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Bacterial Infections and Antibiotic Resistance Rates in SARS-CoV-2 PCR Positive Patients

Year 2022, Volume: 19 Issue: 2, 333 - 337, 28.08.2022
https://doi.org/10.35440/hutfd.1141758

Abstract

Background: In this study, it was aimed to determine the distribution and antibiotic resistance rates of bacteria isolated from endotracheal aspirate (ETA), blood, catheter samples taken from COVID-19 patients admitted Adana City Training and Research Hospital. Material and method: Between April 1, 2020 and March 31, 2021, 254 patients PCR pozitive patients were included in the study. Blood, catheter and respiratory tract culture growths and antibiotic susceptibility test results were retrospectively analyzed from the microbiology laboratory database. Results: 433 bacterial growths were detected in clinical samples taken from 254 COVID PCR positive patients. Among the bacterial agents, Acinetobacter baumannii (.25.17%; n =109) was the most common pathogens, followed by Escherichia coli (.5.54% n =24) and Klebsiella pneumoniae (.5.31%; n =23). Conclusion: Avoiding unnecessary antibiotic use in COVID 19 patients is critical to prevent resistance development and increase culture sensitivity.

References

  • KAYNAKLAR 1. Morris DE, Cleary DW, Clarke SC. Secondary Bacterial Infections Associated with Influenza Pandemics. Front Microbiol. 2017;8:1041.
  • 2. Grasselli G, Cattaneo E, Florio G. Secondary infections in critically ill patients with COVID-19. Crit Care. 2021;25(1):317.
  • 3. Cox MJ, Loman N, Bogaert D, O'Grady J. Co-infections: potentially lethal and unexplored in COVID-19. Lancet Microbe. 2020;1(1):e11.
  • 4. Huttner BD, Catho G, Pano-Pardo JR, Pulcini C, Schouten J. COVID-19: don't neglect antimicrobial stewardship principles! Clin Microbiol Infect. 2020;26(7):808-10.
  • 5. https://hsgm.saglik.gov.tr/depo/kurumsal/plan-ve-faaliyetler/numune-alma-el-kitabi.pdf. [
  • 6. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
  • 7. https://www.eucast.org/clinical_breakpoints/. [
  • 8. Petruk G, Puthia M, Petrlova J, Samsudin F, Strömdahl AC, Cerps S, et al. SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity. J Mol Cell Biol. 2020;12(12):916-32.
  • 9. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020;296(2):E32-E40.
  • 10. Garcia-Vidal C, Sanjuan G, Moreno-García E, Puerta-Alcalde P, Garcia-Pouton N, Chumbita M, et al. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clinical Microbiology and Infection. 2021;27(1):83-8.
  • 11. Karataş M, Yaşar-Duman M, Tünger A, Çilli F, Aydemir Ş, Özenci V. Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study. Ann Clin Microbiol Antimicrob. 2021;20(1):51.
  • 12. Li J, Wang J, Yang Y, Cai P, Cao J, Cai X, et al. Etiology and antimicrobial resistance of secondary bacterial infections in patients hospitalized with COVID-19 in Wuhan, China: a retrospective analysis. Antimicrobial Resistance & Infection Control. 2020;9(1):1-7.
  • 13. Rouzé A, Martin-Loeches I, Povoa P, Makris D, Artigas A, Bouchereau M, et al. Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study. Intensive Care Med. 2021;47(2):188-98.
  • 14. Zhu NJ, Rawson TM, Mookerjee S, Price JR, Davies F, Otter J, et al. Changing Patterns of Bloodstream Infections in the Community and Acute Care Across 2 Coronavirus Disease 2019 Epidemic Waves: A Retrospective Analysis Using Data Linkage. Clinical Infectious Diseases. 2021.
  • 15. LeRose J, Sandhu A, Polistico J, Ellsworth J, Cranis M, Jabbo L, et al. The Impact of COVID-19 Response on Central Line Associated Bloodstream Infections and Blood Culture Contamination Rates at a Tertiary Care Center in Greater Detroit Area. Infection Control and Hospital Epidemiology. 2020:1-15.
  • 16. Rebold N, Alosaimy S, Morrisette T, Holger D, Lagnf AM, Ansari I, et al. Clinical Characteristics Associated with Bacterial Bloodstream Coinfection in COVID-19. Infectious Diseases and Therapy. 2022;11(3):1281-96.
  • 17. Cusumano JA, Dupper AC, Malik Y, Gavioli EM, Banga J, Berbel Caban A, et al. Staphylococcus aureus Bacteremia in Patients Infected With COVID-19: A Case Series. Open Forum Infectious Diseases. 2020;7(11). 18. Adalbert JR, Varshney K, Tobin R, Pajaro R. Clinical outcomes in patients co-infected with COVID-19 and Staphylococcus aureus: a scoping review. BMC Infectious Diseases. 2021;21(1):985.
  • 19. ÇAYCI YT, SEYFİ Z, VURAL DG, BİLGİN K, BİRİNCİ A. COVID-19 Tanısı Alan Hastaların Bakteriyel Kültür Örneklerindeki Üremelerin ve Antibiyotik Duyarlılıklarının İncelenmesi. Sağlık Bilimlerinde Değer.12(2):203-7.
  • 20. Rafat Z, Ramandi A, Khaki PA, Ansari S, Ghaderkhani S, Haidar H, et al. Fungal and bacterial co-infections of the respiratory tract among patients with COVID-19 hospitalized in intensive care units. Gene Rep. 2022;27:101588.

SARS-CoV-2 PCR Pozitif Hastalarda Bakteriyel Enfeksiyonlar ve Antibiyotik Direnci

Year 2022, Volume: 19 Issue: 2, 333 - 337, 28.08.2022
https://doi.org/10.35440/hutfd.1141758

Abstract

Amaç ve kapsam: Bu çalışmada Adana Şehir Eğitim ve Araştırma Hastanesin’de yatan COVID-19 hastalarından alınan endotrakeal aspirat (ETA), kan, kateter, örneklerinden izole edilen bakterilerin dağılımını ve antibiyotik direnç oranlarının belirlenmesi amaçlandı. Materyal ve metod: 1 Nisan 2020 ile 31 Mart 2021 tarihleri arasında PCR testi pozitif olarak tesbit edilen 254 hasta çalışmaya dahil edildi. Hastalardan gönderilen kan, katater ve solunum yolu kültür sonuçları ve antibiyotik duyarlılık test sonuçları mikrobiyoloji laboratuvarı veri tabanından retrospektif olarak incelendi. Bulgular: 254 COVİD PCR pozitif hastadan alınan klinik örneklerde 433 bakteri üremesi saptandı. Bakteriyel etkenler arasında, Acinetobacter baumannii (%.25,17; n =109), ardından Esherichia coli (%.5,54 n =24) ve Klebsiella pneumoniae (%.5,31; n =23) en yaygın patojenler olarak tespit edildi Sonuç: COVİD 19 hastarında gereksiz antibiyotik kullanımından kaçınılması direnç gelişiminin önlenmesi ve kültür duyarlılığının artması için kritik öneme sahiptir.

References

  • KAYNAKLAR 1. Morris DE, Cleary DW, Clarke SC. Secondary Bacterial Infections Associated with Influenza Pandemics. Front Microbiol. 2017;8:1041.
  • 2. Grasselli G, Cattaneo E, Florio G. Secondary infections in critically ill patients with COVID-19. Crit Care. 2021;25(1):317.
  • 3. Cox MJ, Loman N, Bogaert D, O'Grady J. Co-infections: potentially lethal and unexplored in COVID-19. Lancet Microbe. 2020;1(1):e11.
  • 4. Huttner BD, Catho G, Pano-Pardo JR, Pulcini C, Schouten J. COVID-19: don't neglect antimicrobial stewardship principles! Clin Microbiol Infect. 2020;26(7):808-10.
  • 5. https://hsgm.saglik.gov.tr/depo/kurumsal/plan-ve-faaliyetler/numune-alma-el-kitabi.pdf. [
  • 6. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
  • 7. https://www.eucast.org/clinical_breakpoints/. [
  • 8. Petruk G, Puthia M, Petrlova J, Samsudin F, Strömdahl AC, Cerps S, et al. SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity. J Mol Cell Biol. 2020;12(12):916-32.
  • 9. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020;296(2):E32-E40.
  • 10. Garcia-Vidal C, Sanjuan G, Moreno-García E, Puerta-Alcalde P, Garcia-Pouton N, Chumbita M, et al. Incidence of co-infections and superinfections in hospitalized patients with COVID-19: a retrospective cohort study. Clinical Microbiology and Infection. 2021;27(1):83-8.
  • 11. Karataş M, Yaşar-Duman M, Tünger A, Çilli F, Aydemir Ş, Özenci V. Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study. Ann Clin Microbiol Antimicrob. 2021;20(1):51.
  • 12. Li J, Wang J, Yang Y, Cai P, Cao J, Cai X, et al. Etiology and antimicrobial resistance of secondary bacterial infections in patients hospitalized with COVID-19 in Wuhan, China: a retrospective analysis. Antimicrobial Resistance & Infection Control. 2020;9(1):1-7.
  • 13. Rouzé A, Martin-Loeches I, Povoa P, Makris D, Artigas A, Bouchereau M, et al. Relationship between SARS-CoV-2 infection and the incidence of ventilator-associated lower respiratory tract infections: a European multicenter cohort study. Intensive Care Med. 2021;47(2):188-98.
  • 14. Zhu NJ, Rawson TM, Mookerjee S, Price JR, Davies F, Otter J, et al. Changing Patterns of Bloodstream Infections in the Community and Acute Care Across 2 Coronavirus Disease 2019 Epidemic Waves: A Retrospective Analysis Using Data Linkage. Clinical Infectious Diseases. 2021.
  • 15. LeRose J, Sandhu A, Polistico J, Ellsworth J, Cranis M, Jabbo L, et al. The Impact of COVID-19 Response on Central Line Associated Bloodstream Infections and Blood Culture Contamination Rates at a Tertiary Care Center in Greater Detroit Area. Infection Control and Hospital Epidemiology. 2020:1-15.
  • 16. Rebold N, Alosaimy S, Morrisette T, Holger D, Lagnf AM, Ansari I, et al. Clinical Characteristics Associated with Bacterial Bloodstream Coinfection in COVID-19. Infectious Diseases and Therapy. 2022;11(3):1281-96.
  • 17. Cusumano JA, Dupper AC, Malik Y, Gavioli EM, Banga J, Berbel Caban A, et al. Staphylococcus aureus Bacteremia in Patients Infected With COVID-19: A Case Series. Open Forum Infectious Diseases. 2020;7(11). 18. Adalbert JR, Varshney K, Tobin R, Pajaro R. Clinical outcomes in patients co-infected with COVID-19 and Staphylococcus aureus: a scoping review. BMC Infectious Diseases. 2021;21(1):985.
  • 19. ÇAYCI YT, SEYFİ Z, VURAL DG, BİLGİN K, BİRİNCİ A. COVID-19 Tanısı Alan Hastaların Bakteriyel Kültür Örneklerindeki Üremelerin ve Antibiyotik Duyarlılıklarının İncelenmesi. Sağlık Bilimlerinde Değer.12(2):203-7.
  • 20. Rafat Z, Ramandi A, Khaki PA, Ansari S, Ghaderkhani S, Haidar H, et al. Fungal and bacterial co-infections of the respiratory tract among patients with COVID-19 hospitalized in intensive care units. Gene Rep. 2022;27:101588.
There are 19 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Article
Authors

Fatma Erdem 0000-0002-5310-313X

Nevzat Ünal 0000-0001-5121-3100

Mehmet Bankir 0000-0003-3284-2838

Publication Date August 28, 2022
Submission Date July 11, 2022
Acceptance Date August 1, 2022
Published in Issue Year 2022 Volume: 19 Issue: 2

Cite

Vancouver Erdem F, Ünal N, Bankir M. SARS-CoV-2 PCR Pozitif Hastalarda Bakteriyel Enfeksiyonlar ve Antibiyotik Direnci. Harran Üniversitesi Tıp Fakültesi Dergisi. 2022;19(2):333-7.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty