Research Article
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Spontan ve invitro fertilizasyon ikiz gebeliklerinde gebeliğe ait ve neonatal verilerin karşılaştırılması

Year 2018, Volume: 15 Issue: 3, 250 - 254, 12.12.2018

Coşkun Şimşir Ziya Kalem Batuhan Bakırarar Muberra Namlı Kalem

Abstract

Amaç: Bu çalışmanın amacı invitro fertizasyon(IVF) tedavisi ile gerçekleşen ikiz gebelikler ile

spontan gerçekleşen ikiz gebeliklerin gebelik ve perinatal dönem bulguları açısından

karşılaştırılmasıdır.

Materyal ve Method: Bu çalışma, 2015-2018 yılları arasında, canlı doğumu gerçekleşen dikoryonik

diamniotik ikiz gebeliklerin verileri incelenerek gerçekleştirilmiş bir retrospektif kohort çalışmasıdır.

Bu araştırmada gebeliği spontan olarak gerçekleşmiş ikiz gebelikler grubu ve yardımcı üreme

teknikleri kullanılarak gebe kalmış IVF ikiz grubu olmak üzere iki çalışma grubu vardır

Bulgular: Gebeliğe ve doğuma ait problemler her iki grup arasında farklılık göstermemiştir. IVF ikiz

gebeliklerinde prematurite, düşük doğum ağırlığı ve 1. Dakika APGAR skor düşüklüğü oranlarının

daha fazla olduğu görülmüştür. Perinatal mortalite oranları her iki grupta benzer bulunmuştur.

Sonuç: Bu çalışmada gösterilmiştir ki; ikiz gebeliklerde tek gebeliklere göre zaten daha yüksek

riske sahip olan erken doğum ve düşük doğum ağırlığı riskleri, IVF ikiz gebeliklerinde daha da fazla

artmaktadır. Bu sonuçlar gözönüne alınarak tek embryo transferine yönelmek ve iatrojenik çoğul

gebeliklere destek vermemek önerilmelidir.

Keywords

IVF İkiz gebelikler tekil gebelikler neonatal sonuçlar

References

  • Kaveh M, Ghajarzadeh M, Davari Tanha F, Nayeri F, Keramati Z, et al. Pregnancy Complications and Neonatal Outcomes in Multiple Pregnancies:A Comparison between Assisted Reproductive Techniques and Spontaneous Conception. Int J Fertil Steril. 2015;8(4):367-72.
  • Elster N. Less is more: the risks of multiple births. The Institute for Science, Law, and Technology Working Group on Reproductive Technology. Fertil Steril. 2000;74(4):617-23.
  • Kerin JF, Warnes GM, Quinn PJ, Jeffrey R, Kirby C, Matthews CD, et al. Incidence of multiple pregnancy after in-vitro fertilisation and embryo transfer. Lancet. 1983;2(8349):537-40.
  • Pandey S, Shetty A, Hamilton M, Bhattacharya S, Maheshwari A. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Hum Reprod Update. 2012;18(5):485-503
  • Qin J, Wang H, Sheng X, Liang D, Tan H, Xia J. Pregnancy-related complications and adverse pregnancy outcomes in multiple pregnancies resulting from assisted reproductive technology: a meta-analysis of cohort studies. Fertil Steril. 2015;103(6):1492-508.e1-7.
  • Massenkeil G, Alexander T, Rosen O, Dörken B, Burmester G, Radbruch A, et al. Long-term follow-up of fertility and pregnancy in autoimmune diseases after autologous haematopoietic stem cell transplantation. Rheumatol Int. 2016;36(11):1563-1568.
  • Peterson B, Boivin J, Norré J, Smith C, Thorn P, Wischmann, T. An introduction to infertility counseling: a guide for mental health and medical professionals. J Assist Reproduction Gen.2012; 29(3), 243-248.
  • Sazonova A, Källen K, Thurin-Kjellberg A, Wennerholm UB, Bergh C. Factors affecting obstetric outcome of singletons born after IVF. Human Reprod.2011; 26(10), 2878-2886.
  • Greil AL, Slauson‐Blevins K, McQuillan J. The experience of infertility: a review of recent literature. Soc Health Ill . 2010;32(1), 140-162.
  • Barda, G., Gluck, O., Mizrachi, Y., & Bar, J. (2017). A comparison of maternal and perinatal outcome between in vitro fertilization and spontaneous dichorionic-diamniotic twin pregnancies. J Matern Fet Neo Med. 2017; 30(24), 2974-2977.
  • Pinborg A, Loft A, Schmidt L, Langhoff‐Roos J, Andersen AN. Maternal risks and perinatal outcome in a Danish national cohort of 1005 twin pregnancies: the role of in vitro fertilization. Acta Obstet Gynecol Scand. 2004; 83(1), 75-84.
  • Luke B, Gopal D, Cabral H, Stern JE, Diop H. Adverse pregnancy, birth, and infant outcomes in twins: effects of maternal fertility status and infant gender combinations; the Massachusetts Outcomes Study of Assisted Reproductive Technology. Am JObstet Gynecol. 2017;217(3), 330-e1.
  • Caserta D, Bordi G, Stegagno M, Filippini F, Podagrosi M, Roselli D et al. Maternal and perinatal outcomes in spontaneous versus assisted conception twin pregnancies. Eur J Obstet Gynecol Reprod Biol. 2014;174, 64-69.
  • Savitz DA, Danilack VA, Elston B, Lipkind HS. Pregnancy-induced hypertension and diabetes and the risk of cardiovascular disease, stroke, and diabetes hospitalization in the year following delivery. Am J Epidemiol. 2014;180(1), 41-44.
  • Saccone G, Zullo F, Roman A, Ward A, Maruotti G, Martinelli P et al.Risk of spontaneous preterm birth in IVF-conceived twin pregnancies. J Matern-Fet Neonatal Med. 2017; 1-8.
  • McDonald SD, Han Z, Mulla S, Ohlsson A, Beyene J, Murphy KE. Preterm birth and low birth weight among in vitro fertilization twins: a systematic review and meta-analyses. Eur J Obstet Gynecol Reprod Biol. 2010;148(2), 105-113.
  • Helmerhorst FM, Perquin DA, Donker D, Keirse MJ. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. Bmj. 2004;328(7434), 261. McDonald S, Murphy K, Beyene J, Ohlsson A. Perinatal outcomes of in vitro fertilization twins: a systematic review and meta-analyses. Am J Obstet Gynecol. 2005; 193(1), 141-152.
  • Yang H, Choi YS, Nam KH, Kwon JY, Park YW, Kim YH. Obstetric and perinatal outcomes of dichorionic twin pregnancies according to methods of conception: spontaneous versus in-vitro fertilization. Twin Res Human Gen 2011;14(1), 98-103.
  • Qin JB, Wang H, Sheng X, Xie Q, Gao S. Assisted reproductive technology and risk of adverse obstetric outcomes in dichorionic twin pregnancies: a systematic review and meta-analysis. Fertil Steril2016;105(5), 1180-1192.
  • Pinborg A. IVF/ICSI twin pregnancies: risks and prevention. Human Reprod Update 2005;5 11(6), pp.575-593.
  • Bensdorp AJ, Hukkelhoven CW, van der Veen F, Mol BW, Lambalk CB, van Wely M. Dizygotic twin pregnancies after medically assisted reproduction and after natural conception: maternal and perinatal outcomes. Fertil Steril. 2016;106(2), pp.371-377.
  • Nassar AH, Usta IM, Rechdan JB, Harb TS, Adra AM. et al. Pregnancy outcome in spontaneous twins versus twins who were conceived through in vitro fertilization. Am J Obstet Gynecol. 2003; 189(2),513-518.
  • Geisler ME, O’Mahony A, Meaney S, Waterstone JJ. O’Donoghue K. Obstetric and perinatal outcomes of twin pregnancies conceived following IVF/ICSI treatment compared with spontaneously conceived twin pregnancies. Eur J Obstet Gynecol Reprod Biol.2014; 181, pp.78-83.
  • Karami M, Jenabi E, Fereidooni B. The association of placenta previa and assisted reproductive techniques: a meta-analysis. J Matern Fetal Neonatal Med. 2018; 31(14), 1940-1947.

Comparison of pregnancy and neonatal outcome in spontaneous and invitro fertilization (IVF) twin pregnancies

Year 2018, Volume: 15 Issue: 3, 250 - 254, 12.12.2018

Coşkun Şimşir Ziya Kalem Batuhan Bakırarar Muberra Namlı Kalem

Abstract

Background: This study aimed to investigate whether the differences between twin

invitrofertilization (IVF) and twin spontaneous pregnancies in terms of pregnancy and perinatal

outcome.

Material and Methods: This is a retrospective cohort study carried out by examining the data of

dichorionic-diamniotic twin pregnancies with live births in a private hospital between 2015 and 2018.

There were two study groups which were the twin pregnancy group with spontaneous pregnancy

and the IVF twin group with pregnancy via assisted reproductive techniques.

Results: Pregnancy and birth problems did not differ between the two groups. The IVF twin

pregnancies were observed to have higher rates of preterm birth, low birthweight and APGAR 1st

minute scores. Perinatal mortality rates were found similar in both groups.

Conclusion: In conclusion, it was shown in this study that the risks of preterm birth and low

birthweight which are already higher in twin pregnancies than in singleton pregnancies were even

higher in the IVF twin pregnancies. It is recommended in accordance with these results that single

embryo transfers should be preferred and iatrogenic multiple pregnancies should not be

encouraged.

Keywords

Twin pregnancies single pregnancies IVF neonatal outcome

References

  • Kaveh M, Ghajarzadeh M, Davari Tanha F, Nayeri F, Keramati Z, et al. Pregnancy Complications and Neonatal Outcomes in Multiple Pregnancies:A Comparison between Assisted Reproductive Techniques and Spontaneous Conception. Int J Fertil Steril. 2015;8(4):367-72.
  • Elster N. Less is more: the risks of multiple births. The Institute for Science, Law, and Technology Working Group on Reproductive Technology. Fertil Steril. 2000;74(4):617-23.
  • Kerin JF, Warnes GM, Quinn PJ, Jeffrey R, Kirby C, Matthews CD, et al. Incidence of multiple pregnancy after in-vitro fertilisation and embryo transfer. Lancet. 1983;2(8349):537-40.
  • Pandey S, Shetty A, Hamilton M, Bhattacharya S, Maheshwari A. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Hum Reprod Update. 2012;18(5):485-503
  • Qin J, Wang H, Sheng X, Liang D, Tan H, Xia J. Pregnancy-related complications and adverse pregnancy outcomes in multiple pregnancies resulting from assisted reproductive technology: a meta-analysis of cohort studies. Fertil Steril. 2015;103(6):1492-508.e1-7.
  • Massenkeil G, Alexander T, Rosen O, Dörken B, Burmester G, Radbruch A, et al. Long-term follow-up of fertility and pregnancy in autoimmune diseases after autologous haematopoietic stem cell transplantation. Rheumatol Int. 2016;36(11):1563-1568.
  • Peterson B, Boivin J, Norré J, Smith C, Thorn P, Wischmann, T. An introduction to infertility counseling: a guide for mental health and medical professionals. J Assist Reproduction Gen.2012; 29(3), 243-248.
  • Sazonova A, Källen K, Thurin-Kjellberg A, Wennerholm UB, Bergh C. Factors affecting obstetric outcome of singletons born after IVF. Human Reprod.2011; 26(10), 2878-2886.
  • Greil AL, Slauson‐Blevins K, McQuillan J. The experience of infertility: a review of recent literature. Soc Health Ill . 2010;32(1), 140-162.
  • Barda, G., Gluck, O., Mizrachi, Y., & Bar, J. (2017). A comparison of maternal and perinatal outcome between in vitro fertilization and spontaneous dichorionic-diamniotic twin pregnancies. J Matern Fet Neo Med. 2017; 30(24), 2974-2977.
  • Pinborg A, Loft A, Schmidt L, Langhoff‐Roos J, Andersen AN. Maternal risks and perinatal outcome in a Danish national cohort of 1005 twin pregnancies: the role of in vitro fertilization. Acta Obstet Gynecol Scand. 2004; 83(1), 75-84.
  • Luke B, Gopal D, Cabral H, Stern JE, Diop H. Adverse pregnancy, birth, and infant outcomes in twins: effects of maternal fertility status and infant gender combinations; the Massachusetts Outcomes Study of Assisted Reproductive Technology. Am JObstet Gynecol. 2017;217(3), 330-e1.
  • Caserta D, Bordi G, Stegagno M, Filippini F, Podagrosi M, Roselli D et al. Maternal and perinatal outcomes in spontaneous versus assisted conception twin pregnancies. Eur J Obstet Gynecol Reprod Biol. 2014;174, 64-69.
  • Savitz DA, Danilack VA, Elston B, Lipkind HS. Pregnancy-induced hypertension and diabetes and the risk of cardiovascular disease, stroke, and diabetes hospitalization in the year following delivery. Am J Epidemiol. 2014;180(1), 41-44.
  • Saccone G, Zullo F, Roman A, Ward A, Maruotti G, Martinelli P et al.Risk of spontaneous preterm birth in IVF-conceived twin pregnancies. J Matern-Fet Neonatal Med. 2017; 1-8.
  • McDonald SD, Han Z, Mulla S, Ohlsson A, Beyene J, Murphy KE. Preterm birth and low birth weight among in vitro fertilization twins: a systematic review and meta-analyses. Eur J Obstet Gynecol Reprod Biol. 2010;148(2), 105-113.
  • Helmerhorst FM, Perquin DA, Donker D, Keirse MJ. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. Bmj. 2004;328(7434), 261. McDonald S, Murphy K, Beyene J, Ohlsson A. Perinatal outcomes of in vitro fertilization twins: a systematic review and meta-analyses. Am J Obstet Gynecol. 2005; 193(1), 141-152.
  • Yang H, Choi YS, Nam KH, Kwon JY, Park YW, Kim YH. Obstetric and perinatal outcomes of dichorionic twin pregnancies according to methods of conception: spontaneous versus in-vitro fertilization. Twin Res Human Gen 2011;14(1), 98-103.
  • Qin JB, Wang H, Sheng X, Xie Q, Gao S. Assisted reproductive technology and risk of adverse obstetric outcomes in dichorionic twin pregnancies: a systematic review and meta-analysis. Fertil Steril2016;105(5), 1180-1192.
  • Pinborg A. IVF/ICSI twin pregnancies: risks and prevention. Human Reprod Update 2005;5 11(6), pp.575-593.
  • Bensdorp AJ, Hukkelhoven CW, van der Veen F, Mol BW, Lambalk CB, van Wely M. Dizygotic twin pregnancies after medically assisted reproduction and after natural conception: maternal and perinatal outcomes. Fertil Steril. 2016;106(2), pp.371-377.
  • Nassar AH, Usta IM, Rechdan JB, Harb TS, Adra AM. et al. Pregnancy outcome in spontaneous twins versus twins who were conceived through in vitro fertilization. Am J Obstet Gynecol. 2003; 189(2),513-518.
  • Geisler ME, O’Mahony A, Meaney S, Waterstone JJ. O’Donoghue K. Obstetric and perinatal outcomes of twin pregnancies conceived following IVF/ICSI treatment compared with spontaneously conceived twin pregnancies. Eur J Obstet Gynecol Reprod Biol.2014; 181, pp.78-83.
  • Karami M, Jenabi E, Fereidooni B. The association of placenta previa and assisted reproductive techniques: a meta-analysis. J Matern Fetal Neonatal Med. 2018; 31(14), 1940-1947.
There are 24 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Coşkun Şimşir 0000-0003-1825-6584

Ziya Kalem 0000-0002-5435-2074

Batuhan Bakırarar This is me 0000-0002-5662-8193

Muberra Namlı Kalem 0000-0002-2316-5495

Publication Date December 12, 2018
Submission Date December 5, 2018
Acceptance Date December 11, 2018
Published in Issue Year 2018 Volume: 15 Issue: 3

Cite

Vancouver Şimşir C, Kalem Z, Bakırarar B, Namlı Kalem M. Comparison of pregnancy and neonatal outcome in spontaneous and invitro fertilization (IVF) twin pregnancies. Harran Üniversitesi Tıp Fakültesi Dergisi. 2018;15(3):250-4.
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Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty