Research Article
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Year 2022, Volume: 8 Issue: 6, 869 - 881, 04.11.2022
https://doi.org/10.18621/eurj.910253

Abstract

References

  • 1. Scangas, GA, Bleier BS. Anosmia: Differential diagnosis, evaluation, and management. Am J Rhinol Allergy 2017;31:3-7.
  • 2. Whitcroft KL, Hummel T. Clinical diagnosis and current management strategies for olfactory dysfunction: a review. JAMA Otolaryngol Head Neck Surg 2019;145:846-53.
  • 3. Yang J, Pinto JM. The epidemiology of olfactory disorders. Curr Otorhinolaryngol Rep 2016;4:130-41.
  • 4. Doty RL. Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate? Lancet Neurol 2017;16:478-88.
  • 5. Croy I, Hummel T. Olfaction as a marker for depression. J Neurol 2017;264:631-8.
  • 6. Daramola OO, Becker SS. An algorithmic approach to the evaluation and treatment of olfactory disorders. Curr Opin Otolaryngol Head Neck Surg 2015; 23:8-14.
  • 7. Fokkens WJ, Lund VJ, Hopkins C, Hellings P, Kern R, Reitsma S, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 2020;58:1-464.
  • 8. Chambers KJ, Sedaghat AR, Roberts DS, Caradonna DS. Nasal obstruction and anosmia. JAMA Otolaryngol Head Neck Surg 2013;139:851-2.
  • 9. Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo R M, et al. Position paper on olfactory dysfunction. Rhinol Suppl 2017;54:1-30.
  • 10. Mattos JL, Schlosser RJ, Storck KA, Soler ZM. Understanding the relationship between olfactory‐specific quality of life, objective olfactory loss, and patient factors in chronic rhinosinusitis. Int Forum Allergy Rhinol 2017;7:734-40.
  • 11. Goncalves S, Goldstein BJ. Pathophysiology of olfactory disorders and potential treatment strategies. Curr Otorhinolaryngol Rep 2016;4:115-21.
  • 12. Welge-Luessen A, Leopold DA, Miwa T. Smell and taste disorders-diagnostic and clinical work-up. Management of smell and taste disorders-a practical guide for clinicians. Stuttgart: Thieme, 2013.
  • 13. Ekström I, Sjölund S, Nordin S, Nordin Adolfsson A, Adolfsson R, Nilsson LG, et al. Smell loss predicts mortality risk regardless of dementia conversion. J Am Geriatr Soc 2017;65:1238-43.
  • 14. Banglawala SM, Oyer SL, Lohia S, Psaltis AJ, Soler ZM, Schlosser RJ. Olfactory outcomes in chronic rhinosinusitis with nasal polyposis after medical treatments: a systematic review and meta‐analysis. Int Forum Allergy Rhinol 2014;4:986-94.
  • 15. Hom DB, Sun GH, Elluru RG. A contemporary review of wound healing in otolaryngology: current state and future promise. The Laryngoscope 2009;119:2099-110.
  • 16. Jin R, Zhang L, Zhang YG. Does platelet-rich plasma enhance the survival of grafted fat? An update review. Int J Clin Exp Med 2013;6:252-8.
  • 17. Soldatova L, Campbell RG, Elkhatib AH, Schmidt TW, Pinto NR, Pinto JM, et al. Role of leukocyte–platelet-rich fibrin in endoscopic endonasal skull base surgery defect reconstruction. J Neurol Surg B Skull Base 2017;78:59-62.
  • 18. Mavrogeni P, Kanakopoulos A, Maihoub S, Maihoub S, Krasznai M, Szirmai A. Anosmia treatment by platelet rich plasma injection. Int Tinnitus J 2016;20:102-5.
  • 19. Yan CH, Mundy DC, Patel ZM. The use of platelet‐rich plasma in treatment of olfactory dysfunction: a pilot study. Laryngoscope Investig Otolaryngol 2020;5:187-93.
  • 20. Yasak AG, Yigit O, Araz Server E, Durna Dastan S, Gul M. The effectiveness of platelet-rich plasma in an anosmia-induced mice model. Laryngoscope 2018;128:157-62.
  • 21. Jankowski R. Revisiting human nose anatomy: phylogenic and ontogenic perspectives. Laryngoscope 2011;121:2461-7.
  • 22. Landis BN, Konnerth CG, Hummel T. A study on the frequency of olfactory dysfunction. Laryngoscope 2004;114:1764-9.
  • 23. Diaz D, Gomez C, Munoz-Castaneda R, Baltanas F, Alonso JR, Weruaga E. The olfactory system as a puzzle: Playing with its pieces. Anat Rec (Hoboken) 2013;296:1383-400.
  • 24. Nota J, Takahashi H, Hakuba N, Hato N, Gyo K. Treatment of neural anosmia by topical application of basic fibroblast growth factor-gelatin hydrogel in the nasal cavity: an experimental study in mice. JAMA Otolaryngol Head Neck Surg 2013;139:396-400.
  • 25. Rudmik L, Smith TL. Olfactory improvement after endoscopic sinus surgery. Curr Opin Otolaryngol Head Neck Surg 2012;20:29-32.
  • 26. Hulett KJ, Stankiewicz JA. Primer sinüs cerrahisi. Cummings Otolaringoloji Baş ve Boyun Cerrahisi. Çeviri editörü: Koç C. Güneş Tıp Kitapevi: Ankara. 2007; 1229-54.
  • 27. Rudmik L, Soler ZM, Orlandi RR, Stewart MG, Bhattacharyya N, Kennedy DW, et al. Early postoperative care following endoscopic sinus surgery: an evidence‐based review with recommendations. Int Forum Allergy Rhinol 2011;1:417-30.
  • 28. Wright ED, Agrawal S. Impact of perioperative systemic steroids on surgical outcomes in patients with chronic rhinosinusitis with polyposis: evaluation with the novel perioperative Sinus Endoscopy (POSE) scoring system. Laryngoscope 2007;117(11 Pt 2 Suppl 115):1-28.
  • 29. Yilmaz B, Türkçü G, Sengül E, Gül A, Özkurt FE, Akdag M. Efficacy of N-acetylcysteine on wound healing of nasal mucosa. J Craniofac Surg 2015;26,422-6.
  • 30. Cassano M, Russo GM, Granieri C, Cassano P. Cytofunctional changes in nasal ciliated cells in patients treated with hyaluronate after nasal surgery. Am J Rhinol Allergy 2016;30:83-8.
  • 31. Rezaeian A. Outcome of spray cryotherapy plus functional endoscopic sinus surgery on management of healing in nasal polyposis. Am J Otolaryngol 2018;39:10-3.
  • 32. Grzeskowiak B, Wierzchowska M, Walorek R, Seredyka-Burduk M, Wawrzyniak K, Burduk PK. Steroid vs. antibiotic impregnated absorbable nasal packing for wound healing after endoscopic sinus surgery: A randomized, double blind, placebo-controlled study. Braz J Otorhinolaryngol 2019;85:473-80.
  • 33. Testa D, Marcuccio G, Panin G, Bianco A, Tafuri D, Thyrion FZ, et al. Nasal mucosa healing after endoscopic sinus surgery in chronic rhinosinusitis of elderly patients: role of topic alpha-tocopherol acetate. Aging Clin Exp Res 2017;29:191-5.
  • 34. Choi KY, Cho SW, Choi JJ, Zhang YL, Kim DW, Han DH, et al. Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury. World J Otorhinolaryngol Head Neck Surg 2017;3:17-23.
  • 35. Chen M, Guan M, Li J, Wang H, Yang B. Effects of hepatocyte growth factor on wound healing of rabbit maxillary sinus mucosa. J Otolaryngol Head Neck Surg 2012;41:253-8.
  • 36. Jorissen M, Bachert C. Effect of corticosteroids on wound healing after endoscopic sinus surgery. Rhinology 2009;47:280-6.
  • 37. Poetker DM, Reh DD. A comprehensive review of the adverse effects of systemic corticosteroids. Otolaryngol Clin North Am 2010;43:753-68.
  • 38. Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci 2008;13:3532-48.
  • 39. Poetker DM, Mendolia-Loffredo S, Smith TL. Outcomes of endoscopic sinus surgery for chronic rhinosinusitis associated with sinonasal polyposis. Am J Rhinol 2007;21:84-8.
  • 40. Albu S, Lucaciu R. Prophylactic antibiotics in endoscopic sinus surgery: a short follow-up study. Am J Rhinol Allergy 2010;24:306-9.
  • 41. Litvack JR, Mace J, Smith TL. Does olfactory function improve after endoscopic sinus surgery? Otolaryngol Head Neck Surg 2009;140:312-9.
  • 42. Rudmik L, Smith TL. Olfactory improvement after endoscopic sinüs surgery. Curr Opin Otolaryngol Head Neck Surg 2012;20:29-32.
  • 43. Soler ZM, Smith TL. Quality of life outcomes after functional endoscopic sinus surgery. Otolaryngol Clin North Am 2010;43:605-12.
  • 44. Smith TL, Litvack JR, Hwang PH, Loehrl TA, Mace JC, Fong KJ, James KE. Determinants of outcomes of sinus surgery: a multi-institutional prospective cohort study. Otolaryngol Head Neck Surg 2010;142:55-63.
  • 45. Kennedy JL, Hubbard MA, Huyett P, Patrie JT, Borish L, Payne SC. Sino-nasal outcome test (SNOT-22): a predictor of postsurgical improvement in patients with chronic sinusitis. Ann Allergy Asthma Immunol 2013;111:246-51.
  • 46. Kütük SG, Özdaş T. The impact of platelet-rich plasma therapy on short-term postoperative outcomes of pediatric tonsillectomy patients. Eur Arch Otorhinolaryngol 2019;276:489-95.
  • 47. Ricci E, Riva G, Dagna F, Cavalot AL. The use of platelet-rich plasma gel in superficial parotidectomy Acta Otorhinolaryngol Ital 2019;39:363-6.
  • 48. Aksoy MA, Açıkalın MF, Gürbüz MK, Özüdoğru EN, Canaz F, Kaya E, et al. Efficacy of platelet-rich plasma on fat grafts in the repair of tympanic membrane perforations: an experimental study. J Int Adv Oto 2018;14:58-62.
  • 49. Araújo MMD, Murashima AAB, Alves VM, Jamur MC, Hyppolito MA. Spontaneous healing of the tympanic membrane after traumatic perforation in rats. Braz J Otorhinolaryngol 2014;80:330-8.

The effectiveness of platelet rich plasma therapy in chronic sinusitis patients with odor disorder undergoing endoscopic sinus surgery

Year 2022, Volume: 8 Issue: 6, 869 - 881, 04.11.2022
https://doi.org/10.18621/eurj.910253

Abstract

Objectives: In this study, the objective was to compare the effectiveness of fluticasone dipropionate and platelet-rich plasma treatments added to the treatment in patients undergoing functional endoscopic sinus surgery in patients with chronic sinusitis involving odor dysfunction, different stages and types of sinusitis.

Methods: The study included a total of 60 patients between 18 and 60 years who underwent endoscopic sinus surgery due to chronic paranasal sinus infection followed by olfactory dysfunction. Group 1: paranasal sinus surgery + steroid therapy (first 30 patients) and Group 2: paranasal sinus surgery + steroid therapy + PRP therapy (second 30 patients) were grouped together without the patients' knowledge of the operating physician and of the treatment protocol. For the paranasal sinus CT evaluation, Lund-Mackey staging was used and the degree of the disease was determined using the Kennedy staging system. Modified Sniffin Stick test was applied to all patients in the preoperative 1st week and in the 3rd month postoperatively. The Modified Sniffin Stick test was conducted on all patients during the preoperative 1st week and the postoperative 3rd month. The modified Sniffin Stick test and endoscopic evaluation score were evaluated and whether or not the patients benefited from PRP treatment were compared.


Results:
According to the postoperative endoscopy score, there was a difference between the experimental group and the control group in terms of postoperative endoscopy score, and it was found to be statistically significant. Besides, the postoperative endoscopy score of the experimental group was found to be lower than the control group. The average of Modified Sniffin’ Stick Test scores in the postoperative period of the patients in the study was 28.27 ± 7.88 for the experimental group, while it was determined as 20.08 ± 5.75 for the control group, and this difference was statistically significant. The average anosmia times of the experimental and control group patients in the study were compared, and the mean duration of anosmia was 48.53 ± 20.40 (6-96) for the experimental group and 44.27 ± 19.45 (6.96) for the control group. The difference in the mean duration of anosmia between the experimental and control groups was not found statistically significant.

Conclusions: In this research, PRP, which is applied to functional endoscopic sinus surgery and fluticasone dipropionate treatment, has been shown to be a readily applicable, safe and highly efficient method of treatment in patients with chronic sinusitis accompanied by smell dysfunction.

References

  • 1. Scangas, GA, Bleier BS. Anosmia: Differential diagnosis, evaluation, and management. Am J Rhinol Allergy 2017;31:3-7.
  • 2. Whitcroft KL, Hummel T. Clinical diagnosis and current management strategies for olfactory dysfunction: a review. JAMA Otolaryngol Head Neck Surg 2019;145:846-53.
  • 3. Yang J, Pinto JM. The epidemiology of olfactory disorders. Curr Otorhinolaryngol Rep 2016;4:130-41.
  • 4. Doty RL. Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate? Lancet Neurol 2017;16:478-88.
  • 5. Croy I, Hummel T. Olfaction as a marker for depression. J Neurol 2017;264:631-8.
  • 6. Daramola OO, Becker SS. An algorithmic approach to the evaluation and treatment of olfactory disorders. Curr Opin Otolaryngol Head Neck Surg 2015; 23:8-14.
  • 7. Fokkens WJ, Lund VJ, Hopkins C, Hellings P, Kern R, Reitsma S, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology 2020;58:1-464.
  • 8. Chambers KJ, Sedaghat AR, Roberts DS, Caradonna DS. Nasal obstruction and anosmia. JAMA Otolaryngol Head Neck Surg 2013;139:851-2.
  • 9. Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo R M, et al. Position paper on olfactory dysfunction. Rhinol Suppl 2017;54:1-30.
  • 10. Mattos JL, Schlosser RJ, Storck KA, Soler ZM. Understanding the relationship between olfactory‐specific quality of life, objective olfactory loss, and patient factors in chronic rhinosinusitis. Int Forum Allergy Rhinol 2017;7:734-40.
  • 11. Goncalves S, Goldstein BJ. Pathophysiology of olfactory disorders and potential treatment strategies. Curr Otorhinolaryngol Rep 2016;4:115-21.
  • 12. Welge-Luessen A, Leopold DA, Miwa T. Smell and taste disorders-diagnostic and clinical work-up. Management of smell and taste disorders-a practical guide for clinicians. Stuttgart: Thieme, 2013.
  • 13. Ekström I, Sjölund S, Nordin S, Nordin Adolfsson A, Adolfsson R, Nilsson LG, et al. Smell loss predicts mortality risk regardless of dementia conversion. J Am Geriatr Soc 2017;65:1238-43.
  • 14. Banglawala SM, Oyer SL, Lohia S, Psaltis AJ, Soler ZM, Schlosser RJ. Olfactory outcomes in chronic rhinosinusitis with nasal polyposis after medical treatments: a systematic review and meta‐analysis. Int Forum Allergy Rhinol 2014;4:986-94.
  • 15. Hom DB, Sun GH, Elluru RG. A contemporary review of wound healing in otolaryngology: current state and future promise. The Laryngoscope 2009;119:2099-110.
  • 16. Jin R, Zhang L, Zhang YG. Does platelet-rich plasma enhance the survival of grafted fat? An update review. Int J Clin Exp Med 2013;6:252-8.
  • 17. Soldatova L, Campbell RG, Elkhatib AH, Schmidt TW, Pinto NR, Pinto JM, et al. Role of leukocyte–platelet-rich fibrin in endoscopic endonasal skull base surgery defect reconstruction. J Neurol Surg B Skull Base 2017;78:59-62.
  • 18. Mavrogeni P, Kanakopoulos A, Maihoub S, Maihoub S, Krasznai M, Szirmai A. Anosmia treatment by platelet rich plasma injection. Int Tinnitus J 2016;20:102-5.
  • 19. Yan CH, Mundy DC, Patel ZM. The use of platelet‐rich plasma in treatment of olfactory dysfunction: a pilot study. Laryngoscope Investig Otolaryngol 2020;5:187-93.
  • 20. Yasak AG, Yigit O, Araz Server E, Durna Dastan S, Gul M. The effectiveness of platelet-rich plasma in an anosmia-induced mice model. Laryngoscope 2018;128:157-62.
  • 21. Jankowski R. Revisiting human nose anatomy: phylogenic and ontogenic perspectives. Laryngoscope 2011;121:2461-7.
  • 22. Landis BN, Konnerth CG, Hummel T. A study on the frequency of olfactory dysfunction. Laryngoscope 2004;114:1764-9.
  • 23. Diaz D, Gomez C, Munoz-Castaneda R, Baltanas F, Alonso JR, Weruaga E. The olfactory system as a puzzle: Playing with its pieces. Anat Rec (Hoboken) 2013;296:1383-400.
  • 24. Nota J, Takahashi H, Hakuba N, Hato N, Gyo K. Treatment of neural anosmia by topical application of basic fibroblast growth factor-gelatin hydrogel in the nasal cavity: an experimental study in mice. JAMA Otolaryngol Head Neck Surg 2013;139:396-400.
  • 25. Rudmik L, Smith TL. Olfactory improvement after endoscopic sinus surgery. Curr Opin Otolaryngol Head Neck Surg 2012;20:29-32.
  • 26. Hulett KJ, Stankiewicz JA. Primer sinüs cerrahisi. Cummings Otolaringoloji Baş ve Boyun Cerrahisi. Çeviri editörü: Koç C. Güneş Tıp Kitapevi: Ankara. 2007; 1229-54.
  • 27. Rudmik L, Soler ZM, Orlandi RR, Stewart MG, Bhattacharyya N, Kennedy DW, et al. Early postoperative care following endoscopic sinus surgery: an evidence‐based review with recommendations. Int Forum Allergy Rhinol 2011;1:417-30.
  • 28. Wright ED, Agrawal S. Impact of perioperative systemic steroids on surgical outcomes in patients with chronic rhinosinusitis with polyposis: evaluation with the novel perioperative Sinus Endoscopy (POSE) scoring system. Laryngoscope 2007;117(11 Pt 2 Suppl 115):1-28.
  • 29. Yilmaz B, Türkçü G, Sengül E, Gül A, Özkurt FE, Akdag M. Efficacy of N-acetylcysteine on wound healing of nasal mucosa. J Craniofac Surg 2015;26,422-6.
  • 30. Cassano M, Russo GM, Granieri C, Cassano P. Cytofunctional changes in nasal ciliated cells in patients treated with hyaluronate after nasal surgery. Am J Rhinol Allergy 2016;30:83-8.
  • 31. Rezaeian A. Outcome of spray cryotherapy plus functional endoscopic sinus surgery on management of healing in nasal polyposis. Am J Otolaryngol 2018;39:10-3.
  • 32. Grzeskowiak B, Wierzchowska M, Walorek R, Seredyka-Burduk M, Wawrzyniak K, Burduk PK. Steroid vs. antibiotic impregnated absorbable nasal packing for wound healing after endoscopic sinus surgery: A randomized, double blind, placebo-controlled study. Braz J Otorhinolaryngol 2019;85:473-80.
  • 33. Testa D, Marcuccio G, Panin G, Bianco A, Tafuri D, Thyrion FZ, et al. Nasal mucosa healing after endoscopic sinus surgery in chronic rhinosinusitis of elderly patients: role of topic alpha-tocopherol acetate. Aging Clin Exp Res 2017;29:191-5.
  • 34. Choi KY, Cho SW, Choi JJ, Zhang YL, Kim DW, Han DH, et al. Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury. World J Otorhinolaryngol Head Neck Surg 2017;3:17-23.
  • 35. Chen M, Guan M, Li J, Wang H, Yang B. Effects of hepatocyte growth factor on wound healing of rabbit maxillary sinus mucosa. J Otolaryngol Head Neck Surg 2012;41:253-8.
  • 36. Jorissen M, Bachert C. Effect of corticosteroids on wound healing after endoscopic sinus surgery. Rhinology 2009;47:280-6.
  • 37. Poetker DM, Reh DD. A comprehensive review of the adverse effects of systemic corticosteroids. Otolaryngol Clin North Am 2010;43:753-68.
  • 38. Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci 2008;13:3532-48.
  • 39. Poetker DM, Mendolia-Loffredo S, Smith TL. Outcomes of endoscopic sinus surgery for chronic rhinosinusitis associated with sinonasal polyposis. Am J Rhinol 2007;21:84-8.
  • 40. Albu S, Lucaciu R. Prophylactic antibiotics in endoscopic sinus surgery: a short follow-up study. Am J Rhinol Allergy 2010;24:306-9.
  • 41. Litvack JR, Mace J, Smith TL. Does olfactory function improve after endoscopic sinus surgery? Otolaryngol Head Neck Surg 2009;140:312-9.
  • 42. Rudmik L, Smith TL. Olfactory improvement after endoscopic sinüs surgery. Curr Opin Otolaryngol Head Neck Surg 2012;20:29-32.
  • 43. Soler ZM, Smith TL. Quality of life outcomes after functional endoscopic sinus surgery. Otolaryngol Clin North Am 2010;43:605-12.
  • 44. Smith TL, Litvack JR, Hwang PH, Loehrl TA, Mace JC, Fong KJ, James KE. Determinants of outcomes of sinus surgery: a multi-institutional prospective cohort study. Otolaryngol Head Neck Surg 2010;142:55-63.
  • 45. Kennedy JL, Hubbard MA, Huyett P, Patrie JT, Borish L, Payne SC. Sino-nasal outcome test (SNOT-22): a predictor of postsurgical improvement in patients with chronic sinusitis. Ann Allergy Asthma Immunol 2013;111:246-51.
  • 46. Kütük SG, Özdaş T. The impact of platelet-rich plasma therapy on short-term postoperative outcomes of pediatric tonsillectomy patients. Eur Arch Otorhinolaryngol 2019;276:489-95.
  • 47. Ricci E, Riva G, Dagna F, Cavalot AL. The use of platelet-rich plasma gel in superficial parotidectomy Acta Otorhinolaryngol Ital 2019;39:363-6.
  • 48. Aksoy MA, Açıkalın MF, Gürbüz MK, Özüdoğru EN, Canaz F, Kaya E, et al. Efficacy of platelet-rich plasma on fat grafts in the repair of tympanic membrane perforations: an experimental study. J Int Adv Oto 2018;14:58-62.
  • 49. Araújo MMD, Murashima AAB, Alves VM, Jamur MC, Hyppolito MA. Spontaneous healing of the tympanic membrane after traumatic perforation in rats. Braz J Otorhinolaryngol 2014;80:330-8.
There are 49 citations in total.

Details

Primary Language English
Subjects Otorhinolaryngology
Journal Section Original Articles
Authors

Sinem Gökçe Kütük 0000-0002-8036-540X

Muhammet Fatih Topuz 0000-0002-7996-662X

Ali Güvey 0000-0003-2972-4056

Çağrı Açıkgöz This is me 0000-0003-0203-2391

Publication Date November 4, 2022
Submission Date April 6, 2021
Acceptance Date May 21, 2021
Published in Issue Year 2022 Volume: 8 Issue: 6

Cite

AMA Gökçe Kütük S, Topuz MF, Güvey A, Açıkgöz Ç. The effectiveness of platelet rich plasma therapy in chronic sinusitis patients with odor disorder undergoing endoscopic sinus surgery. Eur Res J. November 2022;8(6):869-881. doi:10.18621/eurj.910253

e-ISSN: 2149-3189 


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