Research Article
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Year 2022, Volume: 8 Issue: 5, 567 - 572, 04.09.2022
https://doi.org/10.18621/eurj.1002436

Abstract

References

  • 1. Krebs HA, Eggleston LV. The regulation of the pentose phosphate cycle in rat liver. In: Advances in Enzyme Regulation, Weber G, ed., Adv enzyme regul. Oxford, England: Pergamon Press Ltd, 1978: pp. 421-33.
  • 2. Working Group Glucose 6 phosphate dehydrogenase deficiency. Bull WHO 1989;67:601-11.
  • 3. Luzzatto L, Ally M, Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Blood. 2020;136:1225-40.
  • 4. Beutler E. G6PD deficiency. Blood 1994;81:3613-36.
  • 5. Ruwende C, Hill A. Glucose-6-phosphate dehydrogenase deficiency and malaria. J Mol Med 1998;76:581-8.
  • 6- Akoğlu T, Özer FL, Cig S, Kümi M, Erdoğan A, Anil H. Glucose-6-phosphate dehydrogenase deficiency in Çukurova province, Turkey. Int J Epidemiol 1981;10:27-9.
  • 7. Albayrak C, Albayrak D. Red cellglucose 6-phosphate dehydrogenase deficiency in the northern region of Turkey: is G6PD deficiency exclusively a male disease? Pediatr Hematol Oncol 2015;32:85-91.
  • 8. Çelik HT, Günbey C, Unal Ş, Gümrük F, Yurdakök M. Glucose-6-phosphate dehydrogenase deficiency in neonatal hyperbilirubinaemia: Hacettepe experience. J Paediatr Child Health 2013;9:399-400.
  • 9. Acıpayam C, Orhaner BB, Karal Y. [Screening of glucose-6-phosphate dehydrogenase deficiency in cord blood]. J Clin Anal Med 2014;5(Suppl 1):4-8. [Article in Turkish]
  • 10. Thomas JE, Kang S, Wyatt CJ, Kim FS, Mangelsdorff AD, Weigel FK. Glucose-6- phosphate dehydrogenase deficiency is associated with cardiovascular disease in U.S. military centers. Tex Heart Inst J 2018;45:144-50.
  • 11. Hoiberg A, Ernst J, Uddin DE. Sickle cell trait and glucose-6-phosphate dehydrogenase deficiency: effects on health and military performance in Black naval enlistees. Arch Intern Med 1981;141:1485-8.
  • 12. Jan-Gowth Chang, Ta-Chih Liu. Glucose-6-phosphate dehydrogenase deficiency. Crit Rev Oncol Hematol 1995;20:1-7.
  • 13. Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis 2009;42:267-78.
  • 14. Sodeinde O. Glucose-6-phosphate dehydrogenase deficiency. Baillieres Clin Haematol 1992;5:367-82.
  • 15. Nixon AD, Buchanan JG. Survey for erythrocyte glucose-6-phosphate dehydrogenase deficiency in Polynesians. Am J Hum Genet 1969;21:305-9.
  • 16. Aksu TA, Esen F, Dolunay MS, Alicigüzel Y, Yücel G, Cali S, et al. Erytrocyte glucose-6-phosphate dehydrogenase deficiency in Antalya Province, Turkey: an epidemiologic and biochemical study. Am J Epidemiol 1990;131:1094-7.
  • 17. Turan Y. Prevalence of erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency in the population of western Turkey. Arch Med Res 2006;37:880-2.
  • 18. Lim F, Vulliamy T, Abdalla SH. An Ashkenazi Jewish women presenting with Favisim. J Clin Pathol 2015;58:317-9.
  • 19. Harcke SJ, Rizzolo D, Harcke HT. G6PD deficiency: an update. JAAPA 2019;32:21-6.
  • 20. Altay C, Gumruk F. Red cell glucose-6-phosphate dehydrogenase deficiency in Turkey. Turk J Hematol 2008;25:1-7.
  • 21. Atay E, Bozaykut A, Ipek IO. Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia. J Trop Pediatr. 2006;52:56-8.
  • 22. Eissa AA, Haji BA, Al-Doski AA. G6PD deficiency prevalence as a cause of neonatal jaundice in a neonatal ward in Dohuk, Iraq. Am J Perinatol 2021;38:575-80.
  • 23. Dechyotin S, Sakunthai K, Khemtonglang N, Yamsri S, Sanchaisuriya K, Kitcharoen K, et al. Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency in females from previously malaria endemic regions in Northeastern Thailand and identification of a novel G6PD variant. Mediterr J Hematol Infect Dis 2021;13:e2021029.

Regional distribution of glucose-6-phosphate dehydrogenase deficiency in Turkey and evaluation of clinical findings: a multicenter study

Year 2022, Volume: 8 Issue: 5, 567 - 572, 04.09.2022
https://doi.org/10.18621/eurj.1002436

Abstract

Objectives: The single most inherited enzyme deficiency is that of glucose-6-phosphate dehydrogenase (G6PD) with a presence in almost 400 million of theworld’spopulation. Thenumber of reported G6PD mutations is 186. Furthermore, geographical location is a determining factor for the prevalence of G6PD. Therefore, much of the existing epidemiological literature concerning this issue in Turkey has reported data specific to cities and regions. The purpose of this study was to examine G6PD deficiency in a sample of subjects. Outcome measures reported in this study include the clinical factors as sociated with the deficiency, as well as in geographical dispersion across regional locations in Turkey.


Methods:
This is a retrospective, cross-sectional study. The sample comprised 308 subjects with a G6PD diagnosis. Data collection commenced in January 2011, and was completed by May 2020.

Results: In Turkey, the Mediterranean region has the greatest prevalence of G6PD enzyme deficiency. Subjects presenting with this deficiency were also diagnosed with haemolytic anaemia that was attributed to favism. Subsequently, drug and neonatal hyperbilirubinemia-induced haemolysis ensued. Over 90% of subjects diagnosed with a critical G6PD deficiency and recurrent haemolysis were allocated to the Class II variant.


Conclusions:
The Mediterranean, along with Agean and Marmara regions are where the highest prevalence of G6PD enzyme deficiency are observed. Favism-induced haemolytic anaemia is the most often identified clinical precursor to diagnosis of G6PD deficiency in Turkey. The most common clinical feature after this condition is drug related haemolysis and the onset neonatal hyperbilirubinemia.

References

  • 1. Krebs HA, Eggleston LV. The regulation of the pentose phosphate cycle in rat liver. In: Advances in Enzyme Regulation, Weber G, ed., Adv enzyme regul. Oxford, England: Pergamon Press Ltd, 1978: pp. 421-33.
  • 2. Working Group Glucose 6 phosphate dehydrogenase deficiency. Bull WHO 1989;67:601-11.
  • 3. Luzzatto L, Ally M, Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Blood. 2020;136:1225-40.
  • 4. Beutler E. G6PD deficiency. Blood 1994;81:3613-36.
  • 5. Ruwende C, Hill A. Glucose-6-phosphate dehydrogenase deficiency and malaria. J Mol Med 1998;76:581-8.
  • 6- Akoğlu T, Özer FL, Cig S, Kümi M, Erdoğan A, Anil H. Glucose-6-phosphate dehydrogenase deficiency in Çukurova province, Turkey. Int J Epidemiol 1981;10:27-9.
  • 7. Albayrak C, Albayrak D. Red cellglucose 6-phosphate dehydrogenase deficiency in the northern region of Turkey: is G6PD deficiency exclusively a male disease? Pediatr Hematol Oncol 2015;32:85-91.
  • 8. Çelik HT, Günbey C, Unal Ş, Gümrük F, Yurdakök M. Glucose-6-phosphate dehydrogenase deficiency in neonatal hyperbilirubinaemia: Hacettepe experience. J Paediatr Child Health 2013;9:399-400.
  • 9. Acıpayam C, Orhaner BB, Karal Y. [Screening of glucose-6-phosphate dehydrogenase deficiency in cord blood]. J Clin Anal Med 2014;5(Suppl 1):4-8. [Article in Turkish]
  • 10. Thomas JE, Kang S, Wyatt CJ, Kim FS, Mangelsdorff AD, Weigel FK. Glucose-6- phosphate dehydrogenase deficiency is associated with cardiovascular disease in U.S. military centers. Tex Heart Inst J 2018;45:144-50.
  • 11. Hoiberg A, Ernst J, Uddin DE. Sickle cell trait and glucose-6-phosphate dehydrogenase deficiency: effects on health and military performance in Black naval enlistees. Arch Intern Med 1981;141:1485-8.
  • 12. Jan-Gowth Chang, Ta-Chih Liu. Glucose-6-phosphate dehydrogenase deficiency. Crit Rev Oncol Hematol 1995;20:1-7.
  • 13. Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis 2009;42:267-78.
  • 14. Sodeinde O. Glucose-6-phosphate dehydrogenase deficiency. Baillieres Clin Haematol 1992;5:367-82.
  • 15. Nixon AD, Buchanan JG. Survey for erythrocyte glucose-6-phosphate dehydrogenase deficiency in Polynesians. Am J Hum Genet 1969;21:305-9.
  • 16. Aksu TA, Esen F, Dolunay MS, Alicigüzel Y, Yücel G, Cali S, et al. Erytrocyte glucose-6-phosphate dehydrogenase deficiency in Antalya Province, Turkey: an epidemiologic and biochemical study. Am J Epidemiol 1990;131:1094-7.
  • 17. Turan Y. Prevalence of erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency in the population of western Turkey. Arch Med Res 2006;37:880-2.
  • 18. Lim F, Vulliamy T, Abdalla SH. An Ashkenazi Jewish women presenting with Favisim. J Clin Pathol 2015;58:317-9.
  • 19. Harcke SJ, Rizzolo D, Harcke HT. G6PD deficiency: an update. JAAPA 2019;32:21-6.
  • 20. Altay C, Gumruk F. Red cell glucose-6-phosphate dehydrogenase deficiency in Turkey. Turk J Hematol 2008;25:1-7.
  • 21. Atay E, Bozaykut A, Ipek IO. Glucose-6-phosphate dehydrogenase deficiency in neonatal indirect hyperbilirubinemia. J Trop Pediatr. 2006;52:56-8.
  • 22. Eissa AA, Haji BA, Al-Doski AA. G6PD deficiency prevalence as a cause of neonatal jaundice in a neonatal ward in Dohuk, Iraq. Am J Perinatol 2021;38:575-80.
  • 23. Dechyotin S, Sakunthai K, Khemtonglang N, Yamsri S, Sanchaisuriya K, Kitcharoen K, et al. Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency in females from previously malaria endemic regions in Northeastern Thailand and identification of a novel G6PD variant. Mediterr J Hematol Infect Dis 2021;13:e2021029.
There are 23 citations in total.

Details

Primary Language English
Subjects Haematology
Journal Section Original Articles
Authors

Selim Sayın 0000-0002-7197-6890

Emrah Kılıçaslan 0000-0002-0944-4068

Murat Yıldırım 0000-0001-6416-9575

Gökhan Özgür 0000-0002-8674-8997

Kürşat Kaptan 0000-0002-7335-2133

Cengiz Beyan 0000-0003-1716-539X

Meltem Aylı 0000-0001-5766-5642

Publication Date September 4, 2022
Submission Date September 29, 2021
Acceptance Date April 4, 2022
Published in Issue Year 2022 Volume: 8 Issue: 5

Cite

AMA Sayın S, Kılıçaslan E, Yıldırım M, Özgür G, Kaptan K, Beyan C, Aylı M. Regional distribution of glucose-6-phosphate dehydrogenase deficiency in Turkey and evaluation of clinical findings: a multicenter study. Eur Res J. September 2022;8(5):567-572. doi:10.18621/eurj.1002436

e-ISSN: 2149-3189 


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