Abstract
Abstract
Aim. Angiopoietin-related growth factor (AGF) is associated with angiogenesis but it can also affect glucose and energy metabolism. The aim of this study was to determine AGF levels in preeclampsia. Method. The study included 32 women with preeclampsia (preeclampsia group) and 32 non-preeclamptic, healthy, third trimester pregnant women (Control group). We analyzed serum levels of AGF and other biochemical and anthropometric markers in all subjects. Results. Serum AGF levels were significantly higher in subjects with preeclampsia (98.6 ng/mL) than those in the control group (52.2 ng/mL), (p-value<0.001). In preeclampsia group, mean sistolic blood pressure and mean diastolic blood pressure were found significantly higher than in control group (157.5 mm Hg/114.6 mm Hg, 100.9 mm Hg/70.0 mm Hg respectively). Also mean arterial pressure in preeclampsia group was significantly higher than in control group (119.7 mm Hg/84.8 mm Hg) (p-value<0.001). There was a significant positive association between AGF and systolic blood pressure, mean arterial pressure in preeclampsia group but there was no relationship between AGF and homeostasis model of assessment insulin resistance (HOMA-IR). Conclusion. Although systolic blood pressure can be a predictor of serum AGF level in preeclampsia, further studies are needed to explain the physiologic roles of AGF in physiopathology of preeclampsia.
Keywords: Angiopoietin-related growth factor, preeclampsia
Özet
Amaç. Angiopoietin-ilişkili büyüme faktörü anjiogenez ile ilişkilidir fakat glukoz ve enerji metabolizmasınıda etkileyebilmektedir. Bu çalışmanın amacı preeklampside Angiopoietin-ilişkili büyüme faktörünün serum seviyelerinin belirlenmesidir. Yöntem. Çalışma 32 preeklampsili kadın (preeklampsi grubu) ve 32 sağlıklı 3. trimesterde gebe kadın (Kontrol grubu) ile yapıldı. Tüm olgularda, Angiopoietin-ilişkili büyüme faktörünün serum seviyeleri ile birlikte diğer biyokimyasal ve antropometrik veriler analiz edildi. Bulgular. Preeklampsili olgularda Angiopoietin-ilişkili büyüme faktörünün serum seviyeleri (98,6ng/mL) kontrol grubundan (52,2 ng/mL) anlamlı yüksekti (p-değeri<0,001). Preeklampsi grubunun ortalama sistolik kan basıncı ve ortalama diastolic kan basıncı değerleri kontrol grubundan anlamlı yüksek bulundu (sırasıyla 157,5 mm Hg/114,6 mm Hg, 100,9 mm Hg/70,0 mm Hg). Ayrıca, ortalama arteryel basınç da preeklampsi grubunda kontrol grubundan anlamlı yüksekti (119,7 mm Hg/84,8 mm Hg) (p-değeri<0,001). Preeklampsi grubunda, Angiopoietin-ilişkili büyüme faktörün’ün serum seviyeleri ile sistolik kan basıncı ve ortalama arteryel basınç arasında pozitif ilişki tespit edildi ancak insülin direnci indeksi(HOMA-IR) ile ilişki tespit edilmedi. Sonuç. Sistolik kan basıncı, preeklampsili hastalarda serum Angiopoietin-ilişkili büyüme faktörün’ün seviyeleri için bir belirleyici olabilir ancak preeklampsinin fizyopatolojisinde Angiopoietin-ilişkili büyüme faktörün’ün fizyolojik rolünün açıklanması için başka çalışmalarada ihtiyaç vardır.
Anahtar sözcükler: Angiopoietin-ilişkili büyüme faktörü, preeklampsi
Keywords
References
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- Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005; 365: 785-99.
- Verlohren S, Stepan H, Dechend R. Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia. Clin Sci (Lond) 2012; 122: 43-52.
- Oike Y, Tabata M. Angiopoietin-like proteins--potential therapeutic targets for metabolic syndrome and cardiovascular disease. Circ J 2009; 73: 2192-7.
- Oike Y, Yasunaga K, Suda T. Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis. Int J Hematol 2004; 80: 21-8.
- Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med 2005; 11: 400-8.
- Kadomatsu T, Tabata M, Oike Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. FEBS J 2011; 278: 559- 64.
- Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183: S1-S22.
- Radikova Z, Koska J, Huckova M, Ksinantova L, Imrich R, Vigas M, Trnovec T, Langer P, Sebokova E, Klimes I. Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects. Exp Clin Endocrinol Diabetes 2006; 114: 249-56.
- Oike Y, Ito Y, Maekawa H, Morisada T, Kubota Y, Akao M, Urano T, Yasunaga K, Suda T. Angiopoietin-related growth factor (AGF) promotes angiogenesis. Blood 2004; 103: 3760-5.
- Oike Y, Yasunaga K, Ito Y, Matsumoto S, Maekawa H, Morisada T, Arai F, Nakagata N, Takeya M, Masuho Y, Suda T. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc Natl Acad Sci USA 2003; 100: 9494-9.
- Stepan H, Ebert T, Schrey S, Reisenbüchler C, Stein S, Lossner U, Bluher M, Stumvoll M, Kratzsch J, Faber R, Fasshauer M. Serum levels of angiopoietin- related growth factor are increased in preeclampsia. Am J Hypertens 2009; 22: 314-8.
- Stepan H, Unversucht A, Wessel N, Faber R. Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension 2007; 49: 818-24.
- Namkung J, Koh SB, Kong ID, Choi JW, Yeh BI. Serum levels of angiopoietin- related growth factor are increased in metabolic syndrome. Metabolism 2011; 60: 564-8.
Abstract
Amaç.Angiopoietin-ilişkili büyüme faktörü anjiogenez ile ilişkilidir fakat glukoz ve enerji metabolizmasınıda etkileyebilmektedir. Bu çalışmanın amacı preeklampside Angiopoietin-ilişkili büyüme faktörünün serum seviyelerinin belirlenmesidir. Yöntem. Çalışma 32 preeklampsili kadın (preeklampsi grubu) ve 32 sağlıklı 3. trimesterde gebe kadın (Kontrol grubu) ile yapıldı. Tüm olgularda, Angiopoietin-ilişkili büyüme faktörünün serum seviyeleri ile birlikte diğer biyokimyasal veAngiopoietin-ilişkili büyüme faktörünün serum seviyeleri (98,6ng/mL) kontrol grubundan (52,2 ng/mL) anlamlı yüksekti (p-değeri
References
- Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 2001; 20: IX-XIV.
- Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005; 365: 785-99.
- Verlohren S, Stepan H, Dechend R. Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia. Clin Sci (Lond) 2012; 122: 43-52.
- Oike Y, Tabata M. Angiopoietin-like proteins--potential therapeutic targets for metabolic syndrome and cardiovascular disease. Circ J 2009; 73: 2192-7.
- Oike Y, Yasunaga K, Suda T. Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis. Int J Hematol 2004; 80: 21-8.
- Oike Y, Akao M, Yasunaga K, Yamauchi T, Morisada T, Ito Y, Urano T, Kimura Y, Kubota Y, Maekawa H, Miyamoto T, Miyata K, Matsumoto S, Sakai J, Nakagata N, Takeya M, Koseki H, Ogawa Y, Kadowaki T, Suda T. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med 2005; 11: 400-8.
- Kadomatsu T, Tabata M, Oike Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. FEBS J 2011; 278: 559- 64.
- Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183: S1-S22.
- Radikova Z, Koska J, Huckova M, Ksinantova L, Imrich R, Vigas M, Trnovec T, Langer P, Sebokova E, Klimes I. Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects. Exp Clin Endocrinol Diabetes 2006; 114: 249-56.
- Oike Y, Ito Y, Maekawa H, Morisada T, Kubota Y, Akao M, Urano T, Yasunaga K, Suda T. Angiopoietin-related growth factor (AGF) promotes angiogenesis. Blood 2004; 103: 3760-5.
- Oike Y, Yasunaga K, Ito Y, Matsumoto S, Maekawa H, Morisada T, Arai F, Nakagata N, Takeya M, Masuho Y, Suda T. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc Natl Acad Sci USA 2003; 100: 9494-9.
- Stepan H, Ebert T, Schrey S, Reisenbüchler C, Stein S, Lossner U, Bluher M, Stumvoll M, Kratzsch J, Faber R, Fasshauer M. Serum levels of angiopoietin- related growth factor are increased in preeclampsia. Am J Hypertens 2009; 22: 314-8.
- Stepan H, Unversucht A, Wessel N, Faber R. Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension 2007; 49: 818-24.
- Namkung J, Koh SB, Kong ID, Choi JW, Yeh BI. Serum levels of angiopoietin- related growth factor are increased in metabolic syndrome. Metabolism 2011; 60: 564-8.
Details
| Primary Language | English |
|---|---|
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Publication Date | March 27, 2012 |
| Published in Issue | Year 2012Volume: 34 Issue: 1 |