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Year 2023, Volume: 9 Issue: 5 - September 2023, 1129 - 1134, 04.09.2023
https://doi.org/10.18621/eurj.1297700

Abstract

References

  • 1. Van De Beek D, De Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004;351:1849-59.
  • 2. Ellul M, Solomon T. Acute encephalitis – diagnosis and management. Clin Med 2018;18:155-9.
  • 3. Brouwer MC, Tunkel AR, Van De Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev 2010;23:467-92.
  • 4. McGill F, Heyderman RS, Panagiotou S, Tunkel AR, Solomon T. Acute bacterial meningitis in adults. Lancet 2016;388:3036-47.
  • 5. Adanir H, Akincioğlu P. [The importance of the systemic immune-inflammation index in ulcerative colitis]. Dicle Med J 2022;49:521-8. [Article in Turkish]
  • 6. Güngör A, Göktuğ A, Yaradılmış RM, Güneylioğlu MM, Öztürk B, Bodur İ, et al. Utility of the systemic immune-inflammation index to predict serious bacterial infections in infants with fever without a source. Postgrad Med 2022;134:698-702.
  • 7. Aydogan S, Dilli D, Soysal C, Akduman H, Örün UA, Taşar M, et al. Role of the systemic immune-inflammatory index in early diagnosis of sepsis in newborns with CHD. Cardiol Young 2022;32:1826-32.
  • 8. Uzunoglu H, Kaya S. Does systemic immune inflammation index have predictive value in gastric cancer prognosis? North Clin Istanb 2023;10:24-32.
  • 9. Mei Y, Yang J, Yuan Y, Liu Y, Liu X, Li M, et al. Systemic inflammation index values are associated with worsened disease severity and poor response to autoimmune encephalitis treatment. Front Neurol 2021;12:709553.
  • 10. Si̇vri̇ce ME, Kumbul YÇ, Yasan H, Tüz M. Can We use neutrophil: lymphocyte ratio, platelet: lymphocyte ratio, and systemic immune-inflammation index values to differentiate larynx carcinoma from benign and premalignant laryngeal diseases in the elderly? J Ear Nose Throat Head Neck Surg 2021;29:185-9.
  • 11. Karaali̇ R, Topal F, Payza U, Akyol PY, Kavalci C, Karakaya Z, et al. Neutrophil lymphocyte ratio in predicting severity of injury, complıcatıons and mortality in caustıc ingestıon cases. Acta Medica Mediterranea 2020,36:3501-7.
  • 12. Venkatesan A. Encephalitis and brain abscess. Continuum (Minneap Minn) 2021;27:855-86.

A new adjunct in the differentiation of encephalitis and meningitis after negative cerebrospinal fluid culture: systemic inflammatory immune index

Year 2023, Volume: 9 Issue: 5 - September 2023, 1129 - 1134, 04.09.2023
https://doi.org/10.18621/eurj.1297700

Abstract

Objectives: Encephalitis and meningitis can have serious and potentially life-threatening consequences. This study aims to investigate whether the effects of systemic immune inflammation index (SII) and neutrophil/lymphocyte (N/L) ratio on differential diagnosis, severity, and clinical outcomes are superior to each other in patients diagnosed with encephalitis and meningitis in the emergency department.

Methods: Patients aged 18 years and older who presented to the adult emergency department of the hospital and were diagnosed with meningitis or encephalitis between January and December 2022 were included in the study. Patients under 18 and those with missing data in their files were excluded from the study. N/L ratio, SII values, and other associated parameters were compared between the group with mortality and the group who survived both diseases.

Results: There were significant differences in neutrophil, lymphocyte, N/L ratio, SII, and C-reactive protein (CRP) values between meningitis and encephalitis patients. N/L ratio and SII values were significantly lower in encephalitis patients than in meningitis patients. There was no significant difference in any of the parameters between surviving and deceased patients.

Conclusions: Simple calculable ratios such as SII and N/L ratio can be a supportive parameter in the differential diagnosis of the disease. However, it has been observed that using these indices is not a useful tool in determining the severity and prognosis of patients with encephalitis and meningitis.

References

  • 1. Van De Beek D, De Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004;351:1849-59.
  • 2. Ellul M, Solomon T. Acute encephalitis – diagnosis and management. Clin Med 2018;18:155-9.
  • 3. Brouwer MC, Tunkel AR, Van De Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev 2010;23:467-92.
  • 4. McGill F, Heyderman RS, Panagiotou S, Tunkel AR, Solomon T. Acute bacterial meningitis in adults. Lancet 2016;388:3036-47.
  • 5. Adanir H, Akincioğlu P. [The importance of the systemic immune-inflammation index in ulcerative colitis]. Dicle Med J 2022;49:521-8. [Article in Turkish]
  • 6. Güngör A, Göktuğ A, Yaradılmış RM, Güneylioğlu MM, Öztürk B, Bodur İ, et al. Utility of the systemic immune-inflammation index to predict serious bacterial infections in infants with fever without a source. Postgrad Med 2022;134:698-702.
  • 7. Aydogan S, Dilli D, Soysal C, Akduman H, Örün UA, Taşar M, et al. Role of the systemic immune-inflammatory index in early diagnosis of sepsis in newborns with CHD. Cardiol Young 2022;32:1826-32.
  • 8. Uzunoglu H, Kaya S. Does systemic immune inflammation index have predictive value in gastric cancer prognosis? North Clin Istanb 2023;10:24-32.
  • 9. Mei Y, Yang J, Yuan Y, Liu Y, Liu X, Li M, et al. Systemic inflammation index values are associated with worsened disease severity and poor response to autoimmune encephalitis treatment. Front Neurol 2021;12:709553.
  • 10. Si̇vri̇ce ME, Kumbul YÇ, Yasan H, Tüz M. Can We use neutrophil: lymphocyte ratio, platelet: lymphocyte ratio, and systemic immune-inflammation index values to differentiate larynx carcinoma from benign and premalignant laryngeal diseases in the elderly? J Ear Nose Throat Head Neck Surg 2021;29:185-9.
  • 11. Karaali̇ R, Topal F, Payza U, Akyol PY, Kavalci C, Karakaya Z, et al. Neutrophil lymphocyte ratio in predicting severity of injury, complıcatıons and mortality in caustıc ingestıon cases. Acta Medica Mediterranea 2020,36:3501-7.
  • 12. Venkatesan A. Encephalitis and brain abscess. Continuum (Minneap Minn) 2021;27:855-86.
There are 12 citations in total.

Details

Primary Language English
Subjects Emergency Medicine
Journal Section Original Articles
Authors

Cüneyt Arıkan 0000-0001-6823-5357

Osman Sezer Çınaroğlu 0000-0002-3860-2053

Mehmet Göktuğ Efgan 0000-0002-0794-1239

Efe Kanter 0000-0002-0208-950X

Ejder Saylav Bora 0000-0002-2448-2337

Early Pub Date August 17, 2023
Publication Date September 4, 2023
Submission Date May 16, 2023
Acceptance Date July 12, 2023
Published in Issue Year 2023 Volume: 9 Issue: 5 - September 2023

Cite

AMA Arıkan C, Çınaroğlu OS, Efgan MG, Kanter E, Bora ES. A new adjunct in the differentiation of encephalitis and meningitis after negative cerebrospinal fluid culture: systemic inflammatory immune index. Eur Res J. September 2023;9(5):1129-1134. doi:10.18621/eurj.1297700

e-ISSN: 2149-3189 


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