs EM, Vervoort G, Branten AJ, Klasen I, Smits P, Wetzels JF. Atrial natriuretic peptide increases albuminuria in type I diabetic patients: evidence for blockade of tubular protein reabsorption. Eur J Clin Invest 1999;29:109-15.
  • [9] McKenna K, Smith D, Sherlock M, Moore K, O'Brien E, Tormey W, et al. Elevated plasma concentrations of atrial and brain natriuretic peptide in type 1 diabetic subjects. Ir J Med Sci 2005;174:53-7.
  • [10] Vesely DL, Gower WR, Jr., Dietz JR, Overton RM, Clark LC, Antwi EK, et al. Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats. Metabolism 1999;48:771-8.
  • [11] Rollin R, Mediero A, Martinez-Montero JC, Roldan-Pallares M, Suarez-Leoz M, Vidal-Fernandez P, et al. Atrial natriuretic peptide in the vitreous humor and epiretinal membranes of patients with proliferative diabetic retinopathy. Mol Vis 2004;10:450-7.
  • [12] Salas-Ramirez M, Ariza Andraca R, Frati Munari A, Munoz H, Altamirano P. Effect of plasma volume expansion on auricular natriuretic peptide in non-dependent insulin diabetic patients with autonomic neuropathy. Arch Med Res 1995;26:35-40.

The relationship between atrial natriuretic peptide and microvascular complications of diabetes

Year 2019, Volume: 5 Issue: 1, 14 - 19, 04.01.2019
https://doi.org/10.18621/eurj.410990

Abstract

Objective: In this study, we aimed to determine the relationship between the atrial
natriuretic peptide and microvascular complications of diabetes.

Methods: Sixty patients with type 2 diabetes mellitus were enrolled into the study.
Patients with a chronic disease other than diabetes mellitus were excluded from
the study. The body-mass index, waist circumference, and hip circumference were
measured and blood samples for routine biochemical tests were taken after at
least 12 hours fasting. The microvascular complications of the patients were
evaluated.

Results: Thirty-two of the patients had microvascular complications
whereas 28 of them did not. Age, body mass index, waist and hip circumference,
and atrial natriuretic peptide levels were significantly higher in the group
with microvascular complications than those without complications. There was no
significant difference in parameters like; waist-hip ratio, blood glucose,
HbA1c, fasting insulin, fasting HOMA, sodium, potassium, magnesium, calcium and
lipid levels between the two groups. When the relationship between atrial
natriuretic peptide and obesity, retinopathy, neuropathy, nephropathy, duration
of diabetes, HbA1c, and sex are evaluated separately, the only significant
parameters related to atrial natriuretic peptide were the body-mass index,
waist circumference, hip circumference measurements, and neuropathy.

Conclusions: Positive correlations between serum atrial natriuretic peptide levels and
body-mass index, waist circumference, and hip circumference measurements were
determined. Also, serum atrial natriuretic peptide levels were significantly
higher in patients with obesity or neuropathy than those without obesity or
neuropathy. 











References

  • [1] de Bold AJ. Atrial natriuretic factor: a hormone produced by the heart. Science. 1985;230:767-70.
  • [2] Nosadini R, Semplicini A, Fioretto P, Lusiani L, Trevisan R, Donadon V, et al. Sodium-lithium countertransport and cardiorenal abnormalities in essential hypertension. Hypertension 1991;18:191-8.
  • [3] Fine LG, Badie-Dezfooly B, Lowe AG, Hamzeh A, Wells J, Salehmoghaddam S. Stimulation of Na+/H+ antiport is an early event in hypertrophy of renal proximal tubular cells. Proc Natl Acad Sci U S A 1985;82:1736-40.
  • [4] Wang TJ, Larson MG, Levy D, Benjamin EJ, Leip EP, Wilson PW, et al. Impact of obesity on plasma natriuretic peptide levels. Circulation 2004;109:594-600.
  • [5] Nannipieri M, Seghieri G, Catalano C, Prontera T, Baldi S, Ferrannini E. Defective regulation and action of atrial natriuretic peptide in type 2 diabetes. Horm Metab Res 2002;34:265-70.
  • [6] Moro C, Berlan M. Cardiovascular and metabolic effects of natriuretic peptides. Fundam Clin Pharmacol 2006;20:41-9.
  • [7] Boyuk B, Atalay H, Degirmencioglu S, Altay M, Guzel S, Celebi A, et al. Is there a relation between serum vitamin D level and microvascular comlications in type 2 diabetes? Eurasian J Med Oncol 2017;1:190-6.
  • [8] Jacobs EM, Vervoort G, Branten AJ, Klasen I, Smits P, Wetzels JF. Atrial natriuretic peptide increases albuminuria in type I diabetic patients: evidence for blockade of tubular protein reabsorption. Eur J Clin Invest 1999;29:109-15.
  • [9] McKenna K, Smith D, Sherlock M, Moore K, O'Brien E, Tormey W, et al. Elevated plasma concentrations of atrial and brain natriuretic peptide in type 1 diabetic subjects. Ir J Med Sci 2005;174:53-7.
  • [10] Vesely DL, Gower WR, Jr., Dietz JR, Overton RM, Clark LC, Antwi EK, et al. Elevated atrial natriuretic peptides and early renal failure in type 2 diabetic Goto-Kakizaki rats. Metabolism 1999;48:771-8.
  • [11] Rollin R, Mediero A, Martinez-Montero JC, Roldan-Pallares M, Suarez-Leoz M, Vidal-Fernandez P, et al. Atrial natriuretic peptide in the vitreous humor and epiretinal membranes of patients with proliferative diabetic retinopathy. Mol Vis 2004;10:450-7.
  • [12] Salas-Ramirez M, Ariza Andraca R, Frati Munari A, Munoz H, Altamirano P. Effect of plasma volume expansion on auricular natriuretic peptide in non-dependent insulin diabetic patients with autonomic neuropathy. Arch Med Res 1995;26:35-40.
There are 12 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Pınar Karakaya 0000-0003-3337-4423

Bahar Özdemir This is me 0000-0003-4111-2941

Meral Mert 0000-0003-3431-0915

Hakan Koçoğlu 0000-0002-9208-2693

Abdulbaki Kumbasar 0000-0001-7466-9434

Publication Date January 4, 2019
Submission Date March 29, 2018
Acceptance Date June 17, 2018
Published in Issue Year 2019 Volume: 5 Issue: 1

Cite

AMA Karakaya P, Özdemir B, Mert M, Koçoğlu H, Kumbasar A. The relationship between atrial natriuretic peptide and microvascular complications of diabetes. Eur Res J. January 2019;5(1):14-19. doi:10.18621/eurj.410990

e-ISSN: 2149-3189 


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