Research Article
Year 2023,
Volume: 9 Issue: 1, 73 - 80, 04.01.2023
Abstract
References
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- 2. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054-62.
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- 7. Altuna-Venegas S, Aliaga-Vega R, Maguiña JL, Parodi JF, Runzer-Colmenaresb FM. Risk of community-acquired pneumonia in older adults with sarcopenia of a hospital from Callao, Peru 2010-2015 Arch Gerontol Geriatr 2019;82:100-5.
- 8. Bahat G, Ilhan B. Sarcopenia and the cardiometabolic syndrome: a narrative review. Eur Geriatr Med 2016;6:220-3.
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- 10. Fukuda T, Bouchi R, Asakawa M, Takeuchi T, Shiba K, Tsujimoto K, et al. Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes. Diabet Med 2020;37;105-13.
- 11. Foley RN, Wang C, Ishani A, Collins AJ, Murray AM. Kidney function and sarcopenia in the United States general population: NHANES III. Am J Nephrol 2007;27:279-86.
- 12. De Buyser SL, Petrovic M, Taes YE, Toye KRC, Kaufman JM, Lapauw B, et al. Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men. Age Ageing 2016;45:602-8.
- 13. Kim JW, Yoon JS, Kim EJ, Hong HL, Kwon HH, Jung CY, et al. Prognostic implication of baseline sarcopenia for length of hospital stay and survival in patients with coronavirus disease 2019. J Gerontol A Biol Sci Med Sci 2021;76:e110-6.
- 14. Moctezuma-Velázquez P, Miranda-Zazueta G, Ortiz-Brizuela E, González-Lara MF, Tamez-Torres KM, Román-Montes CM. Low thoracic skeletal muscle area is not associated with negative outcomes in patients with COVID-19. Am J Phys Med Rehabil 2021;100:413-8.
- 15. Feng Z, Zhao H, Kang W, Liu Q, Wu J, Bragazzi NL, et al. Association of paraspinal muscle measurements on chest computed tomography with clinical outcomes in patients with severe coronavirus disease 2019. J Gerontol A Biol Sci Med Sci 2021;76:e78-84.
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- 17. Beaudart C, McCloskey E, Bruyere O, Cesari M, Rolland Y, Rizzoli R, et al. Sarcopenia in daily clinical practice: assessment and management. BMC Geriatr 2016;16:170.
- 18. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307-10.
- 19. Bland JM, Altman DG. Measuring agreement in method comparison studies. Stat Methods Med Res 1999;8:135-60.
- 20. Cosquéric G, Sebag A, Ducolombier C, Thomas C, Piette F, Weill-Engerer S. Sarcopenia is predictive of nosocomial infection in care of the elderly. Br J Nutr 2006;96:895-901.
- 21. Okazaki T, Ebihara S, Mori T, Izumi S, Ebihara T. Association between sarcopenia and pneumonia in older people. Geriatr Gerontol Int 2020;20:7-13.
- 22. Lee YJ, Park HK, Kim WY, Kim MC, Jung W, Ko BS. Muscle mass depletion associated with poor outcome of sepsis in the emergency department. Ann Nutr Metab 2018;72:336-44.
- 23. Nelke C, Dziewas R, Minnerup J, Meuth SG, Ruck T. Skeletal muscle as potential central link between sarcopenia and immune senescence. EBioMedicine 2019;49:381-8.
- 24. Conlon KC, Lugli E, Welles HC, Rosenberg SA, Fojo AT, Morris JC, et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J Clin Oncol 2015;33:74-82.
- 25. Girard D, Paquet ME, Paquin R, Beaulieu AD. Differential effects of interleukin 15 (IL 15) and IL 2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL 15. Blood 1996;88:3176-84.
- 26. Duggal NA, Pollock RD, Lazarus NR, Harridge S, Lord JM. Major features of im- munesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell 2018;17:e12750.
- 27. Tuttle CS, Thang LAN, Maier AB. Markers of inflammation and their association with muscle strength and mass: a systematic review and meta-analysis. Ageing Res Rev 2020;64:101185.
Sarcopenia is associated with mortality in patients with COVID-19 independent of other demographic risk factors
Abstract
Objectives: To investigate whether sarcopenia had an effect on in-hospital mortality independent from other demographic characteristics in patients with Coronavirus disease 2019 (COVID-19), and to determine a reliable cut-off value for sarcopenia if there is such a relationship.
Methods: A total of 302 patients with COVID-19 were included in the study. Sarcopenia was assessed by indexed skeletal muscle mass at T12 vertebrae level (T12-SMI) on initial chest computed tomography (CT). A receiver operating characteristic (ROC) curve analysis was performed to detect a cut-off value of T12-SMI for mortality prediction. Then, sarcopenia was diagnosed by this value. Multivariable logistic regression analysis was used to detect independent variables for mortality.
Results: Patients were separated into groups; 26 (8.6%) patients in the mortality group and 276 (91.4%) patients in the no-mortality group. In ROC analysis, cut-off values of 34.06 cm²/m² (sensitivity: 70%, specificity: 77%) in males and 29.36 cm²/m² (sensitivity: 67%, specificity: 69%) in females for T12-SMI were computed for mortality prediction. There were 110 (36.4%) patients with sarcopenia. Sarcopenia was more frequent in the mortality group than the no-mortality group (73.1% vs 33%, p < 0.001). In multivariate analysis age, previous cardiovascular and respiratory disease, and sarcopenia were independently associated with mortality in COVID-19 patients.
Conclusions: A cut-off value of 34.06 cm²/m² in males and 29.36 cm²/m² in females for T12-SMI can be used to diagnose sarcopenia in patients with COVID-19. Sarcopenia is clearly associated with mortality in these patients.
References
- 1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727-33.
- 2. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054-62.
- 3. Wang L, He W, Yu X, Hu D, Bao M, Liu H, et al. Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up. J Infect 2020;80:639-45.
- 4. Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, et al. COVID-19 and cardiovascular disease. Circulation 2020;141:1648-55.
- 5. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, et al. Sarcopenia: revised Europen consensus on definiton and diagnosis. Age Ageing 2019;48:16-31.
- 6. Nelke C, Dziewas R, Minnerup J, Meuth SG, Ruck T. Skeletal muscle as potential central link between sarcopenia and immune senescence. EBioMedicine 2019;49:381-8.
- 7. Altuna-Venegas S, Aliaga-Vega R, Maguiña JL, Parodi JF, Runzer-Colmenaresb FM. Risk of community-acquired pneumonia in older adults with sarcopenia of a hospital from Callao, Peru 2010-2015 Arch Gerontol Geriatr 2019;82:100-5.
- 8. Bahat G, Ilhan B. Sarcopenia and the cardiometabolic syndrome: a narrative review. Eur Geriatr Med 2016;6:220-3.
- 9. Bone AE, Hepgul N, Kon S, Maddocks M. Sarcopenia and frailty in chronic respiratory disease. Chron Respir Dis 2017;14:85-99.
- 10. Fukuda T, Bouchi R, Asakawa M, Takeuchi T, Shiba K, Tsujimoto K, et al. Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes. Diabet Med 2020;37;105-13.
- 11. Foley RN, Wang C, Ishani A, Collins AJ, Murray AM. Kidney function and sarcopenia in the United States general population: NHANES III. Am J Nephrol 2007;27:279-86.
- 12. De Buyser SL, Petrovic M, Taes YE, Toye KRC, Kaufman JM, Lapauw B, et al. Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men. Age Ageing 2016;45:602-8.
- 13. Kim JW, Yoon JS, Kim EJ, Hong HL, Kwon HH, Jung CY, et al. Prognostic implication of baseline sarcopenia for length of hospital stay and survival in patients with coronavirus disease 2019. J Gerontol A Biol Sci Med Sci 2021;76:e110-6.
- 14. Moctezuma-Velázquez P, Miranda-Zazueta G, Ortiz-Brizuela E, González-Lara MF, Tamez-Torres KM, Román-Montes CM. Low thoracic skeletal muscle area is not associated with negative outcomes in patients with COVID-19. Am J Phys Med Rehabil 2021;100:413-8.
- 15. Feng Z, Zhao H, Kang W, Liu Q, Wu J, Bragazzi NL, et al. Association of paraspinal muscle measurements on chest computed tomography with clinical outcomes in patients with severe coronavirus disease 2019. J Gerontol A Biol Sci Med Sci 2021;76:e78-84.
- 16. China, National Health Commission. Diagnosis and Treatment of Pneumonitis Caused by New Coronavirus (trial Version 7), 2020. Available at: http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1 989.shtml. Accessed: May 30, 2021.
- 17. Beaudart C, McCloskey E, Bruyere O, Cesari M, Rolland Y, Rizzoli R, et al. Sarcopenia in daily clinical practice: assessment and management. BMC Geriatr 2016;16:170.
- 18. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1:307-10.
- 19. Bland JM, Altman DG. Measuring agreement in method comparison studies. Stat Methods Med Res 1999;8:135-60.
- 20. Cosquéric G, Sebag A, Ducolombier C, Thomas C, Piette F, Weill-Engerer S. Sarcopenia is predictive of nosocomial infection in care of the elderly. Br J Nutr 2006;96:895-901.
- 21. Okazaki T, Ebihara S, Mori T, Izumi S, Ebihara T. Association between sarcopenia and pneumonia in older people. Geriatr Gerontol Int 2020;20:7-13.
- 22. Lee YJ, Park HK, Kim WY, Kim MC, Jung W, Ko BS. Muscle mass depletion associated with poor outcome of sepsis in the emergency department. Ann Nutr Metab 2018;72:336-44.
- 23. Nelke C, Dziewas R, Minnerup J, Meuth SG, Ruck T. Skeletal muscle as potential central link between sarcopenia and immune senescence. EBioMedicine 2019;49:381-8.
- 24. Conlon KC, Lugli E, Welles HC, Rosenberg SA, Fojo AT, Morris JC, et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J Clin Oncol 2015;33:74-82.
- 25. Girard D, Paquet ME, Paquin R, Beaulieu AD. Differential effects of interleukin 15 (IL 15) and IL 2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL 15. Blood 1996;88:3176-84.
- 26. Duggal NA, Pollock RD, Lazarus NR, Harridge S, Lord JM. Major features of im- munesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell 2018;17:e12750.
- 27. Tuttle CS, Thang LAN, Maier AB. Markers of inflammation and their association with muscle strength and mass: a systematic review and meta-analysis. Ageing Res Rev 2020;64:101185.
There are 27 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Radiology and Organ Imaging |
| Journal Section | Original Articles |
| Authors | |
| Publication Date | January 4, 2023 |
| Submission Date | January 12, 2022 |
| Acceptance Date | May 27, 2022 |
| Published in Issue | Year 2023 Volume: 9 Issue: 1 |
e-ISSN: 2149-3189
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