Clinical Significance of Monocyte Chemoattractant Protein-1 and CC Chemokine Receptor Type 2 Gene Polymorphisms in Young Patients with Acute Coronary Syndrome
Abstract
References
- 1. Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016;4(13):256.
- 2. Usalp, S. Kalp Hastalıklarında Cinsiyetin Rolü: Kalp ve Cinsiyet. International Journal of Current Medical and Biological Sciences.2021(1-6),
- 3. Tascanov MB, Tanriverdi Z, Gungoren F, Besli F, Erkus ME, Koyuncu I, et al. Comparisons of microbiota-generated metabolites in patients with young and elderly acute coronary syndrome. Anatol J Cardiol. 2020 ;24(3):175-182.
- 4. Hajar R. Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views.2017;18(3):109-114.
- 5. Tascanov MB, Tanriverdi Z, Gungoren F, Besli F, Erkus ME, Gonel A, et al. Association between the No-Reflow Phenomenon and Soluble CD40 Ligand Level in Patients with Acute ST-Segment Elevation Myocardial Infarction. Medicina (Kaunas). 2019;55(7):376.
- 6. Yuasa S, Maruyama T, Yamamoto Y, Hirose H, Kawai T, Matsunaga-Irie S, et al. MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes. Diabetes Res Clin Pract. 2009;86(3):193-8.
- 7. Deshmane SL, Kremlev S, Amini S, Sawaya BE. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res. 2009;29(6):313-326.
- 8. Tsai WC, Wu KY, Lin GM, Chen SJ, Lin WS, Yang SP, et al. Clinical Characteristics of Patients Less than Forty Years Old with Coronary Artery Disease in Taiwan: A Cross-Sectional Study. Acta Cardiol Sin. 2017;33(3):233-240.
- 9. Nordlie MA, Wold LE, Kloner RA. Genetic contributors toward increased risk for ischemic heart disease. J Mol Cell Cardiol. 2005;39(4):667-79.
- 10. Lusis AJ. Atherosclerosis. Nature. 2000;407(6801):233-241.
- 11. Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol. 2009; 27:165-197.
- 12. Nyquist PA, Winkler CA, McKenzie LM, Yanek LR, Becker LC, Becker DM. Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis. Cerebrovasc Dis. 2009;28(2):124-130.
Akut Koroner Sendromlu Genç Hastalarda Monosit Kemoatraktan Protein-1 ve CC Kemokin Reseptörü Tip 2 Gen Polimorfizmlerinin Klinik Önemi
Abstract
Amaç: Akut koroner sendrom (AKS), küresel ölümlerin birincil nedenidir. Genç nüfus arasında AKS'nin risk faktörlerini ve altta yatan nedenlerini belirleme konusunda özel bir endişe vardır. Genetik faktörler, günümüzde hastalık önleme ve erken teşhis açısından popüler bir çalışma konusu haline gelmiştir. Bu çalışmada genç akut koroner sendromlu (GACS) hastalarda Monosit Kemoatraktan Protein-1(MCP-1) (A-2518G) ve C-C kemokin reseptör tip 2 (CCR2) (G190A) gen polimorfizmleri arasındaki klinik önemi araştırmayı amaçladık.
Materyal ve metod: GACS'li (<40 yaş) 63 ve koroner arterleri normal olan 103 hasta bu çalışmaya dahil edildi. Tüm hastalarda MCP-1(A-2518G) ve CCR2(G190A) gen polimorfizmleri ölçüldü.
Bulgular: MCP 1 gen polimorfizmi iki grupla karşılaştırıldığında önemli ölçüde farklıydı. GACS grupta MCP-1 (A-2518G) geni GG (sırasıyla %12,7 ’e karşı %3,7), AG (sırasıyla %33,3’e karşı %50,5), AA (sırasıyla %54’e karşı %45,8), (p: 0.021) genotipleri arasındaki ilişkinin önemli ölçüde yüksek olduğu gösterilmiştir.
Sonuç: Bu çalışmada GACS'li hasta grubunda MCP-1 (A-2518G) GG genotipinin yüksek olduğu ve hastalık riskini 2 kat arttırdığı gösterildi.
References
- 1. Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016;4(13):256.
- 2. Usalp, S. Kalp Hastalıklarında Cinsiyetin Rolü: Kalp ve Cinsiyet. International Journal of Current Medical and Biological Sciences.2021(1-6),
- 3. Tascanov MB, Tanriverdi Z, Gungoren F, Besli F, Erkus ME, Koyuncu I, et al. Comparisons of microbiota-generated metabolites in patients with young and elderly acute coronary syndrome. Anatol J Cardiol. 2020 ;24(3):175-182.
- 4. Hajar R. Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views.2017;18(3):109-114.
- 5. Tascanov MB, Tanriverdi Z, Gungoren F, Besli F, Erkus ME, Gonel A, et al. Association between the No-Reflow Phenomenon and Soluble CD40 Ligand Level in Patients with Acute ST-Segment Elevation Myocardial Infarction. Medicina (Kaunas). 2019;55(7):376.
- 6. Yuasa S, Maruyama T, Yamamoto Y, Hirose H, Kawai T, Matsunaga-Irie S, et al. MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes. Diabetes Res Clin Pract. 2009;86(3):193-8.
- 7. Deshmane SL, Kremlev S, Amini S, Sawaya BE. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res. 2009;29(6):313-326.
- 8. Tsai WC, Wu KY, Lin GM, Chen SJ, Lin WS, Yang SP, et al. Clinical Characteristics of Patients Less than Forty Years Old with Coronary Artery Disease in Taiwan: A Cross-Sectional Study. Acta Cardiol Sin. 2017;33(3):233-240.
- 9. Nordlie MA, Wold LE, Kloner RA. Genetic contributors toward increased risk for ischemic heart disease. J Mol Cell Cardiol. 2005;39(4):667-79.
- 10. Lusis AJ. Atherosclerosis. Nature. 2000;407(6801):233-241.
- 11. Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol. 2009; 27:165-197.
- 12. Nyquist PA, Winkler CA, McKenzie LM, Yanek LR, Becker LC, Becker DM. Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis. Cerebrovasc Dis. 2009;28(2):124-130.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Article |
| Authors | |
| Publication Date | August 28, 2022 |
| Submission Date | June 4, 2022 |
| Acceptance Date | July 7, 2022 |
| Published in Issue | Year 2022 Volume: 19 Issue: 2 |
Harran Üniversitesi Tıp Fakültesi Dergisi / Journal of Harran University Medical Faculty