Relationship Between Blood and Pericardial Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Levels and Ventricular Functions in Coronary Artery Bypass Patients
Abstract
Background: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)- like domain- containing protein 1(SCUBE-1) is a surface cell protein studied as a biomarker in thrombosis and ischemia conditions and secreted at currently studied early embryogenesis. The aim of this study is to investigate the relationship between left ventricular functions and pericardial / serum SCUBE-1 values of patients who underwent coronary artery bypass surgery.
Material and Methods: Forty patients who underwent cardiopulmonary bypass graft surgery were included in the study. Detailed echocardiographic findings of the patients were made before the operation. Left ventricular dysfunction markers were determined according to left ventricular fracshortening. SCUBE-1 levels were studied with ELISA kits in blood plasma and pericardial fluid samples. SCUBE-1 levels were statistically compared between the determined groups.
Results: Statistical differences were observed in LVDs, IVSd, Neutrophil, RBC, CK-MB, Troponin-I and WBC values in low and high FS groups (p <0.05). SCUBE-1 plasma levels did not differ statistically between the FS groups (p> 0.05). The same situation was similar for pericardial fluid levels (p> 0.05). Correlation was seen between SCUBE-1 plasma levels and SCUBE-1 pericardial levels (p <0.05). There was no significant correlation between echocardiographic findings and SCUBE-1 levels (p> 0.05).
Conclusion: These results showed us that SCUBE-1 plasma and the pericardial fluid levels had no effect on the left ventricular dysfunction. SCUBE-1 is not one of the currently identified markers of cardiac dysfunction. Future studies will further increase our knowledge on this subject.
References
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- Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004 Jun 15; 109 (23 Suppl 1): III27-32. doi:10.1161/01. CIR. 0000131515.03336.f8.
- Tu CF, Yan YT, Wu SY, Djoko B, Tsai MT, Cheng CJ, et al. Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1.J Biol Chem. 2008 May 2; 283(18):12478-88. doi: 10.1074/jbc.M705872200. Epub 2008 Feb 26.
- Grimmond S, Larder R, Van Hateren N, P Siggers, T J Hulsebos, R Arkellet al. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). Genomics. 2000 Nov 15; 70(1):74-81. doi:10.1006/geno.2000.6370.
- Yang RB, Ng CK, Wasserman SM, SD, Shenoy S, Mehraban F et al. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. J Biol Chem. 2002 Nov 29; 277(48):46364-73.doi: 10.1074/jbc.M207410200. Epub 2002 Sep 21.
- Dai DF, Thajeb P, Tu CF, Chiang FT, Chen CH, Yang RB, et al. Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. J Am Coll Cardiol. 2008 Jun 3; 51(22):2173-80. doi: 10.1016/j.jacc.2008.01.060.
- Tu CF, Su YH, Huang YN, Tsai MT, Li LT, Chen YL, et al. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Cardiovasc Res. 2006 Aug 1; 71(3):486-95.doi: 10.1016/j.cardiores.2006.04.010. Epub 2006 Apr 27.
- G de Simone , R B Devereux, M J Roman, A Ganau, P S Saba, M H Alderman, et al. Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension. J Am Coll Cardiol. 1994 May; 23(6):1444-51.doi: 10.1016/0735-1097(94)90390-5.
- Lang RM, Goldstein SA, Kronzon I, Khanderia BK, Mor-Avi V. Left Ventricular Systolic Function. ASE’s Comprehensive Echocardiography; 2016.p.p113, 2nded.113–138.
- Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005 Dec; 18(12):1440-63.doi: 10.1016/j.echo.2005.10.005.
- Katia Orvin , Haim Herzberg , Gregory Golovchiner , Ehud Kadmon , Alexander Omelchenko , et al. Relation of Left Ventricular Fractional Shortening to Need for Permanent Pacemaker After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2018 Sep 1; 122(5):833-837. doi: 10.1016/j.amjcard.2018.05.029. Epub 2018 Jun 2.
- Turkmen S, Mentese S, Mentese A, Sumer AU, Saglam K, Yulug E, et al. The value of signal peptide-CUB-EGF domain-containing protein 1 and oxidative stress parameters in the diagnosis of acute mesenteric ischemia. Acad Emerg Med. 2013 Mar; 20(3):257-64. doi: 10.1111/acem.12096.
- Erel Icel , Aykut Icel , Cuma Mertoglu , Nurdan Gamze Tasli , Yucel Karakurt , Turgay Ucak , et al. Serum SCUBE-1 levels in patients with diabetic retinopathy. Int Ophthalmol. 2020 Apr; 40(4):859-865. doi: 10.1007/s10792-019-01249-8. Epub 2019 Dec 2.
- İbrahim Gündüz , İbrahim Batmaz , Turgut Bozan , Aysun Ekinci , Remzi Cevik . The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients. Int J Rheum Dis. 2020 Apr; 23(4):526-531.doi: 10.1111/1756-185X.13798. Epub 2020 Jan 28.
- Lindemann S, Gawaz M. SCUBE1--a new scoop in vascular biology? Cardiovasc Res. 2006 Aug 1;71(3):414-5.doi: 10.1016/j.cardiores.2006.06.005. Epub 2006 Jun 8.
- Etli M, Karahan O. Serum SCUBE-1 levels can predict endothelial dysfunction in healthy young adults. Turkish Journal of Vascular Surgery 2019;28(1):31-35. DOI: 10.9739/tjvs.2019.299
- Sonmez E, Turkdogan KA, Karabacak M, Civelek C, Yilmaz C, Ozer OF, et al. The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome. Am J Emerg Med. 2015 Jan; 33(1):21-4. doi: 10.1016/j.ajem.2014.09.047. Epub 2014 Oct5
- Mücahit G, Süha T, Aynur S, Sümer A , Menteşe A, Türedi S, et al. The diagnostic value of SCUBE1 levels in acute ischemic Stroke. Türk Biyokimya Dergisi [Turkish Journal of Biochemistry–Turk J Biochem]. 2014; 39 (1) ;107–112. DOI:10.5505/tjb.2014.43534
- Hatice Ayan , Rabia Akilli, Bulent Kaya, Saime Paydas, Ertan Kara, Asligul Cureoglu. Relationship Between SCUBE1 Levels and Echocardiography and Electrocardiography Findings and Epicardial Adipose Tissue/Carotid Intima-Media Thickness in Patients Receiving Renal Replacement Therapy. Exp Clin Transplant. 2019 Jan; 17 (Suppl 1):181-187.doi: 10.6002/ect.MESOT2018.P58.
- Raymond RJ, Hinderliter AL, Willis PW, Ralph D, Caldwell EJ, Williams W, et al. Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension. J Am Coll Cardiol. 2002 Apr 3; 39(7):1214-9. doi: 10.1016/s0735-1097(02)01744-8.
- Watanabe M, Kawaguchi S, Nakahara H, Hachimaru T. The roles of natriuretic peptides in pericardial fluid in patients with heart failure. Clin Cardiol. 2009 Mar; 32(3):159-63. doi:10.1002/clc.20306.
- Guclu O, Karahan O, Karabacak M, Yuksel V, Huseyin S, Mavitas B. Evaluation of Pericardial Fluid CType Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery. Thorac Cardiovasc Surg. 2017 Jun; 65(4):311-314. doi: 10.1055/s-0036-1579626. Epub 2016 Mar 10.
- Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Kamikodai Y, et al. Postmortem cardiac troponin t levels in the blood and pericardial fluid. Part 2: Analysis for application in the diagnosis of sudden cardiac death with regard to pathology. Leg Med (Tokyo). 2006 Mar;8(2):94-101. doi: 10.1016/j.legalmed.2005.10.003. Epub 2006 Jan 18.
- Hirowati Ali , Noriaki Emoto, Keiko Yagi, Nicolas Vignon-Zellweger, Kazuhiko Nakayama, Kinta Hatakeyama, et al. Localization and characterization of a novel secreted protein, SCUBE2, in the development and progression of atherosclerosis. Kobe J Med Sci. 2013 Nov 9; 59(4):E122-31.PMID: 24598273
- Xavier, G.M., Cobourne, M.T. SCUBE2 expression extends beyond the central nervous system during mouse development. J Mol Histol. 2011 Oct; 42(5):383-91.doi: 10.1007/s10735-011-9341-7. Epub 2011 Aug 6.
Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki
Abstract
Amaç: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)- like domain- containing protein 1 (SCUBE-1), tromboz ve iskemi koşullarında biyobelirteç olarak incelenen bir yüzey hücresi proteinidir ve erken embriyogenezde salgılanmaktadır. Bu çalışmanın amacı, koroner arter baypas ameliyatı geçiren hastaların sol ventrikül fonksiyonları ile perikardiyal / serum SCUBE-1 değerleri arasındaki ilişkiyi araştırmaktır.
Yöntemler: Çalışmaya kardiyopulmoner baypas greft cerrahisi uygulanan 40 hasta dahil edildi. Hastaların detaylı ekokardiyografik bulguları operasyon öncesi yapıldı. Sol ventrikül disfonksiyon belirteçleri, sol ventrikül fraksiyonunun kısalmasına (left ventricular fracshortening) (FS) göre belirlendi. SCUBE-1 seviyeleri, kan plazması ve perikardiyal sıvı örneklerinde ELISA kitleri ile çalışıldı. SCUBE-1 seviyeleri belirlenen gruplar arasında istatistiksel olarak karşılaştırıldı.
Bulgular: Düşük ve yüksek FS gruplarında LVDs, IVSd, Nötrofil, RBC, CK-MB, Troponin-I ve WBC değerlerinde istatistiksel farklılık gözlendi (p <0,05). SCUBE-1 plazma seviyeleri FS grupları arasında istatistiksel olarak farklılık göstermedi (p> 0.05). Aynı durum perikardiyal sıvı düzeyleri için de benzerdi (p> 0.05). SCUBE-1 plazma seviyeleri ve SCUBE-1 perikardiyal seviyeleri arasında korelasyon görüldü (p <0,05). Ekokardiyografi bulguları ile SCUBE-1 düzeyleri arasında anlamlı korelasyon gözlenmedi (p> 0.05).
Sonuç: Bu sonuçlar bize SCUBE-1 plazma ve perikardiyal sıvı seviyelerinin sol ventrikül disfonksiyonu üzerine etkisi olmadığını gösterdi. SCUBE-1, kardiyak disfonksiyonun şu anda tanımlanmış belirteçlerinden biri değildir. Gelecek çalışmalar bu konudaki bilgimizi daha da artıracaktır.
References
- Javanmard SH, Nematbakhsh M, Sanei MH. Early prevention by L-Arginine attenuates coronary atherosclerosis in a model of hypercholesterolemic animals; no positive results for treatment. Nutr Metab (Lond). 2009 Mar 24; 6:13. doi: 10.1186/1743-7075-6-13.
- Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004 Jun 15; 109 (23 Suppl 1): III27-32. doi:10.1161/01. CIR. 0000131515.03336.f8.
- Tu CF, Yan YT, Wu SY, Djoko B, Tsai MT, Cheng CJ, et al. Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1.J Biol Chem. 2008 May 2; 283(18):12478-88. doi: 10.1074/jbc.M705872200. Epub 2008 Feb 26.
- Grimmond S, Larder R, Van Hateren N, P Siggers, T J Hulsebos, R Arkellet al. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). Genomics. 2000 Nov 15; 70(1):74-81. doi:10.1006/geno.2000.6370.
- Yang RB, Ng CK, Wasserman SM, SD, Shenoy S, Mehraban F et al. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. J Biol Chem. 2002 Nov 29; 277(48):46364-73.doi: 10.1074/jbc.M207410200. Epub 2002 Sep 21.
- Dai DF, Thajeb P, Tu CF, Chiang FT, Chen CH, Yang RB, et al. Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. J Am Coll Cardiol. 2008 Jun 3; 51(22):2173-80. doi: 10.1016/j.jacc.2008.01.060.
- Tu CF, Su YH, Huang YN, Tsai MT, Li LT, Chen YL, et al. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Cardiovasc Res. 2006 Aug 1; 71(3):486-95.doi: 10.1016/j.cardiores.2006.04.010. Epub 2006 Apr 27.
- G de Simone , R B Devereux, M J Roman, A Ganau, P S Saba, M H Alderman, et al. Assessment of left ventricular function by the midwall fractional shortening/end-systolic stress relation in human hypertension. J Am Coll Cardiol. 1994 May; 23(6):1444-51.doi: 10.1016/0735-1097(94)90390-5.
- Lang RM, Goldstein SA, Kronzon I, Khanderia BK, Mor-Avi V. Left Ventricular Systolic Function. ASE’s Comprehensive Echocardiography; 2016.p.p113, 2nded.113–138.
- Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005 Dec; 18(12):1440-63.doi: 10.1016/j.echo.2005.10.005.
- Katia Orvin , Haim Herzberg , Gregory Golovchiner , Ehud Kadmon , Alexander Omelchenko , et al. Relation of Left Ventricular Fractional Shortening to Need for Permanent Pacemaker After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2018 Sep 1; 122(5):833-837. doi: 10.1016/j.amjcard.2018.05.029. Epub 2018 Jun 2.
- Turkmen S, Mentese S, Mentese A, Sumer AU, Saglam K, Yulug E, et al. The value of signal peptide-CUB-EGF domain-containing protein 1 and oxidative stress parameters in the diagnosis of acute mesenteric ischemia. Acad Emerg Med. 2013 Mar; 20(3):257-64. doi: 10.1111/acem.12096.
- Erel Icel , Aykut Icel , Cuma Mertoglu , Nurdan Gamze Tasli , Yucel Karakurt , Turgay Ucak , et al. Serum SCUBE-1 levels in patients with diabetic retinopathy. Int Ophthalmol. 2020 Apr; 40(4):859-865. doi: 10.1007/s10792-019-01249-8. Epub 2019 Dec 2.
- İbrahim Gündüz , İbrahim Batmaz , Turgut Bozan , Aysun Ekinci , Remzi Cevik . The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients. Int J Rheum Dis. 2020 Apr; 23(4):526-531.doi: 10.1111/1756-185X.13798. Epub 2020 Jan 28.
- Lindemann S, Gawaz M. SCUBE1--a new scoop in vascular biology? Cardiovasc Res. 2006 Aug 1;71(3):414-5.doi: 10.1016/j.cardiores.2006.06.005. Epub 2006 Jun 8.
- Etli M, Karahan O. Serum SCUBE-1 levels can predict endothelial dysfunction in healthy young adults. Turkish Journal of Vascular Surgery 2019;28(1):31-35. DOI: 10.9739/tjvs.2019.299
- Sonmez E, Turkdogan KA, Karabacak M, Civelek C, Yilmaz C, Ozer OF, et al. The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome. Am J Emerg Med. 2015 Jan; 33(1):21-4. doi: 10.1016/j.ajem.2014.09.047. Epub 2014 Oct5
- Mücahit G, Süha T, Aynur S, Sümer A , Menteşe A, Türedi S, et al. The diagnostic value of SCUBE1 levels in acute ischemic Stroke. Türk Biyokimya Dergisi [Turkish Journal of Biochemistry–Turk J Biochem]. 2014; 39 (1) ;107–112. DOI:10.5505/tjb.2014.43534
- Hatice Ayan , Rabia Akilli, Bulent Kaya, Saime Paydas, Ertan Kara, Asligul Cureoglu. Relationship Between SCUBE1 Levels and Echocardiography and Electrocardiography Findings and Epicardial Adipose Tissue/Carotid Intima-Media Thickness in Patients Receiving Renal Replacement Therapy. Exp Clin Transplant. 2019 Jan; 17 (Suppl 1):181-187.doi: 10.6002/ect.MESOT2018.P58.
- Raymond RJ, Hinderliter AL, Willis PW, Ralph D, Caldwell EJ, Williams W, et al. Echocardiographic predictors of adverse outcomes in primary pulmonary hypertension. J Am Coll Cardiol. 2002 Apr 3; 39(7):1214-9. doi: 10.1016/s0735-1097(02)01744-8.
- Watanabe M, Kawaguchi S, Nakahara H, Hachimaru T. The roles of natriuretic peptides in pericardial fluid in patients with heart failure. Clin Cardiol. 2009 Mar; 32(3):159-63. doi:10.1002/clc.20306.
- Guclu O, Karahan O, Karabacak M, Yuksel V, Huseyin S, Mavitas B. Evaluation of Pericardial Fluid CType Natriuretic Peptide Levels in Patients Undergoing Coronary Bypass Surgery. Thorac Cardiovasc Surg. 2017 Jun; 65(4):311-314. doi: 10.1055/s-0036-1579626. Epub 2016 Mar 10.
- Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Kamikodai Y, et al. Postmortem cardiac troponin t levels in the blood and pericardial fluid. Part 2: Analysis for application in the diagnosis of sudden cardiac death with regard to pathology. Leg Med (Tokyo). 2006 Mar;8(2):94-101. doi: 10.1016/j.legalmed.2005.10.003. Epub 2006 Jan 18.
- Hirowati Ali , Noriaki Emoto, Keiko Yagi, Nicolas Vignon-Zellweger, Kazuhiko Nakayama, Kinta Hatakeyama, et al. Localization and characterization of a novel secreted protein, SCUBE2, in the development and progression of atherosclerosis. Kobe J Med Sci. 2013 Nov 9; 59(4):E122-31.PMID: 24598273
- Xavier, G.M., Cobourne, M.T. SCUBE2 expression extends beyond the central nervous system during mouse development. J Mol Histol. 2011 Oct; 42(5):383-91.doi: 10.1007/s10735-011-9341-7. Epub 2011 Aug 6.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 29, 2021 |
| Submission Date | August 25, 2021 |
| Acceptance Date | September 24, 2021 |
| Published in Issue | Year 2021 Volume: 18 Issue: 3 |
Cite
Harran Üniversitesi Tıp Fakültesi Dergisi / Journal of Harran University Medical Faculty