A tumor-like trophoblastic lesion (placental site nodule)
Abstract
Abstract
Placental site nodule, developing from intermediate trophoblasts, is a rare benign lesion. Although it is a benign lesion, it’s histopathological differential diagnosis from placental site trophoblastic tumor and epithelioid trophoblastic tumor which are aggressive lesions of the intermediate trophoblasts, and non-trophoblastic neoplasms such as squamous cell carcinoma, is important due to its histological appearance. In our report, placental site nodule diagnosed in 33-year-old, female patient who was suffering from intermittant menometrorrhagia and had a diagnostic curettage is presented.
Keywords: Placental site nodule, intermediate trophoblasts, abnormal uterine bleeding
Özet
Plasental bölge nodülü intermediate trofoblastlardan gelişen nadir görülen benign bir lezyondur.Benign bir lezyon olmasına rağmen histolojik görünümü nedeniyle intermediate trofoblastların agresif lezyonları olan plasental bölge neoplastik tümörü ve epiteloid trofoblastik tümör ile skuamoz hücreli karsinom gibi trofoblastik olmayan neoplazilerden histopatolojik ayrımı önemlidir.Bu makalede intermitan menometroraji şikayeti ile başvurup tanısal küretaj yapılan ve plasental bölge nodülü tanısı alan 33 yaşında bir bayan hasta sunulmuştur.
Anahtar sözcükler: Plasental bölge nodülü, intermediate trofoblastlar, anormal uterin kanama
Keywords
References
- Jacob S, Mohapatra D. Placental site nodule: a tumor-like trophoblastic lesion. Indian J Pathol Microbiol 2009; 52: 240-1.
- O'Neill CJ, Cook I, McCluggage WG. Postcesarean delivery uterine diffuse intermediate trophoblastic lesion resembling placental site plaque. Hum Pathol 2009; 40: 1358-60.
- Shih IM, Kurman RJ. The pathology of intermediate trophoblastic tumors and tumor-like lesions. Int J Gynecol Pathol 2001; 20: 31-47.
- Young RH, Kurman RJ, Scully RE. Placental site nodules and plaques. A clinicopathologic analysis of 20 cases. Am J Surg Pathol 1990; 14: 1001-9.
- Huettner PC, Gersell DJ. Placental site nodule: a clinicopathologic study of 38 cases. Int J Gynecol Pathol 1994; 13: 191-8.
- Stolnicu S, Radulescu D, González-Rocha T, Timar I, Puscasiu L, Nogales FF. Exaggerated placental site lesion with unusual presentation in the cervix of a perimenopausal patient. APMIS 2008; 116:160-2.
- Kurman RJ. The morphology, biology, and pathology of intermediate trophoblast: a look back to the present. Hum Pathol 1991; 22: 847-55.
- Shih IM, Seidman JD, Kurman RJ. Placental site nodule and characterization of distinctive types of intermediate trophoblast. Hum Pathol 1999; 30: 687-94.
Details
Primary Language
English
Subjects
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Journal Section
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Publication Date
June 21, 2012
Submission Date
May 18, 2011
Acceptance Date
-
Published in Issue
Year 2012 Volume: 34 Number: 2